Publication Information

{'id': 'https://openalex.org/W2800555287', 'doi': 'https://doi.org/10.3892/etm.2018.6125', 'title': 'Effects of HSYA on the proliferation and apoptosis of MSCs exposed to hypoxic and serum deprivation conditions', 'display_name': 'Effects of HSYA on the proliferation and apoptosis of MSCs exposed to hypoxic and serum deprivation conditions', 'publication_year': 2018, 'publication_date': '2018-05-03', 'ids': {'openalex': 'https://openalex.org/W2800555287', 'doi': 'https://doi.org/10.3892/etm.2018.6125', 'mag': '2800555287', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29904409', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5996714'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/etm.2018.6125', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/etm.2018.6125/download', 'source': {'id': 'https://openalex.org/S151424340', 'display_name': 'Experimental and Therapeutic Medicine', 'issn_l': '1792-0981', 'issn': ['1792-0981', '1792-1015'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.spandidos-publications.com/10.3892/etm.2018.6125/download', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101977933', 'display_name': 'Xiaoqing Song', 'orcid': 'https://orcid.org/0000-0003-2689-2169'}, 'institutions': [{'id': 'https://openalex.org/I169071405', 'display_name': 'Hebei North University', 'ror': 'https://ror.org/03hqwnx39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I169071405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoqing Song', 'raw_affiliation_strings': ['Biology Office, Basic Medical College of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Biology Office, Basic Medical College of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China', 'institution_ids': ['https://openalex.org/I169071405']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014042586', 'display_name': 'Lining Su', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169071405', 'display_name': 'Hebei North University', 'ror': 'https://ror.org/03hqwnx39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I169071405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lining Su', 'raw_affiliation_strings': ['Biology Office, Basic Medical College of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Biology Office, Basic Medical College of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China', 'institution_ids': ['https://openalex.org/I169071405']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012867572', 'display_name': 'Haifeng Yin', 'orcid': 'https://orcid.org/0000-0001-7042-7630'}, 'institutions': [{'id': 'https://openalex.org/I169071405', 'display_name': 'Hebei North University', 'ror': 'https://ror.org/03hqwnx39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I169071405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Haifeng Yin', 'raw_affiliation_strings': ['Biology Office, Basic Medical College of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Biology Office, Basic Medical College of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China', 'institution_ids': ['https://openalex.org/I169071405']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055921425', 'display_name': 'Jin Dai', 'orcid': 'https://orcid.org/0000-0003-3063-746X'}, 'institutions': [{'id': 'https://openalex.org/I169071405', 'display_name': 'Hebei North University', 'ror': 'https://ror.org/03hqwnx39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I169071405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jin Dai', 'raw_affiliation_strings': ['Biology Office, Basic Medical College of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Biology Office, Basic Medical College of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China', 'institution_ids': ['https://openalex.org/I169071405']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100583013', 'display_name': 'Huiping Wei', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169071405', 'display_name': 'Hebei North University', 'ror': 'https://ror.org/03hqwnx39', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I169071405']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Huiping Wei', 'raw_affiliation_strings': ['Biology Office, Basic Medical College of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Biology Office, Basic Medical College of Hebei North University, Zhangjiakou, Hebei 075000, P.R. China', 'institution_ids': ['https://openalex.org/I169071405']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.57, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.713164, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12742', 'display_name': 'Sunflower and Safflower Cultivation', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12742', 'display_name': 'Sunflower and Safflower Cultivation', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 0.9466, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13775', 'display_name': "Hydrogen's biological and therapeutic effects", 'score': 0.9362, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/propidium-iodide', 'display_name': 'Propidium iodide', 'score': 0.6581624}, {'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.6025456}, {'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.44891766}], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.7360407}, {'id': 'https://openalex.org/C2775934118', 'wikidata': 'https://www.wikidata.org/wiki/Q424169', 'display_name': 'Propidium iodide', 'level': 4, 'score': 0.6581624}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.6025456}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.58543706}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.48244983}, {'id': 'https://openalex.org/C2777025900', 'wikidata': 'https://www.wikidata.org/wiki/Q29725', 'display_name': 'Vascular endothelial growth factor', 'level': 3, 'score': 0.47239873}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.463749}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45679334}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.44891766}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.40237698}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37569284}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.24857247}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.22317082}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.13779181}, {'id': 'https://openalex.org/C167734588', 'wikidata': 'https://www.wikidata.org/wiki/Q4356503', 'display_name': 'VEGF receptors', 'level': 2, 'score': 0.047488153}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/etm.2018.6125', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/etm.2018.6125/download', 'source': {'id': 'https://openalex.org/S151424340', 'display_name': 'Experimental and Therapeutic Medicine', 'issn_l': '1792-0981', 'issn': ['1792-0981', '1792-1015'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5996714', 'pdf_url': 'https://europepmc.org/articles/pmc5996714?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996714', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29904409', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/etm.2018.6125', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/etm.2018.6125/download', 'source': {'id': 'https://openalex.org/S151424340', 'display_name': 'Experimental and Therapeutic Medicine', 'issn_l': '1792-0981', 'issn': ['1792-0981', '1792-1015'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W168828453', 'https://openalex.org/W1894493322', 'https://openalex.org/W1924319313', 'https://openalex.org/W1941120647', 'https://openalex.org/W1957129201', 'https://openalex.org/W1964184380', 'https://openalex.org/W1964293887', 'https://openalex.org/W1974207011', 'https://openalex.org/W1997552025', 'https://openalex.org/W2003345391', 'https://openalex.org/W2005484085', 'https://openalex.org/W2007699933', 'https://openalex.org/W2014581384', 'https://openalex.org/W2015428837', 'https://openalex.org/W2016597337', 'https://openalex.org/W2017964197', 'https://openalex.org/W2022633495', 'https://openalex.org/W2035459661', 'https://openalex.org/W2040745941', 'https://openalex.org/W2043089264', 'https://openalex.org/W2048162688', 'https://openalex.org/W2050293945', 'https://openalex.org/W2065076603', 'https://openalex.org/W2071777259', 'https://openalex.org/W2072922560', 'https://openalex.org/W2074676693', 'https://openalex.org/W2082958780', 'https://openalex.org/W2083123206', 'https://openalex.org/W2087308788', 'https://openalex.org/W2091395040', 'https://openalex.org/W2101042911', 'https://openalex.org/W2102129021', 'https://openalex.org/W2107277218', 'https://openalex.org/W2109127788', 'https://openalex.org/W2128743935', 'https://openalex.org/W2140429835', 'https://openalex.org/W2164620699', 'https://openalex.org/W2165196402', 'https://openalex.org/W2186993861', 'https://openalex.org/W2298700329', 'https://openalex.org/W2303841999', 'https://openalex.org/W2315908945', 'https://openalex.org/W2324995304', 'https://openalex.org/W2334544696', 'https://openalex.org/W2351125975', 'https://openalex.org/W2372211862', 'https://openalex.org/W2386514632', 'https://openalex.org/W2439827999', 'https://openalex.org/W2519267651', 'https://openalex.org/W2590026484', 'https://openalex.org/W2601190572', 'https://openalex.org/W2743931843', 'https://openalex.org/W3021043688', 'https://openalex.org/W30752666', 'https://openalex.org/W4256393956'], 'related_works': ['https://openalex.org/W60177492', 'https://openalex.org/W574198516', 'https://openalex.org/W4385687789', 'https://openalex.org/W3135338445', 'https://openalex.org/W3030667680', 'https://openalex.org/W2414266434', 'https://openalex.org/W2349543669', 'https://openalex.org/W2341333145', 'https://openalex.org/W1973240521', 'https://openalex.org/W1191950147'], 'abstract_inverted_index': {'As': [0], 'a': [1], 'primary': [2], 'active': [3], 'ingredient': [4], 'of': [5, 20, 30, 158, 173, 191, 198], 'safflor': [6], 'yellow,': [7], 'hydroxysafflor': [8], 'yellow': [9], 'A': [10, 117], '(HSYA)': [11], 'exhibits': [12], 'notable': [13], 'antioxidative': [14], 'and': [15, 42, 46, 69, 86, 101, 128, 147, 163, 196], 'neuroprotective': [16], 'effects.': [17], 'The': [18, 91], 'aim': [19], 'the': [21, 27, 49, 106, 132, 135, 140, 156, 171, 174, 192, 199], 'present': [22], 'study': [23, 176], 'was': [24, 58], 'to': [25, 38, 47, 60, 134], 'investigate': [26], 'protective': [28, 181], 'effects': [29, 113, 182], 'HSYA': [31, 57, 97, 110, 123, 152, 179], 'in': [32, 186], 'mesenchymal': [33], 'stem': [34], 'cells': [35], '(MSCs)': [36], 'exposed': [37], 'hypoxia': [39, 159], '(5%': [40], 'O2)': [41], 'serum': [43], 'deprivation': [44], '(H/SD),': [45], 'explore': [48], 'mechanisms': [50], 'underlying': [51], 'HSYA-mediated': [52], 'protection.': [53], 'Under': [54], 'H/SD': [55, 107, 141], 'conditions,': [56], 'applied': [59], 'protect': [61], 'MSCs': [62, 187], 'against': [63, 183], 'injury.': [64], 'Cell': [65], 'viability,': [66], 'proliferation,': [67], 'apoptosis': [68, 100, 185], 'reactive': [70], 'oxygen': [71], 'species': [72], '(ROS)': [73], 'levels': [74, 103], 'were': [75], 'determined': [76], 'using': [77], 'an': [78], "5-ethynyl-2'-deoxyuridine": [79], 'assay,': [80, 82], 'MTT': [81], 'Hoechst': [83], '33342/propidium': [84], 'iodide': [85], "2',7'-dichlorodihydrofluorescein": [87], 'diacetate': [88], 'staining,': [89], 'respectively.': [90], 'results': [92, 172], 'revealed': [93, 150], 'that': [94, 122, 151, 178], '160': [95], 'mg/l': [96], 'significantly': [98, 154], 'reduced': [99, 124], 'ROS': [102], 'compared': [104, 138], 'with': [105, 139], 'group;': [108], 'however,': [109], 'demonstrated': [111, 121, 177], 'minimal': [112], 'on': [114], 'cell': [115], 'proliferation.': [116], 'western': [118, 145], 'blot': [119], 'assay': [120], 'cleaved': [125], 'caspase-3': [126], 'expression': [127, 157], 'cytC': [129], 'release': [130], 'from': [131], 'mitochondria': [133], 'cytoplasm': [136], 'when': [137], 'group.': [142], 'In': [143, 169], 'addition,': [144], 'blotting': [146], 'RT-qPCR': [148], 'analyses': [149], 'treatment': [153], 'increased': [155], 'inducible': [160], 'factor-1α': [161], '(HIF-1α)': [162], 'vascular': [164], 'endothelial': [165], 'growth': [166], 'factor': [167], '(VEGF).': [168], 'conclusion,': [170], 'current': [175], 'exerts': [180], 'H/SD-induced': [184], 'potentially': [188], 'via': [189], 'activation': [190], 'HIF-1α/VEGF': [193], 'signaling': [194], 'pathway': [195], 'stabilization': [197], 'mitochondrial': [200], 'membrane.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2800555287', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-12-24T09:00:13.548724', 'created_date': '2018-05-17'}