Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2802276006', 'doi': 'https://doi.org/10.1038/s41419-018-0622-x', 'title': 'The extent of liver injury determines hepatocyte fate toward senescence or cancer', 'display_name': 'The extent of liver injury determines hepatocyte fate toward senescence or cancer', 'publication_year': 2018, 'publication_date': '2018-05-14', 'ids': {'openalex': 'https://openalex.org/W2802276006', 'doi': 'https://doi.org/10.1038/s41419-018-0622-x', 'mag': '2802276006', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29760381', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5951829'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41419-018-0622-x', 'pdf_url': 'https://www.nature.com/articles/s41419-018-0622-x.pdf', 'source': {'id': 'https://openalex.org/S185208586', 'display_name': 'Cell Death and Disease', 'issn_l': '2041-4889', 'issn': ['2041-4889'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41419-018-0622-x.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100406855', 'display_name': 'Chao Wang', 'orcid': 'https://orcid.org/0000-0001-5196-9426'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chao Wang', 'raw_affiliation_strings': ['Department of Cell Biology, Center for Stem Cell and Medicine, Second Military Medical University, 200433, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Center for Stem Cell and Medicine, Second Military Medical University, 200433, Shanghai, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101500084', 'display_name': 'Wenjian Chen', 'orcid': 'https://orcid.org/0000-0003-1310-8611'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wen-Jian Chen', 'raw_affiliation_strings': ['Department of Cell Biology, Center for Stem Cell and Medicine, Second Military Medical University, 200433, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Center for Stem Cell and Medicine, Second Military Medical University, 200433, Shanghai, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011266301', 'display_name': 'Yingfu Wu', 'orcid': 'https://orcid.org/0000-0002-8142-6999'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ying-Fu Wu', 'raw_affiliation_strings': ['Department of Cell Biology, Center for Stem Cell and Medicine, Second Military Medical University, 200433, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Center for Stem Cell and Medicine, Second Military Medical University, 200433, Shanghai, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101002825', 'display_name': 'Pu You', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I116953780', 'display_name': 'Tongji University', 'ror': 'https://ror.org/03rc6as71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I116953780']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Pu You', 'raw_affiliation_strings': ['School of Medicine, Tongji University, 200092, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine, Tongji University, 200092, Shanghai, China', 'institution_ids': ['https://openalex.org/I116953780']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077569128', 'display_name': 'Shangyong Zheng', 'orcid': 'https://orcid.org/0000-0002-3986-9278'}, 'institutions': [{'id': 'https://openalex.org/I189210763', 'display_name': 'Yunnan University', 'ror': 'https://ror.org/0040axw97', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I189210763']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shang-Yong Zheng', 'raw_affiliation_strings': ['School of Medicine, Yunnan University, 650091, Kunming, Yunnan, China'], 'affiliations': [{'raw_affiliation_string': 'School of Medicine, Yunnan University, 650091, Kunming, Yunnan, China', 'institution_ids': ['https://openalex.org/I189210763']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005786917', 'display_name': 'Changcheng Liu', 'orcid': 'https://orcid.org/0000-0001-7922-7950'}, 'institutions': [{'id': 'https://openalex.org/I4210128175', 'display_name': 'Shanghai East Hospital', 'ror': 'https://ror.org/038xmzj21', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128175']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chang-Cheng Liu', 'raw_affiliation_strings': ['Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, 200123, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, 200123, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210128175']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055538318', 'display_name': 'Dao Xiang', 'orcid': 'https://orcid.org/0000-0003-1590-7193'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dao Xiang', 'raw_affiliation_strings': ['Naval Medicine Research Institute, Second Military Medical University, 200433, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Naval Medicine Research Institute, Second Military Medical University, 200433, Shanghai, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074405393', 'display_name': 'Minjun Wang', 'orcid': 'https://orcid.org/0000-0002-2831-8817'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Min-Jun Wang', 'raw_affiliation_strings': ['Department of Cell Biology, Center for Stem Cell and Medicine, Second Military Medical University, 200433, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, Center for Stem Cell and Medicine, Second Military Medical University, 200433, Shanghai, China', 'institution_ids': ['https://openalex.org/I177933477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050576982', 'display_name': 'Yongchao Cai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210128175', 'display_name': 'Shanghai East Hospital', 'ror': 'https://ror.org/038xmzj21', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128175']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yong-Chao Cai', 'raw_affiliation_strings': ['Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, 200123, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, 200123, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210128175']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101520809', 'display_name': 'Qinghui Zhao', 'orcid': 'https://orcid.org/0000-0002-1542-6333'}, 'institutions': [{'id': 'https://openalex.org/I4210128175', 'display_name': 'Shanghai East Hospital', 'ror': 'https://ror.org/038xmzj21', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128175']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qing-Hui Zhao', 'raw_affiliation_strings': ['Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, 200123, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, 200123, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210128175']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084892948', 'display_name': 'Uyunbilig Borjigin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2722730', 'display_name': 'Inner Mongolia University', 'ror': 'https://ror.org/0106qb496', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I2722730']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Uyunbilig Borjigin', 'raw_affiliation_strings': ['The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, Inner Mongolia University, 010070, Huhhot, China'], 'affiliations': [{'raw_affiliation_string': 'The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, Inner Mongolia University, 010070, Huhhot, China', 'institution_ids': ['https://openalex.org/I2722730']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100431980', 'display_name': 'Wei Liu', 'orcid': 'https://orcid.org/0000-0003-3446-4156'}, 'institutions': [{'id': 'https://openalex.org/I4210128175', 'display_name': 'Shanghai East Hospital', 'ror': 'https://ror.org/038xmzj21', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128175']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Liu', 'raw_affiliation_strings': ['Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, 200123, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, 200123, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210128175']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100672804', 'display_name': 'Wujun Xiong', 'orcid': 'https://orcid.org/0000-0002-4591-0644'}, 'institutions': [{'id': 'https://openalex.org/I4210128175', 'display_name': 'Shanghai East Hospital', 'ror': 'https://ror.org/038xmzj21', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128175']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wu-Jun Xiong', 'raw_affiliation_strings': ['Department of Hepatology, Shanghai East Hospital, School of Medicine, Tongji University, 200120, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Hepatology, Shanghai East Hospital, School of Medicine, Tongji University, 200120, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210128175']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001370323', 'display_name': 'Kirk J. Wangensteen', 'orcid': 'https://orcid.org/0000-0001-6042-6490'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kirk J. Wangensteen', 'raw_affiliation_strings': ['Department of Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, 19104, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, 19104, USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052510869', 'display_name': 'Xin Wang', 'orcid': 'https://orcid.org/0000-0003-2970-5162'}, 'institutions': [{'id': 'https://openalex.org/I2722730', 'display_name': 'Inner Mongolia University', 'ror': 'https://ror.org/0106qb496', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I2722730']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xin Wang', 'raw_affiliation_strings': ['The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, Inner Mongolia University, 010070, Huhhot, China'], 'affiliations': [{'raw_affiliation_string': 'The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, Inner Mongolia University, 010070, Huhhot, China', 'institution_ids': ['https://openalex.org/I2722730']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100660728', 'display_name': 'Zhongmin Liu', 'orcid': 'https://orcid.org/0000-0003-4709-4027'}, 'institutions': [{'id': 'https://openalex.org/I4210128175', 'display_name': 'Shanghai East Hospital', 'ror': 'https://ror.org/038xmzj21', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128175']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhong-Min Liu', 'raw_affiliation_strings': ['Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, 200123, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, 200123, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210128175']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5089231537', 'display_name': 'Zhiying He', 'orcid': 'https://orcid.org/0000-0002-0087-2277'}, 'institutions': [{'id': 'https://openalex.org/I4210128175', 'display_name': 'Shanghai East Hospital', 'ror': 'https://ror.org/038xmzj21', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210128175']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhi-Ying He', 'raw_affiliation_strings': ['Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, 200123, Shanghai, China'], 'affiliations': [{'raw_affiliation_string': 'Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, 200123, Shanghai, China', 'institution_ids': ['https://openalex.org/I4210128175']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2790, 'currency': 'GBP', 'value_usd': 3422, 'provenance': 'doaj'}, 'apc_paid': {'value': 2790, 'currency': 'GBP', 'value_usd': 3422, 'provenance': 'doaj'}, 'fwci': 2.302, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.844039, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '9', 'issue': '5', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10937', 'display_name': 'Telomeres, Telomerase, and Senescence', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10937', 'display_name': 'Telomeres, Telomerase, and Senescence', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11668', 'display_name': 'interferon and immune responses', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/senescence', 'display_name': 'Senescence', 'score': 0.93315053}, {'id': 'https://openalex.org/keywords/liver-cancer', 'display_name': 'Liver Cancer', 'score': 0.41717944}], 'concepts': [{'id': 'https://openalex.org/C522857546', 'wikidata': 'https://www.wikidata.org/wiki/Q2070979', 'display_name': 'Senescence', 'level': 2, 'score': 0.93315053}, {'id': 'https://openalex.org/C2776200302', 'wikidata': 'https://www.wikidata.org/wiki/Q827450', 'display_name': 'Hepatocyte', 'level': 3, 'score': 0.905612}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.75628793}, {'id': 'https://openalex.org/C2776637226', 'wikidata': 'https://www.wikidata.org/wiki/Q6658207', 'display_name': 'Liver injury', 'level': 2, 'score': 0.6902272}, {'id': 'https://openalex.org/C2776996007', 'wikidata': 'https://www.wikidata.org/wiki/Q2399112', 'display_name': 'Hepatocyte growth factor', 'level': 3, 'score': 0.53711915}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.45841572}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42122653}, {'id': 'https://openalex.org/C2776231280', 'wikidata': 'https://www.wikidata.org/wiki/Q623031', 'display_name': 'Liver cancer', 'level': 3, 'score': 0.41717944}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41389814}, {'id': 'https://openalex.org/C2778019345', 'wikidata': 'https://www.wikidata.org/wiki/Q1148337', 'display_name': 'Hepatocellular carcinoma', 'level': 2, 'score': 0.35649478}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.34049377}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3339753}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2484779}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0728485}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016922', 'descriptor_name': 'Cellular Senescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000293', 'qualifier_name': 'injuries', 'is_major_topic': True}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000208', 'descriptor_name': 'Acute Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D022781', 'descriptor_name': 'Hepatocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41419-018-0622-x', 'pdf_url': 'https://www.nature.com/articles/s41419-018-0622-x.pdf', 'source': {'id': 'https://openalex.org/S185208586', 'display_name': 'Cell Death and Disease', 'issn_l': '2041-4889', 'issn': ['2041-4889'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951829', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29760381', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41419-018-0622-x', 'pdf_url': 'https://www.nature.com/articles/s41419-018-0622-x.pdf', 'source': {'id': 'https://openalex.org/S185208586', 'display_name': 'Cell Death and Disease', 'issn_l': '2041-4889', 'issn': ['2041-4889'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.86, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1661700615', 'https://openalex.org/W1772730814', 'https://openalex.org/W1924766827', 'https://openalex.org/W1968572771', 'https://openalex.org/W1969189564', 'https://openalex.org/W1970017176', 'https://openalex.org/W1980878904', 'https://openalex.org/W1982395176', 'https://openalex.org/W1986014209', 'https://openalex.org/W1986947784', 'https://openalex.org/W1989818074', 'https://openalex.org/W1995205742', 'https://openalex.org/W2003146640', 'https://openalex.org/W2004273407', 'https://openalex.org/W2018116689', 'https://openalex.org/W2039766314', 'https://openalex.org/W2041108404', 'https://openalex.org/W2042140414', 'https://openalex.org/W2042418128', 'https://openalex.org/W2047330128', 'https://openalex.org/W2060914434', 'https://openalex.org/W2063470614', 'https://openalex.org/W2067117191', 'https://openalex.org/W2072390567', 'https://openalex.org/W2073223227', 'https://openalex.org/W2076486071', 'https://openalex.org/W2080769506', 'https://openalex.org/W2081505855', 'https://openalex.org/W2104908670', 'https://openalex.org/W2106787323', 'https://openalex.org/W2117912210', 'https://openalex.org/W2125674718', 'https://openalex.org/W2150748567', 'https://openalex.org/W2155019761', 'https://openalex.org/W2164568491', 'https://openalex.org/W2273101790', 'https://openalex.org/W2405635216', 'https://openalex.org/W2419151069', 'https://openalex.org/W2478438166', 'https://openalex.org/W2530995434', 'https://openalex.org/W2727968879', 'https://openalex.org/W2762611634', 'https://openalex.org/W2766367284', 'https://openalex.org/W2767554904', 'https://openalex.org/W2791261459', 'https://openalex.org/W2917837889', 'https://openalex.org/W4232925121'], 'related_works': ['https://openalex.org/W2802276006', 'https://openalex.org/W2791511901', 'https://openalex.org/W2437835228', 'https://openalex.org/W2411734245', 'https://openalex.org/W2206830429', 'https://openalex.org/W2076745895', 'https://openalex.org/W2042326648', 'https://openalex.org/W2031297001', 'https://openalex.org/W1993156922', 'https://openalex.org/W1522985778'], 'abstract_inverted_index': {'Abstract': [0], 'It': [1], 'is': [2, 21, 67], 'well': [3], 'known': [4], 'that': [5, 64, 139], 'induction': [6, 108], 'of': [7, 14, 27, 43, 56, 59, 73, 97, 109, 124, 130, 157, 179], 'hepatocyte': [8, 31, 50, 65, 89, 146, 187], 'senescence': [9, 32, 51, 66, 131, 147, 199], 'could': [10], 'inhibit': [11], 'the': [12, 25, 41, 71, 83, 107, 122], 'development': [13], 'hepatocellular': [15], 'carcinoma': [16], '(HCC).': [17], 'Until': [18], 'now,': [19], 'it': [20], 'still': [22], 'unclear': [23], 'how': [24], 'degree': [26], 'liver': [28, 60, 76, 80, 116, 135, 142], 'injury': [29, 44, 112, 143, 162], 'dictates': [30], 'and': [33, 52, 153, 173, 191], 'carcinogenesis.': [34, 53], 'In': [35, 100], 'this': [36], 'study,': [37], 'we': [38, 62], 'investigated': [39], 'whether': [40], 'severity': [42], 'determines': [45], 'cell': [46, 188], 'fate': [47, 189], 'decisions': [48, 190], 'between': [49], 'After': [54], 'testing': [55], 'different': [57], 'degrees': [58], 'injury,': [61, 81], 'found': [63], 'strongly': [68], 'induced': [69], 'in': [70, 186], 'setting': [72], 'severe': [74, 110, 133, 140], 'acute': [75, 111, 134, 141], 'injury.': [77, 117, 136], 'Longer-term,': [78], 'moderate': [79, 115, 161], 'on': [82], 'contrary': [84], 'did': [85], 'not': [86], 'result': [87], 'into': [88, 171], 'senescence,': [90, 172], 'but': [91], 'led': [92], 'to': [93, 145, 165, 169, 197, 200], 'a': [94, 154, 176, 193], 'significant': [95], 'incidence': [96, 156, 178], 'HCC': [98], 'instead.': [99], 'addition,': [101], 'carcinogenesis': [102], 'was': [103, 126], 'significantly': [104], 'reduced': [105], 'by': [106, 132], 'after': [113, 128], 'chronic': [114, 160], 'Meanwhile,': [118], 'immune': [119, 151], 'surveillance,': [120], 'especially': [121], 'activations': [123], 'macrophages,': [125], 'activated': [127], 're-induction': [129], 'We': [137], 'conclude': [138], 'leads': [144], 'along': [148], 'with': [149, 175], 'activating': [150], 'surveillance': [152], 'low': [155], 'HCC,': [158], 'whereas': [159], 'allows': [163], 'hepatocytes': [164], 'proliferate': [166], 'rather': [167], 'than': [168], 'enter': [170], 'correlates': [174], 'high': [177], 'HCC.': [180, 202], 'This': [181], 'study': [182], 'improves': [183], 'our': [184], 'understanding': [185], 'suggests': [192], 'potential': [194], 'clinical': [195], 'strategy': [196], 'induce': [198], 'treat': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2802276006', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-12-15T15:07:48.058791', 'created_date': '2018-05-17'}