Publication Information

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[370], 'other': [372, 1060, 1494, 1696], 'organs,': [373], 'such': [374, 1194, 1707], 'as': [375, 877, 1195, 1208, 1257, 1667, 1708, 2039, 2072, 2330, 2461, 2551, 2622, 2671, 2760], 'liver3Moore': [377], 'F.A.': [378], 'Moore': [379], 'E.E.': [380], 'Poggetti': [381], 'R.': [382, 695, 2954, 3946], 'McAnena': [383], 'O.J.': [384], 'Peterson': [385], 'V.M.': [386], 'Abernathy': [387], 'C.M.': [388, 941, 2134], 'Parsons': [389], 'P.E.': [390], 'Gut': [391, 554, 3372], 'bacterial': [392, 3419, 3512, 3570, 3656, 3793, 3827], 'translocation': [393], 'via': [394, 509], 'portal': [396, 510], 'vein:': [397], 'clinical': [399], 'perspective': [400], 'torso': [403], 'trauma.J': [404], 'Trauma': [405], 'Acute': [406], 'Care': [407], 'Surg.': [408], '1991;': [409, 921, 2116], '31:': [410], '629-638Crossref': [411], '(447)': [413], 'Scholar,': [415, 551, 628, 719, 895, 970, 1102, 1278, 1440, 1624, 2090, 2163, 2482, 2572, 3402, 3495, 3553, 3617, 3639, 3703, 3754, 3776, 3973], '4Bloemen': [416], 'J.G.': [417], 'Venema': [418], 'K.': [419, 2484, 2782, 2823, 3099, 3264, 3302, 3342, 3983], 'van': [420, 1591, 1594], 'de': [421, 1578], 'Poll': [422], 'M.C.': [423, 976, 2169], 'Damink': [424], 'S.W.O.': [425], 'Buurman': [426], 'W.A.': [427], 'Dejong': [428], 'C.H.': [429], 'Short': [430], 'chain': [431, 707], 'fatty': [432, 664, 708, 740], 'acids': [433], 'exchange': [434], 'across': [435], 'gut': [437, 488, 492, 536, 585, 591, 634, 657, 758, 1145, 1205], 'liver': [439, 3025, 3036], 'humans': [441, 906, 2101], 'measured': [442], 'at': [443, 579, 3908], 'surgery.Clin': [444], 'Nutr.': [445], '2009;': [446, 646, 963, 2156], '28:': [447], '657-661Abstract': [448], 'Full': [449, 451, 499, 501, 619, 621, 888, 1615, 1617, 1638, 2050, 2083, 2515, 2517, 2854, 2856], 'Text': [450, 452, 500, 502, 620, 622, 889, 1616, 1618, 1639, 2051, 2084, 2516, 2518, 2855, 2857], 'PDF': [453, 503, 623, 890, 1619, 1640, 2052, 2085, 2519, 2858], 'PubMed': [454, 504, 547, 567, 624, 649, 715, 750, 891, 924, 966, 1014, 1098, 1171, 1222, 1274, 1305, 1436, 1475, 1543, 1620, 1641, 1682, 1841, 1907, 2053, 2086, 2119, 2159, 2207, 2236, 2261, 2307, 2346, 2390, 2428, 2478, 2520, 2568, 2599, 2638, 2688, 2729, 2777, 2818, 2859, 2898, 2936, 2976, 3007, 3042, 3066, 3092, 3135, 3173, 3211, 3249, 3289, 3327, 3367, 3398, 3433, 3462, 3491, 3526, 3584, 3613, 3670, 3699, 3750, 3807, 3841, 3969, 4100], '(217)': [456], 'pancreas,5Ahuja': [460], 'M.': [461, 465, 469, 473, 727, 731, 972, 1241, 1410, 1418, 1450, 1456, 1518, 1524, 1580, 2165, 2281, 2289, 2316, 2364, 2372, 2403, 2409, 2445, 2535, 2608, 2655, 2695, 2744, 2790, 2871, 2909, 2950, 3107, 3152, 3190, 3228, 3268, 3270, 3306, 3308, 3346, 3348, 3977], 'Schwartz': [462], 'D.M.': [463], 'Tandon': [464], 'Son': [466], 'A.': [467, 699, 1446, 1514, 1590, 1598, 1661, 2399, 2486, 2701, 2825, 2944, 3140, 3178, 3216, 3266, 3304, 3344], 'Zeng': [468], 'Swaim': [470], 'W.': [471, 1593, 1817, 2312, 2604, 2948], 'Eckhaus': [472], 'Hoffman': [474], 'V.': [475, 974, 1231, 2167, 2435, 2525, 2645, 2734, 2956, 3940], 'Cui': [476], 'Y.': [477, 2245, 2865, 2903, 2985, 2987, 3975, 4078, 4080], 'Xiao': [478], 'B.': [479, 937, 2130], 'Orai1-mediated': [480], 'antimicrobial': [481], 'secretion': [482], 'from': [483, 1362, 1371, 1552, 1632, 1875], 'pancreatic': [484], 'acini': [485], 'shapes': [486, 636], 'regulates': [491], 'innate': [493, 945, 2138], 'immunity.Cell': [494], 'Metab.': [495], '2017;': [496, 1838, 2343, 2635, 2895, 2933, 2973, 3063, 3089], '25:': [497], '635-646Abstract': [498], '(84)': [506], 'flow;': [511], 'contain': [514, 1883, 4045], 'enteric': [516], 'nervous': [517], 'system': [518, 880, 2042, 2075, 2253], 'forms': [520, 1758], 'part': [522], 'gut-brain': [525], 'axis.6Cryan': [526], 'J.F.': [527], 'Dinan': [528], 'T.G.': [529], 'Mind-altering': [530], 'microorganisms:': [531], 'impact': [533], 'microbiota': [537], 'on': [538, 1020, 1330, 2706, 2796, 2998, 3113, 3928, 3990, 4030, 4067, 4091], 'brain': [539], 'behaviour.Nat': [541], 'Rev': [542, 562, 644, 1836], 'Neurosci.': [543, 563], '2012;': [544, 1095, 1168, 1219, 1271, 2475, 2565, 2685, 2774, 3395, 3459, 3488, 3610, 3696, 3747], '13:': [545, 1839, 3005, 4098], '701-712Crossref': [546], '(2487)': [549], '7Mayer': [552], 'E.A.': [553, 2958], 'feelings:': [555], 'emerging': [557], 'biology': [558], 'gut–brain': [560], 'communication.Nat': [561], '2011;': [564, 1433, 1472, 1540, 2304, 2387, 2425], '12:': [565, 1096, 1169, 3396, 3460, 3489, 3611, 3697, 3748], '453-466Crossref': [566], '(986)': [569], 'site': [578], 'which': [580, 599, 1141, 1570, 1715, 1882, 3915, 4059], 'microbes': [582, 782], 'live': [587], 'interact': [589], 'lymphoid': [592], 'tissues': [593, 3026], 'host': [596], 'immune': [597, 638, 681, 946, 1713, 1941, 2139], 'system,': [598], 'contributes': [600], 'significantly': [601, 1748, 1788], 'homeostasis.8Garrett': [604], 'W.S.': [605, 735], 'Gordon': [606], 'J.I.': [607], 'Glimcher': [608], 'L.H.': [609], 'Homeostasis': [610], 'inflammation': [612, 3422, 3515, 3573, 3659, 3796, 3830], 'intestine.Cell.': [615], '2010;': [616], '140:': [617], '859-870Abstract': [618], '(556)': [626], '9Round': [629], 'J.L.': [630], 'Mazmanian': [631], 'S.K.': [632], 'responses': [639], 'during': [640], 'health': [641, 1751], 'disease.Nat': [643, 1676], 'Immunol.': [645], '9:': [647], '313-323Crossref': [648], '(3250)': [651], 'For': [654], 'example,': [655], 'its': [660, 4070], 'metabolites': [661], '(eg,': [662, 861, 1065, 1778, 1800, 1879], 'short-chain': [663, 739], 'acids)': [665], 'recently': [668, 1849], 'shown': [669], 'play': [671], 'central': [673], 'role': [674], 'maintenance': [677], 'health,': [680], 'modulation,': [682], 'both': [687, 827], 'enteral': [688], 'nonenteral': [690], 'diseases.10Wong': [691], 'J.M.': [692, 1584], 'De': [693, 1416, 2287, 2370, 2499, 2838], 'Souza': [694], 'Kendall': [696], 'Emam': [698], 'Jenkins': [700], 'D.J.': [701], 'Colonic': [702], 'health:': [703], 'fermentation': [704], 'short': [706], 'acids.J': [709], 'Clin': [710], 'Gastroenterol.': [711], '2006;': [712, 3998], '40:': [713], '235-243Crossref': [714], '(1832)': [717], '11Smith': [720], 'P.M.': [721], 'Howitt': [722], 'M.R.': [723, 933, 2126], 'Panikov': [724], 'N.': [725, 1412, 1665, 2283, 2366], 'Michaud': [726], 'Gallini': [728], 'C.A.': [729], 'Bohlooly-y': [730], 'Glickman': [732], 'J.N.': [733], 'Garrett': [734], 'microbial': [737, 1085, 1158, 1779, 3385, 3449, 3478, 3600, 3686, 3737], 'metabolites,': [738], 'acids,': [741], 'colonic': [743, 1001, 1250, 1468, 1536, 2194, 2421, 2454, 2544, 2664, 2753], 'Treg': [744], 'homeostasis.Science.': [746], '2013;': [747, 1118, 2726, 3004, 3547, 3633, 3719, 3770, 4097], '341:': [748], '569-573Crossref': [749], '(3048)': [752], 'However,': [755, 1687], 'analysis': [756, 772, 823], 'interactions': [760], 'has': [765, 775], 'limited': [767, 1691], 'genetic': [769], 'metagenomics': [771], 'because': [773, 1176, 1755], 'it': [774, 1345, 1768], 'these': [781, 1032], 'epithelium': [785, 4028], 'more': [787, 798, 2002], 'than': [788, 3865], 'about': [789], '1': [790, 3866, 4068], 'day': [791], 'using': [792, 1872, 2718, 3167, 3205, 3243, 3896], 'even': [797, 4023], 'sophisticated': [799], 'cultures.': [802], 'Thus,': [803], 'there': [804], 'great': [807], 'efforts': [808], 'develop': [810, 1334, 1647], 'experimental': [811], 'vitro': [813, 840, 1464, 1532, 1670, 1974, 2333, 2417, 2625, 3278, 3316, 3356], 'ex': [815, 1191], 'vivo': [816, 1192, 1963, 2806, 3123], 'permit': [822, 1948], 'pathophysiology': [826], 'presence': [830], 'absence': [832], 'microbiome.': [835], 'most': [837, 1035], 'common': [838, 4052], 'model': [849, 879, 1207, 1671, 2041, 2074, 2334, 2626, 3157, 3195, 3233, 3279, 3317, 3357], 'absorption': [851, 904, 1264, 2099, 2468, 2558, 2678, 2767], 'involve': [852], 'culturing': [853], 'established': [855], 'line': [860, 875, 1550, 2037, 2070], 'Caco-212Hidalgo': [862], 'I.J.': [863, 2025, 2058], 'Raub': [864, 2026, 2059], 'T.J.': [865, 2027, 2060], 'Borchardt': [866, 2028, 2061], 'R.T.': [867, 2029, 2062], 'Characterization': [868, 2030, 2063, 2988, 4081], 'colon': [872, 2034, 2067], 'carcinoma': [873, 2035, 2068], '(Caco-2)': [876, 916, 2038, 2071, 2111], 'permeability.Gastroenterology.': [884, 2046, 2079], '1989;': [885, 2047, 2080, 2815, 3132], '96:': [886, 2048, 2081], '736-749Abstract': [887, 2049, 2082], '(1952)': [893, 2055, 2088], '13Artursson': [896, 2091], 'P.': [897, 984, 1280, 1442, 1510, 2092, 2177, 2395, 2488, 2574, 2827, 3256, 3294, 3334], 'Karlsson': [898, 2093], 'J.': [899, 1245, 1284, 1288, 1596, 2094, 2247, 2322, 2449, 2496, 2539, 2578, 2582, 2614, 2659, 2748, 2794, 2835, 2952, 3049, 3075, 3111, 3144, 3146, 3150, 3182, 3184, 3188, 3220, 3222, 3226, 3942], 'Correlation': [900, 2095], 'apparent': [908, 2103], 'permeability': [910, 2105, 2710, 2991, 4084], 'coefficients': [911, 2106], 'cells.Biochem': [917, 2112], 'Biophys': [918, 2113], 'Res': [919, 2114], 'Commun.': [920, 2115, 3285, 3323, 3363], '175:': [922, 2117], '880-885Crossref': [923, 2118], '(1674)': [926, 2121], 'HT-2914Pinto': [930], 'M.G.V.': [931, 2124], 'Gómez': [932, 2125], 'Seifert': [934, 2127], 'S.': [935, 978, 1243, 1821, 2128, 2171, 2243, 2326, 2447, 2537, 2618, 2657, 2746, 2792, 3053, 3079, 3109, 3944], 'Watzl': [936, 2129], 'Holzapfel': [938, 2131], 'W.H.': [939, 2132], 'Franz': [940, 2133], 'Lactobacilli': [942, 2135], 'stimulate': [943, 2136], 'response': [947, 2140], 'modulate': [949, 2142], 'TLR': [951, 2144], 'expression': [952, 2145], 'HT29': [954, 1006, 2147, 2199], 'vitro.Int': [959, 2152], 'J': [960, 2153, 2723], 'Food': [961, 2154], 'Microbiol.': [962, 1010, 2155, 2203, 2814, 3131], '133:': [964, 2157], '86-93Crossref': [965, 2158], '(113)': [968, 2161], '15Eveillard': [971, 2164], 'Fourel': [973, 2166], 'Bare': [975, 2168], 'Kernéis': [977, 2170], 'Coconnier': [979, 2172], 'M.H.': [980, 1815, 2173], 'Karjalainen': [981, 2174], 'T.': [982, 1237, 1397, 1444, 1512, 1626, 2175, 2215, 2268, 2351, 2397, 2441, 2531, 2651, 2740, 2786, 3016, 3103, 3979, 3981], 'Bourlioux': [983, 2176], 'Servin': [985, 2178], 'A.L.': [986, 2179], 'Identification': [987, 2180], 'characterization': [989, 2182], 'adhesive': [991, 2184], 'factors': [992, 2185], 'Clostridium': [994, 2187], 'difficile': [995, 2188], 'involved': [996, 2189], 'adhesion': [998, 2191], 'enterocyte-like': [1002, 2195], 'Caco-2': [1003, 2196, 2993, 4086], 'mucus-secreting': [1005, 2198], 'culture.Mol': [1009, 2202], '1993;': [1011, 2204], '7:': [1012, 2205, 3287, 3325, 3365], '371-381Crossref': [1013, 2206], '(74)': [1016, 2209], 'cells)': [1019], 'extracellular': [1021], 'matrix': [1022], '(ECM)-coated,': [1023], 'porous': [1024], 'membranes': [1025], 'within': [1026, 1187, 1482, 1703, 1764], 'Transwell': [1027], 'insert': [1028], 'devices.': [1030], 'Although': [1031, 1344], 'commonly': [1036], 'pharmaceutical': [1040, 1212], 'industry,': [1041], '2-dimensional': [1043], '(2D)': [1044], 'format': [1046], 'fails': [1047], 'physiological': [1050], '3-dimensional': [1051], '(3D)': [1052], 'tissue': [1056, 1251, 1555, 1700, 2455, 2545, 2665, 2754, 3166, 3204, 3242], 'morphology': [1057], 're-establish': [1059], 'key': [1061], 'differentiated': [1063, 1390], 'functions': [1064, 1799], 'mucus': [1066], 'production,': [1067], 'villi': [1068, 3060, 3086], 'formation,': [1069], 'cytochrome': [1070], 'P-450-based': [1071], 'metabolism).16Kim': [1073], 'H.J.': [1074, 1104, 1147, 1402, 1825, 2273, 2356, 3374, 3404, 3438, 3467, 3497, 3533, 3555, 3589, 3619, 3641, 3675, 3705, 3726, 3756, 3778, 3812], 'Huh': [1075, 1148, 3375, 3439, 3468, 3590, 3676, 3727], 'D.': [1076, 1149, 1233, 1452, 1520, 2219, 2405, 2437, 2527, 2647, 2736, 2784, 2979, 3047, 3073, 3101, 3376, 3440, 3469, 3591, 3677, 3728, 4072], 'Hamilton': [1077, 1150, 3377, 3441, 3470, 3592, 3678, 3729], 'G.': [1078, 1151, 1586, 2788, 3105, 3378, 3442, 3471, 3593, 3679, 3730], 'Ingber': [1079, 1105, 1152, 1899, 3379, 3409, 3443, 3472, 3502, 3534, 3560, 3594, 3620, 3646, 3680, 3706, 3731, 3757, 3783, 3817], 'D.E.': [1080, 1106, 1153, 1404, 1900, 2275, 2358, 3380, 3410, 3444, 3473, 3503, 3535, 3561, 3595, 3621, 3647, 3681, 3707, 3732, 3758, 3784, 3818], 'gut-on-a-chip': [1082, 1155, 3057, 3083, 3382, 3446, 3475, 3597, 3683, 3734], 'inhabited': [1083, 1156, 1887, 3383, 3447, 3476, 3598, 3684, 3735], 'flora': [1086, 1159, 3386, 3450, 3479, 3601, 3687, 3738], 'experiences': [1088, 1161, 3388, 3452, 3481, 3603, 3689, 3740], 'peristalsis-like': [1090, 1163, 1956, 3390, 3454, 3483, 3605, 3691, 3742], 'motions': [1091, 1164, 3391, 3455, 3484, 3606, 3692, 3743], 'flow.Lab': [1093, 1166, 3393, 3457, 3486, 3608, 3694, 3745], 'Chip.': [1094, 1167, 2972, 3003, 3038, 3394, 3458, 3487, 3609, 3695, 3746, 3965, 4096], '2165-2174Crossref': [1097, 1170, 3397, 3461, 3490, 3612, 3698, 3749], '(1046)': [1100, 1173, 3400, 3464, 3493, 3615, 3701, 3752], '17Kim': [1103, 3618, 3704, 3755], 'Gut-on-a-Chip': [1107, 3536, 3622, 3708, 3759], 'microenvironment': [1108, 3537, 3623, 3709, 3760], 'induces': [1109, 3538, 3624, 3710, 3761], 'undergo': [1114, 1503, 3543, 3629, 3715, 3766], 'villus': [1115, 3544, 3630, 3716, 3767], 'differentiation.Integr': [1116, 3545, 3631, 3717, 3768], 'Biol.': [1117, 1678, 3546, 3632, 3718, 3769], '5:': [1119, 1303, 2234, 2597, 3548, 3634, 3720, 3771], '1130-1140Crossref': [1120, 3549, 3635, 3721, 3772], '(443)': [1122, 3551, 3637, 3723, 3774], 'These': [1125, 1846], 'static': [1127], 'cannot': [1130], 'support': [1131, 3870], 'cells,': [1140, 1356, 1714, 1780, 1942], 'critical': [1143, 1797, 1810], 'physiology,16Kim': [1146], 'bacteria': [1178, 2503, 2842], 'rapidly': [1179], 'overgrow': [1180], 'contaminate': [1182], 'cultures': [1186, 1360], 'day.': [1189], 'Several': [1190], 'models,': [1193, 1337, 2005], 'everted': [1197], 'sac18Alam': [1198], 'M.A.': [1199, 1458, 1526, 2411], 'Al-Jenoobi': [1200], 'F.I.': [1201], 'Al-mohizea': [1202], 'A.M.': [1203], 'Everted': [1204], 'sac': [1206], 'tool': [1210, 1259, 2463, 2553, 2673, 2762], 'research:': [1213], 'limitations': [1214], 'applications.J': [1216], 'Pharm': [1217, 2724], 'Pharmacol.': [1218], '64:': [1220], '326-336Crossref': [1221], '(131)': [1224], 'Ussing': [1229, 1255, 1294, 2459, 2549, 2588, 2669, 2720, 2758], 'chamber,19Rozehnal': [1230], 'Nakai': [1232, 2436, 2526, 2646, 2735], 'Hoepner': [1234, 2438, 2528, 2648, 2737], 'U.': [1235, 2439, 2529, 2649, 2738], 'Fischer': [1236, 2440, 2530, 2650, 2739], 'Kamiyama': [1238, 2442, 2532, 2652, 2741], 'E.': [1239, 1460, 1528, 2217, 2314, 2413, 2443, 2533, 2606, 2653, 2742, 3260, 3298, 3338], 'Takahashi': [1240, 2444, 2534, 2654, 2743], 'Yasuda': [1242, 2446, 2536, 2656, 2745], 'Mueller': [1244, 2448, 2538, 2658, 2747], 'small': [1247, 1497, 2451, 2541, 2661, 2750, 2892, 2930], 'mounted': [1252, 2456, 2546, 2666, 2755], 'chamber': [1256, 2460, 2550, 2670, 2721, 2759], 'characterizing': [1261, 2465, 2555, 2675, 2764], 'drugs.European': [1266, 2470, 2560, 2680, 2769], 'Journal': [1267, 2471, 2561, 2681, 2770], 'Pharmaceutical': [1269, 2473, 2563, 2683, 2772], 'Sciences.': [1270, 2474, 2564, 2684, 2773], '46:': [1272, 2476, 2566, 2686, 2775], '367-373Crossref': [1273, 2477, 2567, 2687, 2776], '(104)': [1276, 2480, 2570, 2690, 2779], '20Smith': [1279, 2573], 'Mirabelli': [1281, 2575], 'C.': [1282, 1819, 2490, 2494, 2501, 2576, 2697, 2699, 2829, 2833, 2840, 3142, 3180, 3218, 3272, 3274, 3310, 3312, 3350, 3352], 'Fondacaro': [1283, 2577], 'Ryan': [1285, 2579], 'F.': [1286, 1588, 2580], 'Dent': [1287, 2581], '5-fluorouracil': [1290, 2584], 'absorption:': [1291, 2585], 'Use': [1292, 2586], 'chambers': [1295, 1886, 2589], 'assess': [1297, 2591], 'transport': [1298, 1315, 2592], 'metabolism.Pharm': [1300, 2594], 'Res.': [1301, 2595], '1988;': [1302, 2596], '598-603Crossref': [1304, 2598], '(45)': [1307, 2601], 'assays;': [1316], 'however,': [1317], 'expected': [1319], 'lifespan': [1320], '(<8': [1321], 'hours)': [1322], 'sufficient': [1325], 'enable': [1327], 'many': [1328, 1796], 'studies': [1329], 'normal': [1331], 'clinically': [1340], 'relevant': [1341], 'host-microbiome': [1342, 1811, 1827], 'crosstalk.': [1343], 'had': [1346, 4060], 'technically': [1348], 'challenging': [1349], 'primary': [1352], '3D': [1358, 1484], 'derived': [1361, 1551], 'either': [1363], 'crypts': [1365], 'containing': [1366, 1489, 3861], 'endogenous': [1367], 'induced': [1372], 'pluripotent': [1373], 'stem': [1374, 1382, 1428, 1469, 1537, 1633, 2299, 2382, 2422], 'revolutionized': [1377], 'maintaining': [1381], 'niches': [1384], 'supporting': [1386, 1697], 'differentiation': [1387], 'subtypes': [1394], 'vitro.21Sato': [1396], 'Van': [1398, 1407, 1415, 2269, 2278, 2286, 2352, 2361, 2369], 'Es': [1399, 2270, 2353], 'J.H.': [1400, 2271, 2354, 3055, 3081], 'Snippert': [1401, 2272, 2355], 'Stange': [1403, 2274, 2357], 'Vries': [1405, 2276, 2359], 'R.G.': [1406, 2277, 2360], 'Den': [1408, 2279, 2362], 'Born': [1409, 2280, 2363], 'Barker': [1411, 1664, 2282, 2365], 'Shroyer': [1413, 2284, 2367], 'N.F.': [1414, 2285, 2368], 'Wetering': [1417, 1579, 2288, 2371], 'Clevers': [1419, 1627, 2290, 2373], 'H.': [1420, 1454, 1522, 1628, 2221, 2291, 2374, 2407, 2492, 2831, 2981, 3406, 3499, 3557, 3643, 3780, 3814, 4074], 'Paneth': [1421, 2292, 2375], 'constitute': [1423, 2294, 2377], 'niche': [1425, 2296, 2379], 'Lgr5': [1427, 2298, 2381], 'crypts.Nature.': [1432, 2303, 2386], '469:': [1434, 2305, 2388], '415-418Crossref': [1435, 2306, 2389], '(1723)': [1438, 2309, 2392], '22Jung': [1441], 'Sato': [1443, 1511, 2396, 3982], 'Merlos-Suárez': [1445, 1513, 2398], 'Barriga': [1447, 1515, 2400], 'F.M.': [1448, 1516, 2401], 'Iglesias': [1449, 1517, 2402], 'Rossell': [1451, 1519, 2404], 'Auer': [1453, 1521, 2406], 'Gallardo': [1455, 1523, 2408], 'Blasco': [1457, 1525, 2410], 'Sancho': [1459, 1527, 2412], 'Isolation': [1461, 1529, 2414], 'expansion': [1465, 1533, 2418], 'cells.Nat': [1470, 1538, 2423], 'Med.': [1471, 1539, 2424], '17:': [1473, 1541, 2426, 2974, 3999], '1225-1227Crossref': [1474, 1542, 2427], '(497)': [1477, 1545, 2430], 'When': [1480], 'cultured': [1481, 1763, 4066], 'ECM': [1485, 1766], 'gel': [1486], 'medium': [1488, 3904], 'Wnt,': [1490], 'R-spondin,': [1491], 'noggin,': [1492], 'growth': [1495, 4018], 'factors,': [1496, 4019], 'organoids': [1499, 1631, 1688, 2223], '(enteroids)': [1500], 'spontaneously': [1502], 'villus-crypt': [1504], 'morphologic': [1505], 'organization': [1506], 'histogenesis.22Jung': [1509], 'Each': [1548], 'biopsy': [1556], 'patient': [1560], 'can': [1561, 1571, 3916], 'grown,': [1563], 'frozen,': [1564], 'revived': [1566], 'multiple': [1568], 'reuses,': [1569], 'potentially': [1572], 'establish': [1576], 'biobanks23van': [1577], 'Francies': [1581], 'H.E.': [1582], 'Francis': [1583], 'Bounova': [1585], 'Iorio': [1587], 'Pronk': [1589], 'Houdt': [1592], 'Gorp': [1595], 'Taylor-Weiner': [1597], 'Kester': [1599], 'L.': [1600, 2498, 2837, 3148, 3186, 3224], 'Prospective': [1601], 'derivation': [1602], 'biobank': [1607], 'colorectal': [1609], 'cancer': [1610], 'patients.Cell.': [1611], '2015;': [1612, 1635, 2233], '161:': [1613, 1636], '933-945Abstract': [1614], '(1348)': [1622], '24Sato': [1625], 'SnapShot:': [1629], 'growing': [1630], 'cells.Cell.': [1634], '1700-1700.e1Abstract': [1637], '(97)': [1643, 2238], 'multiplexed': [1648], 'screening': [1649], 'platforms': [1650], 'validating': [1652], 'candidates': [1655], 'advance': [1658], 'medicine.25Fatehullah': [1660], 'Tan': [1662], 'S.H.': [1663], 'Organoids': [1666], 'Cell': [1677, 1835], '2016;': [1679, 3170, 3208, 3246, 3286, 3324, 3364, 3430, 3523, 3581, 3667, 3804, 3838], '18:': [1680], '246-254Crossref': [1681], '(837)': [1684], 'lack': [1695], 'types': [1701, 1970], 'found': [1702], 'intestine,': [1706], 'endothelium-lined': [1709], 'blood': [1710, 4008], 'vessels': [1711], 'important': [1717], 'transport,': [1720, 2227], 'pharmacokinetic': [1721], '(PK)': [1722], 'analysis,': [1723], 'modeling.': [1726], 'They': [1727], 'do': [1729], 'experience': [1731], 'fluid': [1732, 3872, 3881, 3922], 'flows': [1733, 3923], 'cyclic': [1735, 1951], 'mechanical': [1736, 1952, 3415, 3508, 3566, 3652, 3789, 3823], 'deformations': [1737, 1957], 'similar': [1738], 'those': [1740], 'experienced': [1741, 1958], 'peristalsing': [1744], 'contribute': [1747], 'function.': [1753], 'Furthermore,': [1754], 'each': [1756, 3913], 'enteroid': [1757], 'closed': [1760], 'lumen': [1761], 'when': [1762], 'surrounding': [1765], 'gel,': [1767], 'experimentally': [1770], 'difficult': [1771], 'sample': [1773], 'manipulate': [1775], 'luminal': [1776], 'components': [1777], 'nutrients,': [1781, 4017], 'drugs,': [1782], 'toxins).': [1784], 'This': [1785, 4010], 'structure': [1786], 'limits': [1789], 'researchers': [1793], 'PK,': [1803], 'metabolism),': [1806], 'interactions.26Park': [1812], 'G.-S.': [1813], 'Park': [1814, 3052, 3078], 'Shin': [1816], 'Zhao': [1818], 'Sheikh': [1820], 'Oh': [1822], 'S.J.': [1823, 2873, 2911], 'Kim': [1824], 'Emulating': [1826], 'ecosystem': [1828], 'gastrointestinal': [1831, 3022, 3282, 3320, 3360], 'tract': [1832, 3023], 'vitro.Stem': [1834], 'Rep.': [1837, 2232, 2257], '321-334Crossref': [1840], '(43)': [1843], 'challenges': [1847], 'overcome': [1851], 'Organ': [1857, 1863, 1917], 'Chip': [1858, 1918], 'intestine.': [1862], 'devices,': [1869], 'originally': [1870], 'fabricated': [1871], 'methods': [1873], 'adapted': [1874], 'computer': [1876], 'microchip': [1877], 'manufacturing': [1878], 'soft': [1880], 'lithography),': [1881], 'continuously': [1884], 'perfused': [1885, 3907], 'arranged': [1891], 'simulate': [1893], 'tissue-': [1894], 'organ-level': [1896], 'physiology.27Bhatia': [1897], 'S.N.': [1898], 'organs-on-chips.Nat': [1902], 'Biotechnol.': [1903], '2014;': [1904, 2258, 3039], '32:': [1905], '760-772Crossref': [1906], '(1976)': [1909], 'Over': [1912], 'past': [1914], '5': [1915], 'years,': [1916], 'engineered': [1924, 1972], 'increasing': [1926], 'complexity': [1927], 'include': [1930], 'neighboring': [1931], 'channels': [1932, 4033, 4048], 'lined': [1933], 'microvascular': [1936], 'endothelium,': [1937], 'microbes,': [1940], 'pathogenic': [1944], 'bacteria,': [1945], 'some': [1947], 'application': [1949], 'forces': [1953], 'mimic': [1955, 3917], '(Figure': [1964], '1).': [1965, 1990], 'Next': [1966], 'emulate': [1977], '(Table': [1989], 'Also': [1991], 'considered': [1992], 'implications': [1995], 'work': [1998], 'complex': [2003], 'development,': [2007], 'medicine': [2010], 'future.Table': [2013], '1Design': [2014], 'Characteristics': [2015], 'ModelsModelTEERAbsorptionCocultureMicrobiomeDifferentiationPeristalsisDrug': [2019], 'metabolismCrypt-villus': [2020], 'axisOxygen': [2021], 'modulationDisease': [2022], 'modelingStatic': [2023], 'TranswellYes12Hidalgo': [2024], 'ScholarYes12Hidalgo': [2057], 'ScholarNoYes14Pinto': [2123], '(<24': [2212, 3332], 'h)NoNoNoNoNoNo': [2213], 'OrganoidNoYes95Zietek': [2214], 'Rath': [2216], 'Haller': [2218], 'Daniel': [2220], 'assessing': [2225], 'nutrient': [2226], 'sensing': [2228], 'incretin': [2230], 'secretion.Sci': [2231], '16831Crossref': [2235], 'ScholarNoYes96Zhang': [2240], 'Y.G.': [2241], 'Xia': [2244], 'Sun': [2246], 'Salmonella-infected': [2248], 'crypt-derived': [2249], 'host–bacterial': [2255], 'interactions.Physiol': [2256], '2:': [2259], 'e12147Crossref': [2260], '(150)': [2263], '(<1': [2266], 'h)Yes21Sato': [2267], 'ScholarNoYes97Lu': [2311, 2603], 'Rettenmeier': [2313, 2605], 'Paszek': [2315, 2607], 'Yueh': [2317, 2609], 'M.-F.': [2318, 2610], 'Tukey': [2319, 2611], 'R.H.': [2320, 2612], 'Trottier': [2321, 2613], 'Barbier': [2323, 2615], 'O.': [2324, 2616], 'Chen': [2325, 2617], 'Crypt': [2327, 2619], 'cytotoxicity': [2339, 2631], 'studies.Drug': [2340, 2632], 'Metab': [2341, 2633], 'Dispos.': [2342, 2634], '45:': [2344, 2636], '748-754Crossref': [2345, 2637], '(28)': [2348, 2640], 'ScholarYes21Sato': [2350], 'ScholarNoYes22Jung': [2394], 'Ex': [2433, 3097], 'vivoYes19Rozehnal': [2434], '98Madsen': [2483], 'Cornish': [2485, 2824], 'Soper': [2487, 2826], 'McKaigney': [2489, 2828], 'Jijon': [2491, 2830], 'Yachimec': [2493, 2832], 'Doyle': [2495, 2834, 2951], 'Jewell': [2497, 2836], 'Simone': [2500, 2839], 'Probiotic': [2502, 2841], 'enhance': [2504, 2843], 'murine': [2505, 2844], 'function.Gastroenterology.': [2511, 2850], '2001;': [2512, 2851], '121:': [2513, 2852], '580-591Abstract': [2514, 2853], '(890)': [2522, 2861], 'ScholarYes19Rozehnal': [2524, 2733], '(<3': [2643], 'h)Yes19Rozehnal': [2644], 'ScholarNoYes100Sjöberg': [2692], 'Å.': [2693], 'Lutz': [2694], 'Tannergren': [2696], 'Wingolf': [2698], 'Borde': [2700], 'Ungell': [2702], 'A.-L.': [2703], 'Comprehensive': [2704], 'regional': [2707], 'prediction': [2712], 'fraction': [2714], 'absorbed': [2715], 'drugs': [2717], 'technique.Eur': [2722], 'Sci.': [2725, 3429, 3522, 3580, 3666, 3803, 3837], '48:': [2727], '166-180Crossref': [2728], '(151)': [2731], 'ScholarYes99Worton': [2781], 'Candy': [2783, 3100], 'Wallis': [2785, 3102], 'Clarke': [2787, 3104], 'Osborne': [2789, 3106], 'Haddon': [2791, 3108], 'Stephen': [2793, 3110], 'Studies': [2795, 3112], 'early': [2797, 3114], 'association': [2798, 3115], 'Salmonella': [2800, 3117], 'typhimurium': [2801, 3118], 'mucosa': [2804, 3121], 'vitro:': [2809, 3126], 'relationship': [2810, 3127], 'virulence.J': [2812, 3129], 'Med': [2813, 3130], '29:': [2816, 3133], '283-294Crossref': [2817, 3134], '(31)': [2820, 3137], 'ScholarYes98Madsen': [2822], 'ScaffoldNoNoNoNoYes40Wang': [2864], 'Gunasekara': [2866, 2904], 'D.B.': [2867, 2905], 'Reed': [2868, 2906], 'M.I.': [2869, 2907], 'DiSalvo': [2870, 2908], 'Bultman': [2872, 2910], 'Sims': [2874, 2912], 'C.E.': [2875, 2913], 'Magness': [2876, 2914], 'S.T.': [2877, 2915], 'Allbritton': [2878, 2916], 'N.L.': [2879, 2917], 'A': [2880, 2918, 3153, 3191, 3229, 3275, 3313, 3353], 'microengineered': [2881, 2919], 'collagen': [2882, 2920], 'scaffold': [2883, 2921], 'generating': [2885, 2923], 'polarized': [2887, 2925], 'crypt-villus': [2888, 2926], 'architecture': [2889, 2927], 'epithelium.Biomaterials.': [2894, 2932], '128:': [2896, 2934], '44-55Crossref': [2897, 2935], '(191)': [2900, 2938], 'ScholarNoNoYes40Wang': [2902], 'ScholarNoNoMicrofluidic': [2940], '2-channelYes32Maoz': [2941], 'B.M.': [2942], 'Herland': [2943], 'Henry': [2945], 'O.Y.F.': [2946], 'Leineweber': [2947], 'Yadid': [2949], 'Mannix': [2953], 'Kujala': [2955], 'Fitzgerald': [2957], 'Parker': [2959], 'K.K.': [2960], 'combined': [2963], 'multi-electrode': [2964], 'array': [2965], 'transepithelial': [2967, 3846, 3856], 'electrical': [2968, 3847, 3857], 'resistance': [2969], 'measurement': [2970], 'capabilities.Lab': [2971], '2294-2302Crossref': [2975], 'ScholarYes30Gao': [2978], 'Liu': [2980, 4073], 'Lin': [2982, 4075], 'J.-M.': [2983, 4076], 'Wang': [2984, 4077], 'Jiang': [2986, 4079], 'monolayers': [2994, 4087], 'mass': [2996, 4089], 'spectrometry': [2997, 4090], 'membrane-based': [3000, 4093], 'device.Lab': [3002, 4095], '978-985Crossref': [3006, 4099], '(94)': [3009, 4102], 'ScholarYes37Esch': [3011], 'M.B.': [3012], 'Mahler': [3013], 'G.J.': [3014], 'Stokol': [3015], 'Shuler': [3017], 'M.L.': [3018], 'Body-on-a-chip': [3019], 'simulation': [3020], 'suggests': [3027], 'ingested': [3029], 'nanoparticles': [3030], 'cause': [3035], 'injury.Lab': [3037], '14:': [3040], '3081-3092Crossref': [3041], 'ScholarNoNoNoYes39Shim': [3044], 'K.-Y.': [3045, 3071], 'Lee': [3046, 3072], 'Han': [3048, 3074], 'Nguyen': [3050, 3076], 'N.-T.': [3051, 3077], 'Sung': [3054, 3080], 'three-dimensional': [3059, 3085, 3959], 'structure.Biomed': [3061, 3087], 'Microdevices.': [3062, 3088], '19:': [3064, 3090], '37Crossref': [3065, 3091], '(120)': [3068, 3094], 'ScholarYes39Shim': [3070], 'ScholarNoNo': [3096], 'vivoNoYes99Worton': [3098], 'ScholarNoNoYes101Dawson': [3139, 3177], 'Dyer': [3141, 3179, 3217], 'Macfie': [3143, 3181, 3219], 'Davies': [3145, 3183, 3221], 'Karsai': [3147, 3185, 3223], 'Greenman': [3149, 3187, 3225], 'Jacobsen': [3151, 3189, 3227], 'chip': [3155, 3193, 3231], 'based': [3156, 3194, 3232], 'full': [3162, 3200, 3238], 'thickness': [3163, 3201, 3239], 'dual': [3168, 3206, 3244], 'flow.Biomicrofluidics.': [3169, 3207, 3245], '10:': [3171, 3209, 3247], '064101Crossref': [3172, 3210, 3248], '(32)': [3175, 3213, 3251], 'ScholarNoYes101Dawson': [3215], 'Multichannel': [3254], '(HuMiX)Yes41Shah': [3255], 'Fritz': [3257, 3295, 3335], 'J.V.': [3258, 3296, 3336], 'Glaab': [3259, 3297, 3337], 'Desai': [3261, 3299, 3339], 'M.S.': [3262, 3300, 3340], 'Greenhalgh': [3263, 3301, 3341], 'Frachet': [3265, 3303, 3343], 'Niegowska': [3267, 3305, 3345], 'Estes': [3269, 3307, 3347], 'Jäger': [3271, 3309, 3349], 'Seguin-Devaux': [3273, 3311, 3351], 'microfluidics-based': [3276, 3314, 3354], 'human–microbe': [3283, 3321, 3361], 'interface.Nat': [3284, 3322, 3362], '11535Crossref': [3288, 3326, 3366], '(326)': [3291, 3329, 3369], 'ScholarNoNoYes41Shah': [3293], 'h)NoNoNoNoYes41Shah': [3333], 'ScholarNo': [3371], 'ChipYes16Kim': [3373], '42Kim': [3403, 3496, 3554, 3640, 3777], 'Li': [3405, 3498, 3556, 3642, 3779, 3813], 'Collins': [3407, 3500, 3558, 3644, 3781, 3815], 'J.J.': [3408, 3501, 3559, 3645, 3782, 3816], 'Contributions': [3411, 3504, 3562, 3648, 3785, 3819], 'deformation': [3416, 3509, 3567, 3653, 3790, 3824], 'overgrowth': [3420, 3513, 3571, 3657, 3794, 3828], 'gut-on-a-chip.Proc': [3426, 3519, 3577, 3663, 3800, 3834], 'Natl': [3427, 3520, 3578, 3664, 3801, 3835], 'Acad': [3428, 3521, 3579, 3665, 3802, 3836], '113:': [3431, 3524, 3582, 3668, 3805, 3839], 'E7-E15Crossref': [3432, 3525, 3583, 3669, 3806, 3840], '(549)': [3435, 3528, 3586, 3672, 3809, 3843], 'ScholarYes16Kim': [3437, 3588, 3674, 3725], 'ScholarNoYes16Kim': [3466], '(>7': [3531], 'd)Yes17Kim': [3532], 'ScholarNoYes42Kim': [3811], 'ScholarTEER,': [3845], 'resistance.': [3848, 3858], 'Open': [3849], 'table': [3850], 'tab': [3854], 'TEER,': [3855], 'devices': [3860], 'hollow': [3862, 4047], 'microchannels': [3863], 'less': [3864], 'mm': [3867], 'width': [3869], 'laminar': [3871], 'flow': [3873, 3910], 'nanoliter': [3877], 'microliter': [3879], 'scale': [3880], 'volumes,': [3882], 'thus,': [3884], 'amenable': [3887], 'use': [3889], 'cells.': [3894], 'By': [3895], 'syringe': [3898], 'peristaltic': [3901], 'pump,': [3902], 'may': [3905], 'desired': [3909], 'rates': [3911], 'through': [3912], 'microchannel,': [3914], 'dynamic': [3919], 'ranges': [3920], 'associated': [3925], 'shear': [3926, 3988], 'stresses': [3927], 'surface': [3931], 'observed': [3934], 'lumen,28Vickerman': [3939], 'Blundo': [3941], 'Chung': [3943], 'Kamm': [3945], 'Design,': [3947], 'fabrication': [3948], 'implementation': [3950], 'novel': [3953], 'multi-parameter': [3954], 'platform': [3957], 'real-time': [3963], 'imaging.Lab': [3964], '2008;': [3966], '8:': [3967], '1468-1477Crossref': [3968], '(294)': [3971], '29Tanaka': [3974], 'Yamato': [3976], 'Okano': [3978], 'Kitamori': [3980], 'Evaluation': [3984], 'effects': [3986], 'stress': [3989], 'hepatocytes': [3991], 'microchip-based': [3994], 'system.Meas': [3995], 'Sci': [3996], 'Technol.': [3997], '3167-3170Crossref': [4000], '(87)': [4002], 'capillaries.': [4009], 'fluidic': [4011], 'enables': [4014], 'delivery': [4015], 'compounds,': [4021], 'toxins': [4024], 'grown': [4029], 'highly': [4036], 'regulated': [4037], 'spatiotemporal': [4038], 'manner.': [4039], 'Most': [4040], '2': [4046], 'separated': [4049], 'porous,': [4053], 'ECM-coated': [4054], 'polyester': [4055], 'polycarbonate': [4057], 'membrane,': [4058], 'immortalized': [4061], 'surfaces.30Gao': [4071], 'monolayer': [4107], 'formed': [4108], 'device': [4111], 'c': [4112]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2799449856', 'counts_by_year': [{'year': 2024, 'cited_by_count': 51}, {'year': 2023, 'cited_by_count': 69}, {'year': 2022, 'cited_by_count': 91}, {'year': 2021, 'cited_by_count': 102}, {'year': 2020, 'cited_by_count': 89}, {'year': 2019, 'cited_by_count': 58}, {'year': 2018, 'cited_by_count': 20}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-20T23:23:20.903451', 'created_date': '2018-05-17'}