Publication Information

{'id': 'https://openalex.org/W2795213157', 'doi': 'https://doi.org/10.1093/schbul/sby016.320', 'title': 'T44. A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE EFFECTS OF VITAMIN B12, B6 AND FOLIC ACID ON COGNITION AND SYMPTOMS IN FIRST-EPISODE PSYCHOSIS: THE VITAMINS IN PSYCHOSIS STUDY', 'display_name': 'T44. A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE EFFECTS OF VITAMIN B12, B6 AND FOLIC ACID ON COGNITION AND SYMPTOMS IN FIRST-EPISODE PSYCHOSIS: THE VITAMINS IN PSYCHOSIS STUDY', 'publication_year': 2018, 'publication_date': '2018-03-31', 'ids': {'openalex': 'https://openalex.org/W2795213157', 'doi': 'https://doi.org/10.1093/schbul/sby016.320', 'mag': '2795213157', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5887527'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/schbul/sby016.320', 'pdf_url': 'https://academic.oup.com/schizophreniabulletin/article-pdf/44/suppl_1/S130/25466015/sby016.320.pdf', 'source': {'id': 'https://openalex.org/S117485531', 'display_name': 'Schizophrenia Bulletin', 'issn_l': '0586-7614', 'issn': ['0586-7614', '1745-1707', '1745-1701'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://academic.oup.com/schizophreniabulletin/article-pdf/44/suppl_1/S130/25466015/sby016.320.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068152389', 'display_name': 'Kelly Allott', 'orcid': 'https://orcid.org/0000-0002-0640-4634'}, 'institutions': [{'id': 'https://openalex.org/I4210092277', 'display_name': 'Orygen Youth Health', 'ror': 'https://ror.org/00ej70p06', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092277']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Kelly Allott', 'raw_affiliation_strings': ['Orygen, The National Centre of Excellence in Youth Mental Health'], 'affiliations': [{'raw_affiliation_string': 'Orygen, The National Centre of Excellence in Youth Mental Health', 'institution_ids': ['https://openalex.org/I4210092277']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058238831', 'display_name': 'Patrick D. McGorry', 'orcid': 'https://orcid.org/0000-0002-3789-6168'}, 'institutions': [{'id': 'https://openalex.org/I4210092277', 'display_name': 'Orygen Youth Health', 'ror': 'https://ror.org/00ej70p06', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092277']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Patrick McGorry', 'raw_affiliation_strings': ['Orygen, The National Centre of Excellence in Youth Mental Health'], 'affiliations': [{'raw_affiliation_string': 'Orygen, The National Centre of Excellence in Youth Mental Health', 'institution_ids': ['https://openalex.org/I4210092277']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073386642', 'display_name': 'Hok Pan Yuen', 'orcid': 'https://orcid.org/0000-0002-1237-1322'}, 'institutions': [{'id': 'https://openalex.org/I4210092277', 'display_name': 'Orygen Youth Health', 'ror': 'https://ror.org/00ej70p06', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092277']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Hok Pan Yuen', 'raw_affiliation_strings': ['Orygen, The National Centre of Excellence in Youth Mental Health'], 'affiliations': [{'raw_affiliation_string': 'Orygen, The National Centre of Excellence in Youth Mental Health', 'institution_ids': ['https://openalex.org/I4210092277']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066622660', 'display_name': 'Colin O’Donnell', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Colin O’Donnell', 'raw_affiliation_strings': ['Donegal Mental Health Service'], 'affiliations': [{'raw_affiliation_string': 'Donegal Mental Health Service', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4562, 'currency': 'USD', 'value_usd': 4562, 'provenance': 'doaj'}, 'apc_paid': {'value': 4562, 'currency': 'USD', 'value_usd': 4562, 'provenance': 'doaj'}, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.506986, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 62, 'max': 70}, 'biblio': {'volume': '44', 'issue': 'suppl_1', 'first_page': 'S130', 'last_page': 'S130'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.9786, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10499', 'display_name': 'Folate and B Vitamins Research', 'score': 0.9786, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12267', 'display_name': 'Diet and metabolism studies', 'score': 0.901, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tolerability', 'display_name': 'Tolerability', 'score': 0.67479384}, {'id': 'https://openalex.org/keywords/b-vitamins', 'display_name': 'B vitamins', 'score': 0.46320096}], 'concepts': [{'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.6885488}, {'id': 'https://openalex.org/C2779750884', 'wikidata': 'https://www.wikidata.org/wiki/Q187706', 'display_name': 'Vitamin B12', 'level': 2, 'score': 0.68257266}, {'id': 'https://openalex.org/C2778375690', 'wikidata': 'https://www.wikidata.org/wiki/Q7814214', 'display_name': 'Tolerability', 'level': 3, 'score': 0.67479384}, {'id': 'https://openalex.org/C2779727114', 'wikidata': 'https://www.wikidata.org/wiki/Q170082', 'display_name': 'Psychosis', 'level': 2, 'score': 0.5278877}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.52528274}, {'id': 'https://openalex.org/C2777090595', 'wikidata': 'https://www.wikidata.org/wiki/Q192466', 'display_name': 'Homocysteine', 'level': 2, 'score': 0.50504595}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.48062223}, {'id': 'https://openalex.org/C3020471959', 'wikidata': 'https://www.wikidata.org/wiki/Q183206', 'display_name': 'B vitamins', 'level': 2, 'score': 0.46320096}, {'id': 'https://openalex.org/C2776412080', 'wikidata': 'https://www.wikidata.org/wiki/Q7431605', 'display_name': 'Schizophrenia (object-oriented programming)', 'level': 2, 'score': 0.4526791}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42989585}, {'id': 'https://openalex.org/C2776940978', 'wikidata': 'https://www.wikidata.org/wiki/Q34956', 'display_name': 'Vitamin', 'level': 2, 'score': 0.42383552}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.3914916}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.22817647}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/schbul/sby016.320', 'pdf_url': 'https://academic.oup.com/schizophreniabulletin/article-pdf/44/suppl_1/S130/25466015/sby016.320.pdf', 'source': {'id': 'https://openalex.org/S117485531', 'display_name': 'Schizophrenia Bulletin', 'issn_l': '0586-7614', 'issn': ['0586-7614', '1745-1707', '1745-1701'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5887527', 'pdf_url': 'https://europepmc.org/articles/pmc5887527?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887527', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/schbul/sby016.320', 'pdf_url': 'https://academic.oup.com/schizophreniabulletin/article-pdf/44/suppl_1/S130/25466015/sby016.320.pdf', 'source': {'id': 'https://openalex.org/S117485531', 'display_name': 'Schizophrenia Bulletin', 'issn_l': '0586-7614', 'issn': ['0586-7614', '1745-1707', '1745-1701'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.65}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4375860418', 'https://openalex.org/W2955852251', 'https://openalex.org/W2285783773', 'https://openalex.org/W2260773357', 'https://openalex.org/W2161842113', 'https://openalex.org/W2095559967', 'https://openalex.org/W2089131917', 'https://openalex.org/W20357304', 'https://openalex.org/W2011422062', 'https://openalex.org/W1600983513'], 'abstract_inverted_index': {'Vitamin': [0, 247], 'B12,': [1, 71, 248], 'vitamin': [2, 41, 70, 129, 133, 234, 258, 331], 'B6': [3, 72, 134, 249, 340], 'and': [4, 46, 73, 79, 82, 102, 111, 121, 132, 168, 183, 201, 217, 233, 250, 311, 339, 345, 350, 378], 'folic': [5, 74, 126, 251], 'acid': [6, 75, 127, 252], 'are': [7, 53], 'homocysteine-reducing': [8], 'agents.': [9], 'People': [10], 'with': [11, 26, 38, 86, 117, 197, 367, 370, 403], 'schizophrenia': [12, 33], 'have': [13, 17], 'been': [14, 24], 'found': [15], 'to': [16, 66, 124, 147, 364], 'increased': [18], 'homocysteine': [19, 22, 50, 78, 254, 264, 352], 'levels.': [20], 'Elevated': [21], 'has': [23, 34], 'associated': [25], 'impaired': [27], 'cognition.': [28], 'Previous': [29], 'research': [30, 382], 'in': [31, 55, 84, 106, 154, 191, 213, 256, 279, 302, 314, 329, 347, 354], 'chronic': [32], 'shown': [35], 'that': [36, 384, 391], 'supplementation': [37, 341, 358], 'folate': [39, 232], 'plus': [40], 'B12': [42, 130, 235, 338], 'can': [43, 76], 'improve': [44, 80], 'cognition': [45, 83, 155, 287, 400], 'clinical': [47], 'symptoms.': [48], 'Whether': [49], 'lowering': [51, 265], 'agents': [52], 'effective': [54], 'first-episode': [56, 87, 118, 348, 368, 404], 'psychosis': [57, 119, 349], 'is': [58], 'unknown.': [59], 'The': [60, 263], 'aim': [61], 'of': [62, 165, 231, 267, 306, 308, 319, 374, 376], 'this': [63, 355], 'study': [64], 'was': [65, 90, 294], 'investigate': [67], 'if': [68], 'adjunctive': [69], 'lower': [77, 229], 'symptomatology': [81, 170], 'people': [85], 'psychosis.': [88, 405], 'This': [89], 'a': [91, 159, 163, 273, 295, 395], 'randomised,': [92], 'double-blind,': [93], 'placebo-controlled': [94], 'trial': [95], 'conducted': [96], 'at': [97], 'the': [98, 187, 192, 207, 214, 219, 224, 257, 268, 281, 303, 316, 320, 330, 371], 'Early': [99], 'Psychosis': [100], 'Prevention': [101], 'Intervention': [103], 'Centre': [104], '(EPPIC)': [105], 'Melbourne,': [107], 'Australia.': [108], 'One': [109], 'hundred': [110], 'twenty': [112], 'patients': [113, 366], 'aged': [114], '15–26': [115], 'years': [116], 'consented': [120], 'were': [122, 152, 202, 212], 'randomised': [123, 190], 'receive': [125], '5mg,': [128], '0.4mg,': [131], '50mg': [135], 'or': [136, 285], 'placebo,': [137], 'each': [138, 245], 'taken': [139], 'once-daily': [140], 'for': [141, 401], '12': [142, 173, 261, 291, 325], 'weeks': [143], 'as': [144, 156], 'an': [145], 'adjunct': [146], 'antipsychotic': [148], 'medication.': [149], 'Co-primary': [150], 'measures': [151], 'change': [153], 'measured': [157], 'by': [158], 'composite': [160, 286], 'score': [161], 'from': [162, 204, 244], 'battery': [164], '11': [166], 'tests': [167], 'total': [169], '(PANSS)': [171], 'over': [172, 260, 276, 290, 324], 'weeks.': [174, 262, 292], 'Secondary': [175], 'outcomes': [176, 289], 'included': [177], 'additional': [178], 'cognitive,': [179], 'symptom,': [180], 'functioning,': [181], 'tolerability': [182], 'safety': [184], 'measures.': [185], 'Of': [186, 206], '120': [188], 'participants': [189], 'study,': [193], '20': [194], 'dropped': [195], 'out': [196], 'no': [198], 'follow-up': [199], 'assessments': [200], 'excluded': [203], 'analysis.': [205], 'remaining': [208], '100': [209], 'participants,': [210], '52': [211], 'vitamins': [215, 269], 'group': [216, 259, 322, 332], '48': [218], 'placebo': [220, 277, 321], 'group.': [221], 'At': [222], 'baseline,': [223], 'two': [225], 'treatment': [226], 'groups': [227, 299], 'had': [228], 'levels': [230, 255, 353], 'intake': [236], 'than': [237], 'healthy': [238], 'controls,': [239], 'but': [240], 'did': [241, 270], 'not': [242, 271, 360], 'differ': [243], 'other.': [246], 'reduced': [253], 'effects': [266], 'confer': [272], 'major': [274], 'advantage': [275], 'therapy': [278], 'improving': [280], 'co-primary': [282], 'PANSS': [283], '(p=.75)': [284], '(p=0.79)': [288], 'There': [293], 'significant': [296], 'difference': [297], 'between': [298], 'among': [300], 'females': [301, 402], 'cognitive': [304], 'domain': [305], 'speed': [307, 375], 'processing': [309, 377], '(p=.049)': [310], 'attention/vigilance': [312], '(p=0.002),': [313], 'which': [315], 'mean': [317], 'performance': [318, 328], 'declined': [323], 'weeks,': [326], 'whereas': [327], 'remained': [333], 'showed': [334], 'improvement.': [335], 'Folic': [336], 'acid,': [337], 'appears': [342], 'well': [343], 'tolerated': [344], 'safe': [346], 'lowers': [351], 'population.': [356], 'However,': [357], 'may': [359, 393], 'offer': [361], 'extra': [362], 'benefits': [363], 'all': [365], 'psychosis,': [369], 'possible': [372], 'exception': [373], 'attention/vigilance.': [379], 'Although': [380], 'previous': [381], 'suggests': [383], 'males': [385], 'preferentially': [386], 'benefit,': [387], 'our': [388], 'findings': [389], 'suggest': [390], 'there': [392], 'be': [394], 'specific': [396], 'beneficial': [397], 'effect': [398], 'on': [399]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2795213157', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-12-17T06:33:41.173136', 'created_date': '2018-04-06'}