Abstract: Tooth morphogenesis, dentin, enamel, and cementum formation are highly regulated developmental processes. Dentin is less mineralized than enamel, but withstands frequent masticatory forces, provides support for dental enamel, and protects the dental pulp. Developmental dentin defects result from genetic or environmental factors. Mutations affecting genes regulating odontoblast differentiation, dentin matrix protein production and/or mineralization result in hereditary dentin defects (HDDs). Genetic studies have determined the etiologies of many forms of hereditary dentin defects, providing fresh insights into dentin formation and have enabled the use of efficient genetic tests to ensure correct diagnoses, appropriate treatment, and improved management of patients with HDDs.
Publication Year: 2018
Publication Date: 2018-01-01
Language: en
Type: book-chapter
Indexed In: ['crossref']
Access and Citation
Cited By Count: 1
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot