Title: P564L-cystathionine metabolism by cystathionine gamma lyase generates H2S to preserve endothelial cell function and decelerate atherosclerosis development in humans
Abstract: junctions, prior to stretching and enlargement of the endothelial cell, followed by alignment around a larger lumen.Conversely, loss of VE-cadherin and inhibition of actin prevented lumen remodelling.Conclusion: Arterial Flt1 by titrating arterial Vegfa regulates the caliber of arterioles during de novo arteriologenesis involving a unique sequence of collective endothelial cell behaviors and actin remodeling events.Plgf and Vegfb, by shifting the Flt1-Vegfa binding equilibrium toward Vegfa release, promote arteriologenesis.Our model suggests that arterial Flt1 may be used as a local cargo to deliver safe Vegfa dosages in revascularization strategies.