Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2803899179', 'doi': 'https://doi.org/10.3389/fnins.2018.00304', 'title': 'Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder', 'display_name': 'Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder', 'publication_year': 2018, 'publication_date': '2018-05-16', 'ids': {'openalex': 'https://openalex.org/W2803899179', 'doi': 'https://doi.org/10.3389/fnins.2018.00304', 'mag': '2803899179', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29867317', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5964170'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fnins.2018.00304', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fnins.2018.00304/pdf', 'source': {'id': 'https://openalex.org/S115201632', 'display_name': 'Frontiers in Neuroscience', 'issn_l': '1662-453X', 'issn': ['1662-453X', '1662-4548'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.frontiersin.org/articles/10.3389/fnins.2018.00304/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5011317903', 'display_name': 'Nermin Eissa', 'orcid': 'https://orcid.org/0000-0001-6159-3936'}, 'institutions': [{'id': 'https://openalex.org/I201726411', 'display_name': 'United Arab Emirates University', 'ror': 'https://ror.org/01km6p862', 'country_code': 'AE', 'type': 'education', 'lineage': ['https://openalex.org/I201726411']}], 'countries': ['AE'], 'is_corresponding': False, 'raw_author_name': 'Nermin Eissa', 'raw_affiliation_strings': ['Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates', 'institution_ids': ['https://openalex.org/I201726411']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081463512', 'display_name': 'Mohammed Al‐Houqani', 'orcid': 'https://orcid.org/0000-0003-4481-3911'}, 'institutions': [{'id': 'https://openalex.org/I201726411', 'display_name': 'United Arab Emirates University', 'ror': 'https://ror.org/01km6p862', 'country_code': 'AE', 'type': 'education', 'lineage': ['https://openalex.org/I201726411']}], 'countries': ['AE'], 'is_corresponding': False, 'raw_author_name': 'Mohammed Al-Houqani', 'raw_affiliation_strings': ['Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates', 'institution_ids': ['https://openalex.org/I201726411']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033380427', 'display_name': 'Adel Sadeq', 'orcid': 'https://orcid.org/0000-0001-9529-8898'}, 'institutions': [{'id': 'https://openalex.org/I161913731', 'display_name': 'Al Ain University', 'ror': 'https://ror.org/023abrt21', 'country_code': 'AE', 'type': 'education', 'lineage': ['https://openalex.org/I161913731']}], 'countries': ['AE'], 'is_corresponding': False, 'raw_author_name': 'Adel Sadeq', 'raw_affiliation_strings': ['Department of Clinical Pharmacy, College of Pharmacy, Al Ain University of Science and Technology, Al Ain, United Arab Emirates'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Pharmacy, College of Pharmacy, Al Ain University of Science and Technology, Al Ain, United Arab Emirates', 'institution_ids': ['https://openalex.org/I161913731']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015791582', 'display_name': 'Shreesh Ojha', 'orcid': 'https://orcid.org/0000-0001-7801-2966'}, 'institutions': [{'id': 'https://openalex.org/I201726411', 'display_name': 'United Arab Emirates University', 'ror': 'https://ror.org/01km6p862', 'country_code': 'AE', 'type': 'education', 'lineage': ['https://openalex.org/I201726411']}], 'countries': ['AE'], 'is_corresponding': False, 'raw_author_name': 'Shreesh K. Ojha', 'raw_affiliation_strings': ['Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates', 'institution_ids': ['https://openalex.org/I201726411']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018691594', 'display_name': 'Astrid Sasse', 'orcid': 'https://orcid.org/0000-0001-8214-8946'}, 'institutions': [{'id': 'https://openalex.org/I205274468', 'display_name': 'Trinity College Dublin', 'ror': 'https://ror.org/02tyrky19', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I205274468']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Astrid Sasse', 'raw_affiliation_strings': ['School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, University of Dublin, Dublin, Ireland'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, University of Dublin, Dublin, Ireland', 'institution_ids': ['https://openalex.org/I205274468']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5034401167', 'display_name': 'Bassem Sadek', 'orcid': 'https://orcid.org/0000-0002-0320-1487'}, 'institutions': [{'id': 'https://openalex.org/I201726411', 'display_name': 'United Arab Emirates University', 'ror': 'https://ror.org/01km6p862', 'country_code': 'AE', 'type': 'education', 'lineage': ['https://openalex.org/I201726411']}], 'countries': ['AE'], 'is_corresponding': True, 'raw_author_name': 'Bassem Sadek', 'raw_affiliation_strings': ['Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates', 'institution_ids': ['https://openalex.org/I201726411']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5034401167'], 'corresponding_institution_ids': ['https://openalex.org/I201726411'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 2.929, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 234, 'citation_normalized_percentile': {'value': 0.998425, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '12', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10106', 'display_name': 'Autism Spectrum Disorder Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10106', 'display_name': 'Autism Spectrum Disorder Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2805', 'display_name': 'Cognitive Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11772', 'display_name': 'Genetics and Neurodevelopmental Disorders', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neurodevelopmental-disorder', 'display_name': 'Neurodevelopmental disorder', 'score': 0.55890965}, {'id': 'https://openalex.org/keywords/etiology', 'display_name': 'Etiology', 'score': 0.41900614}], 'concepts': [{'id': 'https://openalex.org/C2778538070', 'wikidata': 'https://www.wikidata.org/wiki/Q1436063', 'display_name': 'Autism spectrum disorder', 'level': 3, 'score': 0.7214919}, {'id': 'https://openalex.org/C2780057945', 'wikidata': 'https://www.wikidata.org/wiki/Q412443', 'display_name': 'Risperidone', 'level': 3, 'score': 0.6451181}, {'id': 'https://openalex.org/C2779388368', 'wikidata': 'https://www.wikidata.org/wiki/Q3450985', 'display_name': 'Neurodevelopmental disorder', 'level': 3, 'score': 0.55890965}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.5006547}, {'id': 'https://openalex.org/C205778803', 'wikidata': 'https://www.wikidata.org/wiki/Q38404', 'display_name': 'Autism', 'level': 2, 'score': 0.49012622}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.47238755}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.45572537}, {'id': 'https://openalex.org/C551499885', 'wikidata': 'https://www.wikidata.org/wiki/Q183560', 'display_name': 'Intellectual disability', 'level': 2, 'score': 0.41933978}, {'id': 'https://openalex.org/C137627325', 'wikidata': 'https://www.wikidata.org/wiki/Q156318', 'display_name': 'Etiology', 'level': 2, 'score': 0.41900614}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.4175862}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.3790935}, {'id': 'https://openalex.org/C2776412080', 'wikidata': 'https://www.wikidata.org/wiki/Q7431605', 'display_name': 'Schizophrenia (object-oriented programming)', 'level': 2, 'score': 0.32422477}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fnins.2018.00304', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fnins.2018.00304/pdf', 'source': {'id': 'https://openalex.org/S115201632', 'display_name': 'Frontiers in Neuroscience', 'issn_l': '1662-453X', 'issn': ['1662-453X', '1662-4548'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/4e375206742d458ebc34148c649ea48a', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5964170', 'pdf_url': 'https://europepmc.org/articles/pmc5964170?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964170', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29867317', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fnins.2018.00304', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fnins.2018.00304/pdf', 'source': {'id': 'https://openalex.org/S115201632', 'display_name': 'Frontiers in Neuroscience', 'issn_l': '1662-453X', 'issn': ['1662-453X', '1662-4548'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320323593', 'funder_display_name': 'United Arab Emirates University', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 253, 'referenced_works': ['https://openalex.org/W1023621276', 'https://openalex.org/W1434085124', 'https://openalex.org/W1482498530', 'https://openalex.org/W1486504114', 'https://openalex.org/W1488923896', 'https://openalex.org/W1498586118', 'https://openalex.org/W1503836056', 'https://openalex.org/W1511218347', 'https://openalex.org/W1519623007', 'https://openalex.org/W1521522959', 'https://openalex.org/W1545240335', 'https://openalex.org/W1559742681', 'https://openalex.org/W1564965710', 'https://openalex.org/W1568812332', 'https://openalex.org/W1582157917', 'https://openalex.org/W15997792', 'https://openalex.org/W1645273149', 'https://openalex.org/W1657431829', 'https://openalex.org/W1701412057', 'https://openalex.org/W1901504499', 'https://openalex.org/W1913439650', 'https://openalex.org/W1963985457', 'https://openalex.org/W1964831740', 'https://openalex.org/W1965294510', 'https://openalex.org/W1966988500', 'https://openalex.org/W1968430210', 'https://openalex.org/W1968695161', 'https://openalex.org/W1968782484', 'https://openalex.org/W1970038529', 'https://openalex.org/W1970797800', 'https://openalex.org/W1971850026', 'https://openalex.org/W1975890560', 'https://openalex.org/W1978523634', 'https://openalex.org/W1979046783', 'https://openalex.org/W1979228728', 'https://openalex.org/W1979866975', 'https://openalex.org/W1983516002', 'https://openalex.org/W1985840371', 'https://openalex.org/W1986644762', 'https://openalex.org/W1986820918', 'https://openalex.org/W1989468360', 'https://openalex.org/W1992577657', 'https://openalex.org/W1993224249', 'https://openalex.org/W1995647101', 'https://openalex.org/W1997085737', 'https://openalex.org/W2000659747', 'https://openalex.org/W2000757610', 'https://openalex.org/W2001768156', 'https://openalex.org/W2004552109', 'https://openalex.org/W2005130101', 'https://openalex.org/W2005585817', 'https://openalex.org/W2006637413', 'https://openalex.org/W2006718746', 'https://openalex.org/W2007445647', 'https://openalex.org/W2007816528', 'https://openalex.org/W2009942054', 'https://openalex.org/W2013129610', 'https://openalex.org/W2013430328', 'https://openalex.org/W2014760588', 'https://openalex.org/W2015053297', 'https://openalex.org/W2015252064', 'https://openalex.org/W2016079923', 'https://openalex.org/W2016411894', 'https://openalex.org/W2016492084', 'https://openalex.org/W2017055292', 'https://openalex.org/W2018706788', 'https://openalex.org/W2018889813', 'https://openalex.org/W2018998808', 'https://openalex.org/W2020331089', 'https://openalex.org/W2020529206', 'https://openalex.org/W2021277887', 'https://openalex.org/W2023725147', 'https://openalex.org/W2024948778', 'https://openalex.org/W2025552546', 'https://openalex.org/W2029331443', 'https://openalex.org/W2030122206', 'https://openalex.org/W2030699202', 'https://openalex.org/W2031176676', 'https://openalex.org/W2031389945', 'https://openalex.org/W2034102853', 'https://openalex.org/W2034220807', 'https://openalex.org/W2035310577', 'https://openalex.org/W2038517468', 'https://openalex.org/W2038535375', 'https://openalex.org/W2038596292', 'https://openalex.org/W2040034581', 'https://openalex.org/W2040159957', 'https://openalex.org/W2042843923', 'https://openalex.org/W2045040686', 'https://openalex.org/W2045245723', 'https://openalex.org/W2046163003', 'https://openalex.org/W2047143817', 'https://openalex.org/W2047266773', 'https://openalex.org/W2048260661', 'https://openalex.org/W2048433941', 'https://openalex.org/W2049674250', 'https://openalex.org/W2049717607', 'https://openalex.org/W2050597016', 'https://openalex.org/W2050947021', 'https://openalex.org/W2051721392', 'https://openalex.org/W2052477543', 'https://openalex.org/W2060497829', 'https://openalex.org/W2062761535', 'https://openalex.org/W2062974472', 'https://openalex.org/W2064910801', 'https://openalex.org/W2065680191', 'https://openalex.org/W2069180831', 'https://openalex.org/W2071797996', 'https://openalex.org/W2074480115', 'https://openalex.org/W2074579392', 'https://openalex.org/W2075059777', 'https://openalex.org/W2077209303', 'https://openalex.org/W2077697912', 'https://openalex.org/W2077863458', 'https://openalex.org/W2078579311', 'https://openalex.org/W2078866410', 'https://openalex.org/W2079773266', 'https://openalex.org/W2079964367', 'https://openalex.org/W2081161499', 'https://openalex.org/W2081994821', 'https://openalex.org/W2084550269', 'https://openalex.org/W2085242610', 'https://openalex.org/W2086018460', 'https://openalex.org/W2087905544', 'https://openalex.org/W2090450562', 'https://openalex.org/W2091991835', 'https://openalex.org/W2092691320', 'https://openalex.org/W2093289593', 'https://openalex.org/W2093418477', 'https://openalex.org/W2093575302', 'https://openalex.org/W2094013752', 'https://openalex.org/W2094833927', 'https://openalex.org/W2095286708', 'https://openalex.org/W2096253586', 'https://openalex.org/W2097774432', 'https://openalex.org/W2097872763', 'https://openalex.org/W2098709113', 'https://openalex.org/W2099756187', 'https://openalex.org/W2100022067', 'https://openalex.org/W2100456941', 'https://openalex.org/W2102096940', 'https://openalex.org/W2104000439', 'https://openalex.org/W2104054545', 'https://openalex.org/W2104220482', 'https://openalex.org/W2104696168', 'https://openalex.org/W2105245235', 'https://openalex.org/W2106291713', 'https://openalex.org/W2107601960', 'https://openalex.org/W2113620103', 'https://openalex.org/W2118648637', 'https://openalex.org/W2119855769', 'https://openalex.org/W2120574495', 'https://openalex.org/W2121619206', 'https://openalex.org/W2122550040', 'https://openalex.org/W2123035658', 'https://openalex.org/W2123194540', 'https://openalex.org/W2126021422', 'https://openalex.org/W2126056720', 'https://openalex.org/W2127620928', 'https://openalex.org/W2127753140', 'https://openalex.org/W2129032286', 'https://openalex.org/W2130680376', 'https://openalex.org/W2131522463', 'https://openalex.org/W2131568512', 'https://openalex.org/W2131651771', 'https://openalex.org/W2132438753', 'https://openalex.org/W2134906491', 'https://openalex.org/W2137827045', 'https://openalex.org/W2139345487', 'https://openalex.org/W2141881817', 'https://openalex.org/W2142647774', 'https://openalex.org/W2142680666', 'https://openalex.org/W2146441622', 'https://openalex.org/W2147341063', 'https://openalex.org/W2147609603', 'https://openalex.org/W2151631179', 'https://openalex.org/W2152009896', 'https://openalex.org/W2152917714', 'https://openalex.org/W2153010098', 'https://openalex.org/W2155543956', 'https://openalex.org/W2157489226', 'https://openalex.org/W2157729809', 'https://openalex.org/W2158400558', 'https://openalex.org/W2159457615', 'https://openalex.org/W2159568537', 'https://openalex.org/W2160438215', 'https://openalex.org/W2162330264', 'https://openalex.org/W2163492066', 'https://openalex.org/W2164537043', 'https://openalex.org/W2165715618', 'https://openalex.org/W2167684047', 'https://openalex.org/W2177136124', 'https://openalex.org/W2214092289', 'https://openalex.org/W2214916842', 'https://openalex.org/W2266306935', 'https://openalex.org/W2319216822', 'https://openalex.org/W2320983896', 'https://openalex.org/W2331528432', 'https://openalex.org/W2337392459', 'https://openalex.org/W2337632157', 'https://openalex.org/W2337639018', 'https://openalex.org/W2342600362', 'https://openalex.org/W241009001', 'https://openalex.org/W2411686343', 'https://openalex.org/W2412142904', 'https://openalex.org/W2412975393', 'https://openalex.org/W2442239417', 'https://openalex.org/W2464964435', 'https://openalex.org/W2493779250', 'https://openalex.org/W2498946529', 'https://openalex.org/W2520272104', 'https://openalex.org/W2520462646', 'https://openalex.org/W2523353368', 'https://openalex.org/W2536255693', 'https://openalex.org/W2566644527', 'https://openalex.org/W2570496985', 'https://openalex.org/W2582825071', 'https://openalex.org/W2590747033', 'https://openalex.org/W2590949582', 'https://openalex.org/W2592063610', 'https://openalex.org/W2593686237', 'https://openalex.org/W2597459336', 'https://openalex.org/W2599560126', 'https://openalex.org/W2601703801', 'https://openalex.org/W2606394326', 'https://openalex.org/W2610766525', 'https://openalex.org/W2611352611', 'https://openalex.org/W2613763984', 'https://openalex.org/W2614490846', 'https://openalex.org/W2615510373', 'https://openalex.org/W2617929858', 'https://openalex.org/W2619358396', 'https://openalex.org/W2622426750', 'https://openalex.org/W2675424776', 'https://openalex.org/W2733691813', 'https://openalex.org/W2735810414', 'https://openalex.org/W2739669908', 'https://openalex.org/W2743868015', 'https://openalex.org/W2744245475', 'https://openalex.org/W2751111845', 'https://openalex.org/W2752216955', 'https://openalex.org/W2754485959', 'https://openalex.org/W2757271273', 'https://openalex.org/W2762167966', 'https://openalex.org/W2772816701', 'https://openalex.org/W2775647200', 'https://openalex.org/W2782326210', 'https://openalex.org/W2790551111', 'https://openalex.org/W2797426585', 'https://openalex.org/W2937116611', 'https://openalex.org/W4234063125', 'https://openalex.org/W4237134263', 'https://openalex.org/W4244267937'], 'related_works': ['https://openalex.org/W4399206184', 'https://openalex.org/W4398186809', 'https://openalex.org/W4285596854', 'https://openalex.org/W2991544771', 'https://openalex.org/W2982830161', 'https://openalex.org/W2953141112', 'https://openalex.org/W2945207151', 'https://openalex.org/W2804752758', 'https://openalex.org/W2549065491', 'https://openalex.org/W2105181383'], 'abstract_inverted_index': {'Autistic': [0], 'Spectrum': [1], 'Disorder': [2], '(ASD)': [3], 'is': [4, 10, 149], 'a': [5], 'complex': [6], 'neurodevelopmental': [7], 'brain': [8, 85], 'disorder': [9], 'characterized': [11], 'by': [12, 136], 'two': [13, 124], 'core': [14, 238], 'behavioural': [15, 130], 'symptoms,': [16], 'namely': [17], 'impairments': [18, 22], 'in': [19, 44, 55, 107, 194, 240], 'social': [20], 'communication': [21], 'and': [23, 57, 103, 110, 119, 138, 165, 178, 191, 200], 'restricted/repetitive': [24], 'behaviour.': [25], 'The': [26, 220], 'molecular': [27], 'mechanisms': [28], 'underlying': [29], 'ASD': [30, 133, 159, 172, 204], 'are': [31, 121, 169, 205], 'not': [32], 'well': [33, 38], 'understood.': [34], 'Recent,': [35], 'genetic': [36, 61], 'as': [37, 39, 50], 'non-genetic': [40], 'animal': [41], 'models': [42], 'contribute': [43], 'understanding': [45], 'the': [46, 60, 79, 108, 122, 185, 192, 224], 'pathophysiology': [47], 'of': [48, 75, 112, 115, 132, 167, 176, 187, 196, 227], 'ASD,': [49], 'they': [51], 'establish': [52], 'autism-like': [53], 'behaviour': [54], 'mice': [56], 'rats.': [58], 'Among': [59], 'causes,': [62], 'several': [63, 84], 'chromosomal': [64], 'mutations': [65], 'including': [66, 91], 'duplications': [67], 'or': [68], 'deletions': [69], 'could': [70], 'be': [71], 'possible': [72], 'causative': [73], 'factors': [74, 190], 'ASD.': [76, 113, 219, 241], 'In': [77, 182], 'addition,': [78], 'biochemical': [80], 'basis': [81], 'suggests': [82], 'that': [83], 'neurotransmitters,': [86], 'e.g.': [87], 'dopamine': [88], '(DA),': [89], 'systems': [90], 'serotonin': [92], '(5-HT),': [93], 'dopamine,': [94], 'gamma-amino': [95], 'butyric': [96], 'acid': [97], '(GABA),': [98], 'acetylcholine': [99], '(ACh),': [100], 'glutamate': [101], '(Glu)': [102], 'histamine': [104], '(HA)': [105], 'participate': [106], 'onset': [109], 'progression': [111], 'Despite': [114], 'convincible': [116], 'understanding,': [117], 'risperidone': [118], 'aripiprazole': [120], 'only': [123], 'drugs': [125, 210, 228], 'available': [126], 'clinically': [127], 'for': [128, 154, 158, 171], 'improving': [129, 237], 'symptoms': [131, 216, 239], 'following': [134], 'approval': [135], 'Food': [137], 'Drug': [139], 'Administration': [140], '(FDA).': [141], 'Till': [142], 'date,': [143], 'up': [144], 'to': [145, 203, 213, 218], 'our': [146], 'knowledge': [147], 'there': [148], 'no': [150], 'other': [151], 'drug': [152, 163, 180], 'approved': [153], 'clinical': [155, 179, 225], 'usage': [156], 'specifically': [157], 'symptoms.': [160], 'Many': [161], 'novel': [162], 'candidates': [164], 'classes': [166], 'compounds': [168], 'underway': [170], 'at': [173, 236], 'different': [174], 'phases': [175], 'preclinical': [177], 'development.': [181], 'this': [183], 'review,': [184], 'diversity': [186], 'numerous': [188], 'aetiological': [189], 'alterations': [193], 'variety': [195], 'neurotransmitter': [197], 'generation,': [198], 'release': [199], 'function': [201], 'linked': [202], 'discussed': [206], 'with': [207, 229], 'focus': [208], 'on': [209, 231], 'currently': [211], 'used': [212], 'manage': [214], 'neuropsychiatric': [215], 'related': [217], 'review': [221], 'also': [222], 'highlights': [223], 'development': [226], 'emphasis': [230], 'their': [232], 'pharmacological': [233], 'targets': [234], 'aiming': [235]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2803899179', 'counts_by_year': [{'year': 2024, 'cited_by_count': 29}, {'year': 2023, 'cited_by_count': 70}, {'year': 2022, 'cited_by_count': 47}, {'year': 2021, 'cited_by_count': 34}, {'year': 2020, 'cited_by_count': 28}, {'year': 2019, 'cited_by_count': 18}, {'year': 2018, 'cited_by_count': 4}], 'updated_date': '2024-12-21T00:28:59.782607', 'created_date': '2018-06-01'}