Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles

Name: Work Video:
Duration: 3 min 30 s
Claudia Verderio; Martina Gabrielli; Paola Giussani
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'https://openalex.org/W2618283910', 'https://openalex.org/W2619210033', 'https://openalex.org/W2623047193', 'https://openalex.org/W2726430797', 'https://openalex.org/W2745137260', 'https://openalex.org/W2748556198', 'https://openalex.org/W2751240956', 'https://openalex.org/W2751562530', 'https://openalex.org/W2755312835', 'https://openalex.org/W2756069931', 'https://openalex.org/W2758269250', 'https://openalex.org/W2760727189', 'https://openalex.org/W2769383666', 'https://openalex.org/W2770101249', 'https://openalex.org/W2770931140', 'https://openalex.org/W2774942753', 'https://openalex.org/W2783897659', 'https://openalex.org/W2787095062', 'https://openalex.org/W2790407668', 'https://openalex.org/W2790631595', 'https://openalex.org/W2792514959'], 'related_works': ['https://openalex.org/W4381617892', 'https://openalex.org/W4378176405', 'https://openalex.org/W4296993023', 'https://openalex.org/W4224608758', 'https://openalex.org/W4224325546', 'https://openalex.org/W3188041304', 'https://openalex.org/W2890709780', 'https://openalex.org/W2560295122', 'https://openalex.org/W2247699313', 'https://openalex.org/W2004257346'], 'abstract_inverted_index': {'Extracellular': [0, 172, 344, 1201, 1228], 'vesicles': [1, 5, 173, 177, 345, 349, 425, 484, 548, 959, 1143, 1176, 1202, 1229, 3222, 3299, 3326, 3330, 3384, 3514, 3589, 3622], '(EVs)': [2, 174, 346], 'are': [3, 41, 175, 213, 347, 396, 508, 715, 735, 742, 761, 960, 1411, 1441, 1622, 1856, 1880, 1931, 2069, 2114, 3332], 'membrane': [4, 95, 128, 176, 267, 300, 348, 424, 483, 514, 531, 540, 568, 669, 1420, 1863, 2528, 2543, 2570, 2573, 2663, 2912, 2980, 3036, 3044, 3085, 3184, 3206, 3215, 3225, 3531, 3545, 3614], 'released': [6, 178, 350, 1062, 3333, 3643], 'by': [7, 93, 115, 164, 179, 265, 287, 336, 351, 453, 622, 696, 744, 1260, 1611, 1624, 1659, 1882, 2015, 2049, 2058, 2074, 2278, 2699, 2887, 3003, 3073, 3157, 3180, 3207, 3245, 3268, 3272, 3428, 3837, 3974, 4152], 'both': [8, 180, 352, 510, 561, 1325], 'eukaryotic': [9, 49, 181, 221, 353, 505], 'and': [10, 32, 51, 68, 74, 97, 112, 129, 145, 150, 182, 204, 223, 240, 246, 269, 284, 301, 317, 322, 354, 360, 364, 376, 402, 430, 457, 489, 549, 563, 582, 657, 666, 741, 804, 829, 859, 906, 912, 926, 1054, 1058, 1112, 1144, 1165, 1247, 1263, 1272, 1322, 1327, 1330, 1347, 1366, 1392, 1399, 1403, 1421, 1438, 1466, 1484, 1579, 1657, 1704, 1822, 1827, 1864, 1912, 1936, 1960, 1984, 1991, 1995, 2097, 2128, 2136, 2153, 2183, 2244, 2294, 2335, 2406, 2416, 2422, 2444, 2462, 2472, 2481, 2483, 2499, 2530, 2571, 2591, 2598, 2697, 2746, 2759, 2768, 2793, 2802, 2807, 2846, 2884, 2911, 2923, 2946, 2955, 3000, 3031, 3087, 3126, 3187, 3198, 3217, 3317, 3421, 3439, 3442, 3449, 3480, 3533, 3555, 3617, 3669, 3736, 3759, 3878, 3932, 4020, 4038, 4063, 4089, 4193], 'prokaryotic': [11, 183, 355], 'cells;': [12, 184], 'they': [13, 99, 185, 271, 2121], 'not': [14, 77, 186, 249, 1017, 1428], 'only': [15, 187, 1018, 1429], 'serve': [16, 188, 1019], 'physiological': [17, 189, 1021, 1146], 'functions,': [18, 190, 1022], 'such': [19, 142, 191, 314, 357, 1023, 1457], 'as': [20, 143, 192, 315, 358, 763, 1024, 1050, 1257, 1447, 1458, 1588, 1681, 2418, 2420, 2737, 3334], 'disposal': [21, 193, 1113], 'of': [22, 53, 65, 123, 139, 161, 194, 225, 237, 295, 311, 333, 383, 423, 448, 459, 482, 537, 541, 552, 570, 592, 616, 694, 759, 765, 832, 857, 865, 934, 1098, 1114, 1141, 1174, 1249, 1274, 1288, 1295, 1304, 1307, 1311, 1349, 1368, 1389, 1401, 1414, 1454, 1482, 1507, 1552, 1606, 1669, 1675, 1697, 1722, 1733, 1753, 1765, 1809, 1815, 1842, 1845, 1854, 1870, 1876, 1926, 1997, 2031, 2052, 2061, 2077, 2149, 2173, 2191, 2269, 2316, 2372, 2400, 2408, 2413, 2442, 2452, 2535, 2566, 2584, 2626, 2649, 2677, 2702, 2706, 2721, 2762, 2805, 2841, 2949, 2970, 2978, 3089, 3096, 3120, 3154, 3177, 3214, 3220, 3229, 3242, 3297, 3324, 3347, 3382, 3408, 3416, 3423, 3436, 3458, 3468, 3474, 3482, 3512, 3540, 3552, 3587, 3606, 3615, 3620, 3641, 3672, 3693, 3697, 3715, 3762, 3802, 3835, 3886, 3930, 3934, 4066, 4091, 4097, 4134], 'cellular': [23, 195, 462, 1116, 1455, 1573], 'components,': [24, 196], 'but': [25, 197, 1158, 1432], 'also': [26, 198, 516, 1159, 1433, 1658, 2735, 2785, 2862], 'play': [27, 199, 1160, 3080], 'pathophysiologic': [28, 200], 'roles': [29, 201, 1162, 1431, 1994], 'in': [30, 43, 81, 90, 104, 147, 166, 169, 202, 215, 253, 262, 276, 319, 338, 341, 373, 399, 504, 588, 721, 739, 1163, 1177, 1203, 1230, 1298, 1324, 1396, 1417, 1487, 1549, 1702, 1712, 1794, 1849, 1858, 1909, 2023, 2094, 2116, 2134, 2220, 2241, 2272, 2332, 2403, 2425, 2458, 2488, 2502, 2551, 2563, 2672, 2881, 2893, 2997, 3009, 3029, 3056, 3084, 3266, 3321, 3352, 3405, 3418, 3477, 3548, 3626, 3665, 3677, 3742, 3764, 3889, 4059, 4071, 4084, 4086, 4120, 4129, 4156, 4196], 'inflammatory': [31, 203, 1164, 1467, 1553], 'degenerative': [33, 205, 1166], 'diseases.': [34, 206], 'Common': [35, 207], 'molecular': [36, 208, 403, 2447, 2678], 'mechanisms': [37, 209, 1996, 2448, 3346, 3758], 'for': [38, 60, 210, 232, 1317, 1941, 2028, 2045, 2432, 2542, 3530], 'EV': [39, 72, 91, 102, 148, 211, 244, 263, 274, 320, 1289], 'biogenesis': [40, 55, 73, 92, 122, 212, 227, 245, 264, 294, 1246, 1273, 1290, 1329, 1348, 1398, 3323, 3420, 3539], 'evident': [42, 214], 'different': [44, 216], 'cell': [45, 217, 1006, 1459, 1464, 1609, 2145, 2150, 2275, 2375, 2552, 2588, 2596, 2600, 2673, 3043, 3097, 3355, 3633], 'biological': [46, 159, 218, 331, 431, 490, 2503], 'contexts': [47, 219], 'across': [48, 220], 'phyla,': [50, 222], 'inhibition': [52, 224, 3933], 'this': [54, 226, 1871, 2389, 3486], 'may': [56, 228, 1251, 1643], 'provide': [57, 229, 913], 'an': [58, 230, 667, 1046, 1051, 1253, 1660, 1685, 2466, 2675, 3353, 3434], 'avenue': [59, 231], 'therapeutic': [61, 233, 1255, 2433], 'research.': [62, 83, 234, 255], 'The': [63, 235, 1172, 1286, 1805, 1874, 1905, 2090, 2108, 2237, 3414, 3603, 3660, 3709, 4054], 'involvement': [64, 138, 236, 310, 1388, 3473], 'sphingolipids': [66, 238, 1390], '(SLs)': [67, 239, 1391], 'their': [69, 241, 770, 806, 1145, 1393, 3556], 'enzymes': [70, 242, 1395, 1847, 1884, 2402, 2428, 2707], 'on': [71, 243, 716, 1210, 1386, 1866, 2397, 2438, 2476, 2587, 3032, 3182], 'release': [75, 247, 372, 447, 1248, 1400, 2407, 3088, 3422, 3452, 3739], 'has': [76, 248, 1291, 1406, 2538, 2652, 2926], 'received': [78, 250, 1407], 'much': [79, 251], 'attention': [80, 252], 'current': [82, 254, 2395, 2423], 'Here,': [84, 256, 1383], 'we': [85, 108, 154, 257, 280, 326, 1332, 1384, 2391], 'review': [86, 258], 'how': [87, 98, 110, 259, 270, 282], 'SLs': [88, 260, 1410, 1444, 1621, 1642, 1699, 1711, 1724, 1810, 3549], 'participate': [89, 261, 2133, 3320], 'shaping': [94, 266], 'curvature': [96, 268, 2660, 2671, 3611], 'contribute': [100, 272], 'to': [101, 273, 545, 620, 726, 730, 769, 772, 800, 927, 1335, 1558, 1637, 1665, 1684, 1688, 1738, 1819, 1887, 1934, 1982, 2019, 2054, 2063, 2454, 2525, 2661, 2743, 2790, 2929, 3041, 3079, 3114, 3160, 3248, 3612, 3808, 3971, 3985], 'action': [103, 275, 2399, 2701], 'target': [105, 277, 2459], 'cells.': [106, 171, 278, 343, 572, 1713, 2460], 'First,': [107, 279], 'describe': [109, 281], 'acid': [111, 283, 1633, 1663, 2082, 3023], 'neutral': [113, 285, 1992, 2295, 2763, 2810, 2842, 2878, 2950, 2994, 3710], 'SMases,': [114, 286, 2703], 'generating': [116, 288], 'the': [117, 126, 131, 137, 289, 298, 303, 309, 446, 460, 512, 534, 538, 542, 550, 555, 566, 589, 593, 929, 1245, 1299, 1305, 1312, 1387, 1397, 1418, 1442, 1550, 1638, 1647, 1666, 1670, 1694, 1708, 1813, 1830, 1839, 1846, 1850, 1859, 1867, 1877, 1888, 1891, 1924, 1942, 2029, 2032, 2038, 2050, 2059, 2075, 2117, 2398, 2404, 2409, 2439, 2446, 2450, 2477, 2489, 2518, 2527, 2569, 2595, 2599, 2662, 2700, 2744, 2766, 2769, 2791, 2888, 2932, 2953, 2956, 2975, 2979, 3004, 3033, 3042, 3093, 3117, 3174, 3210, 3224, 3227, 3230, 3269, 3329, 3340, 3419, 3459, 3463, 3472, 3475, 3478, 3613, 3639, 3666, 3698, 3716, 4060, 4087, 4101, 4130, 4153, 4197], 'constitutive': [118, 290], 'SL,': [119, 291, 2035], 'ceramide,': [120, 292], 'facilitate': [121, 293], 'EVs': [124, 162, 296, 334, 395, 450, 507, 714, 760, 1016, 1250, 2414, 2443, 2453], 'at': [125, 157, 297, 329, 511, 746, 1422, 1646, 2974, 3544], 'plasma': [127, 299, 513, 556, 1419, 2118, 2770, 2858, 2957, 3035, 3341], 'inside': [130, 302, 524, 3327, 3623], 'endocytic': [132, 304], 'compartment.': [133, 305], 'We': [134, 306, 2435], 'then': [135, 307, 1836, 2436], 'discuss': [136, 308, 2445], 'other': [140, 312, 1337, 2039, 2129, 2484], 'SLs,': [141, 313, 1630, 1928, 2113], 'sphingosine-1-phosphate': [144, 316, 1439], 'galactosyl-sphingosine,': [146, 318], 'formation': [149, 321, 1841, 2405, 3213, 3319, 3479, 3551, 3619], 'cargo': [151, 323, 3349], 'sorting.': [152, 324], 'Last,': [153, 325], 'look': [155, 327], 'ahead': [156, 328], 'some': [158, 330], 'effects': [160, 332], 'mediated': [163, 335], 'changes': [165, 337], 'SL': [167, 339, 2166, 2440, 2456], 'levels': [168, 340, 1581], 'recipient': [170, 342], 'cells,': [356, 506], 'Gram-positive': [359], '-negative': [361], 'bacteria,': [362, 374], 'mycobacteria,': [363], 'Archaea': [365], '(1.Deatherage': [366], 'B.L.': [367], 'Cookson': [368], 'B.T.': [369], 'Membrane': [370, 2670, 3070], 'vesicle': [371, 594, 3564], 'eukaryotes,': [375], 'archaea:': [377], 'a': [378, 428, 487, 559, 662, 862, 1293, 1412, 1451, 1625, 1631, 1652, 1676, 1689, 1757, 2016, 2043, 2070, 2369, 2523, 2539, 2630, 2653, 2658, 2704, 3081, 3203, 3208, 3406, 3527, 3982, 4094], 'conserved': [379], 'yet': [380], 'underappreciated': [381, 830], 'aspect': [382], 'microbial': [384, 2179], 'life.Infect.': [385], 'Immun.': [386], '2012;': [387, 3841, 3895], '80:': [388], '1948-1957Crossref': [389], 'PubMed': [390, 440, 499, 629, 675, 707, 811, 838, 875, 921, 972, 1011, 1070, 1107, 1153, 1186, 1219, 1238, 1281, 1356, 1378, 1497, 1521, 1566, 1616, 1746, 1779, 1800, 1918, 1949, 1973, 2004, 2103, 2159, 2205, 2226, 2250, 2285, 2302, 2323, 2342, 2383, 2508, 2557, 2607, 2642, 2685, 2728, 2777, 2822, 2854, 2902, 2918, 2964, 3018, 3065, 3135, 3168, 3256, 3306, 3391, 3521, 3596, 3684, 3731, 3777, 3815, 3849, 3903, 3944, 3993, 4033, 4078, 4141], 'Scopus': [391, 441, 500, 630, 676, 708, 812, 839, 876, 922, 973, 1012, 1071, 1108, 1154, 1187, 1220, 1239, 1282, 1357, 1379, 1498, 1522, 1567, 1617, 1747, 1780, 1801, 1919, 1950, 1974, 2005, 2104, 2160, 2206, 2227, 2251, 2324, 2343, 2384, 2509, 2558, 2643, 2686, 2778, 2823, 2919, 2965, 3066, 3136, 3169, 3257, 3307, 3392, 3522, 3597, 3685, 3732, 3778, 3816, 3850, 3904, 3945, 3994, 4034, 4079, 4142], '(327)': [392], 'Google': [393, 443, 502, 632, 678, 710, 814, 841, 878, 924, 975, 1014, 1073, 1110, 1156, 1189, 1222, 1241, 1284, 1359, 1381, 1500, 1524, 1569, 1619, 1749, 1782, 1803, 1921, 1952, 1976, 2007, 2106, 2162, 2208, 2229, 2253, 2286, 2303, 2326, 2345, 2386, 2511, 2560, 2608, 2645, 2688, 2729, 2780, 2825, 2855, 2903, 2921, 2967, 3019, 3068, 3138, 3171, 3259, 3309, 3394, 3524, 3599, 3687, 3734, 3780, 3818, 3852, 3906, 3947, 3996, 4036, 4081, 4144], 'Scholar).': [394, 444, 711, 1015, 1242, 1285, 1382, 1570, 1620, 1804, 1922, 2008, 2107, 2163, 2387, 2512, 2730, 2856, 2968, 3020, 3069, 3139, 3260, 4082, 4145], 'highly': [397], 'heterogeneous': [398], 'size,': [400, 722], 'structure,': [401, 2655], 'content': [404, 2441], '(2.Dauros': [405, 464], 'Singorenko': [406, 465], 'P.': [407, 466, 605, 1192, 1470, 1476, 1545, 1789, 2215, 2260, 2354, 3102, 3289, 3374, 3504, 3579], 'Chang': [408, 467], 'V.': [409, 468, 986], 'Whitcombe': [410, 469], 'A.': [411, 417, 470, 476, 681, 691, 778, 823, 848, 984, 1537, 2308, 2310, 2908, 3797, 3866], 'Simonov': [412, 471], 'D.': [413, 472, 596, 601, 1078, 1531, 2749, 2755, 2936, 2942, 3285, 3370, 3500, 3575], 'Hong': [414, 473], 'J.': [415, 474, 671, 782, 790, 817, 881, 982, 1082, 1137, 1213, 1268, 1343, 1491, 1902, 1945, 2087, 2234, 2256, 2615, 2753, 2898, 2940, 3014, 3108, 3659, 3918, 3961, 4053, 4170, 4176], 'Phillips': [416, 475], 'Swift': [418, 477], 'S.': [419, 478, 639, 641, 886, 1028, 1084, 1092, 1602, 1604, 1939, 1955, 2312, 2580, 2582, 2796, 2838, 3281, 3366, 3496, 3571, 3791, 3827, 3912, 3914, 3926, 4111], 'Blenkiron': [420, 479], 'C.': [421, 480, 637, 653, 946, 1076, 1169, 1200, 1266, 1270, 1341, 1345, 1472, 2262, 2264, 3279, 3364, 3494, 3569, 3787, 3789, 3864, 3955, 4172], 'Isolation': [422, 481], 'from': [426, 485, 618, 724, 1512, 1717, 1736, 1770, 1897, 2196, 2568, 3123, 3223, 3644, 3805], 'prokaryotes:': [427, 486], 'technical': [429, 488], 'comparison': [432, 491], 'reveals': [433, 492], 'heterogeneity.J.': [434, 493], 'Extracell.': [435, 494, 1148], 'Vesicles.': [436, 495, 1149], '2017;': [437, 496, 969, 1183, 1278, 1353], '6:': [438, 497], '1324731Crossref': [439, 498], '(29)': [442, 501, 3686, 4080], 'While': [445, 3343], 'bacterial': [449, 1559], 'is': [451, 861, 1045, 1582, 1586, 1634, 1693, 1835, 1895, 1980, 2042, 2368, 2522, 2693, 2788, 2885, 2972, 3001, 3027, 3663, 4057, 4122], 'predominantly': [452], 'direct': [454], 'outward': [455], '"blebbing"': [456], 'pinching': [458], 'external': [461], 'membranes': [463, 2464], 'Scholar)': [503, 925, 1111, 2689, 3172, 3395, 3525, 3600, 3735], 'generated': [509], '[ectosomes,': [515], 'called': [517, 2786], 'shed': [518, 1275, 1350], 'microparticles': [519, 798], 'or': [520, 523, 1207, 1751, 2057, 2079, 2430, 2712, 3690], 'microvesicles': [521, 903], '(MVs)]': [522], 'multivesicular': [525, 543, 3301, 3386, 3516, 3591], 'bodies': [526, 3091], '(MVBs)': [527], '(exosomes)': [528], 'through': [529, 1756, 2147, 3550, 3981], 'two': [530, 2410, 3443], 'inversion': [532], 'processes:': [533], 'inward': [535, 3563], 'budding': [536, 3296, 3381, 3511, 3565, 3586], 'limiting': [539], 'endosome': [544], 'form': [546, 1820], 'intraluminal': [547, 3325], 'fusion': [551, 3040, 3338], 'MVBs': [553], 'with': [554, 750, 964, 1651, 1812, 1817, 1838, 2111, 2123, 2171, 2470, 2629, 3202, 3339, 3432, 3461, 3875, 4124, 4160], 'membrane.': [557, 3342], 'As': [558], 'result,': [560], 'ectosomes': [562, 751, 1402], 'exosomes': [564, 617, 660, 720, 734, 1002, 1099, 3335, 3351, 3409, 3425, 3542, 3642, 3702, 3804, 3873, 3976, 4016], 'have': [565, 583, 1427, 2168, 2861], 'same': [567, 4154], 'topology': [569], 'donor': [571], 'However,': [573, 2857], 'EVs,': [574], 'especially': [575], 'ectosomes,': [576], 'often': [577], 'lose': [578], 'transmembrane': [579], 'lipid': [580, 664, 1509, 1767, 2193, 2468, 2485, 2520, 3183], 'asymmetry': [581, 2498], 'phosphatidylserine': [584], '(PS)': [585], 'residues': [586, 2083], 'externalized': [587], 'outer': [590, 3034], 'leaflet': [591, 2490, 2977, 3037], '(3.Fitzner': [595], 'Schnaars': [597], 'M.': [598, 607, 613, 780, 784, 819, 850, 892, 954, 1034, 1040, 1119, 1364, 1533, 2358, 2798, 2834, 3293, 3378, 3508, 3583, 3655, 3785, 3858, 3868, 3916, 3959, 4049], 'van': [599, 884, 3109], 'Rossum': [600], 'Krishnamoorthy': [602], 'G.': [603, 1032, 1535, 1539, 1594, 1785, 2211, 2578, 3856, 3862, 4113, 4115, 4174], 'Dibaj': [604], 'Bakhti': [606], 'Regen': [608], 'T.': [609, 647, 883, 942, 988, 992, 1225, 1362, 2876, 2992, 3104, 3756, 3920, 3928], 'Hanisch': [610], 'U.K.': [611], 'Simons': [612, 3292, 3377, 3507, 3582], 'Selective': [614], 'transfer': [615, 773, 856, 1097, 3761, 3801, 3969], 'oligodendrocytes': [619], 'microglia': [621, 3908, 3931], 'macropinocytosis.J.': [623], 'Cell': [624, 870, 916, 1372, 1516, 1774, 1963, 1999, 2200, 2680, 2849, 3130], 'Sci.': [625, 1215, 1493, 2850, 3061], '2011;': [626, 1067, 3062, 3812], '124:': [627, 3166, 3254], '447-458Crossref': [628], '(436)': [631], 'Scholar,': [633, 679, 815, 842, 879, 976, 1074, 1190, 1223, 1360, 1501, 1525, 1783, 1953, 2209, 2230, 2254, 2287, 2304, 2327, 2346, 2609, 2826, 2904], '4.Laulagnier': [634], 'K.': [635, 846, 1131, 1900, 2085, 2232, 2306, 2546, 2830, 3277, 3362, 3492, 3567, 3823], 'Motta': [636], 'Hamdi': [638], 'Roy': [640], 'Fauvelle': [642], 'F.': [643, 821, 1030, 1036, 1038, 1088, 1135, 2364, 2667, 3287, 3372, 3502, 3577, 3752, 3793, 3799], 'Pageaux': [644], 'J.F.': [645], 'Kobayashi': [646, 2833], 'Salles': [648], 'J.P.': [649, 2576, 3046], 'Perret': [650], 'B.': [651, 1478, 1596, 2329, 2352, 3291, 3376, 3506, 3581, 3922, 4008], 'Bonnerot': [652], 'et': [654, 957, 998, 1095, 1138, 1546, 3143, 3274, 3359, 3489], 'al.Mast': [655], 'cell-': [656], 'dendritic': [658, 3972], 'cell-derived': [659], 'display': [661, 2465], 'specific': [663], 'composition': [665, 2521], 'unusual': [668], 'organization.Biochem.': [670], '2004;': [672, 2001, 2505], '380:': [673], '161-171Crossref': [674], '(0)': [677, 1155], '5.MacKenzie': [680], 'Wilson': [682], 'H.L.': [683], 'Kiss-Toth': [684], 'E.': [685, 940, 1133, 1527, 2360, 2548, 2717, 3870, 4012, 4117, 4185], 'Dower': [686], 'S.K.': [687], 'North': [688], 'R.A.': [689], 'Surprenant': [690], 'Rapid': [692], 'secretion': [693, 3481, 3832], 'interleukin-1beta': [695], 'microvesicle': [697], 'shedding.Immunity.': [698], '2001;': [699, 808, 2851, 2899, 3015], '15:': [700, 1495], '825-835Abstract': [701], 'Full': [702, 704, 1968, 1970, 2637, 2639, 2817, 2819, 3726, 3728, 3772, 3774, 3844, 3846, 3898, 3900, 4028, 4030], 'Text': [703, 705, 1969, 1971, 2638, 2640, 2818, 2820, 3727, 3729, 3773, 3775, 3845, 3847, 3899, 3901, 4029, 4031], 'PDF': [706, 1972, 2641, 2821, 3730, 3776, 3848, 3902, 4032], '(642)': [709], 'Plasma': [712, 2461], 'membrane-derived': [713], 'average': [717], 'larger': [718, 3559], 'than': [719, 3403], 'ranging': [723], '100': [725], '300': [727], 'nm': [728, 738], 'up': [729], '1': [731, 3438], 'μm,': [732], 'while': [733, 1978, 2647, 2782, 3631], 'generally': [736], '30–100': [737], 'diameter': [740], 'isolated': [743], 'centrifugation': [745], 'higher': [747], 'speeds': [748], 'compared': [749], '(100,000': [752], 'g': [753], 'vs.': [754], '10,000': [755], 'g).': [756], 'Both': [757], 'types': [758, 2412], 'recognized': [762], 'mediators': [764, 831], 'cell-to-cell': [766, 833], 'communication': [767], 'due': [768], 'ability': [771], 'biomolecules': [774], 'among': [775, 3740], 'cells': [776, 803, 3431, 3460, 3647, 3676, 3744, 3783, 3807, 3821, 3973, 4041, 4070], '(6.Janowska-Wieczorek': [777], 'Majka': [779], 'Kijowski': [781], 'Baj-Krzyworzeka': [783], 'Reca': [785], 'R.': [786, 1042, 1196, 1198, 1227, 1543, 1787, 2213, 2496, 2719, 2874, 2990], 'Turner': [787], 'A.R.': [788], 'Ratajczak': [789, 795, 824], 'Emerson': [791], 'S.G.': [792], 'Kowalska': [793], 'M.A.': [794, 3795], 'M.Z.': [796, 825], 'Platelet-derived': [797], 'bind': [799], 'hematopoietic': [801], 'stem/progenitor': [802], 'enhance': [805, 3986], 'engraftment.Blood.': [807], '98:': [809], '3143-3149Crossref': [810], '(251)': [813, 2006], '7.Ratajczak': [816], 'Wysoczynski': [818], 'Hayek': [820], 'Janowska-Wieczorek': [822], 'Membrane-derived': [826], 'microvesicles:': [827], 'important': [828, 1254], 'communication.Leukemia.': [834], '2006;': [835], '20:': [836, 1916, 2101, 2248], '1487-1495Crossref': [837], '(923)': [840], '8.Valadi': [843], 'H.': [844, 978, 2267, 2314, 3150, 3238, 3748, 3825, 3910, 3963, 3967, 4000], 'Ekstrom': [845], 'Bossios': [847], 'Sjostrand': [849], 'Lee': [851], 'J.J.': [852], 'Lotvall': [853], 'J.O.': [854], 'Exosome-mediated': [855], 'mRNAs': [858], 'microRNAs': [860, 3763], 'novel': [863], 'mechanism': [864, 1287, 3529, 3885], 'genetic': [866, 3691], 'exchange': [867], 'between': [868, 1577, 2594, 2765, 2952], 'cells.Nat.': [869, 3810], 'Biol.': [871, 917, 968, 1103, 1374, 1517, 1562, 1742, 1775, 1964, 2000, 2201, 2632, 2681, 2812, 3131, 3721, 3767, 3839, 3893], '2007;': [872], '9:': [873, 1519, 1777, 2203], '654-659Crossref': [874], '(6850)': [877], '9.Skog': [880], 'Wurdinger': [882], 'Rijn': [885], 'Meijer': [887], 'D.H.': [888], 'Gainche': [889], 'L.': [890, 948, 980, 1194, 1474, 1791, 2217, 2258, 3283, 3368, 3498, 3573, 3957, 4006], 'Sena-Esteves': [891], 'Curry': [893], 'Jr.,': [894, 4182], 'W.T.': [895], 'Carter': [896], 'B.S.': [897], 'Krichevsky': [898], 'A.M.': [899, 2613], 'Breakefield': [900], 'X.O.': [901], 'Glioblastoma': [902], 'transport': [904, 1318, 2761, 2948], 'RNA': [905], 'proteins': [907], 'that': [908, 1445, 1879, 2132, 2516, 2708, 3314, 3331, 3397, 3538], 'promote': [909, 2455, 3562], 'tumour': [910, 2894, 3010], 'growth': [911, 2124], 'diagnostic': [914], 'biomarkers.Nat.': [915], '2008;': [918, 1518, 1776, 1915, 2100, 2202, 2247, 3303, 3388, 3518, 3593], '10:': [919], '1470-1476Crossref': [920], '(3019)': [923], 'influence': [928], 'extracellular': [930, 1142, 1175, 1370], 'microenvironment': [931, 1000], 'via': [932, 1063, 2931, 4022], 'regulation': [933, 1551], 'critical': [935], 'nutrients': [936], '(10.Iraci': [937], 'N.': [938, 1529, 1987, 2832, 2868, 2984, 3746], 'Gaude': [939], 'Leonardi': [941], 'Costa': [943], 'A.S.H.': [944], 'Cossetti': [945], 'Peruzzotti-Jametti': [947], 'Bernstock': [949], 'J.D.': [950], 'Saini': [951], 'H.K.': [952], 'Gelati': [953], 'Vescovi': [955], 'A.L.': [956], 'al.Extracellular': [958], 'independent': [961], 'metabolic': [962, 1394], 'units': [963], 'asparaginase': [965], 'activity.Nat.': [966], 'Chem.': [967, 2633, 2813, 3163, 3251, 3722, 3768, 3840, 3894], '13:': [970], '951-955Crossref': [971], '(49)': [974], '11.Zhao': [977], 'Yang': [979, 3954], 'Baddour': [981], 'Achreja': [983], 'Bernard': [985], 'Moss': [987], 'Marini': [989], 'J.C.': [990], 'Tudawe': [991], 'Seviour': [993], 'E.G.': [994], 'San': [995], 'Lucas': [996], 'F.A.': [997], 'al.Tumor': [999], 'derived': [1001], 'pleiotropically': [1003], 'modulate': [1004], 'cancer': [1005, 1488, 2333], 'metabolism.eLife.': [1007], '2016;': [1008, 2320, 2380, 2682, 3990, 4025], '5:': [1009, 2506], 'e10250Crossref': [1010], '(344)': [1013], 'several': [1020, 2165, 2174], 'neurotrophic': [1025], 'support': [1026], '(12.Wang': [1027], 'Cesca': [1029], 'Loers': [1031], 'Schweizer': [1033], 'Buck': [1035], 'Benfenati': [1037], 'Schachner': [1039], 'Kleene': [1041], 'Synapsin': [1043], 'I': [1044], 'oligomannose-carrying': [1047], 'glycoprotein,': [1048], 'acts': [1049], 'oligomannose-binding': [1052], 'lectin,': [1053], 'promotes': [1055, 3833], 'neurite': [1056], 'outgrowth': [1057], 'neuronal': [1059], 'survival': [1060], 'when': [1061], 'glia-derived': [1064], 'exosomes.J.': [1065, 3720], 'Neurosci.': [1066, 3940, 4200], '31:': [1068], '7275-7290Crossref': [1069], '(140)': [1072, 1283, 1358], '13.Frühbeis': [1075], 'Fröhlich': [1077], 'Kuo': [1079], 'W.P.': [1080], 'Amphornrat': [1081], 'Thilemann': [1083], 'Saab': [1085], 'A.S.': [1086], 'Kirchhoff': [1087], 'Möbius': [1089], 'W.': [1090, 2800, 3965], 'Goebbels': [1091], 'Nave': [1093], 'K.A.': [1094], 'al.Neurotransmitter-triggered': [1096], 'mediates': [1100], 'oligodendrocyte-neuron': [1101], 'communication.PLoS': [1102], '2013;': [1104, 2299], '11:': [1105], 'e1001604Crossref': [1106], '(388)': [1109], 'unwanted': [1115], 'components': [1117], '(14.Yáñez-Mo': [1118], 'Siljander': [1120], 'P.R.': [1121], 'Andreu': [1122], 'Z.': [1123], 'Zavec': [1124], 'A.B.': [1125, 4014], 'Borràs': [1126], 'F.E.': [1127], 'Buzas': [1128, 1130], 'E.I.': [1129], 'Casal': [1132], 'Cappello': [1134], 'Carvalho': [1136], 'al.Biological': [1139], 'properties': [1140], 'functions.J.': [1147], '2015;': [1150, 1216, 3723, 3941], '4:': [1151], '27066Crossref': [1152], 'Scholar),': [1157, 1750, 1977, 2561, 2646, 2781, 2922, 3310, 3688, 3781, 3819, 3853, 3907, 3948, 3997, 4037], 'pathophysiological': [1161], 'diseases': [1167], '(15.Quek': [1168], 'Hill': [1170, 3707], 'A.F.': [1171, 3708], 'role': [1173, 1306, 1548, 3083, 3415], 'neurodegenerative': [1178, 1231], 'diseases.Biochem.': [1179], 'Biophys.': [1180, 2602, 2772, 2959], 'Res.': [1181], 'Commun.': [1182, 3811], '483:': [1184], '1178-1186Crossref': [1185], '(84)': [1188], '16.Joshi': [1191], 'Benussi': [1193], 'Furlan': [1195, 1226], 'Ghidoni': [1197], 'Verderio': [1199], "Alzheimer's": [1204, 4098, 4135], 'disease:': [1205], 'friends': [1206], 'foes?': [1208], 'Focus': [1209], 'abeta-vesicle': [1211], 'interaction.Int.': [1212], 'Mol.': [1214, 1492, 1515, 1773, 2199, 3059], '16:': [1217], '4800-4813Crossref': [1218], '(58)': [1221, 1499], '17.Croese': [1224], 'diseases.Mol.': [1232], 'Aspects': [1233], 'Med.': [1234, 1741, 2281], '2018;': [1235, 1375, 1563, 2339, 3681, 4075], '60:': [1236], '52-61Crossref': [1237], '(20)': [1240], 'Therefore,': [1243], 'inhibiting': [1244], 'be': [1252, 1644, 2013, 2026], 'goal,': [1256], 'recently': [1258], 'outlined': [1259], 'Tricarico,': [1261], 'Clancy,': [1262], "D'Souza-Schorey": [1264, 1269, 1344], '(18.Tricarico': [1265, 1340], 'Clancy': [1267, 1342], 'Biology': [1271, 1346], 'microvesicles.Small': [1276, 1351], 'GTPases.': [1277, 1352], '8:': [1279, 1354, 1966], '220-232Crossref': [1280, 1355], 'been': [1292, 2169, 2863, 2927], 'matter': [1294], 'intense': [1296], 'research': [1297], 'recent': [1300], 'years.': [1301], 'For': [1302, 2532], 'discussion': [1303], 'proteins,': [1308], 'including': [1309, 2176], 'members': [1310], 'endosomal': [1313, 2463], 'sorting': [1314, 3345], 'complex': [1315, 1723, 1927], 'required': [1316], '(ESCRT),': [1319], 'small': [1320, 3221], 'GTPases,': [1321], 'glutaminase,': [1323], 'exo-': [1326], 'ectosome': [1328], 'fission,': [1331], 'refer': [1333], 'readers': [1334], 'these': [1336, 1572, 1883, 2427], 'excellent': [1338], 'reviews': [1339], '19.Juan': [1361], 'Furthauer': [1363], 'Biogenesis': [1365], 'function': [1367], 'ESCRT-dependent': [1369], 'vesicles.Semin.': [1371], 'Dev.': [1373], '74:': [1376], '66-77Crossref': [1377], '(76)': [1380], 'focus': [1385, 2437], 'exosomes,': [1404], 'which': [1405, 1426, 1706, 2537, 2651, 3561, 4163], 'less': [1408], 'attention.': [1409], 'class': [1413, 2072], 'lipids': [1415], 'located': [1416, 2115], 'intracellular': [1423], 'organelle': [1424], 'membranes,': [1425], 'structural': [1430, 1695], 'signaling': [1434, 1448], 'function.': [1435], 'Ceramide': [1436, 3294, 3379, 3509, 3584], '(Cer)': [1437], '(S1P)': [1440], 'main': [1443, 2411], 'act': [1446, 1865], 'molecules,': [1449], 'controlling': [1450, 2143], 'vast': [1452], 'number': [1453, 3640], 'processes,': [1456], 'growth,': [1460, 2151], 'adhesion,': [1461, 2152], 'migration,': [1462], 'senescence,': [1463], 'death,': [1465], 'response': [1468, 3881], '(20.Giussani': [1469], 'Tringali': [1471], 'Riboni': [1473, 1790, 2216], 'Viani': [1475, 1788, 2214], 'Venerando': [1477], 'Sphingolipids:': [1479], 'key': [1480, 2130, 3082], 'regulators': [1481], 'apoptosis': [1483, 3121, 3668, 3880, 3887, 4062], 'pivotal': [1485], 'players': [1486], 'drug': [1489], 'resistance.Int.': [1490], '2014;': [1494, 2282, 4138], '4356-4392Crossref': [1496], '21.Hannun': [1502], 'Y.A.': [1503, 1730, 1761, 1904, 1989, 2089, 2187, 2236, 2291, 2757, 2944], 'Obeid': [1504, 1727, 1762, 2188], 'L.M.': [1505, 1728, 1763, 2189], 'Principles': [1506, 1764, 2190], 'bioactive': [1508, 1766, 2034, 2192], 'signalling:': [1510, 1768, 2194], 'lessons': [1511, 1769, 2195], 'sphingolipids.Nat.': [1513, 1771, 2197], 'Rev.': [1514, 1772, 2198, 2337], '139-150Crossref': [1520, 1778, 2204], '(2104)': [1523, 1781, 2207], '22.Chiricozzi': [1526], 'Loberto': [1528], 'Schiumarini': [1530], 'Samarani': [1532], 'Mancini': [1534], 'Tamanini': [1536], 'Lippi': [1538], 'Dechecchi': [1540], 'M.C.': [1541], 'Bassi': [1542, 1786, 2212], 'Giussani': [1544, 2259], 'al.Sphingolipids': [1547], 'response:': [1554], 'From': [1555], 'leukocyte': [1556], 'biology': [1557], 'infection.J.': [1560], 'Leukoc.': [1561], '103:': [1564], '445-456Crossref': [1565], '(14)': [1568], 'In': [1571, 1628, 1829, 1890, 2388, 3140], 'activities,': [1574], 'dynamic': [1575], 'balance': [1576], 'S1P': [1578], 'Cer': [1580, 1855, 1894, 1937, 1983, 2011, 2041, 2698, 3318, 3399, 3417, 3553, 3607, 3636], 'crucial.': [1583], 'This': [1584, 3261], 'process': [1585], 'known': [1587, 1680, 2736], '"SL': [1589], 'rheostat"': [1590], '(23.Cuvillier': [1591], 'O.': [1592, 2356, 3924], 'Pirianov': [1593], 'Kleuser': [1595, 4007], 'Vanek': [1597], 'P.G.': [1598, 2621], 'Coso': [1599], 'O.A.': [1600], 'Gutkind': [1601], 'Spiegel': [1603], 'Suppression': [1605], 'ceramide-mediated': [1607], 'programmed': [1608], 'death': [1610], 'sphingosine-1-phosphate.Nature.': [1612], '1996;': [1613, 2634], '381:': [1614], '800-803Crossref': [1615], '(1263)': [1618], 'constituted': [1623], 'sphingoid': [1626, 1639], 'base.': [1627, 1640], 'bilayer-forming': [1629], 'fatty': [1632, 1662, 1691], 'tethered/covalently': [1635], 'linked': [1636, 1683], 'All': [1641, 1844], 'modified': [1645], 'first': [1648, 3312], 'hydroxyl': [1649], 'group': [1650, 1668, 4155], 'variable': [1653], 'polar': [1654], 'head': [1655], 'group,': [1656], 'esterified': [1661], 'tethered': [1664], 'amino': [1667, 1678], 'sphingosine': [1671], '(Sph).': [1672], 'Cer,': [1673, 1714, 2650], 'composed': [1674], 'long-chain': [1677, 1690, 1754], 'alcohol,': [1679], 'Sph,': [1682], 'amide': [1686], 'bond': [1687], 'acid,': [1692, 2710], 'unit': [1696], 'membrane-forming': [1698], '(not': [1700], 'present': [1701, 2973, 3028], 'Sph': [1703, 1898, 2021], 'S1P),': [1705], 'represent': [1707], 'most': [1709], 'abundant': [1710], 'can': [1715, 2012, 2025, 2656], 'originate': [1716], '"de': [1718, 1806], 'novo': [1719, 1832, 1852], 'synthesis,"': [1720], 'degradation': [1721, 1925, 2586], '(24.Gault': [1725], 'C.R.': [1726], 'Hannun': [1729, 1903, 1988, 2088, 2235, 2290, 2756, 2943], 'An': [1731], 'overview': [1732], 'sphingolipid': [1734, 1906, 2091, 2238, 2270], 'metabolism:': [1735], 'synthesis': [1737, 2030, 3936], 'breakdown.Adv.': [1739], 'Exp.': [1740, 2297], '2010;': [1743, 2156, 2774, 2961, 3769], '688:': [1744], '1-23Crossref': [1745], '(490)': [1748], 'recycling': [1752], 'bases': [1755], 'salvage': [1758, 1892, 1907, 2092, 2239], 'pathway': [1759, 1908, 2093, 2240, 3662, 3712, 3984, 4056], '(21.Hannun': [1760, 2186], '25.Tettamanti': [1784, 2210], 'Salvage': [1792, 2218], 'pathways': [1793, 2219], 'glycosphingolipid': [1795, 1943, 1961, 2221], 'metabolism.Biochimie.': [1796, 2222], '2003;': [1797, 2223], '85:': [1798, 2224], '423-437Crossref': [1799, 2225], '(101)': [1802, 2228], 'novo"': [1807], 'biosynthesis': [1808, 1853], 'begins': [1811], 'condensation': [1814], 'palmitoyl-CoA': [1816], 'l-serine': [1818], 'sphinganine': [1821], 'dihydroceramide,': [1823], 'respectively,': [1824], 'after': [1825, 3456], 'reduction': [1826, 4119], 'acylation.': [1828], 'de': [1831, 1851], 'biosynthesis,': [1833], 'dihydroceramide': [1834], 'desaturated': [1837], 'consequent': [1840], 'Cer.': [1843], 'involved': [1848, 3664, 4058], 'localized': [1857, 2789], 'endoplasmic': [1860], 'reticulum': [1861], '(ER)': [1862], 'cytosolic': [1868, 2976], 'surface': [1869, 2597], 'subcellular': [1872, 2803], 'organelle.': [1873], 'products': [1875], 'reactions': [1878], 'catalyzed': [1881], 'remain': [1885], 'anchored': [1886], 'ER.': [1889], 'pathway,': [1893], 'synthesized': [1896], '(26.Kitatani': [1899, 2084], 'Idkowiak-Baldys': [1901, 2086, 2233, 2752, 2939], 'ceramide': [1910, 2095, 2242, 3115, 3661, 3877, 4055], 'metabolism': [1911, 2096, 2243, 2271, 2293, 2331, 2457], 'signaling.Cell': [1913, 2098, 2245], 'Signal.': [1914, 2099, 2246], '1010-1018Crossref': [1917, 2102, 2249], '(326)': [1920, 2105, 2252], 'During': [1923], 'glycosphingolipids': [1929], '(GSLs)': [1930], 'constitutively': [1932], 'degraded': [1933, 1981], 'monosaccharides': [1935, 2062], '(27.Hakomori': [1938], 'Traveling': [1940], 'path.Glycoconj.': [1944], '2000;': [1946, 2725, 2814, 3132], '17:': [1947], '627-647Crossref': [1948], '(155)': [1951], '28.Ichikawa': [1954], 'Hirabayashi': [1956, 2835], 'Y.': [1957, 2348, 2362, 2828, 2836, 3653, 3750, 3754, 3829, 3951, 3953, 4047, 4180], 'Glucosylceramide': [1958], 'synthase': [1959], 'synthesis.Trends': [1962], '1998;': [1965], '198-202Abstract': [1967], '(168)': [1975], 'SM': [1979, 2056, 2471, 2692, 2738, 3074, 3178, 3315], 'phosphocholine': [1985, 2053], '(29.Marchesini': [1986], 'Acid': [1990, 2365, 3054], 'sphingomyelinases:': [1993], 'regulation.Biochem.': [1998], '82:': [2002], '27-44Crossref': [2003], 'Once': [2009], 'generated,': [2010], 'cleaved': [2014], 'ceramidase': [2017], '(CDase)': [2018], 'generate': [2020], 'that,': [2022, 3630], 'turn,': [2024], 'phosphorylated': [2027], 'crucial': [2033], 'S1P.': [2036], 'On': [2037, 3485], 'hand,': [2040], 'substrate': [2044], 'various': [2046], 'enzymes,': [2047], 'mainly': [2048], 'addition': [2051, 2060], 'produce': [2055, 2064], 'GSLs.': [2065], 'Among': [2066], 'GSLs,': [2067, 2109], 'gangliosides': [2068], 'particular': [2071], 'characterized': [2073, 2864], 'presence': [2076], 'one': [2078], 'more': [2080, 3402], 'sialic': [2081], 'together': [2110], 'simple': [2112], 'membrane,': [2119], 'where': [2120], 'interact': [2122], 'factor': [2125, 2896, 3012], 'receptors,': [2126], 'integrins,': [2127], 'molecules': [2131], 'cell-cell': [2135], 'cell-matrix': [2137], 'interactions': [2138], '(30.Hakomori': [2139], 'S.I.': [2140], 'Glycosynaptic': [2141], 'microdomains': [2142, 2883, 2999, 3216, 3554], 'tumor': [2144], 'phenotype': [2146], 'alteration': [2148], 'motility.FEBS': [2154], 'Lett.': [2155, 2914], '584:': [2157], '1901-1906Crossref': [2158], '(82)': [2161, 2824], 'Importantly,': [2164, 4146], 'metabolites': [2167], 'associated': [2170, 4123], 'development': [2172], 'pathologies,': [2175], 'diabetes,': [2177], 'cancer,': [2178], 'infections,': [2180], 'neurological': [2181], 'syndromes,': [2182], 'cardiovascular': [2184], 'disease': [2185, 3891, 4099, 4191], '26.Kitatani': [2231], '31.Véret': [2255], 'Bellini': [2257], 'Ng': [2261], 'Magnan': [2263], 'Le': [2265], 'Stunff': [2266], 'Roles': [2268], 'pancreatic': [2273], 'beta': [2274], 'dysfunction': [2276], 'induced': [2277], 'lipotoxicity.J.': [2279], 'Clin.': [2280], '3:': [2283], '646-662Crossref': [2284], '32.Airola': [2288], 'M.V.': [2289], 'Sphingolipid': [2292, 2330], 'sphingomyelinases.Handb.': [2296], 'Pharmacol.': [2298, 3679, 4073], '215:': [2300], '57-76Crossref': [2301], '33.Bienias': [2305], 'Fiedorowicz': [2307], 'Sadowska': [2309], 'Prokopiuk': [2311], 'Car': [2313], 'Regulation': [2315], 'sphingomyelin': [2317, 2585], 'metabolism.Pharmacol.': [2318], 'Rep.': [2319], '68:': [2321, 3063], '570-581Crossref': [2322], '(59)': [2325], '34.Ogretmen': [2328], 'signalling': [2334], 'therapy.Nat.': [2336], 'Cancer.': [2338], '18:': [2340, 3942], '33-50Crossref': [2341], '(269)': [2344], '35.Zhou': [2347], 'Salker': [2349], 'M.S.': [2350], 'Walker': [2351], 'Munzer': [2353], 'Borst': [2355, 3107], 'Gawaz': [2357], 'Gulbins': [2359, 4011], 'Singh': [2361], 'Lang': [2363], 'sphingomyelinase': [2366, 2722, 2843, 2879, 2995, 3055, 3158, 3246, 3711], '(ASM)': [2367], 'negative': [2370, 3610], 'regulator': [2371], 'regulatory': [2373], 'T': [2374, 3782, 3806], '(Treg)': [2376], 'development.Cell.': [2377], 'Physiol.': [2378], 'Biochem.': [2379], '39:': [2381, 3682, 4076], '985-995Crossref': [2382], '(19)': [2385], 'review,': [2390], 'will': [2392], 'critically': [2393], 'summarize': [2394], 'knowledge': [2396], 'SL-metabolizing': [2401], '(ectosomes': [2415], 'exosomes)': [2417], 'well': [2419], 'past': [2421], 'efforts': [2424], 'targeting': [2426], 'pharmacologically': [2429], 'genetically': [2431], 'purposes.': [2434], 'underlying': [2449], 'capability': [2451], 'asymmetric': [2467], 'distribution,': [2469], 'phosphatidylcholine': [2473], '(PC)': [2474], 'enriched': [2475, 2487, 3401, 3547, 3874], 'noncytosolic': [2478], '(luminal)': [2479], 'side,': [2480], 'PS': [2482], 'classes': [2486], 'facing': [2491], 'cytosol': [2492], '(36.Devaux': [2493], 'P.F.': [2494], 'Morris': [2495], 'Transmembrane': [2497], 'lateral': [2500], 'domains': [2501, 3546], 'membranes.Traffic.': [2504], '241-246Crossref': [2507], '(202)': [2510], 'Consolidated': [2513], 'evidence': [2514], 'indicates': [2515], 'changing': [2517], 'local': [2519], 'way': [2524], 'alter': [2526], 'fluidity': [2529, 2574], 'curvature.': [2531], 'example,': [2533], 'breakdown': [2534, 3179], 'SM,': [2536], 'high': [2540], 'affinity': [2541], 'cholesterol': [2544, 2567, 2589, 2627], '(37.Simons': [2545], 'Ikonen': [2547], 'Functional': [2549], 'rafts': [2550], 'membranes.Nature.': [2553], '1997;': [2554], '387:': [2555], '569-572Crossref': [2556], '(7595)': [2559], 'results': [2562, 3122], 'increased': [2564, 2572], 'efflux': [2565], '(38.Slotte': [2575], 'Hedstrom': [2577], 'Rannstrom': [2579], 'Ekman': [2581], 'Effects': [2583], 'oxidizability': [2590], 'steady-state': [2592], 'distribution': [2593], 'interior.Biochim.': [2601], 'Acta.': [2603, 2773, 2960], '1989;': [2604], '985:': [2605], '90-96Crossref': [2606], '39.Neufeld': [2610], 'E.B.': [2611], 'Cooney': [2612], 'Pitha': [2614], 'Dawidowicz': [2616], 'E.A.': [2617], 'Dwyer': [2618], 'N.K.': [2619], 'Pentchev': [2620], 'Blanchette-Mackie': [2622], 'E.J.': [2623], 'Intracellular': [2624], 'trafficking': [2625], 'monitored': [2628], 'cyclodextrin.J.': [2631], '271:': [2635], '21604-21613Abstract': [2636], '(311)': [2644], 'generation': [2648], 'cone-shaped': [2654, 3604], 'give': [2657], 'spontaneous': [2659, 3609], '(40.Jarsch': [2664], 'I.K.': [2665], 'Daste': [2666], 'Gallop': [2668], 'J.L.': [2669], 'biology:': [2674], 'integration': [2676], 'mechanisms.J.': [2679], '214:': [2683], '375-387Crossref': [2684], '(127)': [2687], '(Fig.': [2690, 3601], '1A).': [2691, 3602], 'hydrolyzed': [2694], 'into': [2695, 3200, 3226, 3300, 3350, 3385, 3515, 3558, 3590, 3701, 3719], 'phosphorylcholine': [2696], 'family': [2705], 'possesses': [2709], 'neutral,': [2711], 'alkaline': [2713], 'optimal': [2714], 'pH': [2715], '(41.Gulbins': [2716], 'Kolesnick': [2718], 'Measurement': [2720], 'activity.Methods': [2723], 'Enzymol.': [2724], '322:': [2726], '382-388Crossref': [2727], 'Neutral': [2731, 4186], 'SMase': [2732, 3024, 3192], '(n-SMase)': [2733], '2,': [2734, 3441], 'phosphodiesterase': [2739], '(SMPD)3,': [2740], 'mostly': [2741], 'localizes': [2742], 'Golgi': [2745, 2767, 2792, 2954], 'ER': [2747], '(42.Milhas': [2748, 2935], 'Clarke': [2750, 2937], 'C.J.': [2751, 2938], 'Canals': [2754, 2941], 'Anterograde': [2758, 2945], 'retrograde': [2760, 2947], 'sphingomyelinase-2': [2764, 2951, 4187], 'membrane.Biochim.': [2771, 2958], '1801:': [2775, 2962], '1361-1374Crossref': [2776, 2963], '(36)': [2779, 2966], 'n-SMase': [2783, 2924, 3437, 3440, 3446, 3464, 3469, 3694, 4102, 4165], '1,': [2784], 'SMPD2,': [2787], 'nucleus': [2794], '(43.Tomiuk': [2795], 'Zumbansen': [2797], 'Stoffel': [2799], 'Characterization': [2801], 'localization': [2804, 2840], 'murine': [2806], 'human': [2808, 3673, 4067], 'magnesium-dependent': [2809], 'sphingomyelinase.J.': [2811], '275:': [2815], '5710-5717Abstract': [2816], '44.Mizutani': [2827], 'Tamiya-Koizumi': [2829], 'Nakamura': [2831], 'Yoshida': [2837], 'Nuclear': [2839], '1:': [2844], 'biochemical': [2845], 'immunocytochemical': [2847], 'analyses.J.': [2848], '114:': [2852], '3727-3736Crossref': [2853], 'membrane-associated': [2859], 'n-SMases': [2860, 2971], '(45.Veldman': [2865, 2981], 'R.J.': [2866, 2982], 'Maestre': [2867, 2983], 'Aduib': [2869, 2985], 'O.M.': [2870, 2986], 'Medin': [2871, 2987], 'J.A.': [2872, 2988], 'Salvayre': [2873, 2989], 'Levade': [2875, 2991], 'A': [2877, 2993], 'resides': [2880, 2996], 'sphingolipid-enriched': [2882, 2998], 'inhibited': [2886, 3002, 3695], 'caveolin-scaffolding': [2889, 3005], 'domain:': [2890, 3006], 'potential': [2891, 3007, 3884], 'implications': [2892, 3008], 'necrosis': [2895, 3011], 'signalling.Biochem.': [2897, 3013], '355:': [2900, 3016], '859-868Crossref': [2901, 3017], '46.Goñi': [2905], 'F.M.': [2906], 'Alonso': [2907], 'Sphingomyelinases:': [2909], 'enzymology': [2910], 'activity.FEBS': [2913], '2002;': [2915, 3165, 3253], '531:': [2916], '38-46Crossref': [2917], '(254)': [2920], '2': [2925, 3470, 4166], 'reported': [2928, 3078, 3629, 4151], 'recycle': [2930], 'endosomal/recycling': [2933], 'compartment': [2934], 'Activity': [2969], 'By': [3021], 'contrast,': [3022], '(a-SMase)': [3025], 'activity': [3026], 'lysosomes': [3030], 'following': [3038], 'lysosome': [3039], '(47.Truman': [3045], 'Al': [3047], 'Gadban': [3048], 'M.M.': [3049], 'Smith': [3050], 'K.J.': [3051], 'Hammad': [3052], 'S.M.': [3053], 'macrophage': [3057], 'biology.Cell.': [3058], 'Life': [3060], '3293-3305Crossref': [3064], '(23)': [3067, 3995], 'destabilization': [3071], 'driven': [3072], 'hydrolysis': [3075, 3113, 3316], 'was': [3076, 3193, 3264, 3400, 3426, 3453, 4150], 'initially': [3077], 'blebbing': [3086], 'apoptotic': [3090], 'during': [3092, 3116], 'late': [3094], 'phase': [3095, 3119], 'damage': [3098], '(48.Tepper': [3099], 'A.D.': [3100], 'Ruurs': [3101], 'Wiedmer': [3103], 'Sims': [3105], 'P.J.': [3106], 'Blitterswijk': [3110], 'W.J.': [3111], 'Sphingomyelin': [3112], 'execution': [3118], 'phospholipid': [3124], 'scrambling': [3125], 'alters': [3127], 'cell-surface': [3128], 'morphology.J.': [3129], '150:': [3133], '155-164Crossref': [3134], '(160)': [3137], '2002,': [3141], 'Nurminen': [3142], 'al.': [3144, 3275, 3360, 3490], '(49.Nurminen': [3145, 3233], 'T.A.': [3146, 3234], 'Holopainen': [3147, 3235], 'J.M.': [3148, 3236], 'Zhao': [3149, 3237], 'Kinnunen': [3151, 3239], 'P.K.': [3152, 3240], 'Observation': [3153, 3241], 'topical': [3155, 3243], 'catalysis': [3156, 3244], 'coupled': [3159, 3247], 'microspheres.J.': [3161, 3249], 'Am.': [3162, 3250], 'Soc.': [3164, 3252], '12129-12134Crossref': [3167, 3255], '(75)': [3170, 3258], 'visualized': [3173], 'macroscopic': [3175], 'consequence': [3176], 'SMases': [3181], 'using': [3185], 'fluorescence': [3186], 'differential': [3188], 'interference': [3189], 'contrast': [3190], 'microscopy.': [3191], 'immobilized': [3194], 'onto': [3195], 'synthetic': [3196], 'microspheres': [3197], 'brought': [3199], 'contact': [3201, 3211], 'giant': [3204, 3231], 'liposome': [3205, 3232], 'micromanipulator:': [3209], 'caused': [3212], 'subsequent': [3218], 'shedding': [3219], 'interior': [3228], 'elegant': [3262], 'study': [3263], 'followed': [3265], '2008': [3267], 'seminal': [3270], 'work': [3271], 'Trajokovic': [3273], '(50.Trajkovic': [3276, 3361, 3491, 3566], 'Hsu': [3278, 3363, 3493, 3568], 'Chiantia': [3280, 3365, 3495, 3570], 'Rajendran': [3282, 3367, 3497, 3572], 'Wenzel': [3284, 3369, 3499, 3574], 'Wieland': [3286, 3371, 3501, 3576], 'Schwille': [3288, 3373, 3503, 3578], 'Brugger': [3290, 3375, 3505, 3580], 'triggers': [3295, 3380, 3510, 3585], 'exosome': [3298, 3383, 3513, 3534, 3588, 3670, 3738, 3831, 3935, 4064, 4106, 4148], 'endosomes.Science.': [3302, 3387, 3517, 3592], '319:': [3304, 3389, 3519, 3594], '1244-1247Crossref': [3305, 3390, 3520, 3595], '(1699)': [3308, 3393, 3523, 3598], 'who': [3311], 'described': [3313], 'ESCRT-independent': [3322], 'MVBs,': [3328], 'upon': [3336], 'MVB': [3337], 'investigating': [3344], 'protein': [3348, 3412, 3700, 3718], 'oligodendrocyte': [3354], 'line': [3356], '(oli-Neu),': [3357], 'Trajkovic': [3358, 3488], 'observed': [3396], 'total': [3398], '3-fold': [3404], 'subpopulation': [3407], 'containing': [3410, 3977], 'proteolipid': [3411], '(PLP).': [3413], 'PLP-positive': [3424, 3483, 3541], 'analyzed': [3427], 'treating': [3429], 'Oli-neu': [3430], 'GW4869,': [3433, 4104], 'inhibitor': [3435], 'structurally': [3444], 'unrelated': [3445], 'blockers,': [3447], 'spiroepoxide': [3448], 'glutathione.': [3450], 'Exosome': [3451, 4118], 'markedly': [3454], 'reduced': [3455, 3737], 'treatment': [3457], 'all': [3462], 'inhibitors.': [3465], 'siRNA': [3466], 'depletion': [3467], 'confirmed': [3471], 'enzyme': [3476], 'exosomes.': [3484], 'basis,': [3487], 'proposed': [3526, 3537], 'lipid-based': [3528], 'bending': [3532], 'formation.': [3535], 'They': [3536], 'occurs': [3543], 'coalescence': [3557], 'domains,': [3560], 'structure': [3605], 'induces': [3608], 'endosomes': [3616], 'favors': [3618], 'internal': [3621], 'MVBs.': [3624], 'Subsequent': [3625], 'vitro': [3627], 'works': [3628], 'exogenous': [3632], 'permeable': [3634], 'C6': [3635], 'dose-dependently': [3637], 'increases': [3638], 'multiple': [3645, 3674, 4039, 4068], 'myeloma': [3646, 3675, 4040, 4069], '(51.Cheng': [3648, 4042], 'Q.': [3649, 3860, 4043], 'Li': [3650, 4044], 'X.': [3651, 4045], 'Wang': [3652, 3958, 4046, 4112, 4173], 'Dong': [3654, 4048], 'Zhan': [3656, 4050], 'F.H.': [3657, 4051], 'Liu': [3658, 3952, 4052, 4179], 'survival,': [3667, 4061], 'functions': [3671, 4065], 'vitro.Acta': [3678, 4072], 'Sin.': [3680, 4074], '561-568Crossref': [3683, 4077], 'pharmacological': [3689], 'block': [3692], 'packaging': [3696, 3714], 'prion': [3699, 3717], '(52.Guo': [3703], 'B.B.': [3704], 'Bellingham': [3705], 'S.A.': [3706], 'regulates': [3713], '290:': [3724], '3455-3467Abstract': [3725], '(106)': [3733], 'others': [3741], 'HEK': [3743], '(53.Kosaka': [3745], 'Iguchi': [3747], 'Yoshioka': [3749], 'Takeshita': [3751], 'Matsuki': [3753], 'Ochiya': [3755], 'Secretory': [3757], 'intercellular': [3760], 'living': [3765], 'cells.J.': [3766], '285:': [3770], '17442-17452Abstract': [3771], '(1242)': [3779], '(54.Mittelbrunn': [3784], 'Gutierrez-Vazquez': [3786], 'Villarroya-Beltri': [3788], 'Gonzalez': [3790, 3794], 'Sanchez-Cabo': [3792], 'Bernad': [3796], 'Sanchez-Madrid': [3798], 'Unidirectional': [3800], 'microRNA-loaded': [3803], 'antigen-presenting': [3809], '2:': [3813], '282Crossref': [3814], '(1053)': [3817], 'N2a': [3820], '(55.Yuyama': [3822], 'Sun': [3824], 'Mitsutake': [3826], 'Igarashi': [3828], 'Sphingolipid-modulated': [3830], 'clearance': [3834], 'amyloid-beta': [3836], 'microglia.J.': [3838], '287:': [3842, 3896], '10977-10989Abstract': [3843], '(279)': [3851], 'astrocytes': [3854], '(56.Wang': [3855], 'Dinkins': [3857], 'He': [3859, 3962], 'Zhu': [3861, 4114], 'Poirier': [3863], 'Campbell': [3865], 'Mayer-Proschel': [3867], 'Bieberich': [3869, 4116, 4184], 'Astrocytes': [3871], 'secrete': [3872], 'proapoptotic': [3876], 'prostate': [3879], '4': [3882], '(PAR-4):': [3883], 'induction': [3888], 'Alzheimer': [3890], '(AD).J.': [3892], '21384-21395Abstract': [3897], '(206)': [3905], '(57.Asai': [3909], 'Ikezu': [3911, 3927], 'Tsunoda': [3913], 'Medalla': [3915], 'Luebke': [3917], 'Haydar': [3919], 'Wolozin': [3921], 'Butovsky': [3923], 'Kugler': [3925], 'Depletion': [3929], 'halt': [3937], 'tau': [3938], 'propagation.Nat.': [3939], '1584-1593Crossref': [3943], '(564)': [3946], 'macrophages': [3949], '(58.Xu': [3950], 'Kang': [3956], 'Hu': [3960], 'Song': [3964], 'Tang': [3966], 'Macrophages': [3968], 'antigens': [3970, 3979], 'releasing': [3975], 'dead-cell-associated': [3978], 'partially': [3980], 'ceramide-dependent': [3983], 'CD4(+)': [3987], 'T-cell': [3988], 'responses.Immunology.': [3989], '149:': [3991], '157-171Crossref': [3992], 'hepatocytes': [3998], '(59.Nojima': [3999], 'Freeman': [4001], 'C.M.': [4002], 'Schuster': [4003], 'R.M.': [4004], 'Japtok': [4005], 'Edwards': [4009], 'M.J.': [4010], 'Lentsch': [4013], 'Hepatocyte': [4015], 'mediate': [4017], 'liver': [4018], 'repair': [4019], 'regeneration': [4021], 'sphingosine-1-phosphate.J.': [4023], 'Hepatol.': [4024], '64:': [4026], '60-68Abstract': [4027], '(115)': [4035], 'Also,': [4083], 'vivo,': [4085], 'brain': [4088], 'serum': [4090], '5XFAD': [4092, 4131, 4157, 4198], 'mice,': [4093, 4162], 'transgenic': [4095], 'model': [4096, 4133], '(AD),': [4100], 'inhibitor,': [4103], 'decreased': [4105, 4147], 'concentration': [4107], '(60.Dinkins': [4108], 'M.B.': [4109, 4168], 'Dasgupta': [4110], 'vivo': [4121], 'lower': [4125], 'amyloid': [4126], 'plaque': [4127], 'load': [4128], 'mouse': [4132], 'disease.Neurobiol.': [4136], 'Aging.': [4137], '35:': [4139], '1792-1800Crossref': [4140], '(183)': [4143], 'production': [4149], 'mice': [4158], 'crossed': [4159], 'fro/fro': [4161], 'lack': [4164], '(61.Dinkins': [4167], 'Enasko': [4169], 'Hernandez': [4171], 'Kong': [4175], 'Helwa': [4177], 'I.': [4178], 'Terry': [4181], 'A.V.': [4183], 'deficiency': [4188], 'ameliorates': [4189], "alzheimer's": [4190], 'pathology': [4192], 'improves': [4194], 'cognition': [4195], 'mouse.J.': [4199], '2016': [4201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2806776072', 'counts_by_year': [{'year': 2024, 'cited_by_count': 26}, {'year': 2023, 'cited_by_count': 42}, {'year': 2022, 'cited_by_count': 35}, {'year': 2021, 'cited_by_count': 36}, {'year': 2020, 'cited_by_count': 29}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 3}], 'updated_date': '2024-12-22T20:42:39.009597', 'created_date': '2018-06-13'}
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