Title: Su1955 - One-Carbon Metabolism Nutrients in Relation to Mucosa-associated Gut Microbiome in Healthy Individuals
Abstract: the antitumor effects and mechanisms of butyrate-producing Clostridium butyricum on the composition of intestinal microbiota and CRC progression.Methods: high-fat diet-fed Apc min/ + mice were gavaged with C. butyricum at a dose of 2.5 × 10 8 CFU/0.3 ml 3-times a week for 12 weeks.Mice with high-fat diet and basal diet were used as high-fat controls and untreated controls, respectively.Feces from the three groups were collected for microbiota pyrosequencing analysis and short chain fatty acids (SCFAs) analysis.Parameters of intestinal tumor development, cell proliferation and apoptosis, intestinal barrier function, colonic inflammation and Wnt signaling pathway were also determined.Results: Administration of C. butyricum decreased intestinal tumor burden in Apc min/+ mice compared with these fed a single high-fat diet.Increased intestinal tumor burden was accompanied with impaired intestinal barrier, intestinal chronic low-grade inflammation.C. butyricum administration improved deteriorative composition of intestinal microbiota, which increased probiotics including SCFA-producing bacteria and decreased opportunistic pathogens.Moreover, SCFAs concentrations in cecal contents were also increased comparing with the two control groups.C. butyricum induced microbiota alteration inhibited the tumor associated Wnt signaling pathway.Conclusions: Supplementation of butyrate-producing bacteria inhibited intestinal carcinogenesis accompanied with modulating intestinal microbiota and Wnt signaling.These findings broaden our understanding for the butyrate-producing bacteria supplement in the prevention and treatment of CRC.<embed height="0" id="xunlei_com_thunder_ helper_plugin_d462f475-c18e-46be-bd10-327458d045bd" type="application/thunder_ download_plugin" width="0" /> Su1954
Publication Year: 2018
Publication Date: 2018-05-01
Language: en
Type: article
Indexed In: ['crossref']
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