Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus

Name: Work Video:
Duration: 3 min 30 s
Nilce Maria Martinez-Rossi; Tamires A. Bitencourt; Nalu T. A. Peres; Elza A. S. Lang; Eriston Vieira Gomes; Natália Renault Quaresemin; Maíra Pompeu Martins; Lucia Rossetti Lopes; Antônio Rossi
{'id': 'https://openalex.org/W2801735179', 'doi': 'https://doi.org/10.3389/fmicb.2018.01108', 'title': 'Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus', 'display_name': 'Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus', 'publication_year': 2018, 'publication_date': '2018-05-29', 'ids': {'openalex': 'https://openalex.org/W2801735179', 'doi': 'https://doi.org/10.3389/fmicb.2018.01108', 'mag': '2801735179', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29896175', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5986900'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fmicb.2018.01108', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fmicb.2018.01108/pdf', 'source': {'id': 'https://openalex.org/S2484704948', 'display_name': 'Frontiers in Microbiology', 'issn_l': '1664-302X', 'issn': ['1664-302X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.frontiersin.org/articles/10.3389/fmicb.2018.01108/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028434225', 'display_name': 'Nilce Maria Martinez-Rossi', 'orcid': 'https://orcid.org/0000-0002-5723-4276'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': True, 'raw_author_name': 'Nilce M. Martinez-Rossi', 'raw_affiliation_strings': ['Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038283931', 'display_name': 'Tamires A. Bitencourt', 'orcid': 'https://orcid.org/0000-0001-7373-3780'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Tamires A. Bitencourt', 'raw_affiliation_strings': ['Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110596399', 'display_name': 'Nalu T. A. Peres', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I190085865', 'display_name': 'Universidade Federal de Sergipe', 'ror': 'https://ror.org/028ka0n85', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I190085865']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Nalu T. A. Peres', 'raw_affiliation_strings': ['Department of Morphology, Federal University of Sergipe, Aracaju, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Morphology, Federal University of Sergipe, Aracaju, Brazil', 'institution_ids': ['https://openalex.org/I190085865']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078714398', 'display_name': 'Elza A. S. Lang', 'orcid': 'https://orcid.org/0000-0002-4019-9830'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Elza A. S. Lang', 'raw_affiliation_strings': ['Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070292264', 'display_name': 'Eriston Vieira Gomes', 'orcid': 'https://orcid.org/0000-0002-5538-0106'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Eriston V. Gomes', 'raw_affiliation_strings': ['Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063007669', 'display_name': 'Natália Renault Quaresemin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Natalia R. Quaresemin', 'raw_affiliation_strings': ['Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069415294', 'display_name': 'Maíra Pompeu Martins', 'orcid': 'https://orcid.org/0000-0002-9462-5145'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Maíra P. Martins', 'raw_affiliation_strings': ['Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057988988', 'display_name': 'Lucia Rossetti Lopes', 'orcid': 'https://orcid.org/0000-0003-0530-7805'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Lucia Lopes', 'raw_affiliation_strings': ['Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5046600085', 'display_name': 'Antônio Rossi', 'orcid': 'https://orcid.org/0000-0003-1951-4741'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Antonio Rossi', 'raw_affiliation_strings': ['Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5028434225'], 'corresponding_institution_ids': ['https://openalex.org/I17974374'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 3.098, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 144, 'citation_normalized_percentile': {'value': 0.999519, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '9', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11253', 'display_name': 'Nail Diseases and Treatments', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11253', 'display_name': 'Nail Diseases and Treatments', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11085', 'display_name': 'Fungal Biology and Applications', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10150', 'display_name': 'Antifungal resistance and susceptibility', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dermatophyte', 'display_name': 'Dermatophyte', 'score': 0.6433164}, {'id': 'https://openalex.org/keywords/antifungal-drug', 'display_name': 'Antifungal drugs', 'score': 0.60887414}, {'id': 'https://openalex.org/keywords/efflux', 'display_name': 'Efflux', 'score': 0.5985205}, {'id': 'https://openalex.org/keywords/antifungal-drugs', 'display_name': 'Antifungal drugs', 'score': 0.5620507}, {'id': 'https://openalex.org/keywords/detoxification', 'display_name': 'Detoxification', 'score': 0.5111175}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6552436}, {'id': 'https://openalex.org/C2777220567', 'wikidata': 'https://www.wikidata.org/wiki/Q613894', 'display_name': 'Dermatophyte', 'level': 2, 'score': 0.6433164}, {'id': 'https://openalex.org/C2991737395', 'wikidata': 'https://www.wikidata.org/wiki/Q578726', 'display_name': 'Antifungal drug', 'level': 3, 'score': 0.60887414}, {'id': 'https://openalex.org/C200082930', 'wikidata': 'https://www.wikidata.org/wiki/Q22327148', 'display_name': 'Efflux', 'level': 2, 'score': 0.5985205}, {'id': 'https://openalex.org/C114851261', 'wikidata': 'https://www.wikidata.org/wiki/Q12147416', 'display_name': 'Drug resistance', 'level': 2, 'score': 0.57272977}, {'id': 'https://openalex.org/C2909919671', 'wikidata': 'https://www.wikidata.org/wiki/Q578726', 'display_name': 'Antifungal drugs', 'level': 3, 'score': 0.5620507}, {'id': 'https://openalex.org/C2780497538', 'wikidata': 'https://www.wikidata.org/wiki/Q1192006', 'display_name': 'Detoxification (alternative medicine)', 'level': 3, 'score': 0.5111175}, {'id': 'https://openalex.org/C2779548794', 'wikidata': 'https://www.wikidata.org/wiki/Q578726', 'display_name': 'Antifungal', 'level': 2, 'score': 0.50577116}, {'id': 'https://openalex.org/C44312359', 'wikidata': 'https://www.wikidata.org/wiki/Q286958', 'display_name': 'ATP-binding cassette transporter', 'level': 4, 'score': 0.501245}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.47955868}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3729264}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3229673}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.3105782}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.2873538}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.23442823}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.21404046}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.11575633}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fmicb.2018.01108', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fmicb.2018.01108/pdf', 'source': {'id': 'https://openalex.org/S2484704948', 'display_name': 'Frontiers in Microbiology', 'issn_l': '1664-302X', 'issn': ['1664-302X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/8927dde723344bdea50722d8988c17a4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5986900', 'pdf_url': 'https://europepmc.org/articles/pmc5986900?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986900', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29896175', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fmicb.2018.01108', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fmicb.2018.01108/pdf', 'source': {'id': 'https://openalex.org/S2484704948', 'display_name': 'Frontiers in Microbiology', 'issn_l': '1664-302X', 'issn': ['1664-302X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.84, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320320997', 'funder_display_name': 'Fundação de Amparo à Pesquisa do Estado de São Paulo', 'award_id': '2014/03847-7'}, {'funder': 'https://openalex.org/F4320320997', 'funder_display_name': 'Fundação de Amparo à Pesquisa do Estado de São Paulo', 'award_id': '2016/04274-6'}, {'funder': 'https://openalex.org/F4320320997', 'funder_display_name': 'Fundação de Amparo à Pesquisa do Estado de São Paulo', 'award_id': '2015/23435-8'}, {'funder': 'https://openalex.org/F4320320997', 'funder_display_name': 'Fundação de Amparo à Pesquisa do Estado de São Paulo', 'award_id': '2011/08424-9'}, {'funder': 'https://openalex.org/F4320321091', 'funder_display_name': 'Coordenação de Aperfeiçoamento de Pessoal de Nível Superior', 'award_id': None}, {'funder': 'https://openalex.org/F4320335309', 'funder_display_name': 'Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 183, 'referenced_works': ['https://openalex.org/W1548087739', 'https://openalex.org/W1549061855', 'https://openalex.org/W1581371393', 'https://openalex.org/W1593527021', 'https://openalex.org/W1596013790', 'https://openalex.org/W1647692986', 'https://openalex.org/W1659569703', 'https://openalex.org/W1864285360', 'https://openalex.org/W1898396041', 'https://openalex.org/W1915738035', 'https://openalex.org/W1948677335', 'https://openalex.org/W1952548524', 'https://openalex.org/W1953036619', 'https://openalex.org/W1958748204', 'https://openalex.org/W1958993263', 'https://openalex.org/W1965291654', 'https://openalex.org/W1968729556', 'https://openalex.org/W1970177198', 'https://openalex.org/W1970482041', 'https://openalex.org/W1972736746', 'https://openalex.org/W1973091891', 'https://openalex.org/W1973550055', 'https://openalex.org/W1974598566', 'https://openalex.org/W1978374794', 'https://openalex.org/W1981024948', 'https://openalex.org/W1983100386', 'https://openalex.org/W1984612322', 'https://openalex.org/W1985406800', 'https://openalex.org/W1986323678', 'https://openalex.org/W1988825409', 'https://openalex.org/W1989710863', 'https://openalex.org/W1993059538', 'https://openalex.org/W1993525477', 'https://openalex.org/W2001308529', 'https://openalex.org/W2003426535', 'https://openalex.org/W2007978356', 'https://openalex.org/W2010543755', 'https://openalex.org/W2012766399', 'https://openalex.org/W2015714994', 'https://openalex.org/W2022326366', 'https://openalex.org/W2022592344', 'https://openalex.org/W2024087206', 'https://openalex.org/W2026158066', 'https://openalex.org/W2028111549', 'https://openalex.org/W2028793515', 'https://openalex.org/W2034351706', 'https://openalex.org/W2037736620', 'https://openalex.org/W2040359453', 'https://openalex.org/W2044326691', 'https://openalex.org/W2044795711', 'https://openalex.org/W2045278828', 'https://openalex.org/W2050687766', 'https://openalex.org/W2050701503', 'https://openalex.org/W2054314467', 'https://openalex.org/W2057877473', 'https://openalex.org/W2059069217', 'https://openalex.org/W2059987991', 'https://openalex.org/W2061461461', 'https://openalex.org/W2061648749', 'https://openalex.org/W2065139915', 'https://openalex.org/W2066624240', 'https://openalex.org/W2067694823', 'https://openalex.org/W2068328991', 'https://openalex.org/W2068744822', 'https://openalex.org/W2069408563', 'https://openalex.org/W2074223657', 'https://openalex.org/W2078621152', 'https://openalex.org/W2079122560', 'https://openalex.org/W2084062425', 'https://openalex.org/W2087273774', 'https://openalex.org/W2089061681', 'https://openalex.org/W2092807701', 'https://openalex.org/W2093516457', 'https://openalex.org/W2093914439', 'https://openalex.org/W2094768851', 'https://openalex.org/W2095406747', 'https://openalex.org/W2095480980', 'https://openalex.org/W2098719212', 'https://openalex.org/W2101382252', 'https://openalex.org/W2102500167', 'https://openalex.org/W2104217343', 'https://openalex.org/W2106192857', 'https://openalex.org/W2106567443', 'https://openalex.org/W2106582220', 'https://openalex.org/W2106849152', 'https://openalex.org/W2107512595', 'https://openalex.org/W2109091559', 'https://openalex.org/W2110466942', 'https://openalex.org/W2111229199', 'https://openalex.org/W2111448607', 'https://openalex.org/W2112630661', 'https://openalex.org/W2112936110', 'https://openalex.org/W2114599108', 'https://openalex.org/W2115527176', 'https://openalex.org/W2117385041', 'https://openalex.org/W2117709732', 'https://openalex.org/W2121289639', 'https://openalex.org/W2127209060', 'https://openalex.org/W2129312417', 'https://openalex.org/W2129937209', 'https://openalex.org/W2131487381', 'https://openalex.org/W2131821856', 'https://openalex.org/W2131909808', 'https://openalex.org/W2131926524', 'https://openalex.org/W2134220168', 'https://openalex.org/W2134790121', 'https://openalex.org/W2134944658', 'https://openalex.org/W2136677555', 'https://openalex.org/W2139062810', 'https://openalex.org/W2139173424', 'https://openalex.org/W2139234330', 'https://openalex.org/W2140656375', 'https://openalex.org/W2141696542', 'https://openalex.org/W2142269012', 'https://openalex.org/W2144088019', 'https://openalex.org/W2144726832', 'https://openalex.org/W2144795145', 'https://openalex.org/W2146996393', 'https://openalex.org/W2147654973', 'https://openalex.org/W2150392209', 'https://openalex.org/W2150419084', 'https://openalex.org/W2152645964', 'https://openalex.org/W2154601244', 'https://openalex.org/W2163309755', 'https://openalex.org/W2164188721', 'https://openalex.org/W2164713805', 'https://openalex.org/W2165644297', 'https://openalex.org/W2168361207', 'https://openalex.org/W2169135536', 'https://openalex.org/W2177561254', 'https://openalex.org/W2191316347', 'https://openalex.org/W2214680690', 'https://openalex.org/W2222265666', 'https://openalex.org/W2222950739', 'https://openalex.org/W2228816633', 'https://openalex.org/W2303282363', 'https://openalex.org/W2314322923', 'https://openalex.org/W2326587704', 'https://openalex.org/W2335631580', 'https://openalex.org/W2344835504', 'https://openalex.org/W2345246915', 'https://openalex.org/W2345339043', 'https://openalex.org/W2394775772', 'https://openalex.org/W2412695678', 'https://openalex.org/W2413702044', 'https://openalex.org/W2415487738', 'https://openalex.org/W2418775883', 'https://openalex.org/W2474128066', 'https://openalex.org/W2478702959', 'https://openalex.org/W2517549700', 'https://openalex.org/W2522400009', 'https://openalex.org/W2529676164', 'https://openalex.org/W2532067600', 'https://openalex.org/W2556150282', 'https://openalex.org/W2564078599', 'https://openalex.org/W2565813012', 'https://openalex.org/W2568567825', 'https://openalex.org/W2586677995', 'https://openalex.org/W2588480133', 'https://openalex.org/W2593605037', 'https://openalex.org/W2595726515', 'https://openalex.org/W2606000026', 'https://openalex.org/W2606824156', 'https://openalex.org/W2608385659', 'https://openalex.org/W2622188456', 'https://openalex.org/W2733677659', 'https://openalex.org/W2734476205', 'https://openalex.org/W2742305482', 'https://openalex.org/W2745871749', 'https://openalex.org/W2751530162', 'https://openalex.org/W2769470002', 'https://openalex.org/W2771040523', 'https://openalex.org/W2778267304', 'https://openalex.org/W2783921383', 'https://openalex.org/W2791611748', 'https://openalex.org/W2792873330', 'https://openalex.org/W2803762640', 'https://openalex.org/W2806095052', 'https://openalex.org/W2951409137', 'https://openalex.org/W3146978641', 'https://openalex.org/W3187158005', 'https://openalex.org/W4211106100', 'https://openalex.org/W4297695326'], 'related_works': ['https://openalex.org/W4376254095', 'https://openalex.org/W4308078547', 'https://openalex.org/W4298064930', 'https://openalex.org/W3148688799', 'https://openalex.org/W2625675304', 'https://openalex.org/W2368727485', 'https://openalex.org/W2361744660', 'https://openalex.org/W2056859986', 'https://openalex.org/W2020605995', 'https://openalex.org/W1445902623'], 'abstract_inverted_index': {'Dermatophytes': [0], 'comprise': [1], 'pathogenic': [2], 'fungi': [3, 47], 'that': [4, 92, 106, 228], 'have': [5], 'a': [6], 'high': [7], 'affinity': [8], 'for': [9, 109, 119, 137, 237], 'the': [10, 34, 58, 74, 89, 100, 120, 123, 126, 149, 186, 192, 197, 200, 209, 230], 'keratinized': [11], 'structures': [12], 'present': [13], 'in': [14, 66, 79, 104, 134, 144, 148, 185, 196], 'nails,': [15], 'skin,': [16], 'and': [17, 46, 63, 84, 157, 225], 'hair,': [18], 'causing': [19], 'superficial': [20], 'infections': [21], 'known': [22], 'as': [23, 206, 208], 'dermatophytosis.': [24], 'A': [25], 'reasonable': [26], 'number': [27], 'of': [28, 76, 122, 128, 151, 164, 167, 170, 191, 202, 211, 234], 'antifungal': [29, 62, 152, 204, 213, 238], 'drugs': [30, 65], 'currently': [31], 'exist': [32], 'on': [33], 'pharmaceutical': [35], 'market': [36], 'to': [37, 53, 95, 117, 142, 159, 172, 177, 222], 'control': [38], 'mycoses;': [39], 'however,': [40], 'their': [41, 155], 'cellular': [42, 80, 110], 'targets': [43], 'are': [44, 107, 220], 'restricted,': [45], 'may': [48, 93], 'exhibit': [49], 'tolerance': [50, 130], 'or': [51, 217, 232], 'resistance': [52, 171], 'these': [54, 168], 'agents.': [55], 'For': [56], 'example,': [57], 'stress': [59, 71], 'caused': [60], 'by': [61], 'cytotoxic': [64], 'sub-inhibitory': [67], 'concentrations': [68], 'promotes': [69], 'compensatory': [70], 'responses,': [72], 'with': [73], 'over-expression': [75], 'genes': [77, 135], 'involved': [78, 147, 195], 'detoxification,': [81], 'drug': [82, 96, 129], 'efflux,': [83], 'signaling': [85], 'pathways': [86], 'being': [87], 'among': [88, 215], 'various': [90], 'mechanisms': [91, 169, 194], 'contribute': [94], 'tolerance.': [97], 'In': [98], 'addition,': [99], 'ATP-binding': [101], 'cassette': [102], 'transporters': [103], 'dermatophytes': [105], 'responsible': [108], 'efflux': [111], 'can': [112, 182], 'act': [113, 183], 'synergistically,': [114], 'allowing': [115], 'one': [116, 166], 'compensate': [118], 'absence': [121], 'other,': [124], 'revealing': [125], 'complexity': [127], 'phenomena.': [131], 'Moreover,': [132], 'mutations': [133], 'coding': [136], 'target': [138], 'enzymes': [139], 'could': [140], 'lead': [141], 'substitutions': [143], 'amino': [145], 'acids': [146], 'binding': [150], 'agents,': [153], 'hindering': [154], 'performance': [156], 'leading': [158], 'treatment': [160], 'failure.': [161], 'The': [162], 'relevance': [163], 'each': [165], 'fungal': [173], 'survival': [174], 'is': [175], 'hard': [176], 'define,': [178], 'mainly': [179], 'because': [180], 'they': [181], 'simultaneously': [184], 'cell.': [187], 'However,': [188], 'an': [189], 'understanding': [190], 'molecular': [193], 'resistance/tolerance': [198], 'processes,': [199], 'identification': [201], 'new': [203, 212, 226], 'targets,': [205], 'well': [207], 'prospective': [210], 'compounds': [214], 'natural': [216], 'synthetic': [218], 'products,': [219], 'expected': [221], 'bring': [223], 'advances': [224], 'insights': [227], 'facilitate': [229], 'improvement': [231], 'development': [233], 'novel': [235], 'strategies': [236], 'therapy.': [239]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2801735179', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 29}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 36}, {'year': 2020, 'cited_by_count': 26}, {'year': 2019, 'cited_by_count': 15}, {'year': 2018, 'cited_by_count': 2}], 'updated_date': '2025-01-09T14:19:57.349952', 'created_date': '2018-05-17'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
