Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2806030824', 'doi': 'https://doi.org/10.1016/j.bbamem.2018.05.014', 'title': 'Aluminum inhibits the plasma membrane and sarcoplasmic reticulum Ca2+-ATPases by different mechanisms', 'display_name': 'Aluminum inhibits the plasma membrane and sarcoplasmic reticulum Ca2+-ATPases by different mechanisms', 'publication_year': 2018, 'publication_date': '2018-08-01', 'ids': {'openalex': 'https://openalex.org/W2806030824', 'doi': 'https://doi.org/10.1016/j.bbamem.2018.05.014', 'mag': '2806030824', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29859139'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbamem.2018.05.014', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210187475', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Biomembranes', 'issn_l': '0005-2736', 'issn': ['0005-2736', '1879-2642'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://ri.conicet.gov.ar/bitstream/11336/93097/2/CONICET_Digital_Nro.237ba6ff-384b-47a8-9895-346fb6000187_A.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5065641295', 'display_name': 'Marilina de Sautu', 'orcid': 'https://orcid.org/0000-0001-5725-160X'}, 'institutions': [{'id': 'https://openalex.org/I4210149401', 'display_name': 'Instituto de Química y Fisicoquímica Biológicas', 'ror': 'https://ror.org/0469ejq24', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4210149401', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Marilina de Sautu', 'raw_affiliation_strings': ['Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina', 'institution_ids': ['https://openalex.org/I4210149401', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085619776', 'display_name': 'Nicolás A. Saffioti', 'orcid': 'https://orcid.org/0000-0002-5722-182X'}, 'institutions': [{'id': 'https://openalex.org/I4210149401', 'display_name': 'Instituto de Química y Fisicoquímica Biológicas', 'ror': 'https://ror.org/0469ejq24', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4210149401', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Nicolás A. Saffioti', 'raw_affiliation_strings': ['Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina', 'institution_ids': ['https://openalex.org/I4210149401', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030606872', 'display_name': 'Mariela Ferreira-Gomes', 'orcid': 'https://orcid.org/0000-0003-2848-8266'}, 'institutions': [{'id': 'https://openalex.org/I4210149401', 'display_name': 'Instituto de Química y Fisicoquímica Biológicas', 'ror': 'https://ror.org/0469ejq24', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4210149401', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Mariela S. Ferreira-Gomes', 'raw_affiliation_strings': ['Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina', 'institution_ids': ['https://openalex.org/I4210149401', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077686769', 'display_name': 'Rolando Rossi', 'orcid': 'https://orcid.org/0000-0003-4831-7210'}, 'institutions': [{'id': 'https://openalex.org/I4210149401', 'display_name': 'Instituto de Química y Fisicoquímica Biológicas', 'ror': 'https://ror.org/0469ejq24', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4210149401', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Rolando C. Rossi', 'raw_affiliation_strings': ['Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina', 'institution_ids': ['https://openalex.org/I4210149401', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071072938', 'display_name': 'Juan Pablo F.C. Rossi', 'orcid': 'https://orcid.org/0000-0001-7087-844X'}, 'institutions': [{'id': 'https://openalex.org/I4210149401', 'display_name': 'Instituto de Química y Fisicoquímica Biológicas', 'ror': 'https://ror.org/0469ejq24', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4210149401', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': False, 'raw_author_name': 'Juan Pablo F.C. Rossi', 'raw_affiliation_strings': ['Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina', 'institution_ids': ['https://openalex.org/I4210149401', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017125180', 'display_name': 'Irene C. Mangialavori', 'orcid': 'https://orcid.org/0000-0003-3187-3130'}, 'institutions': [{'id': 'https://openalex.org/I4210149401', 'display_name': 'Instituto de Química y Fisicoquímica Biológicas', 'ror': 'https://ror.org/0469ejq24', 'country_code': 'AR', 'type': 'facility', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4210149401', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I151201029', 'display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'ror': 'https://ror.org/03cqe8w59', 'country_code': 'AR', 'type': 'government', 'lineage': ['https://openalex.org/I151201029', 'https://openalex.org/I4210123736', 'https://openalex.org/I4387155568']}, {'id': 'https://openalex.org/I24354313', 'display_name': 'University of Buenos Aires', 'ror': 'https://ror.org/0081fs513', 'country_code': 'AR', 'type': 'education', 'lineage': ['https://openalex.org/I24354313']}], 'countries': ['AR'], 'is_corresponding': True, 'raw_author_name': 'Irene C. Mangialavori', 'raw_affiliation_strings': ['Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina'], 'affiliations': [{'raw_affiliation_string': 'Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina', 'institution_ids': ['https://openalex.org/I4210149401', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5017125180'], 'corresponding_institution_ids': ['https://openalex.org/I4210149401', 'https://openalex.org/I151201029', 'https://openalex.org/I24354313'], 'apc_list': {'value': 3980, 'currency': 'USD', 'value_usd': 3980, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.824, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.8813, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '1860', 'issue': '8', 'first_page': '1580', 'last_page': '1588'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12211', 'display_name': 'Mechanisms of Aluminum Toxicity and Tolerance in Plants', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12211', 'display_name': 'Mechanisms of Aluminum Toxicity and Tolerance in Plants', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic Islet Dysfunction and Regeneration', 'score': 0.9887, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10724', 'display_name': 'Molecular Mechanisms of Aquaporins in Physiology and Disease', 'score': 0.9855, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/serca', 'display_name': 'SERCA', 'score': 0.9515449}, {'id': 'https://openalex.org/keywords/dephosphorylation', 'display_name': 'Dephosphorylation', 'score': 0.8410565}, {'id': 'https://openalex.org/keywords/calcium-atpase', 'display_name': 'Calcium ATPase', 'score': 0.5536684}, {'id': 'https://openalex.org/keywords/aluminum-toxicity', 'display_name': 'Aluminum Toxicity', 'score': 0.532465}, {'id': 'https://openalex.org/keywords/calcium-pump', 'display_name': 'Calcium pump', 'score': 0.4678287}, {'id': 'https://openalex.org/keywords/homeostasis', 'display_name': 'Homeostasis', 'score': 0.442625}], 'concepts': [{'id': 'https://openalex.org/C2781414619', 'wikidata': 'https://www.wikidata.org/wiki/Q24785512', 'display_name': 'SERCA', 'level': 4, 'score': 0.9515449}, {'id': 'https://openalex.org/C51705589', 'wikidata': 'https://www.wikidata.org/wiki/Q7201782', 'display_name': 'Plasma membrane Ca2+ ATPase', 'level': 4, 'score': 0.8602675}, {'id': 'https://openalex.org/C181912034', 'wikidata': 'https://www.wikidata.org/wiki/Q1101143', 'display_name': 'Dephosphorylation', 'level': 4, 'score': 0.8410565}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.7815443}, {'id': 'https://openalex.org/C23265538', 'wikidata': 'https://www.wikidata.org/wiki/Q300033', 'display_name': 'ATPase', 'level': 3, 'score': 0.65376616}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.57022876}, {'id': 'https://openalex.org/C101571972', 'wikidata': 'https://www.wikidata.org/wiki/Q3396061', 'display_name': 'Calcium ATPase', 'level': 4, 'score': 0.5536684}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.55162466}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.53477365}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.5033094}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.49190164}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.47845864}, {'id': 'https://openalex.org/C935647', 'wikidata': 'https://www.wikidata.org/wiki/Q17113155', 'display_name': 'Calcium pump', 'level': 4, 'score': 0.4678287}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.44661656}, {'id': 'https://openalex.org/C63645605', 'wikidata': 'https://www.wikidata.org/wiki/Q103191', 'display_name': 'Homeostasis', 'level': 2, 'score': 0.442625}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.42453456}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.31882578}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.24404493}, {'id': 'https://openalex.org/C178666793', 'wikidata': 'https://www.wikidata.org/wiki/Q422476', 'display_name': 'Phosphatase', 'level': 3, 'score': 0.20655954}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000535', 'descriptor_name': 'Aluminum', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D053498', 'descriptor_name': 'Sarcoplasmic Reticulum Calcium-Transporting ATPases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000244', 'descriptor_name': 'Adenosine Diphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000244', 'descriptor_name': 'Adenosine Diphosphate', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000244', 'descriptor_name': 'Adenosine Diphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000535', 'descriptor_name': 'Aluminum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006863', 'descriptor_name': 'Hydrogen-Ion Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D011817', 'descriptor_name': 'Rabbits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053498', 'descriptor_name': 'Sarcoplasmic Reticulum Calcium-Transporting ATPases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053498', 'descriptor_name': 'Sarcoplasmic Reticulum Calcium-Transporting ATPases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbamem.2018.05.014', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210187475', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Biomembranes', 'issn_l': '0005-2736', 'issn': ['0005-2736', '1879-2642'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11336/93097', 'pdf_url': 'https://ri.conicet.gov.ar/bitstream/11336/93097/2/CONICET_Digital_Nro.237ba6ff-384b-47a8-9895-346fb6000187_A.pdf', 'source': {'id': 'https://openalex.org/S4306401400', 'display_name': 'Conicet', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210104196', 'host_organization_name': 'Centro Científico Tecnológico - Nordeste', 'host_organization_lineage': ['https://openalex.org/I4210104196'], 'host_organization_lineage_names': ['Centro Científico Tecnológico - Nordeste'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29859139', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11336/93097', 'pdf_url': 'https://ri.conicet.gov.ar/bitstream/11336/93097/2/CONICET_Digital_Nro.237ba6ff-384b-47a8-9895-346fb6000187_A.pdf', 'source': {'id': 'https://openalex.org/S4306401400', 'display_name': 'Conicet', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210104196', 'host_organization_name': 'Centro Científico Tecnológico - Nordeste', 'host_organization_lineage': ['https://openalex.org/I4210104196'], 'host_organization_lineage_names': ['Centro Científico Tecnológico - Nordeste'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.43, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [{'funder': 'https://openalex.org/F4320321594', 'funder_display_name': 'Consejo Nacional de Investigaciones Científicas y Técnicas', 'award_id': 'PIP 0250'}, {'funder': 'https://openalex.org/F4320323257', 'funder_display_name': 'Universidad de Buenos Aires', 'award_id': 'UBACYT- 20020130100254B'}, {'funder': 'https://openalex.org/F4320334832', 'funder_display_name': 'Agencia Nacional de Promoción Científica y Tecnológica', 'award_id': 'PRESTAMO BID-PICT-2015-0067'}], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1487437286', 'https://openalex.org/W1493463750', 'https://openalex.org/W1497503028', 'https://openalex.org/W1518120013', 'https://openalex.org/W1531005781', 'https://openalex.org/W1550458975', 'https://openalex.org/W1583305131', 'https://openalex.org/W1584087556', 'https://openalex.org/W1591510024', 'https://openalex.org/W1836838655', 'https://openalex.org/W1964743049', 'https://openalex.org/W1966112781', 'https://openalex.org/W1971335946', 'https://openalex.org/W1974047868', 'https://openalex.org/W1976639389', 'https://openalex.org/W1977740532', 'https://openalex.org/W1989910458', 'https://openalex.org/W1992138517', 'https://openalex.org/W1999284612', 'https://openalex.org/W2000340660', 'https://openalex.org/W2003756021', 'https://openalex.org/W2005668432', 'https://openalex.org/W2022191302', 'https://openalex.org/W2040527991', 'https://openalex.org/W2042579604', 'https://openalex.org/W2047667409', 'https://openalex.org/W2052131745', 'https://openalex.org/W2053473716', 'https://openalex.org/W2061007320', 'https://openalex.org/W2074839041', 'https://openalex.org/W2078624364', 'https://openalex.org/W2084233178', 'https://openalex.org/W2090055042', 'https://openalex.org/W2090081233', 'https://openalex.org/W2091565573', 'https://openalex.org/W2094218961', 'https://openalex.org/W2108866489', 'https://openalex.org/W2135393487', 'https://openalex.org/W2294979821', 'https://openalex.org/W2323651872', 'https://openalex.org/W2327167168', 'https://openalex.org/W2607399337', 'https://openalex.org/W2976975081', 'https://openalex.org/W4240584345', 'https://openalex.org/W611620210'], 'related_works': ['https://openalex.org/W3021639856', 'https://openalex.org/W2806030824', 'https://openalex.org/W2585134597', 'https://openalex.org/W2142974466', 'https://openalex.org/W2141975785', 'https://openalex.org/W2088563955', 'https://openalex.org/W2077574523', 'https://openalex.org/W2066994490', 'https://openalex.org/W2055551136', 'https://openalex.org/W2026727437'], 'abstract_inverted_index': {'Aluminum': [0], '(Al3+)': [1], 'is': [2, 113, 129, 174], 'involved': [3], 'in': [4, 27, 133, 137, 164], 'the': [5, 18, 28, 33, 48, 58, 62, 77, 80, 85, 97, 141, 147, 156, 165, 178, 185, 199], 'pathophysiology': [6], 'of': [7, 20, 42, 52, 96, 99, 104, 117, 123, 127, 143, 149, 155, 167, 191, 198, 202], 'neurodegenerative': [8], 'disorders.': [9], 'The': [10, 40, 125, 151], 'mechanisms': [11], 'that': [12, 111, 172, 194], 'have': [13], 'been': [14], 'proposed': [15], 'to': [16, 25, 46, 84], 'explain': [17], 'action': [19], 'Al3+': [21, 53, 100, 112, 128, 139, 162, 192], 'toxicity': [22], 'are': [23], 'linked': [24], 'changes': [26], 'cellular': [29], 'calcium': [30, 35, 65], 'homeostasis,': [31], 'placing': [32], 'transporting': [34], 'pumps': [36, 66], 'as': [37, 57], 'potential': [38], 'targets.': [39], 'aim': [41], 'this': [43, 90], 'work': [44, 182], 'was': [45], 'study': [47], 'molecular': [49], 'inhibitory': [50], 'mechanism': [51, 190], 'on': [54, 101], 'Ca2+-ATPases': [55], 'such': [56], 'plasma': [59], 'membrane': [60], 'and': [61, 68, 83, 106, 119, 161], 'sarcoplasmic': [63, 86], 'reticulum': [64], '(PMCA': [67], 'SERCA,': [69, 134], 'respectively).': [70], 'These': [71], 'P-ATPases': [72], 'transport': [73], 'Ca2+': [74, 132], 'actively': [75], 'from': [76], 'cytoplasm': [78], 'towards': [79], 'extracellular': [81], 'medium': [82], 'reticulum,': [87], 'respectively.': [88], 'For': [89], 'purpose,': [91], 'we': [92], 'performed': [93], 'enzymatic': [94], 'measurements': [95], 'effect': [98], 'purified': [102], 'preparations': [103], 'PMCA': [105, 118, 160], 'SERCA.': [107, 124], 'Our': [108], 'results': [109], 'show': [110, 171], 'an': [114], 'irreversible': [115], 'inhibitor': [116, 122], 'a': [120, 188], 'slowly-reversible': [121], 'binding': [126], 'affected': [130], 'by': [131, 159, 177], 'though': [135], 'not': [136], 'PMCA.': [138, 150], 'prevents': [140], 'phosphorylation': [142], 'SERCA': [144], 'and,': [145], 'conversely,': [146], 'dephosphorylation': [148, 152], 'time': [153, 187], 'courses': [154], 'complex': [157], 'formed': [158], '(EPAl)': [163], 'presence': [166], 'ADP': [168], 'or': [169], 'ATP': [170], 'EPAl': [173], 'composed': [175], 'mainly': [176], 'conformer': [179], 'E2P.': [180], 'This': [181], 'shows': [183], 'for': [184], 'first': [186], 'distinct': [189], 'inhibition': [193], 'involves': [195], 'different': [196], 'intermediates': [197], 'reaction': [200], 'cycle': [201], 'these': [203], 'two': [204], 'Ca2+-ATPases.': [205]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2806030824', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-08-15T15:12:01.537610', 'created_date': '2018-06-13'}