Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2795353688', 'doi': 'https://doi.org/10.1186/s12943-018-0782-4', 'title': 'Mechanisms of receptor tyrosine kinase activation in cancer', 'display_name': 'Mechanisms of receptor tyrosine kinase activation in cancer', 'publication_year': 2018, 'publication_date': '2018-02-16', 'ids': {'openalex': 'https://openalex.org/W2795353688', 'doi': 'https://doi.org/10.1186/s12943-018-0782-4', 'mag': '2795353688', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29455648', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5817791'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12943-018-0782-4', 'pdf_url': 'https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-018-0782-4', 'source': {'id': 'https://openalex.org/S132829192', 'display_name': 'Molecular Cancer', 'issn_l': '1476-4598', 'issn': ['1476-4598'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-018-0782-4', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020496167', 'display_name': 'Zhenfang Du', 'orcid': 'https://orcid.org/0000-0001-6364-1321'}, 'institutions': [{'id': 'https://openalex.org/I901861585', 'display_name': 'Vanderbilt University Medical Center', 'ror': 'https://ror.org/05dq2gs74', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210162197', 'https://openalex.org/I901861585']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhenfang Du', 'raw_affiliation_strings': ['Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA', 'institution_ids': ['https://openalex.org/I901861585']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074068244', 'display_name': 'Christine M. Lovly', 'orcid': 'https://orcid.org/0000-0002-3641-6361'}, 'institutions': [{'id': 'https://openalex.org/I901861585', 'display_name': 'Vanderbilt University Medical Center', 'ror': 'https://ror.org/05dq2gs74', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210162197', 'https://openalex.org/I901861585']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christine M. Lovly', 'raw_affiliation_strings': ['Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Division of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA', 'institution_ids': ['https://openalex.org/I901861585']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3170, 'currency': 'GBP', 'value_usd': 3888, 'provenance': 'doaj'}, 'apc_paid': {'value': 3170, 'currency': 'GBP', 'value_usd': 3888, 'provenance': 'doaj'}, 'fwci': 8.292, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 811, 'citation_normalized_percentile': {'value': 0.999406, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '17', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10755', 'display_name': 'HER2/EGFR in Cancer Research', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/receptor-protein-tyrosine-kinases', 'display_name': 'Receptor Protein-Tyrosine Kinases', 'score': 0.6893381}], 'concepts': [{'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.8676801}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7900925}, {'id': 'https://openalex.org/C128240485', 'wikidata': 'https://www.wikidata.org/wiki/Q786998', 'display_name': 'Autocrine signalling', 'level': 3, 'score': 0.7407108}, {'id': 'https://openalex.org/C2911166042', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor Protein-Tyrosine Kinases', 'level': 4, 'score': 0.6893381}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.52630687}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4654717}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.41918096}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.40794712}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.38332835}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3206017}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.25335425}], 'mesh': [{'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002471', 'descriptor_name': 'Cell Transformation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054730', 'descriptor_name': 'Protein Interaction Domains and Motifs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055503', 'descriptor_name': 'Protein Multimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12943-018-0782-4', 'pdf_url': 'https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-018-0782-4', 'source': {'id': 'https://openalex.org/S132829192', 'display_name': 'Molecular Cancer', 'issn_l': '1476-4598', 'issn': ['1476-4598'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/7ef4fd15475c4e329d172b59797bcc21', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5817791', 'pdf_url': 'https://europepmc.org/articles/pmc5817791?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817791', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29455648', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/s12943-018-0782-4', 'pdf_url': 'https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-018-0782-4', 'source': {'id': 'https://openalex.org/S132829192', 'display_name': 'Molecular Cancer', 'issn_l': '1476-4598', 'issn': ['1476-4598'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.77, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01CA121210'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'P01CA129243'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'P30CA068485-13S5'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'U10CA180864'}], 'datasets': [], 'versions': [], 'referenced_works_count': 200, 'referenced_works': ['https://openalex.org/W1228651778', 'https://openalex.org/W1263532934', 'https://openalex.org/W1485850033', 'https://openalex.org/W1486674271', 'https://openalex.org/W1510864192', 'https://openalex.org/W1568588443', 'https://openalex.org/W1760363395', 'https://openalex.org/W176315691', 'https://openalex.org/W1763715083', 'https://openalex.org/W1807852583', 'https://openalex.org/W1928064989', 'https://openalex.org/W1960850967', 'https://openalex.org/W1963558982', 'https://openalex.org/W1964582717', 'https://openalex.org/W1964747353', 'https://openalex.org/W1965850768', 'https://openalex.org/W1965950769', 'https://openalex.org/W1967394241', 'https://openalex.org/W1967899512', 'https://openalex.org/W1968602572', 'https://openalex.org/W1974873948', 'https://openalex.org/W1975316624', 'https://openalex.org/W1975655522', 'https://openalex.org/W1978546090', 'https://openalex.org/W1979188008', 'https://openalex.org/W1983354135', 'https://openalex.org/W1986250311', 'https://openalex.org/W1988735060', 'https://openalex.org/W1988859557', 'https://openalex.org/W1989344307', 'https://openalex.org/W1990626198', 'https://openalex.org/W1992568090', 'https://openalex.org/W1992945955', 'https://openalex.org/W1996910928', 'https://openalex.org/W1999368908', 'https://openalex.org/W2000223052', 'https://openalex.org/W2002215779', 'https://openalex.org/W2002547764', 'https://openalex.org/W2003984225', 'https://openalex.org/W2004789146', 'https://openalex.org/W2005815829', 'https://openalex.org/W2008075361', 'https://openalex.org/W2011207394', 'https://openalex.org/W2016736559', 'https://openalex.org/W2018056175', 'https://openalex.org/W2018336040', 'https://openalex.org/W2021987008', 'https://openalex.org/W2026920664', 'https://openalex.org/W2028415754', 'https://openalex.org/W2028959752', 'https://openalex.org/W2030155901', 'https://openalex.org/W2030205108', 'https://openalex.org/W2033406586', 'https://openalex.org/W2033488181', 'https://openalex.org/W2035495099', 'https://openalex.org/W2035707605', 'https://openalex.org/W2037143505', 'https://openalex.org/W2038586807', 'https://openalex.org/W2038670745', 'https://openalex.org/W2040935952', 'https://openalex.org/W2041415161', 'https://openalex.org/W2042103473', 'https://openalex.org/W2042816516', 'https://openalex.org/W2043058822', 'https://openalex.org/W2044246917', 'https://openalex.org/W2044293524', 'https://openalex.org/W2044433401', 'https://openalex.org/W2044563596', 'https://openalex.org/W2046151919', 'https://openalex.org/W2048396830', 'https://openalex.org/W2048528629', 'https://openalex.org/W2049184213', 'https://openalex.org/W2049229287', 'https://openalex.org/W2050046701', 'https://openalex.org/W2052160959', 'https://openalex.org/W2052249651', 'https://openalex.org/W2053343049', 'https://openalex.org/W2055402151', 'https://openalex.org/W2055810955', 'https://openalex.org/W2055842662', 'https://openalex.org/W2058620780', 'https://openalex.org/W2059780149', 'https://openalex.org/W2060084956', 'https://openalex.org/W2062083469', 'https://openalex.org/W2063391304', 'https://openalex.org/W2063867686', 'https://openalex.org/W2065799563', 'https://openalex.org/W2067578884', 'https://openalex.org/W2069347512', 'https://openalex.org/W2071522285', 'https://openalex.org/W2073028958', 'https://openalex.org/W2073051869', 'https://openalex.org/W2074932188', 'https://openalex.org/W2075543095', 'https://openalex.org/W2076178766', 'https://openalex.org/W2078541419', 'https://openalex.org/W2084817237', 'https://openalex.org/W2085365699', 'https://openalex.org/W2085474754', 'https://openalex.org/W2086216067', 'https://openalex.org/W2089471687', 'https://openalex.org/W2091166689', 'https://openalex.org/W2091448280', 'https://openalex.org/W2094654898', 'https://openalex.org/W2095492902', 'https://openalex.org/W2096079353', 'https://openalex.org/W2096198395', 'https://openalex.org/W2099203391', 'https://openalex.org/W2100794900', 'https://openalex.org/W2104340741', 'https://openalex.org/W2104830962', 'https://openalex.org/W2106402868', 'https://openalex.org/W2107977954', 'https://openalex.org/W2109816625', 'https://openalex.org/W2111109297', 'https://openalex.org/W2111550284', 'https://openalex.org/W2111662961', 'https://openalex.org/W2112845420', 'https://openalex.org/W2116713491', 'https://openalex.org/W2117122875', 'https://openalex.org/W2117521607', 'https://openalex.org/W2118460316', 'https://openalex.org/W2118948392', 'https://openalex.org/W2120181506', 'https://openalex.org/W2122133689', 'https://openalex.org/W2122800348', 'https://openalex.org/W2122858192', 'https://openalex.org/W2124054226', 'https://openalex.org/W2125195105', 'https://openalex.org/W2128407849', 'https://openalex.org/W2129360604', 'https://openalex.org/W2129656399', 'https://openalex.org/W2130488043', 'https://openalex.org/W2130923413', 'https://openalex.org/W2132157071', 'https://openalex.org/W2132578211', 'https://openalex.org/W2132763214', 'https://openalex.org/W2134094496', 'https://openalex.org/W2140120206', 'https://openalex.org/W2140333474', 'https://openalex.org/W2143536404', 'https://openalex.org/W2146384083', 'https://openalex.org/W2147474070', 'https://openalex.org/W2149971061', 'https://openalex.org/W2150501295', 'https://openalex.org/W2151504205', 'https://openalex.org/W2154149901', 'https://openalex.org/W2154905832', 'https://openalex.org/W2155008672', 'https://openalex.org/W2155789164', 'https://openalex.org/W2160982674', 'https://openalex.org/W2163924299', 'https://openalex.org/W2165530442', 'https://openalex.org/W2166084034', 'https://openalex.org/W2166494017', 'https://openalex.org/W2167789193', 'https://openalex.org/W2168340462', 'https://openalex.org/W2168404690', 'https://openalex.org/W2168752603', 'https://openalex.org/W2168959119', 'https://openalex.org/W2169816570', 'https://openalex.org/W2170344607', 'https://openalex.org/W2172208023', 'https://openalex.org/W2178407848', 'https://openalex.org/W2180481128', 'https://openalex.org/W2205646851', 'https://openalex.org/W2230916201', 'https://openalex.org/W2281972632', 'https://openalex.org/W2287162034', 'https://openalex.org/W2292016096', 'https://openalex.org/W2317177623', 'https://openalex.org/W2320726673', 'https://openalex.org/W2323150316', 'https://openalex.org/W2327902685', 'https://openalex.org/W2329648702', 'https://openalex.org/W2337791749', 'https://openalex.org/W2395583420', 'https://openalex.org/W2412900786', 'https://openalex.org/W2414179052', 'https://openalex.org/W2465486368', 'https://openalex.org/W2547430251', 'https://openalex.org/W2549442450', 'https://openalex.org/W2557036169', 'https://openalex.org/W2586704604', 'https://openalex.org/W2604826279', 'https://openalex.org/W2614323479', 'https://openalex.org/W2620626563', 'https://openalex.org/W2624590002', 'https://openalex.org/W2626754773', 'https://openalex.org/W266869416', 'https://openalex.org/W2738181268', 'https://openalex.org/W2761670703', 'https://openalex.org/W2769008284', 'https://openalex.org/W2770828094', 'https://openalex.org/W32529658', 'https://openalex.org/W4211075026', 'https://openalex.org/W4229791800', 'https://openalex.org/W4243930828', 'https://openalex.org/W4245849692', 'https://openalex.org/W64490004'], 'related_works': ['https://openalex.org/W4392916155', 'https://openalex.org/W284991352', 'https://openalex.org/W2755584095', 'https://openalex.org/W2394863043', 'https://openalex.org/W2321063763', 'https://openalex.org/W2244368680', 'https://openalex.org/W2198509606', 'https://openalex.org/W2088346679', 'https://openalex.org/W2075091575', 'https://openalex.org/W2061697147'], 'abstract_inverted_index': {'Receptor': [0], 'tyrosine': [1], 'kinases': [2], '(RTKs)': [3], 'play': [4], 'an': [5, 28], 'important': [6, 117], 'role': [7], 'in': [8, 47, 64, 109], 'a': [9], 'variety': [10], 'of': [11, 23, 30, 44, 113, 121], 'cellular': [12], 'processes': [13, 90], 'including': [14], 'growth,': [15], 'motility,': [16], 'differentiation,': [17], 'and': [18, 56, 79, 99], 'metabolism.': [19], 'As': [20], 'such,': [21], 'dysregulation': [22], 'RTK': [24, 62], 'signaling': [25], 'leads': [26], 'to': [27], 'assortment': [29], 'human': [31, 65, 110], 'diseases,': [32], 'most': [33], 'notably,': [34], 'cancers.': [35, 111], 'Recent': [36], 'large-scale': [37], 'genomic': [38, 75], 'studies': [39], 'have': [40], 'revealed': [41], 'the': [42, 48, 89], 'presence': [43], 'various': [45], 'alterations': [46], 'genes': [49], 'encoding': [50], 'RTKs': [51, 92, 104], 'such': [52], 'as': [53], 'EGFR,': [54], 'HER2/ErbB2,': [55], 'MET,': [57], 'amongst': [58], 'many': [59], 'others.': [60], 'Abnormal': [61], 'activation': [63], 'cancers': [66], 'is': [67], 'mediated': [68], 'by': [69], 'four': [70], 'principal': [71], 'mechanisms:': [72], 'gain-of-function': [73], 'mutations,': [74], 'amplification,': [76], 'chromosomal': [77], 'rearrangements,': [78], '/': [80], 'or': [81], 'autocrine': [82], 'activation.': [83], 'In': [84], 'this': [85], 'manuscript,': [86], 'we': [87], 'review': [88], 'whereby': [91, 103], 'are': [93], 'activated': [94, 108], 'under': [95], 'normal': [96], 'physiological': [97], 'conditions': [98], 'discuss': [100], 'several': [101], 'mechanisms': [102, 115], 'can': [105], 'be': [106], 'aberrantly': [107], 'Understanding': [112], 'these': [114], 'has': [116], 'implications': [118], 'for': [119], 'selection': [120], 'anti-cancer': [122], 'therapies.': [123]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2795353688', 'counts_by_year': [{'year': 2024, 'cited_by_count': 210}, {'year': 2023, 'cited_by_count': 182}, {'year': 2022, 'cited_by_count': 152}, {'year': 2021, 'cited_by_count': 140}, {'year': 2020, 'cited_by_count': 89}, {'year': 2019, 'cited_by_count': 31}, {'year': 2018, 'cited_by_count': 7}], 'updated_date': '2024-12-31T11:20:44.359272', 'created_date': '2018-04-06'}