Safety and efficacy of pasireotide in dumping syndrome-results from a phase 2, multicentre study

Name: Work Video:
Duration: 3 min 30 s
Jan Tack; Jens Aberle; Joris Arts; M. Laville; J.‐M. Oppert; G Bender; Sunil Bhoyrul; Tracey McLaughlin; T. Yoshikawa; Adrian Vella; Jingwen Zhou; Vanessa Q. Passos; P.R. O'Connell; André P. van Beek
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[10, 18, 27, 66, 123, 189, 215], 'gastric': [11], 'surgery': [12], 'characterised': [13], 'by': [14], 'early': [15], '(postprandial': [16], 'tachycardia)': [17], 'late': [19, 113], '(hypoglycaemia)': [20], 'postprandial': [21], 'symptoms.': [22], 'Aim': [23], 'To': [24], 'evaluate': [25], 'efficacy': [26], 'safety': [28], 'the': [30, 75, 95, 119, 126, 163, 196], 'somatostatin': [31], 'analogue,': [32], 'pasireotide': [33, 224], 'in': [34, 150, 162, 173, 229], 'patients': [35, 78, 111, 132, 169, 230], 'with': [36, 56, 112, 170, 231], 'dumping': [37, 114, 232], 'after': [39, 234], 'bariatric': [40, 235], 'or': [41, 236], 'upper': [42, 237], 'gastrointestinal': [43, 238], 'cancer': [44, 239], 'surgery.': [45, 240], 'Methods': [46], 'A': [47, 101], 'single‐arm,': [48], 'open‐label,': [49], 'multicentre,': [50], 'intrapatient': [51], 'dose‐escalation,': [52], 'phase': [53, 122], '2': [54], 'study': [55], '4': [57], 'phases:': [58], 'screening,': [59], '3‐month': [60, 63, 98, 120], 'SC': [61, 99, 121, 157], '(subcutaneous),': [62], 'IM': [64, 70, 164], '(intramuscular)': [65], '6‐month': [67], 'optional': [68], 'extension': [69], 'phase.': [71, 100, 165], 'Primary': [72], 'endpoint': [73], 'was': [74, 105, 140, 154, 160], 'proportion': [76, 130, 167], 'without': [79, 133], 'hypoglycaemia': [80, 134, 208], '(plasma': [81], 'glucose': [82, 90], '&lt;3.3': [83], 'mmol/L': [84], '[60': [85], 'mg/dL]': [86], 'during': [87, 156, 179], 'an': [88], 'oral': [89], 'tolerance': [91], 'test,': [92], 'OGTT)': [93], 'at': [94, 135], 'end': [96], '≥50%': [102], 'response': [103], 'rate': [104, 175], 'considered': [106], 'clinically': [107], 'relevant.': [108], 'Results': [109], 'Forty‐three': [110], 'were': [115, 204], 'enrolled;': [116], '33': [117], 'completed': [118, 125], '23': [124], '12‐month': [127], 'study.': [128], 'The': [129, 166], 'month': [136, 186, 190], '3': [137, 187], '(primary': [138], 'endpoint)': [139], '60.5%': [141], '(26': [142], '43;': [144], '95%': [145], 'confidence': [146], 'interval,': [147], '44.4%‐75.0%).': [148], 'Improvement': [149], 'quality': [151], 'life': [153], 'observed': [155], 'phase,': [158], 'which': [159], 'maintained': [161], 'rise': [172], 'pulse': [174], '≥10': [177], 'beats/min': [178], 'OGTT': [180], 'reduced': [181], 'from': [182], 'baseline': [183], '(60.5%)': [184], 'to': [185], '(18.6%)': [188], '12': [191], '(27.3%).': [192], 'Overall': [193], '(month': [194], '0‐12),': [195], 'most': [197], 'frequent': [198], '(&gt;20%': [199], 'patients)': [201], 'adverse': [202], 'events': [203], 'headache': [205], '(34.9%);': [206], 'diarrhoea,': [207], '(27.9%': [209], 'each);': [210, 214], 'fatigue,': [211], 'nausea': [212], '(23.3%': [213], 'abdominal': [216], 'pain': [217], '(20.9%).': [218], 'Conclusion': [219], 'These': [220], 'results': [221], 'suggest': [222], 'that': [223], 'promising': [227], 'option': [228]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2800939367', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-14T01:20:28.204212', 'created_date': '2018-05-17'}
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