Exosomes in melanoma: a role in tumor progression, metastasis and impaired immune system activity

Name: Work Video:
Duration: 3 min 30 s
Marco Tucci; Francesco Mannavola; Anna Passarelli; Luigia Stefania Stucci; Mauro Cives; Franco Silvestris
{'id': 'https://openalex.org/W2801148143', 'doi': 'https://doi.org/10.18632/oncotarget.24846', 'title': 'Exosomes in melanoma: a role in tumor progression, metastasis and impaired immune system activity', 'display_name': 'Exosomes in melanoma: a role in tumor progression, metastasis and impaired immune system activity', 'publication_year': 2018, 'publication_date': '2018-04-16', 'ids': {'openalex': 'https://openalex.org/W2801148143', 'doi': 'https://doi.org/10.18632/oncotarget.24846', 'mag': '2801148143', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29755693', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5945529'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.24846', 'pdf_url': 'https://www.oncotarget.com/article/24846/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/24846/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005250000', 'display_name': 'Marco Tucci', 'orcid': 'https://orcid.org/0000-0003-4008-4897'}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Marco Tucci', 'raw_affiliation_strings': ['Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy', 'institution_ids': ['https://openalex.org/I5561750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050716086', 'display_name': 'Francesco Mannavola', 'orcid': 'https://orcid.org/0000-0003-2623-4166'}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Mannavola', 'raw_affiliation_strings': ['Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy', 'institution_ids': ['https://openalex.org/I5561750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019738500', 'display_name': 'Anna Passarelli', 'orcid': 'https://orcid.org/0000-0003-4643-7809'}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Anna Passarelli', 'raw_affiliation_strings': ['Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy', 'institution_ids': ['https://openalex.org/I5561750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078260129', 'display_name': 'Luigia Stefania Stucci', 'orcid': 'https://orcid.org/0000-0003-2063-1435'}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Luigia Stefania Stucci', 'raw_affiliation_strings': ['Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy', 'institution_ids': ['https://openalex.org/I5561750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037900791', 'display_name': 'Mauro Cives', 'orcid': 'https://orcid.org/0000-0002-3013-1816'}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mauro Cives', 'raw_affiliation_strings': ['Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy', 'institution_ids': ['https://openalex.org/I5561750']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039750643', 'display_name': 'Franco Silvestris', 'orcid': 'https://orcid.org/0000-0002-5555-2617'}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Franco Silvestris', 'raw_affiliation_strings': ['Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari, Italy', 'institution_ids': ['https://openalex.org/I5561750']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5005250000'], 'corresponding_institution_ids': ['https://openalex.org/I5561750'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.006, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 103, 'citation_normalized_percentile': {'value': 0.999733, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '9', 'issue': '29', 'first_page': '20826', 'last_page': '20837'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10773', 'display_name': 'Extracellular vesicles in disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10773', 'display_name': 'Extracellular vesicles in disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9812, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/exosome', 'display_name': 'Exosome', 'score': 0.5685164}, {'id': 'https://openalex.org/keywords/granzyme', 'display_name': 'Granzyme', 'score': 0.46478721}, {'id': 'https://openalex.org/keywords/tumor-progression', 'display_name': 'Tumor progression', 'score': 0.4425624}], 'concepts': [{'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.7849786}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.74588525}, {'id': 'https://openalex.org/C20518536', 'wikidata': 'https://www.wikidata.org/wiki/Q6840469', 'display_name': 'Microvesicles', 'level': 4, 'score': 0.70608395}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6070996}, {'id': 'https://openalex.org/C2777701055', 'wikidata': 'https://www.wikidata.org/wiki/Q1427096', 'display_name': 'Immunotherapy', 'level': 3, 'score': 0.5898026}, {'id': 'https://openalex.org/C2781261824', 'wikidata': 'https://www.wikidata.org/wiki/Q903634', 'display_name': 'Exosome', 'level': 5, 'score': 0.5685164}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.5653817}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.5570783}, {'id': 'https://openalex.org/C2780380082', 'wikidata': 'https://www.wikidata.org/wiki/Q12646460', 'display_name': 'Granzyme B', 'level': 4, 'score': 0.5025356}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.49135843}, {'id': 'https://openalex.org/C183193105', 'wikidata': 'https://www.wikidata.org/wiki/Q425068', 'display_name': 'Granzyme', 'level': 5, 'score': 0.46478721}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4581503}, {'id': 'https://openalex.org/C2779256057', 'wikidata': 'https://www.wikidata.org/wiki/Q16909647', 'display_name': 'Tumor progression', 'level': 3, 'score': 0.4425624}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.42288908}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.27565995}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.26629412}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.24528095}, {'id': 'https://openalex.org/C2776062744', 'wikidata': 'https://www.wikidata.org/wiki/Q21103279', 'display_name': 'Perforin', 'level': 4, 'score': 0.24472964}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.14377472}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.24846', 'pdf_url': 'https://www.oncotarget.com/article/24846/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5945529', 'pdf_url': 'https://europepmc.org/articles/pmc5945529?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945529', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11586/219306', 'pdf_url': 'https://ricerca.uniba.it/bitstream/11586/219306/2/30_Oncotarget.pdf', 'source': {'id': 'https://openalex.org/S4377196296', 'display_name': 'CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I5561750', 'host_organization_name': 'University of Bari Aldo Moro', 'host_organization_lineage': ['https://openalex.org/I5561750'], 'host_organization_lineage_names': ['University of Bari Aldo Moro'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29755693', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.24846', 'pdf_url': 'https://www.oncotarget.com/article/24846/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.75, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 98, 'referenced_works': ['https://openalex.org/W127707871', 'https://openalex.org/W1511924115', 'https://openalex.org/W1574663134', 'https://openalex.org/W1639310471', 'https://openalex.org/W1685748173', 'https://openalex.org/W1762620449', 'https://openalex.org/W1824585857', 'https://openalex.org/W1877686344', 'https://openalex.org/W1881338771', 'https://openalex.org/W1898690520', 'https://openalex.org/W1909037907', 'https://openalex.org/W1914452730', 'https://openalex.org/W1915536483', 'https://openalex.org/W1925340186', 'https://openalex.org/W1950118853', 'https://openalex.org/W1960512949', 'https://openalex.org/W1963497094', 'https://openalex.org/W1966904548', 'https://openalex.org/W1969621613', 'https://openalex.org/W1974954833', 'https://openalex.org/W1979254251', 'https://openalex.org/W1981820123', 'https://openalex.org/W1983401107', 'https://openalex.org/W1983970047', 'https://openalex.org/W1989603382', 'https://openalex.org/W2002811765', 'https://openalex.org/W2003343932', 'https://openalex.org/W2006274267', 'https://openalex.org/W2008677826', 'https://openalex.org/W2012528990', 'https://openalex.org/W2013946487', 'https://openalex.org/W2037484272', 'https://openalex.org/W2043779633', 'https://openalex.org/W2048883725', 'https://openalex.org/W2064577709', 'https://openalex.org/W2068755566', 'https://openalex.org/W2072167135', 'https://openalex.org/W2080879611', 'https://openalex.org/W2084271408', 'https://openalex.org/W2085462535', 'https://openalex.org/W2089713288', 'https://openalex.org/W2095798079', 'https://openalex.org/W2097995306', 'https://openalex.org/W2098240454', 'https://openalex.org/W2098637032', 'https://openalex.org/W2103779343', 'https://openalex.org/W2107008239', 'https://openalex.org/W2108375854', 'https://openalex.org/W2110683593', 'https://openalex.org/W2112121482', 'https://openalex.org/W2112395933', 'https://openalex.org/W2114332197', 'https://openalex.org/W2117375925', 'https://openalex.org/W2119764013', 'https://openalex.org/W2119906582', 'https://openalex.org/W2121354606', 'https://openalex.org/W2128106976', 'https://openalex.org/W2141819495', 'https://openalex.org/W2142433114', 'https://openalex.org/W2145852879', 'https://openalex.org/W2147672691', 'https://openalex.org/W2152897456', 'https://openalex.org/W2155366992', 'https://openalex.org/W2159114297', 'https://openalex.org/W2160153675', 'https://openalex.org/W2168086409', 'https://openalex.org/W2169491358', 'https://openalex.org/W2202689921', 'https://openalex.org/W2221231509', 'https://openalex.org/W2274237531', 'https://openalex.org/W2286221692', 'https://openalex.org/W2307984341', 'https://openalex.org/W2320025075', 'https://openalex.org/W2328757094', 'https://openalex.org/W2403293254', 'https://openalex.org/W2510540705', 'https://openalex.org/W2510844606', 'https://openalex.org/W2523675486', 'https://openalex.org/W2535485523', 'https://openalex.org/W2552834147', 'https://openalex.org/W2557771720', 'https://openalex.org/W2560272594', 'https://openalex.org/W2560367415', 'https://openalex.org/W2560435584', 'https://openalex.org/W2566408036', 'https://openalex.org/W2572174216', 'https://openalex.org/W2596133050', 'https://openalex.org/W2605377619', 'https://openalex.org/W2615948242', 'https://openalex.org/W2725858897', 'https://openalex.org/W2733726992', 'https://openalex.org/W2734802465', 'https://openalex.org/W2739038820', 'https://openalex.org/W2739635003', 'https://openalex.org/W2766512176', 'https://openalex.org/W2766831660', 'https://openalex.org/W4230882199', 'https://openalex.org/W4244068819'], 'related_works': ['https://openalex.org/W4387637728', 'https://openalex.org/W4386033707', 'https://openalex.org/W4378085118', 'https://openalex.org/W4321166613', 'https://openalex.org/W4312061069', 'https://openalex.org/W2111545764', 'https://openalex.org/W2062137773', 'https://openalex.org/W1970650594', 'https://openalex.org/W1507634793', 'https://openalex.org/W150405246'], 'abstract_inverted_index': {'//': [0], 'Marco': [1, 42], 'Tucci': [2], '1': [3, 7, 11, 16, 20, 24, 25], ',': [4, 8, 12, 17], 'Francesco': [5], 'Mannavola': [6], 'Anna': [9], 'Passarelli': [10], 'Luigia': [13], 'Stefania': [14], 'Stucci': [15], 'Mauro': [18], 'Cives': [19], 'and': [21, 30, 73, 86, 89, 103, 128, 159, 163, 171, 200, 254], 'Franco': [22], 'Silvestris': [23], 'Department': [26], 'of': [27, 34, 77, 95, 157, 184, 191, 205, 217], 'Biomedical': [28], 'Sciences': [29], 'Human': [31], 'Oncology,': [32], 'University': [33], 'Bari': [35], 'Aldo': [36], 'Moro,': [37], 'Bari,': [38], 'Italy': [39], 'Correspondence': [40], 'to:': [41], 'Tucci,': [43], 'email:': [44], '[email protected]': [45], 'Keywords:': [46], 'exosomes;': [47], 'melanoma;': [48], 'immune': [49, 125, 136, 141], 'system': [50, 126], 'Received:': [51], 'January': [52], '26,': [53], '2018&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;': [54, 58], 'Accepted:': [55], 'March': [56], '07,': [57], 'Published:': [59], 'April': [60], '17,': [61], '2018': [62], 'ABSTRACT': [63], 'Exosomes': [64], '(Exo)': [65], 'are': [66, 109, 244], 'small': [67], 'vesicles': [68], 'produced': [69], 'by': [70, 107, 174], 'melanoma': [71, 185, 206], 'cells': [72, 76], 'the': [74, 78, 121, 155, 182, 202], 'accessory': [75], 'tumor': [79, 93, 122, 129, 239], 'microenvironment.': [80], 'They': [81, 167], 'emerge': [82], 'via': [83], 'both': [84, 161, 196], 'classical': [85], 'direct': [87], 'pathways': [88], 'actively': [90], 'participate': [91], 'in': [92, 144, 201, 225, 232, 252, 257], 'colonisation': [94], 'distant': [96], 'tissues.': [97], 'The': [98, 187, 213], 'proteins,': [99], 'nucleic': [100], 'acids,': [101], 'cytokines': [102], 'growth': [104], 'factors': [105], 'engulfed': [106], 'Exo': [108, 139, 179, 192, 218, 247], 'transferred': [110], 'to': [111, 209, 211, 237], 'recipient': [112], 'cells,': [113], 'where': [114], 'they': [115], 'drive': [116], 'numerous': [117], 'functions': [118], 'required': [119, 245], 'for': [120, 197], 'escape': [123], 'from': [124, 220], 'control': [127, 181], 'progression.': [130], 'By': [131], 'positively': [132], 'or': [133], 'negatively': [134], 'modulating': [135], 'cell': [137, 148], 'properties,': [138], 'provoke': [140], 'suppression': [142], 'and,': [143], 'turn,': [145], 'defective': [146], 'dendritic': [147], '(DC)': [149], 'functions.': [150], 'Together,': [151], 'these': [152], 'effects': [153], 'limit': [154], 'cytotoxicity': [156], 'T-cells': [158], 'expand': [160], 'T-regulatory': [162], 'myeloid-derived': [164], 'suppressor': [165], 'populations.': [166], 'also': [168, 180], 'hinder': [169], 'perforin': [170], 'granzyme': [172], 'production': [173], 'natural': [175], 'killer': [176], 'cells.': [177, 186, 240], 'Finally,': [178], 'organotropism': [183], 'distinct': [188], 'phenotypic': [189], 'properties': [190], 'can': [193, 248], 'be': [194, 249], 'exploited': [195], 'diagnostic': [198, 253], 'purposes': [199], 'early': [203], 'identification': [204], 'patients': [207], 'likely': [208], 'respond': [210], 'immunotherapy.': [212], 'potential': [214], 'therapeutic': [215, 255], 'application': [216], 'derived': [219], 'DCs': [221], 'has': [222], 'been': [223], 'demonstrated': [224], 'vaccination': [226], 'trials,': [227], 'which': [228], 'showed': [229], 'an': [230], 'increase': [231], 'anti-melanoma': [233], 'activity': [234], 'with': [235], 'respect': [236], 'circulating': [238], 'However,': [241], 'additional': [242], 'studies': [243], 'before': [246], 'effectively': [250], 'used': [251], 'applications': [256], 'melanoma.': [258]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2801148143', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 30}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-12T22:26:32.630430', 'created_date': '2018-05-17'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
