Signature program: a platform of basket trials

Name: Work Video:
Duration: 3 min 30 s
Eric D. Slosberg; Barinder Kang; Julio A. Peguero; Matthew H. Taylor; Todd M. Bauer; Donald A. Berry; Fadi Braiteh; Alexander I. Spira; Funda Meric‐Bernstam; Steven Stein; Sarina A. Piha‐Paul; August J. Salvado
{'id': 'https://openalex.org/W2799326392', 'doi': 'https://doi.org/10.18632/oncotarget.25109', 'title': 'Signature program: a platform of basket trials', 'display_name': 'Signature program: a platform of basket trials', 'publication_year': 2018, 'publication_date': '2018-04-20', 'ids': {'openalex': 'https://openalex.org/W2799326392', 'doi': 'https://doi.org/10.18632/oncotarget.25109', 'mag': '2799326392', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29765547', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5940401'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.25109', 'pdf_url': 'https://www.oncotarget.com/article/25109/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.oncotarget.com/article/25109/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049525954', 'display_name': 'Eric D. Slosberg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117619', 'display_name': 'Novartis (United States)', 'ror': 'https://ror.org/028fhxy95', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1283582996', 'https://openalex.org/I4210117619']}, {'id': 'https://openalex.org/I4210162815', 'display_name': 'Daiichi Sankyo (United States)', 'ror': 'https://ror.org/055werx92', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210104626', 'https://openalex.org/I4210162815']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric D. Slosberg', 'raw_affiliation_strings': ['Current affiliation: Daiichi Sankyo, Inc, Basking Ridge, NJ, USA', 'Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA', 'institution_ids': ['https://openalex.org/I4210117619']}, {'raw_affiliation_string': 'Current affiliation: Daiichi Sankyo, Inc, Basking Ridge, NJ, USA', 'institution_ids': ['https://openalex.org/I4210162815']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112474654', 'display_name': 'Barinder Kang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117619', 'display_name': 'Novartis (United States)', 'ror': 'https://ror.org/028fhxy95', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1283582996', 'https://openalex.org/I4210117619']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Barinder P. Kang', 'raw_affiliation_strings': ['Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA', 'institution_ids': ['https://openalex.org/I4210117619']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075473235', 'display_name': 'Julio A. Peguero', 'orcid': 'https://orcid.org/0000-0002-9464-4901'}, 'institutions': [{'id': 'https://openalex.org/I4210150882', 'display_name': 'Hematology Oncology Consultants', 'ror': 'https://ror.org/04qqn5v91', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210150882']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julio Peguero', 'raw_affiliation_strings': ['Oncology Consultants PA, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'Oncology Consultants PA, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I4210150882']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033482846', 'display_name': 'Matthew H. Taylor', 'orcid': 'https://orcid.org/0000-0003-2409-9001'}, 'institutions': [{'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew Taylor', 'raw_affiliation_strings': ['Oregon Health and Science University, Portland, OR, USA'], 'affiliations': [{'raw_affiliation_string': 'Oregon Health and Science University, Portland, OR, USA', 'institution_ids': ['https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037195922', 'display_name': 'Todd M. Bauer', 'orcid': 'https://orcid.org/0000-0002-3078-5043'}, 'institutions': [{'id': 'https://openalex.org/I4210135086', 'display_name': 'Tennessee Oncology', 'ror': 'https://ror.org/03754ky26', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210135086']}, {'id': 'https://openalex.org/I4210100810', 'display_name': 'Sarah Cannon', 'ror': 'https://ror.org/014t21j89', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210100810']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Todd M. Bauer', 'raw_affiliation_strings': ['Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, TN, USA'], 'affiliations': [{'raw_affiliation_string': 'Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, TN, USA', 'institution_ids': ['https://openalex.org/I4210135086', 'https://openalex.org/I4210100810']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073571977', 'display_name': 'Donald A. Berry', 'orcid': 'https://orcid.org/0000-0002-7657-3871'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}, {'id': 'https://openalex.org/I4210100030', 'display_name': 'Berry & Associates (United States)', 'ror': 'https://ror.org/01a5r1q21', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210100030']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Donald A. Berry', 'raw_affiliation_strings': ['Berry Consultants, Austin, TX, USA', 'The University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'Berry Consultants, Austin, TX, USA', 'institution_ids': ['https://openalex.org/I4210100030']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108833256', 'display_name': 'Fadi Braiteh', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210163348', 'display_name': 'Comprehensive Cancer Centers of Nevada', 'ror': 'https://ror.org/05etxbz89', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210163348']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fadi Braiteh', 'raw_affiliation_strings': ['US Oncology Research and Comprehensive Cancer Centers of Nevada, Las Vegas, NV, USA'], 'affiliations': [{'raw_affiliation_string': 'US Oncology Research and Comprehensive Cancer Centers of Nevada, Las Vegas, NV, USA', 'institution_ids': ['https://openalex.org/I4210163348']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044613951', 'display_name': 'Alexander I. Spira', 'orcid': 'https://orcid.org/0000-0003-1303-0447'}, 'institutions': [{'id': 'https://openalex.org/I4210122908', 'display_name': 'Virginia Cancer Specialists', 'ror': 'https://ror.org/03tbabt10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210122908']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexander Spira', 'raw_affiliation_strings': ['Virginia Cancer Specialists, Fairfax, VA, USA'], 'affiliations': [{'raw_affiliation_string': 'Virginia Cancer Specialists, Fairfax, VA, USA', 'institution_ids': ['https://openalex.org/I4210122908']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076426660', 'display_name': 'Funda Meric‐Bernstam', 'orcid': 'https://orcid.org/0000-0001-6816-6072'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Funda Meric-Bernstam', 'raw_affiliation_strings': ['The University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112351678', 'display_name': 'Steven Stein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I924451375', 'display_name': 'Incyte (United States)', 'ror': 'https://ror.org/00cvzzg84', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I924451375']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven Stein', 'raw_affiliation_strings': ['Incyte, Wilmington, DE, USA'], 'affiliations': [{'raw_affiliation_string': 'Incyte, Wilmington, DE, USA', 'institution_ids': ['https://openalex.org/I924451375']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026538331', 'display_name': 'Sarina A. Piha‐Paul', 'orcid': 'https://orcid.org/0000-0001-9455-1660'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sarina A. Piha-Paul', 'raw_affiliation_strings': ['The University of Texas MD Anderson Cancer Center, Houston, TX, USA'], 'affiliations': [{'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center, Houston, TX, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5047951860', 'display_name': 'August J. Salvado', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117619', 'display_name': 'Novartis (United States)', 'ror': 'https://ror.org/028fhxy95', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1283582996', 'https://openalex.org/I4210117619']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'August Salvado', 'raw_affiliation_strings': ['Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA'], 'affiliations': [{'raw_affiliation_string': 'Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA', 'institution_ids': ['https://openalex.org/I4210117619']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 11, 'corresponding_author_ids': ['https://openalex.org/A5112474654'], 'corresponding_institution_ids': ['https://openalex.org/I4210117619'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.35, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 35, 'citation_normalized_percentile': {'value': 0.745561, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '9', 'issue': '30', 'first_page': '21383', 'last_page': '21395'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9931, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 0.9928, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12829', 'display_name': 'Advanced Breast Cancer Therapies', 'score': 0.9895, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.6223699}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8099122}, {'id': 'https://openalex.org/C2777609662', 'wikidata': 'https://www.wikidata.org/wiki/Q416356', 'display_name': 'PTEN', 'level': 4, 'score': 0.6228044}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.6223699}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.5736243}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.5279894}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.49372897}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.36295092}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.1990059}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.08552927}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.25109', 'pdf_url': 'https://www.oncotarget.com/article/25109/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5940401', 'pdf_url': 'https://europepmc.org/articles/pmc5940401?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940401', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29765547', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.25109', 'pdf_url': 'https://www.oncotarget.com/article/25109/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1513438095', 'https://openalex.org/W1846586690', 'https://openalex.org/W1965815757', 'https://openalex.org/W1984999562', 'https://openalex.org/W2000482060', 'https://openalex.org/W2018872626', 'https://openalex.org/W2076647600', 'https://openalex.org/W2080992857', 'https://openalex.org/W2094615848', 'https://openalex.org/W2100396735', 'https://openalex.org/W2107185109', 'https://openalex.org/W2108353976', 'https://openalex.org/W2113113178', 'https://openalex.org/W2128497441', 'https://openalex.org/W2133369878', 'https://openalex.org/W2133382697', 'https://openalex.org/W2147965664', 'https://openalex.org/W2154841567', 'https://openalex.org/W2163774814', 'https://openalex.org/W2273267066', 'https://openalex.org/W2292375548', 'https://openalex.org/W2471493685', 'https://openalex.org/W2474664935', 'https://openalex.org/W2560688864', 'https://openalex.org/W257954806', 'https://openalex.org/W2601520864', 'https://openalex.org/W2622396222', 'https://openalex.org/W2726405642', 'https://openalex.org/W2753535533', 'https://openalex.org/W2783112448'], 'related_works': ['https://openalex.org/W4255321854', 'https://openalex.org/W3146426108', 'https://openalex.org/W3024085365', 'https://openalex.org/W2884617011', 'https://openalex.org/W2587680012', 'https://openalex.org/W2167243939', 'https://openalex.org/W2087724775', 'https://openalex.org/W2077739050', 'https://openalex.org/W2074517075', 'https://openalex.org/W1588484713'], 'abstract_inverted_index': {'//': [0], 'Eric': [1], 'D.': [2], 'Slosberg': [3], '1,': [4, 11], '10,': [5], '*': [6, 12, 145], ',': [7, 13, 17, 21, 26, 32, 36, 40, 44, 48, 320, 322, 324], 'Barinder': [8, 156], 'P.': [9, 157], 'Kang': [10], 'Julio': [14], 'Peguero': [15], '2': [16, 65], 'Matthew': [18], 'Taylor': [19], '3': [20, 72], 'Todd': [22], 'M.': [23], 'Bauer': [24], '4': [25, 81], 'Donald': [27], 'A.': [28, 50], 'Berry': [29, 104], '5,': [30], '6': [31, 103, 337], 'Fadi': [33], 'Braiteh': [34], '7': [35, 109], 'Alexander': [37], 'Spira': [38], '8': [39, 123, 209], 'Funda': [41], 'Meric-Bernstam': [42], '5': [43, 52, 91], 'Steven': [45], 'Stein': [46], '9': [47, 130], 'Sarina': [49], 'Piha-Paul': [51], 'and': [53, 75, 113, 195, 247, 311, 325, 349, 359, 384], 'August': [54], 'Salvado': [55], '1': [56, 57, 229], 'Novartis': [58], 'Pharmaceuticals': [59], 'Corporation,': [60], 'East': [61], 'Hanover,': [62], 'NJ,': [63, 143], 'USA': [64, 71, 80, 90, 102, 108, 122, 129, 134, 144], 'Oncology': [66, 111], 'Consultants': [67], 'PA,': [68], 'Houston,': [69, 100], 'TX,': [70, 101, 107], 'Oregon': [73], 'Health': [74], 'Science': [76], 'University,': [77], 'Portland,': [78], 'OR,': [79], 'Sarah': [82], 'Cannon': [83], 'Research': [84, 112], 'Institute/Tennessee': [85], 'Oncology,': [86], 'PLLC,': [87], 'Nashville,': [88], 'TN,': [89], 'The': [92, 202, 251, 293, 343], 'University': [93], 'of': [94, 117, 208, 254, 275, 290], 'Texas': [95], 'MD': [96], 'Anderson': [97], 'Cancer': [98, 115, 125], 'Center,': [99], 'Consultants,': [105], 'Austin,': [106], 'US': [110], 'Comprehensive': [114], 'Centers': [116], 'Nevada,': [118], 'Las': [119], 'Vegas,': [120], 'NV,': [121], 'Virginia': [124], 'Specialists,': [126], 'Fairfax,': [127], 'VA,': [128], 'Incyte,': [131], 'Wilmington,': [132], 'DE,': [133], '10': [135], 'Current': [136], 'affiliation:': [137], 'Daiichi': [138], 'Sankyo,': [139], 'Inc,': [140], 'Basking': [141], 'Ridge,': [142], 'These': [146], 'authors': [147], 'have': [148], 'contributed': [149], 'equally': [150], 'to': [151, 191, 363, 380], 'this': [152], 'work': [153], 'Correspondence': [154], 'to:': [155], 'Kang,': [158], 'email:': [159], '[email protected]': [160], 'Keywords:': [161], 'signature;': [162], 'clinical': [163, 200, 259], 'trial': [164, 382], 'design;': [165], 'basket': [166, 213], 'trial;': [167], 'mutations;': [168], 'tissue': [169], 'agnostic': [170], 'Received:': [171], 'September': [172], '30,': [173], '2017': [174], 'Accepted:': [175], 'March': [176], '21,': [177], '2018': [178, 182], 'Published:': [179], 'April': [180], '20,': [181], 'ABSTRACT': [183], 'Investigating': [184], 'targeted': [185], 'therapies': [186], 'can': [187], 'be': [188, 364], 'challenging': [189], 'due': [190], 'diverse': [192], 'tumor': [193, 296, 341], 'mutations': [194], 'slow': [196], 'patient': [197, 385], 'accrual': [198], 'for': [199, 352], 'studies.': [201], 'Signature': [203, 344], 'Program': [204, 345], 'is': [205], 'a': [206, 216, 286, 347], 'series': [207], 'phase': [210], '2,': [211], 'agent-specific': [212], 'protocols': [214], 'using': [215], 'rapid': [217, 353], 'study': [218, 224, 256], 'start-up': [219, 288], 'approach': [220, 351], 'involving': [221], 'no': [222], 'predetermined': [223], 'sites.': [225], 'Each': [226], 'protocol': [227], 'evaluated': [228, 365], 'agent': [230], '(buparlisib,': [231], 'dovitinib,': [232], 'binimetinib,': [233], 'encorafenib,': [234], 'sonidegib,': [235], 'BGJ398,': [236], 'ceritinib,': [237], 'or': [238, 244, 264, 267, 331], 'ribociclib)': [239], 'in': [240, 281, 318, 339, 366, 375], 'patients': [241, 302, 367], 'with': [242, 285, 336, 368], 'solid': [243], 'hematologic': [245], 'malignancies': [246], 'an': [248], 'actionable': [249], 'mutation.': [250], 'primary': [252], 'endpoint': [253], 'each': [255], 'was': [257], 'the': [258, 282, 299], 'benefit': [260], 'rate': [261], '(ie,': [262], 'complete': [263, 332], 'partial': [265, 330], 'response,': [266], 'stable': [268], 'disease)': [269], 'at': [270], '16': [271, 340], 'weeks.': [272, 292], 'A': [273], 'total': [274], '192': [276], 'individual': [277], 'sites': [278], 'were': [279, 303, 317, 334], 'opened': [280], 'United': [283], 'States,': [284], 'median': [287], 'time': [289], '3.6': [291], 'most': [294], 'common': [295], 'types': [297], 'among': [298], '595': [300], 'treated': [301], 'colorectal': [304], '(9.2%),': [305], 'non-small': [306], 'cell': [307], 'lung': [308], 'adenocarcinoma': [309], '(9.1%),': [310], 'ovarian': [312], '(8.4%).': [313], 'Frequent': [314], 'genetic': [315], 'alterations': [316], 'PIK3CA': [319], 'RAS': [321], 'p16': [323], 'PTEN': [326], '.': [327], 'Overall,': [328], '30': [329], 'responses': [333], 'observed': [335], 'compounds': [338], 'types.': [342], 'presents': [346], 'unique': [348], 'successful': [350], 'signal': [354], 'finding': [355], 'across': [356], 'multiple': [357], 'tumors': [358], 'allowed': [360], 'various': [361], 'agents': [362], 'rare': [369], 'alterations.': [370], 'Incorporating': [371], 'these': [372], 'program': [373], 'features': [374], 'conventional': [376], 'studies': [377], 'could': [378], 'lead': [379], 'improved': [381], 'efficiencies': [383], 'outcomes.': [386]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2799326392', 'counts_by_year': [{'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 4}], 'updated_date': '2025-01-11T15:36:43.207221', 'created_date': '2018-05-17'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
