A new role for extracellular vesicles: how small vesicles can feed tumors' big appetite

Name: Work Video:
Duration: 3 min 30 s
Ikrame Lazar; Emily Clement; Camille Attané; Catherine Muller; Laurence Nieto
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3072, 3133, 3195, 3254, 3375, 3578, 3585, 3763, 3782, 3838, 3892, 3991], 'progression': [87, 224, 575, 1410, 1941, 2072, 2109, 2159, 2594], 'especially': [89, 226], 'metabolic': [91, 135, 228, 272, 399, 4006, 4155, 4165], 'reprogramming.': [92, 229], 'Particular': [93, 230, 1359], 'attention': [94, 231], 'granted': [97, 234], 'adipocytes.': [99, 236], 'These': [100, 237, 2209], 'cells,': [101, 238, 1036, 1096, 2016, 2129, 2132, 2305, 2397, 3373], 'which': [102, 239, 952, 1151, 1473, 2026, 2225, 2359, 2854, 3009, 3141, 3283, 3698, 4182], 'are': [103, 110, 240, 247, 543, 630, 705, 723, 936, 1071, 1120, 1468, 1934, 2545, 2890, 2982, 3377, 3393], 'specialized': [104, 241, 533], 'storing': [106, 243, 539], 'releasing': [108, 245, 541], 'FAs,': [109, 246], 'able': [111, 248], 'shift': [113, 250], 'toward': [116, 253, 2284, 3117, 3137], 'use': [118, 255, 397, 4177], 'FAs': [120, 257], 'and,': [121, 258, 2862], 'subsequently,': [122, 259, 2863], 'increase': [123, 260, 1755], 'aggressiveness.': [125, 262], 'Recent': [126, 263, 1652], 'work': [127, 264, 3214, 3263], 'demonstrates': [128, 265, 1213], 'involvement': [130, 267, 1673], 'symbiosis.': [136, 273], 'Tumor': [274], 'traits': [276], 'were': [277, 327, 2931, 3480], 'first': [278, 2923], 'limited': [279], 'six': [281], 'hallmarks:': [282], 'self-supporting': [283], 'insensitivity': [285], 'growth': [287, 378, 1396, 2352, 2717, 2809, 3050, 4064], 'suppressors,': [288], 'evading': [289], 'death,': [291], 'infinite': [292], 'replicative': [293], 'potential,': [294], 'supporting': [295], 'angiogenesis,': [296, 1963], 'invasion/metastasis': [298], '(1.Hanahan': [299], 'D.': [300, 339, 849, 1974, 2661, 3404], 'Weinberg': [301, 340], 'R.A.': [302, 341, 4110], 'The': [303, 361, 564, 602, 1374, 1502, 1912, 2003, 2042, 2061, 2083, 2238, 3190, 3572], 'hallmarks': [304], 'cancer.Cell.': [306], '2000;': [307], '100:': [308], '57-70Abstract': [309], 'Full': [310, 312, 351, 353, 640, 642, 1081, 1083, 1130, 1132, 1606, 1608, 1763, 1765, 1845, 1847, 1993, 1995, 2115, 2117, 3466, 3468, 3633, 3635, 3750, 3752], 'Text': [311, 313, 352, 354, 641, 643, 1082, 1084, 1131, 1133, 1607, 1609, 1764, 1766, 1846, 1848, 1994, 1996, 2116, 2118, 3467, 3469, 3634, 3636, 3751, 3753], 'PDF': [314, 355, 644, 1085, 1134, 1610, 1767, 1849, 1997, 2119, 3470, 3637, 3754], 'PubMed': [315, 356, 452, 499, 524, 581, 645, 778, 887, 1003, 1025, 1086, 1135, 1195, 1269, 1317, 1417, 1462, 1497, 1557, 1611, 1663, 1726, 1768, 1850, 1928, 1998, 2056, 2096, 2120, 2166, 2251, 2294, 2340, 2383, 2446, 2495, 2536, 2586, 2615, 2651, 2685, 2728, 2778, 2814, 2843, 2905, 2974, 3061, 3127, 3185, 3243, 3313, 3358, 3433, 3471, 3522, 3567, 3638, 3687, 3755, 3823, 3888, 3929, 3985, 4044, 4071, 4125, 4148], 'Scopus': [316, 357, 453, 500, 525, 582, 646, 779, 888, 1004, 1026, 1087, 1136, 1196, 1270, 1318, 1418, 1463, 1498, 1558, 1612, 1664, 1727, 1769, 1803, 1851, 1900, 1929, 1999, 2057, 2097, 2121, 2167, 2252, 2295, 2341, 2384, 2496, 2537, 2616, 2652, 2686, 2729, 2815, 2844, 2906, 2975, 3062, 3128, 3186, 3244, 3314, 3359, 3434, 3472, 3523, 3568, 3639, 3824, 3930, 4072, 4126, 4149], '(20078)': [317], 'Google': [318, 359, 455, 502, 527, 584, 648, 781, 837, 890, 1006, 1028, 1089, 1138, 1198, 1272, 1320, 1420, 1465, 1500, 1560, 1614, 1666, 1729, 1771, 1805, 1853, 1902, 1931, 2001, 2059, 2099, 2123, 2169, 2254, 2297, 2343, 2386, 2447, 2498, 2539, 2587, 2618, 2654, 2688, 2731, 2779, 2817, 2846, 2908, 2977, 3064, 3130, 3188, 3246, 3316, 3361, 3436, 3474, 3525, 3570, 3641, 3688, 3756, 3826, 3889, 3932, 3986, 4045, 4074, 4128, 4151], 'Scholar).': [319, 360, 456, 528, 585, 782, 891, 1029, 1090, 1139, 1199, 1321, 1421, 1466, 1501, 1667, 1854, 2002, 2060, 2170, 2298, 2344, 2387, 2540, 2588, 2619, 2689, 2732, 2818, 2847, 2909, 2978, 3065, 3131, 3189, 3475, 3571, 3757, 3827, 3890, 4075, 4152], 'However,': [320, 783, 1210, 2819], 'decade': [322], 'later,': [323], 'four': [324], 'other': [325, 768, 993, 1035, 2127, 2303, 3365, 3575, 3771, 3830, 4168], 'characteristics': [326], 'advanced:': [328], 'genome': [329], 'instability,': [330], 'immune': [331, 2018, 2128, 2605, 2833, 3193, 3258, 3349, 3368, 3998], 'evasion,': [332], 'inflammation,': [333], 'altered': [335], '(2.Hanahan': [338], 'Hallmarks': [342], 'cancer:': [344, 1651, 1891], 'next': [346], 'generation.Cell.': [347], '2011;': [348, 1760, 2811, 2971, 3519, 4122], '144:': [349], '646-674Abstract': [350], '(32364)': [358], 'latter': [362, 1351], 'hallmark': [363], 'refers': [364], 'ability': [367], 'cancer': [369, 440, 487, 512, 1184, 1451, 1474, 1491, 1593, 1756, 1794, 1921, 1951, 2049, 2304, 2329, 2347, 2712, 2722, 3372, 3516, 3558, 3588, 3627, 3692, 3711, 3741, 3785, 3835, 3879, 4038, 4117, 4172], 'reprogram': [372], 'fuel': [376], 'promote': [380, 1617, 2527, 2592, 3042, 3384, 3587, 3784], 'local': [381], 'distant': [383, 2207, 2917], 'Moreover,': [385, 721, 1322, 1855, 2690, 2979, 3066, 3476, 3758], 'microenvironment': [388, 474, 2005, 4031], 'often': [390], 'nutrient-': [391], 'oxygen-deprived,': [393], 'driving': [394], 'alternative': [398, 1301], 'pathways': [400, 4089], 'survive.': [404], 'Although': [405], 'importance': [407, 1424, 1503, 2062], 'glycolysis': [409], 'has': [413, 423, 2073, 3198], 'long': [414, 2074], 'been': [415, 2075, 3199, 3323], 'recognized,': [416], 'key': [418, 546, 571], 'lipid': [421, 437, 484, 509, 550, 940, 1348, 1372], 'only': [424, 678, 1156, 3580], 'emerged': [425, 3581], 'more': [426, 1218, 3207, 3582], 'recently': [427], '(3.Liu': [428, 475], 'Q.': [429, 431, 476, 478, 3538], 'Luo': [430, 477, 2662, 2707, 3537], 'Halim': [432, 479], 'A.': [433, 480, 555, 1536, 1811, 1817, 2235, 2371, 2410, 2511, 2570, 2757, 2786, 2870, 2874, 3030, 3032, 3154, 3162, 3172, 3406, 3660, 3791, 3952, 3956, 3960], 'Song': [434, 481, 3505], 'G.': [435, 482, 757, 820, 982, 1179, 1446, 1741, 2267, 2273, 2324, 2514, 2872, 3028, 3036, 3100, 3106, 3160, 3220, 3290, 3410, 3542, 3851, 3948], 'Targeting': [436, 483], 'cells:': [441, 488], 'promising': [443, 490], 'therapeutic': [444, 491, 4139], 'strategy': [445, 492], 'cancer.Cancer': [447, 494], 'Lett.': [448, 495, 2724], '2017;': [449, 496, 578, 1192, 1314, 1459, 1660, 1800, 1897, 1925, 2337, 2445, 3355, 3564], '401:': [450, 497], '39-45Crossref': [451, 498], '(112)': [454, 501], 'Lipid': [457], 'reprogramming': [459], 'tumors': [464, 1337, 1381, 2191, 3197], 'external': [469], 'stimuli': [470], 'Scholar,': [503, 838, 1007, 1273, 1730, 1772, 1903, 2100, 2255, 2655, 2780, 3437, 4046, 4129], '4.Ray': [504], 'U.': [505], 'Roy': [506], 'S.S.': [507, 3912], 'Aberrant': [508], '-': [514], 'oncolipid-activated': [518], 'signaling.FEBS': [519], 'J.': [520, 840, 1009, 1177, 1253, 1283, 1444, 1530, 1538, 1828, 1923, 2322, 2363, 2467, 2761, 2868, 3428, 3494, 4200], '2018;': [521], '285:': [522], '432-443Crossref': [523], '(0)': [526, 1665, 2687, 3063], 'adipocytes,': [531, 570], 'maintaining': [535], 'homeostasis': [537], 'lipids,': [542, 955], 'regulators': [547], '(5.Duong': [552], 'M.N.': [553], 'Geneste': [554], 'Fallone': [556], 'F.': [557, 844, 1169, 1251, 1436, 1640, 2314, 2884, 3496, 3801, 3805, 4050, 4194], 'Li': [558, 1579, 2703, 2705], 'X.': [559, 2659, 3536], 'Dumontet': [560], 'C.': [561, 563, 623, 759, 851, 984, 1013, 1064, 1113, 1175, 1442, 1578, 1705, 1813, 2271, 2275, 2320, 2663, 2876, 2878, 2880, 3104, 3108, 3332, 3664, 3729, 4048, 4209], 'Muller': [562, 1704], 'fat': [565], 'bad:': [568], 'mature': [569], 'actors': [572], 'resistance.Oncotarget.': [577], '8:': [579], '57622-57641Crossref': [580], '(64)': [583], 'Cells': [586, 3924], 'communicate': [588], 'direct': [590], 'contact,': [591], 'secretion': [593, 1016], 'soluble': [595, 1390], 'factors,': [596, 1397], 'via': [598, 2806], '(EVs).': [601], 'term': [603, 805, 898, 913, 925], 'EV': [604, 660, 914, 926, 1215], 'subsumes': [605], 'three': [606], 'types': [607, 681], 'vesicles:': [609, 627, 1068, 1117], 'microvesicles': [610, 696, 722, 1547, 2792, 3041], '(also': [611], 'named': [612], 'microparticles': [613], 'ectosomes),': [615], 'exosomes,': [616], 'apoptotic': [618], 'bodies': [619, 709], '(6.Tkach': [620, 1061, 1110], 'M.': [621, 755, 980, 1011, 1062, 1111, 1235, 1275, 1277, 1285, 1287, 1566, 1580, 1691, 1735, 1776, 1883, 2259, 2269, 2461, 2463, 2469, 2505, 2564, 2784, 2790, 3092, 3102, 3165, 3336, 3492, 3610, 3614, 3646, 3799, 3867, 3946, 3950, 3962], 'Thery': [622, 758, 983, 1012, 1063, 1112, 2875], 'Communication': [624, 1065, 1114], 'by': [625, 654, 665, 690, 911, 1034, 1066, 1115, 1389, 1546, 1792, 2395, 2521, 2548, 2555, 2595, 2607, 2642, 2715, 2835, 2960, 2985, 3014, 3371, 3380, 3509, 3777], 'where': [628, 632, 1069, 1073, 1118, 1122, 2929, 2940], 'need': [634, 1075, 1124], 'go.Cell.': [636, 1077, 1126], '2016;': [637, 1078, 1127, 2093, 2725, 3885, 3982, 4041, 4068], '164:': [638, 1079, 1128], '1226-1232Abstract': [639, 1080, 1129], '(1270)': [647, 1088, 1137], 'Scholar),': [649, 1615, 2448, 2499, 3317, 3987], 'last': [651, 2185], 'being': [652, 1352], 'produced': [653], 'membrane': [655, 715], 'blebbing': [656], 'during': [657, 2485], 'apoptosis.': [658], 'Most': [659, 1200], 'studies': [661, 1201, 1669], 'concern': [662], 'secreted': [664, 810, 1791, 3379, 3508], 'living': [666], '(i.e.,': [668], 'exosomes': [669, 686, 704, 738, 766, 932, 991, 1588, 1711, 1754, 1790, 1915, 2278, 2373, 2572, 2669, 2720, 2770, 2889, 3111, 3456, 3813, 3872], 'microvesicles).': [671], 'Therefore,': [672, 795], 'review': [675], 'focus': [677, 1204], 'on': [679, 966, 1205, 1364, 1943, 2148, 2916, 3054, 3196, 3413, 3974], 'EVs.': [683], 'Microvesicles': [684, 3507], 'distinguished': [689], 'mode': [692], 'biogenesis.': [694], 'Indeed,': [695, 1668, 1950, 2848, 3206, 3774, 4085, 4171], 'bud': [697], 'directly': [698], 'plasma': [701, 714], 'membrane,': [702], 'whereas': [703, 737], 'formed': [706], 'multivesicular': [708], 'that': [710, 1214, 1616, 3070, 3150, 3265, 3376, 3702, 3764, 3783, 3989], 'fuse': [711], 'with': [712, 734, 825, 919, 1047, 1163, 1479, 1796, 1947, 2797, 3048, 4167], 'release': [717], 'contained': [719], 'vesicles.': [720], 'highly': [724, 962, 1469], 'heterogeneous': [725, 1470], 'size': [727], 'density': [729, 753], '(100–1,000': [730], 'nm': [731, 744], 'diameter': [733, 746], 'varying': [735, 1797], 'densities),': [736], 'range': [739], '50': [741], '150': [743], '1.13': [749], '1.19': [751], '(7.Colombo': [754, 979], 'Raposo': [756, 819, 981, 2871, 3216], 'Biogenesis,': [760, 985], 'secretion,': [761, 986], 'intercellular': [763, 988, 1596], 'interactions': [764, 989], 'vesicles.Annu.': [770, 995], 'Rev.': [771, 996, 2091, 2610, 2838, 4120], 'Cell': [772, 997, 1020, 1552, 1720, 2051, 3682], 'Dev.': [773, 998, 3925], 'Biol.': [774, 999, 1021, 1553, 1759, 2052, 3683], '2014;': [775, 884, 1000, 1022, 2612, 2840, 3463, 3684, 3747, 3926], '30:': [776, 1001], '255-289Crossref': [777, 1002], '(2290)': [780, 1005], 'discriminating': [784], 'two': [787, 3592], 'populations': [788], 'proves': [791], 'extremely': [792], 'challenging': [793], 'experimentally.': [794], 'International': [797, 877], 'Society': [798, 878], 'Extracellular': [800, 880, 1180, 1447, 1645, 2325], 'Vesicles': [801], 'suggests': [802], 'using': [803], '"EVs"': [806], 'subsume': [808], 'all': [809], 'isolated': [812], 'medium': [816], '(8.Gould': [817], 'S.J.': [818, 1487, 3863], 'As': [821, 2190], 'wait:': [823], 'coping': [824], 'imperfect': [827], 'nomenclature': [828], 'vesicles.J.': [831, 3237, 3307, 3352], 'Extracell.': [832, 882, 1264, 3353], 'Vesicles.': [833, 883, 1265, 3354], '2013;': [834, 1414, 1494, 1603, 2163, 2492, 2648, 2682, 3430, 3820], '2:': [835, 4042], '20389Crossref': [836], '9.Lötvall': [839], 'Hill': [841], 'A.F.': [842, 2422], 'Hochberg': [843], 'Buzás': [845], 'E.I.': [846, 1245], 'Di': [847, 3170], 'Vizio': [848], 'Gardiner': [850], 'Gho': [852], 'Y.S.': [853], 'Kurochkin': [854], 'I.V.': [855], 'Mathivanan': [856, 1785], 'S.': [857, 1281, 1289, 1697, 1699, 1780, 1786, 2261, 2509, 2706, 2763, 2882, 3034, 3094, 3169, 3174, 3445, 3648, 3865], 'Quesenberry': [858], 'P.': [859, 1881, 2037, 2451, 3024, 3532, 3793, 4192], 'et': [860, 1254, 1294, 1706, 1752, 1831, 2276, 2431, 2887, 3109, 3175, 3217, 3665, 3734, 3808, 3868, 4212], 'al.Minimal': [861], 'experimental': [862], 'definition': [865], 'functions:': [871], 'position': [873], 'statement': [874], 'Vesicles.J.': [881], '3:': [885], '26913Crossref': [886], '(1306)': [889], 'For': [892, 2345, 2620, 3387], 'clarity,': [893], '"exosome"': [899], '(used': [900], 'many': [902, 2028, 3326, 4086], 'cited': [905], 'publications)': [906], 'therefore': [908], 'replaced': [910], 'accordance': [918], 'new': [921], 'guidelines.': [922], 'Consequently,': [923], 'refer,': [928], 'here,': [929], 'both': [931], 'microvesicles.': [934], 'composed': [937, 2007], 'bilayer': [941], 'encapsulating': [942], 'large': [944], 'variety': [945], 'molecules,': [947, 1521], 'referred': [948], 'cargo,': [951, 1042], 'includes': [953, 1221], 'proteins,': [954, 2032], 'nucleic': [957], 'acids.': [958], 'This': [959], 'cargo': [960, 1216], 'variable': [963, 1480], 'depends': [965], 'type': [969], 'origin': [971], 'state': [975], 'its': [977], 'environment': [978, 2945], '10.Kowal': [1008], 'Tkach': [1010], 'Biogenesis': [1014], 'exosomes.Curr.': [1018], 'Opin.': [1019], '29:': [1023], '116-125Crossref': [1024], '(785)': [1027], 'internalized': [1033, 2394], 'allowing': [1037], 'horizontal': [1039], 'transfer': [1040, 1520, 1540, 1597, 1677, 3548, 3736], 'interact': [1046], 'receptors': [1051], 'ligands': [1053], 'carried': [1054], 'at': [1055, 1101, 2356, 3280], 'surface,': [1057, 2358, 3282], 'inducing': [1058], 'cascades': [1060], 'mediate': [1092, 1153, 1858, 2479, 3618], 'communication': [1093, 1154, 1188, 1375, 1455, 1508, 2333], 'neighboring': [1095], 'but': [1097, 1161], 'act': [1100], 'distance': [1103], 'they': [1105, 1152, 2941, 3142, 3151], 'circulate': [1106], 'body': [1108], 'fluids': [1109], 'particularly': [1143], 'cancer,': [1147], 'disease': [1149], 'not': [1155], 'themselves': [1160], 'micro-': [1165], 'macroenvironment': [1167], '(11.Wendler': [1168, 1435, 2313], 'Favicchio': [1170, 1437, 2315], 'R.': [1171, 1438, 1819, 2082, 2316, 2365, 2430, 2516, 2560, 2704, 2708, 3020, 3226, 3296, 3408, 3958, 4052], 'Simon': [1172, 1439, 2317], 'T.': [1173, 1293, 1440, 2318, 2424, 2886, 3449, 3724, 4196], 'Alifrangis': [1174, 1441, 2319], 'Stebbing': [1176, 1443, 2321], 'Giamas': [1178, 1445, 2323], 'swarm': [1182, 1449, 2327], 'microenvironment:': [1185, 1452, 2330], 'tumor-stroma': [1187, 1454, 2332], 'drug': [1190, 1457, 1635, 1859, 1888, 2335], 'intervention.Oncogene.': [1191, 1458, 2336], '36:': [1193, 1460, 2338, 3565], '877-884Crossref': [1194, 1461, 2339], '(82)': [1197, 1464, 2342], 'involving': [1202, 3595], 'protein': [1206], 'RNA': [1208], 'content.': [1209], 'increasing': [1211], 'evidence': [1212], 'complex': [1219, 1935], 'metabolites,': [1222], 'such': [1223, 1392, 1522, 1620], 'organic': [1225], 'acids': [1226], 'derivatives,': [1229], 'nucleotides,': [1230], 'sugars,': [1231], 'amines': [1233], '(12.Yáñez-Mó': [1234], 'Siljander': [1236], 'P.R.': [1237], 'Andreu': [1238], 'Z.': [1239, 2041, 2369, 2568, 2767], 'Zavec': [1240], 'A.B.': [1241, 3914], 'Borràs': [1242], 'F.E.': [1243], 'Buzas': [1244, 1246], 'K.': [1247, 1526, 1638, 1644, 3400, 3859], 'Casal': [1248], 'E.': [1249, 1689, 1821, 1826, 2459, 2465, 3506, 3608, 3807], 'Cappello': [1250], 'Carvalho': [1252], 'al.Biological': [1255], 'properties': [1256, 2826, 3013], 'physiological': [1262], 'functions.J.': [1263], '2015;': [1266, 1723, 1842, 2248, 2583, 3182, 4145], '4:': [1267], '27066Crossref': [1268], '(1680)': [1271], '13.Puhka': [1274], 'Takatalo': [1276], 'Nordberg': [1278], 'M.E.': [1279], 'Valkonen': [1280], 'Nandania': [1282], 'Aatonen': [1284], 'Yliperttula': [1286], 'Laitinen': [1288], 'Velagapudi': [1290], 'V.': [1291, 1532, 1695, 3022, 3447, 3598, 3652], 'Mirtti': [1292], 'al.Metabolomic': [1295], 'profiling': [1296, 1788], 'normalization': [1302], 'methods': [1303], 'reveal': [1304], 'enriched': [1305], 'metabolites': [1306], 'strategies': [1308], 'study': [1310], 'prostate': [1311, 2556], 'cancer-related': [1312], 'changes.Theranostics.': [1313], '7:': [1315, 2903], '3824-3841Crossref': [1316], '(47)': [1319], 'influence': [1325, 2174, 3765], 'recipient': [1329], 'cells.': [1330, 3693, 3773, 4170], 'We': [1331], 'discuss': [1333], 'how': [1334, 3253], 'EVs,': [1335], 'within': [1336, 1380, 2197, 2695], 'environment,': [1341, 2201], 'affect': [1343, 2309, 3483], 'glycolysis,': [1344, 4101], 'oxidative': [1345, 4186], 'phosphory\xadlation,': [1346], 'metabolism,': [1349], 'main': [1354], 'subject': [1355], 'review.': [1358, 2189], 'emphasis': [1360], 'placed': [1363], 'adipocyte': [1368], 'metabolism.': [1373], 'found': [1379, 2694, 2932, 3481], 'stroma': [1385, 2147, 2312], 'mediated': [1388, 2714], 'factors': [1391], 'cytokines,': [1394], 'chemokines,': [1395], 'matrix': [1399], 'remodeling': [1400, 4156], 'enzymes': [1401, 4098], '(14.Quail': [1402, 2151], 'D.F.': [1403, 2152], 'Joyce': [1404, 2153], 'J.A.': [1405, 2154], 'Microenvironmental': [1406, 2155], 'regulation': [1407, 2156], 'metastasis.Nat.': [1412, 2161], 'Med.': [1413, 2162, 2290, 2901, 3123, 3239, 3309], '19:': [1415, 2164], '1423-1437Crossref': [1416, 2165], '(2851)': [1419, 2168], 'Nevertheless,': [1422], 'dialog': [1429], 'now': [1431, 1513], 'clearly': [1433, 1514], 'recognized': [1434], 'Tumors': [1467, 1933], 'tissues': [1471], 'different': [1477, 3484], 'phenotypes': [1478], 'levels': [1481], 'aggressiveness': [1483], '(15.Meacham': [1484], 'C.E.': [1485, 2413], 'Morrison': [1486], 'Tumour': [1488], 'heterogeneity': [1489], 'plasticity.Nature.': [1493], '501:': [1495], '328-337Crossref': [1496], '(1203)': [1499], 'recognized.': [1515], 'Briefly,': [1516], 'EGFRvIII': [1524, 1545], '(16.Al-Nedawi': [1525], 'Meehan': [1527], 'B.': [1528, 2265, 3098, 3156, 3498, 3720, 3906], 'Micallef': [1529], 'Lhotak': [1531], 'May': [1533], 'L.': [1534, 1693, 1703, 1774, 2657, 2665, 2702, 3026, 3038, 3338, 3500, 3534, 3546, 3600], 'Guha': [1535], 'Rak': [1537], 'Intercellular': [1539], 'oncogenic': [1543, 1618], 'receptor': [1544, 2751], 'derived': [1548, 3416], 'tumour': [1550], 'cells.Nat.': [1551], '2008;': [1554, 2775], '10:': [1555, 3520], '619-624Crossref': [1556], '(1167)': [1559], 'Scholar)': [1561, 1806, 3247, 3526, 3642, 3689, 3933], 'KRAS': [1563, 1591], '(17.Demory': [1564], 'Beckler': [1565, 1734], 'Higginbotham': [1567], 'J.N.': [1568, 1732], 'Franklin': [1569, 1738], 'J.L.': [1570, 1739, 2953, 3616], 'Ham': [1571], 'A.J.': [1572], 'Halvey': [1573], 'P.J.': [1574], 'Imasuen': [1575], 'I.E.': [1576], 'Whitwell': [1577], 'Liebler': [1581], 'D.C.': [1582], 'Coffey': [1583], 'R.J.': [1584, 4033], 'Proteomic': [1585, 1787], 'analysis': [1586], 'mutant': [1590, 1599], 'colon': [1592], 'identifies': [1595], 'KRAS.Mol.': [1600], 'Cell.': [1601, 1989], 'Proteomics.': [1602], '12:': [1604], '343-355Abstract': [1605], '(288)': [1613], 'signaling,': [1619], 'MAPK,': [1622], 'PTEN,': [1623], 'GSK3β,': [1624], 'NOTCH,': [1625], 'AKT': [1627], 'pathways,': [1628], 'consequently': [1629], 'promoting': [1630, 3012], 'initiation,': [1632], 'progression,': [1633, 2176, 3488], 'and/or': [1634, 1865], 'resistance': [1636, 1860, 1889, 3528, 3555, 3745, 3845], '(18.Wu': [1637], 'Xing': [1639], 'Wu': [1641, 2658, 3715], 'S.Y.': [1642], 'Watabe': [1643], 'targets': [1649], 'development': [1653, 1939, 3002, 3083], 'bench': [1655], 'bedside.Biochim.': [1657], 'Biophys.': [1658], 'Acta.': [1659], '1868:': [1661], '538-563Crossref': [1662], 'have': [1670, 3321, 3579], 'proven': [1671], 'metastatic': [1679, 1717, 1798, 1840, 3139], 'potential': [1680, 3346], 'vitro': [1685], '(19.Lazar': [1686], 'I.': [1687, 2263, 3096], 'Clement': [1688], 'Ducoux-Petit': [1690], 'Denat': [1692], 'Soldan': [1694], 'Dauvillier': [1696], 'Balor': [1698], 'Burlet-Schiltz': [1700], 'O.': [1701], 'Larue': [1702], 'al.Proteome': [1707], 'characterization': [1708], 'melanoma': [1710, 2927, 2961, 3071], 'reveals': [1712, 1835], 'specific': [1714, 3138], 'signature': [1715], 'lines.Pigment': [1719], 'Melanoma': [1721], 'Res.': [1722, 2247, 2379, 2970, 3057, 3563, 3884, 4067, 4144], '28:': [1724], '464-475Crossref': [1725], '(77)': [1728], '20.Higginbotham': [1731], 'Demory': [1733], 'Gephart': [1736], 'J.D.': [1737, 3504], 'Bogatcheva': [1740], 'Kremers': [1742], 'G.J.': [1743, 4131], 'Piston': [1744], 'D.W.': [1745], 'Ayers': [1746], 'G.D.': [1747], 'McConnell': [1748], 'R.E.': [1749], 'Tyska': [1750], 'M.J.': [1751, 2782], 'al.Amphiregulin': [1753], 'invasion.Curr.': [1758], '21:': [1761, 1991], '779-786Abstract': [1762], '(231)': [1770], '21.Gangoda': [1773], 'Liem': [1775], 'Ang': [1777], 'C.S.': [1778], 'Keerthikumar': [1779], 'Adda': [1781], 'C.G.': [1782], 'Parker': [1783], 'B.S.': [1784], 'breast': [1793, 2711, 3515, 3626, 3710, 3740, 3834, 3878], 'potential.Proteomics.': [1799], '17:': [1801, 1898], '201600370Crossref': [1802], '(39)': [1804], 'vivo': [1809, 1833], '(22.Zomer': [1810], 'Maynard': [1812], 'Verweij': [1814], 'F.J.': [1815], 'Kamermans': [1816], 'Schafer': [1818], 'Beerling': [1820], 'Schiffelers': [1822], 'R.M.': [1823], 'de': [1824, 2411, 2427], 'Wit': [1825], 'Berenguer': [1827], 'Ellenbroek': [1829], 'S.I.J.': [1830], 'al.In': [1832], 'imaging': [1834], 'vesicle-mediated': [1837], 'phenocopying': [1838], 'behavior.Cell.': [1841], '161:': [1843], '1046-1057Abstract': [1844], '(406)': [1852], 'sequestration,': [1863], 'transport,': [1864], 'expulsion': [1866], 'chemotherapeutic': [1868], 'drugs': [1869, 3530], '[for': [1873, 2077, 3328], 'recent': [1874, 2078], 'reviews': [1875], 'concerning': [1876], 'point,': [1878], 'see': [1879, 2080, 3330], '(23.Samuel': [1880], 'Fabbri': [1882, 3335], 'Carter': [1884], 'D.R.F.': [1885], 'Mechanisms': [1886], 'vesicles.Proteomics.': [1896], '201600375Crossref': [1899], '(23)': [1901], '24.Bach': [1904], 'D.H.': [1905], 'Hong': [1906], 'J.Y.': [1907, 3402], 'Park': [1908], 'H.J.': [1909, 3232, 3302], 'Lee': [1910], 'S.K.': [1911, 3916], 'miRNAs': [1917], 'drug-resistance': [1919], 'cells.Int.': [1922], 'Cancer.': [1924, 2092, 3518, 4121], '141:': [1926, 2113], '220-230Crossref': [1927], '(118)': [1930], 'Scholar)].': [1932, 2124, 3362], 'tissue': [1936], 'diseases': [1937], 'whose': [1938], 'depend': [1942], 'dynamic': [1945, 2046], 'interaction': [1946], 'profoundly': [1953], 'modify': [1954, 4090], 'stroma,': [1957], 'which,': [1958], 'turn,': [1960], 'promotes': [1961], 'growth,': [1964], 'dissemination,': [1966], 'influences': [1968], 'outcome': [1970], 'therapy': [1972, 3744, 3847], '(25.Hanahan': [1973], 'Coussens': [1975], 'L.M.': [1976, 3803, 3855], 'Accessories': [1977], 'crime:': [1980], 'functions': [1981, 2598, 2700], 'recruited': [1984], 'microenvironment.Cancer': [1988], '2012;': [1990, 2053, 2291, 2533, 3124, 3630], '309-322Abstract': [1992], '(2102)': [2000], 'noncancer': [2009], '(mainly': [2011], 'fibroblasts,': [2012], 'bone': [2013, 2214, 2280, 2990, 3074, 3113, 3759, 3882], 'marrow-derived': [2014, 2215], 'inflammatory': [2015], 'endothelial': [2020, 2131, 2396], 'cells)': [2021], 'matrix,': [2025], 'contains': [2027], 'distinct': [2029, 3147], 'components': [2030], 'including': [2031, 3489], 'glycoproteins,': [2033], 'proteoglycans': [2035], '(26.Lu': [2036], 'Weaver': [2038], 'V.M.': [2039], 'Werb': [2040], 'matrix:': [2044], 'niche': [2047, 2951, 3088], 'progression.J.': [2050, 3817], '196:': [2054], '395-406Crossref': [2055], '(1657)': [2058], 'cancer-associated': [2064], 'fibroblasts': [2065, 2088, 2361], '(CAFs)': [2066], 'tumor-associated': [2068, 3477, 3550], 'macrophages': [2069, 3510], 'described': [2076], 'reviews,': [2079], '(27.Kalluri': [2081], 'biology': [2084], 'function': [2086, 2805], 'cancer.Nat.': [2090], '16:': [2094, 3685], '582-598Crossref': [2095], '(1168)': [2098], '28.Qian': [2101], 'B.Z.': [2102, 3731], 'Pollard': [2103], 'J.W.': [2104], 'Macrophage': [2105], 'diversity': [2106], 'enhances': [2107], 'metastasis.Cell.': [2111], '2010;': [2112, 2380], '39-51Abstract': [2114], '(2578)': [2122], 'addition,': [2126], 'vascular': [2130, 2483], 'pericytes,': [2133], 'bone-marrow': [2135], 'mesenchymal': [2136, 2549, 2574, 3810, 3969], 'stromal': [2137, 3576, 3619, 3738, 3772, 3811, 3970], 'contribute': [2140], 'deleterious': [2143], 'impact': [2144], 'behavior': [2150, 3768], 'Lastly,': [2171], 'adipocytes': [2172], 'topic': [2179], 'addressed': [2182, 2936], 'section': [2186], 'progress': [2192], 'advanced': [2194], 'stages,': [2195], 'systemic': [2199], 'macroenvironment,': [2203], 'favor': [2204, 3994], 'dissemination': [2205, 4024], 'sites.': [2208], 'include': [2211], 'modifications': [2212], 'mobilization': [2217, 3620], 'preparation': [2220], 'pre-metastatic': [2222, 2950, 3087], 'niches': [2223], 'home': [2229], '(29.Rutkowski': [2230], 'M.R.': [2231, 2415, 3606], 'Svoronos': [2232], 'N.': [2233], 'Perales-Puchalt': [2234], 'Conejo-Garcia': [2236], 'J.R.': [2237], 'macroenvironment:': [2240], 'cancer-promoting': [2241], 'networks': [2242], 'beyond': [2243], 'beds.Adv.': [2245], '128:': [2249], '235-262Crossref': [2250], '(32)': [2253], '30.Peinado': [2256], 'H.': [2257, 3090, 3167, 3654, 3733], 'Aleckovic': [2258, 3091], 'Lavotshkin': [2260, 3093], 'Matei': [2262, 3095], 'Costa-Silva': [2264, 3097, 3155], 'Moreno-Bueno': [2266, 3099], 'Hergueta-Redondo': [2268, 3101], 'Williams': [2270, 3103, 3854], 'Garcia-Santos': [2272, 3105], 'Ghajar': [2274, 3107], 'al.Melanoma': [2277, 3110], 'educate': [2279, 3112], 'marrow': [2281, 3075, 3114, 3760], 'progenitor': [2282, 3115], 'pro-metastatic': [2286, 3119], 'phenotype': [2287, 3120, 3842], 'MET.Nat.': [2289, 3122], '18:': [2292, 3125], '883-891Crossref': [2293, 3126], '(2021)': [2296, 3129], 'addition': [2300], 'influencing': [2302], 'tumor-derived': [2306, 2769, 2820, 2914, 2980], 'example,': [2346], 'cell-derived': [2348, 2668, 3350, 3577, 3812, 3871, 3971], 'exhibit': [2350], 'transforming': [2351, 2716, 2808, 3049], 'factor': [2353], 'β': [2354], '(TGFβ)': [2355], 'activates': [2360], '(31.Webber': [2362], 'Steadman': [2364], 'Mason': [2366, 2565, 2764], 'M.D.': [2367, 2566, 2765], 'Tabi': [2368, 2567, 2766], 'Clayton': [2370, 2569], 'trigger': [2374, 2573], 'fibroblast': [2375], 'myofibroblast': [2377], 'differentiation.Cancer': [2378], '70:': [2381], '9621-9630Crossref': [2382], '(477)': [2385], 'leading': [2398, 2999, 3077, 3843, 4093], 'activation': [2401, 2481, 2554, 2858, 3370], 'angiogenesis': [2403, 2528], 'squamous': [2405, 2436], 'carcinoma': [2407, 2437, 2667], '(32.de': [2408], 'Andrade': [2409], 'Oliveira': [2412], 'Dourado': [2414], 'Macedo': [2416], 'C.C.S.': [2417], 'Winck': [2418], 'F.V.': [2419], 'Paes': [2420], 'Leme': [2421], 'Salo': [2423], 'Coletta': [2425], 'R.D.': [2426], 'Almeida': [2428], 'Freitas': [2429], 'al.Extracellular': [2432], 'oral': [2435], 'display': [2439, 4003], 'pro-': [2440], 'antiangiogenic': [2442], 'properties.Oral': [2443], 'Dis.': [2444], 'glioma': [2449, 2476], '(33.Kucharzewska': [2450], 'Christianson': [2452], 'H.C.': [2453], 'Welch': [2454], 'J.E.': [2455], 'Svensson': [2456], 'K.J.': [2457], 'Fredlund': [2458], 'Ringner': [2460], 'Morgelin': [2462], 'Bourseau-Guilmain': [2464], 'Bengzon': [2466], 'Belting': [2468], 'Exosomes': [2470, 2519, 2958, 3617], 'reflect': [2471], 'hypoxic': [2473, 4175], 'status': [2474], 'hypoxia-dependent': [2480], 'development.Proc.': [2487], 'Natl.': [2488], 'Acad.': [2489], 'Sci.': [2490], 'USA.': [2491], '110:': [2493], '7312-7317Crossref': [2494], '(513)': [2497], 'chronic': [2501, 2523], 'myeloid': [2502, 2524, 2799, 2986, 3046], 'leukemia': [2503, 2525, 2800], '(34.Mineo': [2504], 'Garfield': [2506], 'S.H.': [2507], 'Taverna': [2508], 'Flugy': [2510], 'De': [2512, 4203], 'Leo': [2513], 'Alessandro': [2515], 'Kohn': [2517], 'E.C.': [2518], 'released': [2520, 2959], 'K562': [2522], 'Src-dependent': [2531], 'fashion.Angiogenesis.': [2532], '15:': [2534], '33-45Crossref': [2535], '(172)': [2538], 'Angiogenesis': [2541], 'invasion': [2544, 3490], 'promoted': [2547], 'stem': [2550, 2575, 3870, 3918], '(MSCs)': [2552], 'upon': [2553], 'cancer-derived': [2557], '(35.Chowdhury': [2559], 'Webber': [2561], 'J.P.': [2562, 2759], 'Gurney': [2563], 'differentiation': [2577, 2994, 3044], 'into': [2578, 2995, 3514], 'pro-angiogenic': [2579], 'pro-invasive': [2581], 'myofibroblasts.Oncotarget.': [2582], '6:': [2584, 3356, 3983], '715-731Crossref': [2585], 'Tumor-derived': [2589], 'exerting': [2596], 'immunosuppressive': [2597, 2699], '(36.Robbins': [2599, 2827], 'P.D.': [2600, 2828, 3662], 'Morelli': [2601, 2829], 'A.E.': [2602, 2830], 'Regulation': [2603, 2831, 4115], 'responses': [2606, 2834], 'vesicles.Nat.': [2609, 2837], 'Immunol.': [2611, 2774, 2839, 3429], '14:': [2613, 2841], '195-208Crossref': [2614, 2842], '(964)': [2617, 2845], 'instance,': [2621, 3388], 'vesicular': [2622], 'Fas': [2623], 'ligand': [2624], 'induces': [2625], 'CD8+': [2626], 'T': [2627, 2676, 3016, 3055, 3287, 3390, 3421, 3459, 3899, 3903], 'apoptosis': [2629, 2678], '(37.Whiteside': [2630], 'T.L.': [2631, 2788, 3158], 'Immune': [2632], 'modulation': [2633], 'T-cell': [2635], 'NK': [2637, 3978], '(natural': [2638], 'killer)': [2639], 'activities': [2641], 'TEXs': [2643], '(tumour-derived': [2644], 'exosomes).Biochem.': [2645], 'Soc.': [2646], 'Trans.': [2647], '41:': [2649, 3464], '245-251Crossref': [2650], '(196)': [2653], '38.Yang': [2656], 'Wang': [2660, 3337], 'Chen': [2664, 3493, 3533], 'Renal': [2666], 'induce': [2670, 2856, 3839, 3894], 'human': [2671], 'immortalized': [2672], 'line': [2673], 'Jurkat': [2675], 'lymphocyte': [2677, 3391], 'vitro.Urol.': [2680], 'Int.': [2681], '91:': [2683], '363-369Crossref': [2684], 'TGFβ': [2691, 2734], 'IL10': [2693], 'exert': [2698], '(39.Rong': [2701], 'Immunosuppression': [2709], 'factor-beta': [2718], 'cells.Oncol.': [2723], '11:': [2726, 4123], '500-504Crossref': [2727], '(69)': [2730], 'Vesicular': [2733], 'involved': [2737, 3394, 4099], 'inhibition': [2739], 'natural': [2741, 2802, 3941], 'killer': [2742, 2803, 3942], 'downregulation': [2745], 'NKG2D/KLRK1': [2747], '(killer': [2748], 'lectin-like': [2750], 'subfamily': [2752], 'K': [2753], 'member': [2754], '1)': [2755], '(40.Clayton': [2756], 'Mitchell': [2758], 'Court': [2760], 'Linnane': [2762], 'Human': [2768, 3039], 'down-modulate': [2771], 'NKG2D': [2772], 'expression.J.': [2773], '180:': [2776], '7249-7258Crossref': [2777], '41.Szczepanski': [2781], 'Szajnik': [2783], 'Welsh': [2785], 'Whiteside': [2787], 'Boyiadzis': [2789], 'Blast-derived': [2791], 'sera': [2794], 'patients': [2796], 'acute': [2798], 'suppress': [2801, 3457], 'membrane-associated': [2807], 'factor-beta1.Haematologica.': [2810], '96:': [2812], '1302-1309Crossref': [2813], '(225)': [2816], 'immunoactivation': [2825], 'carry': [2851], 'antigens,': [2853], 'effectively': [2855], 'dendritic': [2860, 2996], 'anti-tumor': [2865], '(42.Wolfers': [2867], 'Lozier': [2869], 'Regnault': [2873], 'Masurier': [2877], 'Flament': [2879], 'Pouzieux': [2881], 'Faure': [2883], 'Tursz': [2885], 'al.Tumor-derived': [2888], 'source': [2892], 'shared': [2894], 'rejection': [2896], 'antigens': [2897], 'CTL': [2899], 'cross-priming.Nat.': [2900], '2001;': [2902], '297-303Crossref': [2904], '(1017)': [2907], 'Finally,': [2910], 'organs': [2918], 'was': [2919, 3068], 'shown': [2920], 'time': [2924], 'model,': [2928, 3836], 'preferentially': [2935], 'lymph': [2938, 2965], 'nodes': [2939, 2966], 'induced': [2942], 'permissive': [2944], 'metastasis': [2947], 'called': [2948], '(43.Hood': [2952], 'San': [2954], 'R.S.': [2955], 'Wickline': [2956], 'S.A.': [2957, 3849], 'prepare': [2963], 'sentinel': [2964], 'metastasis.Cancer': [2969, 4066], '71:': [2972], '3792-3801Crossref': [2973], '(599)': [2976], 'taken': [2983], 'up': [2984], 'marrow,': [2991], 'inhibiting': [2992, 3015], 'myeloid-derived': [3005], 'suppressor': [3006], 'phenotype,': [3008], 'exerts': [3010], 'proliferation': [3018, 3787, 3937, 4022], '(44.Valenti': [3019], 'Huber': [3021], 'Filipazzi': [3023], 'Pilla': [3025], 'Sovena': [3027], 'Villa': [3029], 'Corbelli': [3031], 'Fais': [3033], 'Parmiani': [3035], 'Rivoltini': [3037], 'tumor-released': [3040], 'factor-beta-mediated': [3051], 'suppressive': [3052], 'activity': [3053], 'lymphocytes.Cancer': [3056], '2006;': [3058], '66:': [3059], '9290-9298Crossref': [3060], 'it': [3067], 'demonstrated': [3069], '"educate"': [3073], 'progenitors,': [3076], 'recruitment': [3080], 'favorable': [3086], '(30.Peinado': [3089], 'control': [3135], 'organotropism': [3136], 'sites,': [3140], 'target': [3143], 'due': [3144, 4081], 'integrin': [3148], 'combinations': [3149], 'transport': [3152], '(45.Hoshino': [3153], 'Shen': [3157, 3545], 'Rodrigues': [3159], 'Hashimoto': [3161], 'Tesic': [3163], 'Mark': [3164], 'Molina': [3166], 'Kohsaka': [3168], 'Giannatale': [3171], 'Ceder': [3173], 'al.Tumour': [3176], 'exosome': [3177], 'integrins': [3178], 'determine': [3179], 'organotropic': [3180], 'metastasis.Nature.': [3181], '527:': [3183], '329-335Crossref': [3184], '(1871)': [3187], 'well-studied': [3201], 'field': [3202], 'some': [3204], 'time.': [3205], 'than': [3208], '20': [3209], 'years': [3210], 'ago,': [3211], 'pioneering': [3213], 'al.': [3218], '(46.Raposo': [3219, 3289], 'Nijman': [3221, 3291], 'H.W.': [3222, 3292, 3650], 'Stoorvogel': [3223, 3293], 'W.': [3224, 3294], 'Liejendekker': [3225, 3295], 'Harding': [3227, 3297], 'C.V.': [3228, 3298], 'Melief': [3229, 3299], 'C.J.': [3230, 3300, 4205], 'Geuze': [3231, 3301], 'B': [3233, 3303, 3939, 3976], 'lymphocytes': [3234, 3304, 3904], 'secrete': [3235, 3268, 3305, 3762, 3781, 3920], 'antigen-presenting': [3236, 3266, 3306], 'Exp.': [3238, 3308, 3560, 4141], '1996;': [3240, 3310], '183:': [3241, 3311], '1161-1172Crossref': [3242, 3312], '(1964)': [3245, 3315], 'paved': [3248], 'way': [3250], 'understanding': [3252], 'modulate': [3256, 3770], 'Their': [3262], 'showed': [3264], 'exhibiting': [3270], 'major': [3271], 'histocompatibility': [3272], 'complexes': [3273], 'I': [3274], 'II,': [3276], 'costimulatory': [3278], 'molecules': [3279], 'prime': [3285], 'naïve': [3286], 'similar': [3319], 'processes': [3320], 'since': [3322], 'observed': [3324], 'models': [3327], '(47.Wen': [3331], 'Seeger': [3333], 'R.C.': [3334, 3910], 'Wayne': [3339], 'A.S.': [3340], 'Jong': [3341], 'A.Y.': [3342], 'Biological': [3343], 'roles': [3344], 'applications': [3347], '1400370Crossref': [3357], '(54)': [3360], 'On': [3363, 3828], 'hand,': [3366, 3831], 'after': [3367], 'then': [3378, 4183], 'progression.': [3386], 'regulatory': [3389, 3426, 3902], 'immunosuppression': [3396], '(48.Smyth': [3397], 'L.A.': [3398], 'Ratnasothy': [3399], 'Tsang': [3401], 'Boardman': [3403], 'Warley': [3405], 'Lechler': [3407], 'Lombardi': [3409], 'CD73': [3411], 'CD4+': [3418], 'CD25+': [3419], 'Foxp3+': [3420], 'contributes': [3423], 'function.Eur.': [3427], '43:': [3431], '2430-2440Crossref': [3432], '(111)': [3435], '49.Okoye': [3438], 'I.S.': [3439, 4112], 'Coomes': [3440], 'S.M.': [3441], 'Pelly': [3442], 'V.S.': [3443], 'Czieso': [3444], 'Papayannopoulos': [3446], 'Tolmachova': [3448], 'Seabra': [3450], 'M.C.': [3451, 3714, 4198], 'Wilson': [3452], 'M.S.': [3453], 'MicroRNA-containing': [3454], 'T-regulatory-cell-derived': [3455], 'pathogenic': [3458], 'helper': [3460], '1': [3461], 'cells.Immunity.': [3462], '89-103Abstract': [3465], '(256)': [3473], 'macrophage-derived': [3478, 3551], 'aspects': [3485], '(50.Yang': [3491], 'Su': [3495], 'Yu': [3497], 'Lin': [3499], 'Liu': [3501, 3539], 'Y.': [3502, 3540, 3544, 3722, 3908], 'Huang': [3503], 'shuttle': [3511], 'invasion-potentiating': [3512], 'microRNAs': [3513], 'cells.Mol.': [3517], '117Crossref': [3521], '(452)': [3524, 3825], '(51.Zheng': [3531], 'Yuan': [3535], 'Xie': [3541], 'Ma': [3543], 'Exosomal': [3547], 'miR-21': [3552], 'confers': [3553], 'cisplatin': [3554], 'gastric': [3557], 'cells.J.': [3559], 'Clin.': [3561, 3818, 4142], '53Crossref': [3566], '(195)': [3569], 'effects': [3573, 3967], 'recently.': [3583], 'CAF-derived': [3584], 'motility': [3590], 'independent': [3593], 'mechanisms': [3594], 'WNT': [3596], '(52.Luga': [3597], 'Zhang': [3599], 'Viloria-Petit': [3601], 'A.M.': [3602, 3789], 'Ogunjimi': [3603], 'A.A.': [3604], 'Inanlou': [3605], 'Chiu': [3607], 'Buchanan': [3609], 'Hosein': [3611], 'A.N.': [3612], 'Basik': [3613], 'Wrana': [3615], 'autocrine': [3622], 'Wnt-PCP': [3623], 'migration.Cell.': [3629], '151:': [3631], '1542-1556Abstract': [3632], '(740)': [3640], 'NOTCH': [3644], '(53.Shimoda': [3645], 'Principe': [3647], 'Jackson': [3649], 'Luga': [3651], 'Fang': [3653], 'Molyneux': [3655], 'S.D.': [3656], 'Shao': [3657], 'Y.W.': [3658], 'Aiken': [3659], 'Waterhouse': [3661], 'Karamboulas': [3663], 'al.Loss': [3666], 'Timp': [3669], 'family': [3671], 'sufficient': [3673], 'acquisition': [3676], 'CAF-like': [3679], 'state.Nat.': [3681], '889-901Crossref': [3686], 'They': [3694], 'convey': [3696], 'RNAs,': [3697], 'prompt': [3699], 'STAT1': [3700], 'leads': [3703], 'radio-': [3705], 'chemoresistance': [3707], 'model': [3712], '(54.Boelens': [3713], 'T.J.': [3716], 'Nabet': [3717], 'B.Y.': [3718], 'Xu': [3719], 'Qiu': [3721], 'Yoon': [3723], 'Azzam': [3725], 'D.J.': [3726, 3857], 'Twyman-Saint': [3727], 'Victor': [3728], 'Wiemann': [3730], 'Ishwaran': [3732], 'al.Exosome': [3735], 'regulates': [3743], 'pathways.Cell.': [3746], '159:': [3748], '499-513Abstract': [3749], 'MSCs': [3761, 3775], 'activated': [3776, 3898], 'multiple': [3778, 3815], 'myeloma': [3779, 3816], '(55.Roccaro': [3788], 'Sacco': [3790], 'Maiso': [3792], 'Azab': [3794, 3800], 'A.K.': [3795], 'Tai': [3796], 'Y.T.': [3797], 'Reagan': [3798], 'Flores': [3802], 'Campigotto': [3804], 'Weller': [3806], 'al.BM': [3809], 'facilitate': [3814], 'Invest.': [3819], '123:': [3821], '1542-1555Crossref': [3822], 'quiescent': [3841], '(56.Bliss': [3848], 'Sinha': [3850], 'Sandiford': [3852], 'O.A.': [3853], 'Engelberth': [3856], 'Guiro': [3858], 'Isenalumhe': [3860], 'L.L.': [3861], 'Greco': [3862], 'Ayer': [3864], 'Bryan': [3866], 'al.Mesenchymal': [3869], 'stimulate': [3873], 'cycling': [3874], 'quiescence': [3875], 'early': [3877], 'dormancy': [3880], 'marrow.Cancer': [3883], '76:': [3886, 4069], '5832-5844Crossref': [3887], 'MSC-derived': [3891, 3990], 'switching': [3896], '(57.Zhang': [3905], 'Yin': [3907], 'Lai': [3909], 'Tan': [3911], 'Choo': [3913], 'Lim': [3915], 'Mesenchymal': [3917], 'immunologically': [3921], 'active': [3922], 'exosomes.Stem': [3923], '23:': [3927], '1233-1244Crossref': [3928], '(319)': [3931], 'reduce': [3935], '(58.Di': [3944], 'Trapani': [3945], 'Bassi': [3947], 'Midolo': [3949], 'Gatti': [3951], 'Kamga': [3953], 'P.T.': [3954], 'Cassaro': [3955], 'Carusone': [3957], 'Adamo': [3959], 'Krampera': [3961], 'Differential': [3963], 'transferable': [3965], 'modulatory': [3966], 'T,': [3975], 'functions.Sci.': [3980], 'Rep.': [3981], '24120Crossref': [3984], 'suggesting': [3988], 'escape': [3996], 'surveillance.': [3999], 'high': [4005], 'plasticity': [4007, 4058], 'generate': [4009], 'biosynthetic': [4016], 'demand': [4017], 'required': [4018], 'support': [4020], 'poorly': [4027], 'oxygenated': [4028], '(59.DeBerardinis': [4032], 'Chandel': [4034], 'N.S.': [4035], 'Fundamentals': [4036], 'metabolism.Sci.': [4039], 'Adv.': [4040], 'e1600200Crossref': [4043], '60.Lehuédé': [4047], 'Dupuy': [4049], 'Rabinovitch': [4051], 'Jones': [4053], 'R.G.': [4054], 'Siegel': [4055], 'P.M.': [4056], 'Metabolic': [4057, 4132], 'determinant': [4061], '5201-5208Crossref': [4070], '(106)': [4073], 'metabolically': [4079], 'alterations.': [4084], 'oncogene': [4087], 'expression,': [4092], 'upregulation': [4096], 'pentose': [4103], 'phosphate': [4104], 'pathway,': [4105], 'synthesis': [4108], '(61.Cairns': [4109], 'Harris': [4111], 'Mak': [4113], 'T.W.': [4114], 'metabolism.Nat.': [4119], '85-95Crossref': [4124], '(2950)': [4127], '62.Yoshida': [4130], 'reprogramming:': [4133], 'concept': [4136], 'associated': [4138], 'strategies.J.': [4140], '34:': [4146], '111Crossref': [4147], '(215)': [4150], 'take': [4159], 'place': [4160], 'cooperation': [4166], 'regions': [4176, 4190], 'glucose': [4178], 'produce': [4180], 'lactate,': [4181], 'fuels': [4184], 'well-oxygenated': [4189], '(63.Sonveaux': [4191], 'Vegran': [4193], 'Schroeder': [4195], 'Wergin': [4197], 'Verrax': [4199], 'Rabbani': [4201], 'Z.N.': [4202], 'Saedeleer': [4204], 'Kennedy': [4206], 'K.M.': [4207], 'Diepart': [4208], 'Jordan': [4210], 'B.F.': [4211], 'al.Targeting': [4213], 'lactate-fueled': [4214], 'r': [4215]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2801248283', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-18T16:45:24.175066', 'created_date': '2018-05-17'}
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