Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2803488008', 'doi': 'https://doi.org/10.1016/j.bmc.2018.05.025', 'title': 'Synthesis of 4′-C-aminoalkyl-2′-O-methyl modified RNA and their biological properties', 'display_name': 'Synthesis of 4′-C-aminoalkyl-2′-O-methyl modified RNA and their biological properties', 'publication_year': 2018, 'publication_date': '2018-05-17', 'ids': {'openalex': 'https://openalex.org/W2803488008', 'doi': 'https://doi.org/10.1016/j.bmc.2018.05.025', 'mag': '2803488008', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29789208'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bmc.2018.05.025', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10422866', 'display_name': 'Bioorganic & Medicinal Chemistry', 'issn_l': '0968-0896', 'issn': ['0968-0896', '1464-3391'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051984266', 'display_name': 'Kana Koizumi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I42405503', 'display_name': 'Gifu University', 'ror': 'https://ror.org/024exxj48', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I42405503']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kana Koizumi', 'raw_affiliation_strings': ['Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Japan', 'institution_ids': ['https://openalex.org/I42405503']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051611788', 'display_name': 'Yusuke Maeda', 'orcid': 'https://orcid.org/0000-0003-4601-497X'}, 'institutions': [{'id': 'https://openalex.org/I42405503', 'display_name': 'Gifu University', 'ror': 'https://ror.org/024exxj48', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I42405503']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yusuke Maeda', 'raw_affiliation_strings': ['Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Japan', 'institution_ids': ['https://openalex.org/I42405503']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068452181', 'display_name': 'Toshifumi Kano', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I42405503', 'display_name': 'Gifu University', 'ror': 'https://ror.org/024exxj48', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I42405503']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshifumi Kano', 'raw_affiliation_strings': ['Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Japan', 'institution_ids': ['https://openalex.org/I42405503']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014422542', 'display_name': 'Hisae YOSHIDA', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I104946051', 'display_name': 'Nihon University', 'ror': 'https://ror.org/05jk51a88', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I104946051']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hisae Yoshida', 'raw_affiliation_strings': ['Department of Chemical Biology and Applied Chemistry, College of Engineering, Nihon University, 1 Aza-nakagawara, Tokusada, Tamuramachi, Koriyama, Fukushima 963-8642, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Biology and Applied Chemistry, College of Engineering, Nihon University, 1 Aza-nakagawara, Tokusada, Tamuramachi, Koriyama, Fukushima 963-8642, Japan', 'institution_ids': ['https://openalex.org/I104946051']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053346109', 'display_name': 'Taiichi Sakamoto', 'orcid': 'https://orcid.org/0000-0002-1450-9372'}, 'institutions': [{'id': 'https://openalex.org/I8488066', 'display_name': 'Chiba Institute of Technology', 'ror': 'https://ror.org/00qwnam72', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I8488066']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Taiichi Sakamoto', 'raw_affiliation_strings': ['Faculty of Advanced Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275-0016, Japan'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Advanced Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275-0016, Japan', 'institution_ids': ['https://openalex.org/I8488066']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101721861', 'display_name': 'Kenji Yamagishi', 'orcid': 'https://orcid.org/0000-0001-6808-7462'}, 'institutions': [{'id': 'https://openalex.org/I104946051', 'display_name': 'Nihon University', 'ror': 'https://ror.org/05jk51a88', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I104946051']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenji Yamagishi', 'raw_affiliation_strings': ['Department of Chemical Biology and Applied Chemistry, College of Engineering, Nihon University, 1 Aza-nakagawara, Tokusada, Tamuramachi, Koriyama, Fukushima 963-8642, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Biology and Applied Chemistry, College of Engineering, Nihon University, 1 Aza-nakagawara, Tokusada, Tamuramachi, Koriyama, Fukushima 963-8642, Japan', 'institution_ids': ['https://openalex.org/I104946051']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085548255', 'display_name': 'Yoshihito Ueno', 'orcid': 'https://orcid.org/0000-0003-3492-4677'}, 'institutions': [{'id': 'https://openalex.org/I42405503', 'display_name': 'Gifu University', 'ror': 'https://ror.org/024exxj48', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I42405503']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yoshihito Ueno', 'raw_affiliation_strings': ['Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University 1-1 Yanagido, Gifu 501-1193, Japan', 'Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Japan', 'United Graduate School of Agricultural Science, Gifu University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Japan', 'institution_ids': ['https://openalex.org/I42405503']}, {'raw_affiliation_string': 'United Graduate School of Agricultural Science, Gifu University, Japan', 'institution_ids': ['https://openalex.org/I42405503']}, {'raw_affiliation_string': 'Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University 1-1 Yanagido, Gifu 501-1193, Japan', 'institution_ids': ['https://openalex.org/I42405503']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5085548255'], 'corresponding_institution_ids': ['https://openalex.org/I42405503'], 'apc_list': {'value': 3690, 'currency': 'USD', 'value_usd': 3690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.576, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '26', 'issue': '12', 'first_page': '3521', 'last_page': '3534'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9895, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/carboxamide', 'display_name': 'Carboxamide', 'score': 0.41787106}], 'concepts': [{'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.9570775}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.60248125}, {'id': 'https://openalex.org/C114373084', 'wikidata': 'https://www.wikidata.org/wiki/Q273499', 'display_name': 'Chemical synthesis', 'level': 3, 'score': 0.55425584}, {'id': 'https://openalex.org/C116073593', 'wikidata': 'https://www.wikidata.org/wiki/Q864491', 'display_name': 'Biological activity', 'level': 3, 'score': 0.5105542}, {'id': 'https://openalex.org/C2778327999', 'wikidata': 'https://www.wikidata.org/wiki/Q188777', 'display_name': 'Carboxamide', 'level': 2, 'score': 0.41787106}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.33692184}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.29912978}], 'mesh': [{'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002942', 'descriptor_name': 'Circular Dichroism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009682', 'descriptor_name': 'Magnetic Resonance Spectroscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009691', 'descriptor_name': 'Nucleic Acid Denaturation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020871', 'descriptor_name': 'RNA Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044366', 'descriptor_name': 'Transition Temperature', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bmc.2018.05.025', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10422866', 'display_name': 'Bioorganic & Medicinal Chemistry', 'issn_l': '0968-0896', 'issn': ['0968-0896', '1464-3391'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29789208', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320311405', 'funder_display_name': 'Japan Agency for Medical Research and Development', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1647075334', 'https://openalex.org/W1967485248', 'https://openalex.org/W1969744746', 'https://openalex.org/W1975088062', 'https://openalex.org/W1976499671', 'https://openalex.org/W1977911233', 'https://openalex.org/W2002221161', 'https://openalex.org/W2008161734', 'https://openalex.org/W2033184129', 'https://openalex.org/W2034394760', 'https://openalex.org/W2035199159', 'https://openalex.org/W2041594569', 'https://openalex.org/W2043116561', 'https://openalex.org/W2051544732', 'https://openalex.org/W2053716401', 'https://openalex.org/W2061822610', 'https://openalex.org/W2067174909', 'https://openalex.org/W2067803032', 'https://openalex.org/W2071596792', 'https://openalex.org/W2076011658', 'https://openalex.org/W2082213106', 'https://openalex.org/W2083164919', 'https://openalex.org/W2084389257', 'https://openalex.org/W2091980264', 'https://openalex.org/W2094503153', 'https://openalex.org/W2098431098', 'https://openalex.org/W2100293534', 'https://openalex.org/W2106140689', 'https://openalex.org/W2107762071', 'https://openalex.org/W2110385304', 'https://openalex.org/W2111452477', 'https://openalex.org/W2130397530', 'https://openalex.org/W2139115320', 'https://openalex.org/W2143026251', 'https://openalex.org/W2147993766', 'https://openalex.org/W2151043147', 'https://openalex.org/W2152778335', 'https://openalex.org/W2216033157', 'https://openalex.org/W2254397565', 'https://openalex.org/W2417786350', 'https://openalex.org/W2595327991', 'https://openalex.org/W2788693636', 'https://openalex.org/W4247851298', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4249833830', 'https://openalex.org/W2559899463', 'https://openalex.org/W2077340934', 'https://openalex.org/W2076777936', 'https://openalex.org/W2070320679', 'https://openalex.org/W2036610614', 'https://openalex.org/W2029073800', 'https://openalex.org/W2015674430', 'https://openalex.org/W2004676005', 'https://openalex.org/W1982357134'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2803488008', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}], 'updated_date': '2025-01-05T06:11:10.026458', 'created_date': '2018-06-01'}