Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2801562008', 'doi': 'https://doi.org/10.1016/j.humpath.2018.04.004', 'title': 'SWI/SNF protein expression status in fumarate hydratase–deficient renal cell carcinoma: immunohistochemical analysis of 32 tumors from 28 patients', 'display_name': 'SWI/SNF protein expression status in fumarate hydratase–deficient renal cell carcinoma: immunohistochemical analysis of 32 tumors from 28 patients', 'publication_year': 2018, 'publication_date': '2018-04-22', 'ids': {'openalex': 'https://openalex.org/W2801562008', 'doi': 'https://doi.org/10.1016/j.humpath.2018.04.004', 'mag': '2801562008', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29689242'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.humpath.2018.04.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S63477337', 'display_name': 'Human Pathology', 'issn_l': '0046-8177', 'issn': ['0046-8177', '1532-8392'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5024236651', 'display_name': 'Abbas Agaimy', 'orcid': 'https://orcid.org/0000-0002-0445-8161'}, 'institutions': [{'id': 'https://openalex.org/I181369854', 'display_name': 'Friedrich-Alexander-Universität Erlangen-Nürnberg', 'ror': 'https://ror.org/00f7hpc57', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I181369854']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Abbas Agaimy', 'raw_affiliation_strings': ['Institute of Pathology, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital of Erlangen, 91054 Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pathology, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital of Erlangen, 91054 Erlangen, Germany', 'institution_ids': ['https://openalex.org/I181369854']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102981230', 'display_name': 'Mahul B. Amin', 'orcid': 'https://orcid.org/0000-0001-5943-3634'}, 'institutions': [{'id': 'https://openalex.org/I160606119', 'display_name': 'University of Tennessee Health Science Center', 'ror': 'https://ror.org/0011qv509', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I160606119']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mahul B. Amin', 'raw_affiliation_strings': ['Department of Pathology and Laboratory Medicine, University of Tennessee Health Sciences, Memphis, TN 38103, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Laboratory Medicine, University of Tennessee Health Sciences, Memphis, TN 38103, USA', 'institution_ids': ['https://openalex.org/I160606119']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032567530', 'display_name': 'Anthony J. Gill', 'orcid': 'https://orcid.org/0000-0002-9447-1967'}, 'institutions': [{'id': 'https://openalex.org/I2800079252', 'display_name': 'Royal North Shore Hospital', 'ror': 'https://ror.org/02gs2e959', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800079252']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Anthony J. Gill', 'raw_affiliation_strings': ['University of Sydney NSW Australia 2006, Cancer Diagnosis and Pathology Group, Kolling Institute, Royal North Shore Hospital NSW Australia 2065 and NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia'], 'affiliations': [{'raw_affiliation_string': 'University of Sydney NSW Australia 2006, Cancer Diagnosis and Pathology Group, Kolling Institute, Royal North Shore Hospital NSW Australia 2065 and NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia', 'institution_ids': ['https://openalex.org/I2800079252']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067753808', 'display_name': 'Bernt Popp', 'orcid': 'https://orcid.org/0000-0002-3679-1081'}, 'institutions': [{'id': 'https://openalex.org/I181369854', 'display_name': 'Friedrich-Alexander-Universität Erlangen-Nürnberg', 'ror': 'https://ror.org/00f7hpc57', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I181369854']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Bernt Popp', 'raw_affiliation_strings': ['Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany', 'institution_ids': ['https://openalex.org/I181369854']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082130600', 'display_name': 'André Reis', 'orcid': 'https://orcid.org/0000-0002-6301-6363'}, 'institutions': [{'id': 'https://openalex.org/I181369854', 'display_name': 'Friedrich-Alexander-Universität Erlangen-Nürnberg', 'ror': 'https://ror.org/00f7hpc57', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I181369854']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'André Reis', 'raw_affiliation_strings': ['Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Human Genetics, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany', 'institution_ids': ['https://openalex.org/I181369854']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074984909', 'display_name': 'Daniel M. Berney', 'orcid': 'https://orcid.org/0000-0001-5474-8696'}, 'institutions': [{'id': 'https://openalex.org/I166337079', 'display_name': 'Queen Mary University of London', 'ror': 'https://ror.org/026zzn846', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I166337079']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Daniel M. Berney', 'raw_affiliation_strings': ['Barts Cancer Institute, Queen Mary University of London, London ECIM 6BQ, UK'], 'affiliations': [{'raw_affiliation_string': 'Barts Cancer Institute, Queen Mary University of London, London ECIM 6BQ, UK', 'institution_ids': ['https://openalex.org/I166337079']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034716746', 'display_name': 'Cristina Magi‐Galluzzi', 'orcid': 'https://orcid.org/0000-0003-1219-3797'}, 'institutions': [{'id': 'https://openalex.org/I1316902750', 'display_name': 'Cleveland Clinic', 'ror': 'https://ror.org/03xjacd83', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cristina Magi-Galluzzi', 'raw_affiliation_strings': ['Cleveland Clinic, Cleveland, OH 44195, USA'], 'affiliations': [{'raw_affiliation_string': 'Cleveland Clinic, Cleveland, OH 44195, USA', 'institution_ids': ['https://openalex.org/I1316902750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047485754', 'display_name': 'Mathilde Sibony', 'orcid': 'https://orcid.org/0000-0002-1282-8732'}, 'institutions': [{'id': 'https://openalex.org/I4210092774', 'display_name': 'Hôpital Cochin', 'ror': 'https://ror.org/00ph8tk69', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092774', 'https://openalex.org/I4210097159', 'https://openalex.org/I4210124464']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Mathilde Sibony', 'raw_affiliation_strings': ['Hospital Cochin, 75679 Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Hospital Cochin, 75679 Paris, France', 'institution_ids': ['https://openalex.org/I4210092774']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077087475', 'display_name': 'Steven C. Smith', 'orcid': 'https://orcid.org/0000-0003-0982-4607'}, 'institutions': [{'id': 'https://openalex.org/I4210166857', 'display_name': "Children's Hospital of Richmond at VCU", 'ror': 'https://ror.org/05vp5x049', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210166857']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven C. Smith', 'raw_affiliation_strings': ['Department of Pathology, VCU School of Medicine, Richmond, VA 23298, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, VCU School of Medicine, Richmond, VA 23298, USA', 'institution_ids': ['https://openalex.org/I4210166857']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032579505', 'display_name': 'Saul Suster', 'orcid': 'https://orcid.org/0000-0001-5483-3508'}, 'institutions': [{'id': 'https://openalex.org/I204308271', 'display_name': 'Medical College of Wisconsin', 'ror': 'https://ror.org/00qqv6244', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204308271']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Saul Suster', 'raw_affiliation_strings': ['Medical College of Wisconsin, Milwaukee, WI 53226, USA'], 'affiliations': [{'raw_affiliation_string': 'Medical College of Wisconsin, Milwaukee, WI 53226, USA', 'institution_ids': ['https://openalex.org/I204308271']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014660151', 'display_name': 'Kiril Trpkov', 'orcid': 'https://orcid.org/0000-0003-3142-8846'}, 'institutions': [{'id': 'https://openalex.org/I4210092646', 'display_name': 'Calgary Laboratory Services', 'ror': 'https://ror.org/00g6ztp19', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I126859394', 'https://openalex.org/I4210092646']}, {'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Kiril Trpkov', 'raw_affiliation_strings': ['Calgary Laboratory Services and University of Calgary, Calgary, Alberta, Canada'], 'affiliations': [{'raw_affiliation_string': 'Calgary Laboratory Services and University of Calgary, Calgary, Alberta, Canada', 'institution_ids': ['https://openalex.org/I4210092646', 'https://openalex.org/I168635309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045150707', 'display_name': 'Ondřej Hes', 'orcid': 'https://orcid.org/0000-0002-3236-3127'}, 'institutions': [{'id': 'https://openalex.org/I21250087', 'display_name': 'Charles University', 'ror': 'https://ror.org/024d6js02', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I21250087']}, {'id': 'https://openalex.org/I4210113757', 'display_name': 'University Hospital Plzen', 'ror': 'https://ror.org/02c1tfz23', 'country_code': 'CZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210113757']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Ondřej Hes', 'raw_affiliation_strings': ['Charles University and University Hospital Plzen, 304 60 Plzen, Czech Republic'], 'affiliations': [{'raw_affiliation_string': 'Charles University and University Hospital Plzen, 304 60 Plzen, Czech Republic', 'institution_ids': ['https://openalex.org/I21250087', 'https://openalex.org/I4210113757']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049585448', 'display_name': 'Arndt Hartmann', 'orcid': 'https://orcid.org/0000-0002-4860-4626'}, 'institutions': [{'id': 'https://openalex.org/I181369854', 'display_name': 'Friedrich-Alexander-Universität Erlangen-Nürnberg', 'ror': 'https://ror.org/00f7hpc57', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I181369854']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Arndt Hartmann', 'raw_affiliation_strings': ['Institute of Pathology, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital of Erlangen, 91054 Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pathology, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital of Erlangen, 91054 Erlangen, Germany', 'institution_ids': ['https://openalex.org/I181369854']}]}], 'institution_assertions': [], 'countries_distinct_count': 7, 'institutions_distinct_count': 12, 'corresponding_author_ids': ['https://openalex.org/A5024236651'], 'corresponding_institution_ids': ['https://openalex.org/I181369854'], 'apc_list': {'value': 3460, 'currency': 'USD', 'value_usd': 3460, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.098, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.787198, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '77', 'issue': None, 'first_page': '139', 'last_page': '146'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12820', 'display_name': 'Chromatin Remodeling in Cancer and Development', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12820', 'display_name': 'Chromatin Remodeling in Cancer and Development', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10449', 'display_name': 'Renal Cell Carcinoma', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12140', 'display_name': 'Molecular Mechanisms of Kidney Development and Disease', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/smarcb1', 'display_name': 'SMARCB1', 'score': 0.979678}, {'id': 'https://openalex.org/keywords/smarca4', 'display_name': 'SMARCA4', 'score': 0.9490831}, {'id': 'https://openalex.org/keywords/arid1a', 'display_name': 'ARID1A', 'score': 0.9191155}, {'id': 'https://openalex.org/keywords/swi/snf', 'display_name': 'SWI/SNF', 'score': 0.8692045}, {'id': 'https://openalex.org/keywords/swi/snf-complexes', 'display_name': 'SWI/SNF Complexes', 'score': 0.578362}, {'id': 'https://openalex.org/keywords/renal-cell-carcinoma', 'display_name': 'Renal Cell Carcinoma', 'score': 0.517569}], 'concepts': [{'id': 'https://openalex.org/C177450382', 'wikidata': 'https://www.wikidata.org/wiki/Q18031596', 'display_name': 'SMARCB1', 'level': 5, 'score': 0.979678}, {'id': 'https://openalex.org/C80828422', 'wikidata': 'https://www.wikidata.org/wiki/Q18031595', 'display_name': 'SMARCA4', 'level': 5, 'score': 0.9490831}, {'id': 'https://openalex.org/C2781273526', 'wikidata': 'https://www.wikidata.org/wiki/Q18032797', 'display_name': 'ARID1A', 'level': 4, 'score': 0.9191155}, {'id': 'https://openalex.org/C166941617', 'wikidata': 'https://www.wikidata.org/wiki/Q421708', 'display_name': 'SWI/SNF', 'level': 5, 'score': 0.8692045}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.56768644}, {'id': 'https://openalex.org/C2778560582', 'wikidata': 'https://www.wikidata.org/wiki/Q18347894', 'display_name': 'Clear cell', 'level': 3, 'score': 0.5179912}, {'id': 'https://openalex.org/C2777472916', 'wikidata': 'https://www.wikidata.org/wiki/Q1164529', 'display_name': 'Renal cell carcinoma', 'level': 2, 'score': 0.45154378}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41812998}, {'id': 'https://openalex.org/C2776531350', 'wikidata': 'https://www.wikidata.org/wiki/Q16877679', 'display_name': 'Papillary renal cell carcinomas', 'level': 3, 'score': 0.4164061}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.38643396}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36047652}, {'id': 'https://openalex.org/C167227067', 'wikidata': 'https://www.wikidata.org/wiki/Q5113739', 'display_name': 'Chromatin remodeling', 'level': 4, 'score': 0.28338885}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.21147564}, {'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.12388274}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.11047837}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08115575}], 'mesh': [{'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005649', 'descriptor_name': 'Fumarate Hydratase', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': True}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002868', 'descriptor_name': 'Chromosomal Proteins, Non-Histone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002868', 'descriptor_name': 'Chromosomal Proteins, Non-Histone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004265', 'descriptor_name': 'DNA Helicases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004265', 'descriptor_name': 'DNA Helicases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004265', 'descriptor_name': 'DNA Helicases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005649', 'descriptor_name': 'Fumarate Hydratase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.humpath.2018.04.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S63477337', 'display_name': 'Human Pathology', 'issn_l': '0046-8177', 'issn': ['0046-8177', '1532-8392'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29689242', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.67}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1895774468', 'https://openalex.org/W1985408575', 'https://openalex.org/W2004805159', 'https://openalex.org/W2005657436', 'https://openalex.org/W2029641872', 'https://openalex.org/W2048121496', 'https://openalex.org/W2050540286', 'https://openalex.org/W2052747035', 'https://openalex.org/W2069216696', 'https://openalex.org/W2069781144', 'https://openalex.org/W2080212907', 'https://openalex.org/W2086072858', 'https://openalex.org/W2106578986', 'https://openalex.org/W2110394707', 'https://openalex.org/W2115494288', 'https://openalex.org/W2138601221', 'https://openalex.org/W2144195427', 'https://openalex.org/W2171987817', 'https://openalex.org/W2282366831', 'https://openalex.org/W2337209831', 'https://openalex.org/W2513105811', 'https://openalex.org/W2519800643', 'https://openalex.org/W2565755851', 'https://openalex.org/W2573357293', 'https://openalex.org/W2609187871', 'https://openalex.org/W2781495894', 'https://openalex.org/W2949183854', 'https://openalex.org/W2952488094', 'https://openalex.org/W2969835655', 'https://openalex.org/W2984117449'], 'related_works': ['https://openalex.org/W4379337130', 'https://openalex.org/W4281711008', 'https://openalex.org/W3032637176', 'https://openalex.org/W3009510454', 'https://openalex.org/W2946876116', 'https://openalex.org/W2911645717', 'https://openalex.org/W2887592686', 'https://openalex.org/W2801562008', 'https://openalex.org/W2588343457', 'https://openalex.org/W2056556069'], 'abstract_inverted_index': {'Fumarate': [0], 'hydratase-deficient': [1], 'renal': [2, 45], 'cell': [3, 51], 'carcinoma': [4, 47], '(FH-RCC)': [5], 'is': [6, 24, 42, 236], 'a': [7, 196, 202], 'rare,': [8], 'aggressive': [9, 82], 'RCC': [10, 21, 52, 59, 75, 221], 'type,': [11], 'originally': [12], 'described': [13], 'in': [14, 44, 114, 175, 185, 255], 'the': [15, 35, 186, 251], 'setting': [16], 'of': [17, 32, 34, 57, 60, 68, 107, 116, 119, 123, 129, 140, 190, 198, 205, 222, 226, 243], 'hereditary': [18], 'leiomyomatosis': [19], 'and': [20, 55, 64, 73, 80, 103, 110, 121, 154, 165, 228, 247], 'syndrome,': [22], 'which': [23], 'defined': [25], 'by': [26], 'germline': [27], 'FH': [28, 136, 227], 'gene': [29], 'inactivation.': [30], 'Inactivation': [31], 'components': [33, 172], 'switch/sucrose': [36], 'nonfermentable': [37], '(SWI/SNF)': [38], 'chromatin': [39], 'remodeling': [40], 'complex': [41, 207], 'involved': [43, 184], 'medullary': [46], '(SMARCB1/INI1': [48], 'loss),': [49, 54], 'clear': [50, 61], '(PBRM1': [53], 'subsets': [56], 'dedifferentiated': [58], 'cell,': [62], 'chromophobe,': [63], 'papillary': [65], 'types': [66], '(loss': [67], 'different': [69], 'SWI/SNF': [70, 95, 141, 159, 171, 206, 229], 'components).': [71], 'FH-RCC': [72, 199], 'SWI/SNF-deficient': [74, 132, 220], 'share': [76], 'anaplastic': [77], 'nuclear': [78], 'features': [79, 147], 'highly': [81], 'course.': [83], 'We': [84], 'analyzed': [85], '32': [86], 'FH-RCCs': [87], 'from': [88], '28': [89], 'patients': [90], 'using': [91], '7': [92], 'commercially': [93], 'available': [94, 158], 'antibodies': [96], '(SMARCB1/INI1,': [97], 'SMARCA2,': [98], 'SMARCA4,': [99], 'SMARCC1,': [100], 'SMARCC2,': [101], 'PBRM1,': [102], 'ARID1A).': [104], 'Variable': [105], 'loss': [106, 142, 204], 'SMARCB1,': [108], 'ARID1A,': [109], 'SMARCC1': [111], 'was': [112, 148], 'observed': [113], '1': [115, 122], '31,': [117, 120], '2': [118], '29': [124], 'evaluable': [125], 'cases,': [126], 'respectively;': [127], '3': [128], 'these': [130], '4': [131], 'tumors': [133, 151], 'had': [134, 157], 'confirmed': [135], 'mutations.': [137, 167], 'No': [138], 'correlation': [139], 'with': [143, 152, 219, 231], 'solid': [144], 'or': [145, 188], 'sarcomatoid': [146], 'observed.': [149], 'Two': [150], 'SMARCB1': [153, 164], 'ARID1A': [155, 166], 'deficiency': [156, 246], 'molecular': [160, 233], 'data;': [161], 'both': [162], 'lacked': [163], 'The': [168], 'remaining': [169], '5': [170], 'were': [173], 'intact': [174], 'all': [176], 'cases.': [177], 'Especially': [178], 'PBRM1': [179], 'seems': [180], 'not': [181, 216], 'to': [182, 238, 248], 'be': [183, 217], 'pathogenesis': [187], 'progression': [189], 'FH-RCC.': [191], 'Our': [192], 'data': [193], 'showed': [194], 'that': [195], 'subset': [197], '(12%)': [200], 'have': [201], 'variable': [203], 'subunits,': [208], 'likely': [209], 'as': [210], 'secondary': [211], 'genetic': [212, 234], 'events.': [213], 'This': [214], 'should': [215], 'confused': [218], 'other': [223], 'types.': [224], 'Evaluation': [225], 'together': [230], 'comprehensive': [232], 'profiling': [235], 'needed': [237], 'explore': [239], 'possible': [240], 'prognostic': [241], 'implications': [242], 'FH/SWI-SNF': [244], 'double': [245], 'better': [249], 'understand': [250], 'somatic': [252], 'mutation': [253], 'landscape': [254], 'high-grade': [256], 'RCC.': [257]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2801562008', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}], 'updated_date': '2024-09-19T14:07:57.162938', 'created_date': '2018-05-17'}