Publication Information

{'id': 'https://openalex.org/W2805295219', 'doi': 'https://doi.org/10.1080/14786419.2018.1480019', 'title': 'Sikokianin A from <i>Wikstroemia indica</i> protects PC12 cells against OGD/R-induced injury via inhibiting oxidative stress and activating Nrf2', 'display_name': 'Sikokianin A from <i>Wikstroemia indica</i> protects PC12 cells against OGD/R-induced injury via inhibiting oxidative stress and activating Nrf2', 'publication_year': 2018, 'publication_date': '2018-05-28', 'ids': {'openalex': 'https://openalex.org/W2805295219', 'doi': 'https://doi.org/10.1080/14786419.2018.1480019', 'mag': '2805295219', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29806503'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/14786419.2018.1480019', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205999849', 'display_name': 'Natural Product Research', 'issn_l': '1478-6419', 'issn': ['1478-6419', '1478-6427'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://figshare.com/articles/journal_contribution/Sikokianin_A_from_i_Wikstroemia_indica_i_protects_PC12_cells_against_OGD_R-induced_injury_via_inhibiting_oxidative_stress_and_activating_Nrf2/6374129/1/files/11713454.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049250379', 'display_name': 'Huankai Yao', 'orcid': 'https://orcid.org/0000-0002-6316-3523'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huankai Yao', 'raw_affiliation_strings': ['School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100350558', 'display_name': 'Wenting Zhang', 'orcid': 'https://orcid.org/0009-0004-8931-6171'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenting Zhang', 'raw_affiliation_strings': ['School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090335118', 'display_name': 'Huiling Wu', 'orcid': 'https://orcid.org/0000-0001-8880-8714'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huiling Wu', 'raw_affiliation_strings': ['School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104093340', 'display_name': 'Ming Yang', 'orcid': 'https://orcid.org/0000-0001-7695-6170'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ming Yang', 'raw_affiliation_strings': ['Physical Education College, Jilin Sport University, Changchun, China'], 'affiliations': [{'raw_affiliation_string': 'Physical Education College, Jilin Sport University, Changchun, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088680102', 'display_name': 'Pengxiang Wei', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Pengxiang Wei', 'raw_affiliation_strings': ['School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068751110', 'display_name': 'Hang Ma', 'orcid': 'https://orcid.org/0000-0001-7565-6889'}, 'institutions': [{'id': 'https://openalex.org/I17626003', 'display_name': 'University of Rhode Island', 'ror': 'https://ror.org/013ckk937', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I17626003']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hang Ma', 'raw_affiliation_strings': ['Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA'], 'affiliations': [{'raw_affiliation_string': 'Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA', 'institution_ids': ['https://openalex.org/I17626003']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061502718', 'display_name': 'Jingyu Duan', 'orcid': 'https://orcid.org/0009-0006-4009-5130'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jingyu Duan', 'raw_affiliation_strings': ['School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018623969', 'display_name': 'Chunping Zhang', 'orcid': 'https://orcid.org/0000-0002-0159-4547'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chunping Zhang', 'raw_affiliation_strings': ['School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5047350976', 'display_name': 'Yan Li', 'orcid': 'https://orcid.org/0000-0002-9402-1093'}, 'institutions': [{'id': 'https://openalex.org/I177388780', 'display_name': 'Xuzhou Medical College', 'ror': 'https://ror.org/04fe7hy80', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177388780']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yan Li', 'raw_affiliation_strings': ['School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy and Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, China', 'institution_ids': ['https://openalex.org/I177388780']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5047350976'], 'corresponding_institution_ids': ['https://openalex.org/I177388780'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.314, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 22, 'citation_normalized_percentile': {'value': 0.770185, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '33', 'issue': '23', 'first_page': '3450', 'last_page': '3453'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12530', 'display_name': 'Bioactive Natural Diterpenoids Research', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12530', 'display_name': 'Bioactive Natural Diterpenoids Research', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12360', 'display_name': 'Plant-derived Lignans Synthesis and Bioactivity', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13130', 'display_name': 'Biological and pharmacological studies of plants', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.59853745}], 'concepts': [{'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.83649206}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.8041837}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.69391185}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.64251506}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.59853745}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.48667508}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.46450636}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.42814887}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.27013898}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21259564}], 'mesh': [{'descriptor_ui': 'D044946', 'descriptor_name': 'Biflavonoids', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': True}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051267', 'descriptor_name': 'NF-E2-Related Factor 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D032365', 'descriptor_name': 'Wikstroemia', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044946', 'descriptor_name': 'Biflavonoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D044946', 'descriptor_name': 'Biflavonoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006419', 'descriptor_name': 'Heme Oxygenase (Decyclizing)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006419', 'descriptor_name': 'Heme Oxygenase (Decyclizing)', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051267', 'descriptor_name': 'NF-E2-Related Factor 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018696', 'descriptor_name': 'Neuroprotective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016716', 'descriptor_name': 'PC12 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D032365', 'descriptor_name': 'Wikstroemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/14786419.2018.1480019', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205999849', 'display_name': 'Natural Product Research', 'issn_l': '1478-6419', 'issn': ['1478-6419', '1478-6427'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Sikokianin_A_from_i_Wikstroemia_indica_i_protects_PC12_cells_against_OGD_R-induced_injury_via_inhibiting_oxidative_stress_and_activating_Nrf2/6374129', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Sikokianin_A_from_i_Wikstroemia_indica_i_protects_PC12_cells_against_OGD_R-induced_injury_via_inhibiting_oxidative_stress_and_activating_Nrf2/6374129/1/files/11713454.pdf', 'source': {'id': 'https://openalex.org/S4306400572', 'display_name': 'OPAL (Open@LaTrobe) (La Trobe University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I196829312', 'host_organization_name': 'La Trobe University', 'host_organization_lineage': ['https://openalex.org/I196829312'], 'host_organization_lineage_names': ['La Trobe University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29806503', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Sikokianin_A_from_i_Wikstroemia_indica_i_protects_PC12_cells_against_OGD_R-induced_injury_via_inhibiting_oxidative_stress_and_activating_Nrf2/6374129', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Sikokianin_A_from_i_Wikstroemia_indica_i_protects_PC12_cells_against_OGD_R-induced_injury_via_inhibiting_oxidative_stress_and_activating_Nrf2/6374129/1/files/11713454.pdf', 'source': {'id': 'https://openalex.org/S4306400572', 'display_name': 'OPAL (Open@LaTrobe) (La Trobe University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I196829312', 'host_organization_name': 'La Trobe University', 'host_organization_lineage': ['https://openalex.org/I196829312'], 'host_organization_lineage_names': ['La Trobe University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'No poverty', 'score': 0.63, 'id': 'https://metadata.un.org/sdg/1'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 9, 'referenced_works': ['https://openalex.org/W1551656939', 'https://openalex.org/W2015843046', 'https://openalex.org/W2043336768', 'https://openalex.org/W2063960864', 'https://openalex.org/W2068659488', 'https://openalex.org/W2121410339', 'https://openalex.org/W2525535049', 'https://openalex.org/W2761987038', 'https://openalex.org/W2771011136'], 'related_works': ['https://openalex.org/W4295886409', 'https://openalex.org/W2995727304', 'https://openalex.org/W2808663575', 'https://openalex.org/W2481738341', 'https://openalex.org/W2095198015', 'https://openalex.org/W2077655479', 'https://openalex.org/W2034773528', 'https://openalex.org/W1988725105', 'https://openalex.org/W1593223226', 'https://openalex.org/W1517805603'], 'abstract_inverted_index': {'Ischemic': [0], 'cerebral': [1, 25], 'stroke': [2], 'is': [3], 'a': [4], 'severe': [5], 'cause': [6], 'of': [7, 21, 33, 57, 105, 145], 'human': [8], 'death': [9], 'and': [10, 55, 73, 94, 114, 125], 'disability.': [11], 'Natural': [12], 'products': [13], 'play': [14], 'an': [15], 'important': [16], 'role': [17], 'in': [18, 60, 128, 141], 'the': [19, 30, 52, 70, 102, 142], 'discovery': [20], 'novel': [22], 'therapy': [23], 'for': [24], 'ischemia.': [26], 'Herein,': [27], 'we': [28], 'investigate': [29], 'neuroprotective': [31], 'effects': [32, 104, 144], 'sikokianin': [34, 48, 83, 106, 120, 146], 'A': [35, 49, 107, 121], 'identifiedfrom': [36], 'Wikstroemia': [37], 'indica': [38], 'using': [39], 'PC12': [40, 61, 129], 'cell': [41], 'exposed': [42], 'to': [43], 'OGD/R.': [44, 65, 118], 'The': [45], 'results': [46, 100], 'revealed': [47], 'can': [50, 122], 'improve': [51], 'poor': [53], 'viability': [54], 'release': [56], 'intracellular': [58], 'LDH': [59], 'cells': [62, 130], 'induced': [63], 'by': [64, 82, 132], 'Further': [66], 'studies': [67], 'have': [68], 'demonstrated': [69], 'increased': [71], 'ROS': [72], 'MDA': [74], 'together': [75], 'with': [76, 110], 'reduced': [77], 'SOD': [78], 'activity': [79], 'were': [80, 97], 'attenuated': [81], 'A.': [84, 147], 'Meanwhile,': [85], 'decreased': [86], 'mitochondrial': [87], 'membrane': [88], 'potential,': [89], 'activated': [90], 'Caspase-3,': [91], 'down-regulated': [92], 'Bcl-2': [93], 'up-regulated': [95], 'Bax': [96], 'reversed.': [98], 'These': [99], 'indicate': [101], 'protective': [103, 143], 'are': [108], 'associated': [109], 'inhibiting': [111], 'oxidative': [112], 'stress': [113], 'apoptosis': [115], 'resulting': [116], 'from': [117], 'Additionally,': [119], 'activate': [123], 'Nrf2': [124], 'downstream': [126], 'HO-1': [127], 'treated': [131], 'OGD/R,': [133], 'which': [134], 'implied': [135], 'Nrf2/HO-1': [136], 'signaling': [137], 'pathway': [138], 'was': [139], 'involved': [140]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2805295219', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 6}], 'updated_date': '2024-12-11T07:02:02.079885', 'created_date': '2018-06-13'}