Publication Information

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3538, 3726, 3758, 3853, 3903, 3966, 3998, 4093, 4119, 4161, 4219, 4244, 4313], 'facilitate': [9, 655, 758, 794, 1243, 3333, 4162, 4314], 'the': [10, 513, 552, 571, 575, 593, 599, 602, 633, 636, 647, 656, 671, 682, 705, 713, 723, 727, 738, 747, 759, 773, 795, 873, 881, 930, 941, 949, 953, 958, 963, 966, 982, 986, 994, 1044, 1049, 1061, 1082, 1134, 1161, 1166, 1196, 1208, 1221, 1244, 1248, 1255, 1259, 1264, 1304, 1336, 1388, 1405, 1416, 1450, 1461, 1476, 1517, 1523, 1548, 1632, 1657, 1672, 1718, 1740, 1744, 1747, 1763, 1769, 1827, 1871, 1878, 1900, 1923, 1951, 1962, 1967, 1979, 2001, 2034, 2076, 2094, 2125, 2188, 2230, 2237, 2253, 2300, 2338, 2363, 2379, 2393, 2399, 2410, 2418, 2451, 2454, 2460, 2476, 2495, 2510, 2534, 2568, 2613, 2624, 2658, 2672, 2679, 2692, 2709, 2716, 2749, 2754, 2767, 2953, 2974, 2978, 3002, 3046, 3057, 3065, 3097, 3104, 3194, 3206, 3221, 3254, 3278, 3330, 3349, 3365, 3382, 3414, 3464, 3489, 3524, 3529, 3571, 3574, 3580, 3586, 3599, 3644, 3655, 3663, 3666, 3679, 3719, 3743, 3805, 3840, 3865, 3911, 3932, 3937, 3946, 3976, 4006, 4020, 4035, 4040, 4056, 4078, 4104, 4121, 4126, 4129, 4138, 4143, 4152, 4163, 4166, 4179, 4195, 4200, 4205, 4264, 4303, 4315], 'quality': [11, 684, 714, 730, 799, 809, 868, 914, 946, 1076, 1361, 1509], 'control': [12, 685, 715, 731, 800, 810, 869, 915, 947, 1077, 1510, 1664, 1834, 2077, 2166, 2217, 3219], 'of': [13, 23, 31, 49, 57, 75, 83, 101, 109, 127, 135, 157, 165, 183, 191, 214, 222, 238, 246, 264, 272, 290, 298, 316, 324, 342, 350, 372, 380, 398, 406, 429, 437, 476, 484, 502, 512, 574, 601, 635, 658, 677, 686, 716, 726, 732, 761, 766, 780, 801, 923, 955, 1004, 1025, 1030, 1065, 1084, 1092, 1136, 1149, 1176, 1247, 1258, 1267, 1280, 1335, 1390, 1404, 1424, 1460, 1516, 1522, 1540, 1580, 1600, 1653, 1674, 1705, 1717, 1737, 1746, 1756, 1768, 1792, 1804, 1812, 1836, 1892, 1910, 1953, 1975, 2003, 2010, 2036, 2065, 2070, 2098, 2117, 2127, 2203, 2250, 2262, 2274, 2317, 2346, 2365, 2374, 2381, 2395, 2409, 2429, 2453, 2459, 2490, 2494, 2512, 2525, 2545, 2570, 2596, 2671, 2718, 2763, 2831, 2837, 2873, 2944, 2958, 2969, 3100, 3122, 3230, 3348, 3352, 3370, 3397, 3445, 3456, 3461, 3491, 3518, 3537, 3573, 3585, 3617, 3623, 3642, 3654, 3665, 3742, 3888, 3913, 3931, 3965, 4008, 4089, 4099, 4125, 4131, 4142, 4165, 4175, 4194, 4212, 4232, 4241, 4271, 4317, 4345], 'cytosolic': [14, 724, 874, 1141, 1152, 1256, 1507, 2987, 3222], 'tail-anchored': [16, 637, 690, 720, 774, 1288, 3353], 'proteins': [17, 542, 721, 816, 841, 864, 897, 956, 1094, 1153, 1186, 1229, 1289, 3328, 3354], 'Sandra': [18, 20, 233, 235, 450], 'Stefanovic-Barrett': [19, 21, 234, 236], 'Department': [22, 48, 74, 100, 126, 156, 182, 213, 237, 263, 289, 315, 341, 371, 397, 428], 'Medicine,': [24, 50, 76, 102, 128, 158, 184, 215, 239, 265, 291, 317, 343, 373, 399, 430, 477], 'Cambridge': [25, 51, 77, 103, 129, 159, 185, 216, 240, 266, 292, 318, 344, 374, 400, 431, 478], 'Institute': [26, 52, 78, 104, 130, 160, 186, 217, 241, 267, 293, 319, 345, 375, 401, 432, 479], 'for': [27, 36, 53, 62, 79, 88, 105, 114, 131, 140, 161, 170, 187, 196, 218, 227, 242, 251, 268, 277, 294, 303, 320, 329, 346, 355, 376, 385, 402, 411, 433, 442, 480, 546, 704, 858, 944, 960, 1073, 1109, 1200, 1225, 1359, 1487, 1506, 1563, 1611, 1637, 1699, 1712, 1751, 1856, 1950, 1973, 1992, 2027, 2124, 2167, 2181, 2218, 2226, 2243, 2290, 2559, 2702, 2727, 3131, 3152, 3201, 3220, 3267, 3501, 3595, 3721, 3804, 3821, 3940, 4052, 4061, 4083, 4096, 4263], 'Medical': [28, 54, 80, 106, 132, 162, 188, 219, 243, 269, 295, 321, 347, 377, 403, 434, 481], 'Research,': [29, 55, 81, 107, 133, 163, 189, 220, 244, 270, 296, 322, 348, 378, 404, 435, 482], 'University': [30, 56, 82, 108, 134, 164, 190, 221, 245, 271, 297, 323, 349, 379, 405, 436, 483], 'Cambridge,': [32, 33, 58, 59, 84, 85, 110, 111, 136, 137, 166, 167, 192, 193, 223, 224, 247, 248, 273, 274, 299, 300, 325, 326, 351, 352, 381, 382, 407, 408, 438, 439, 485, 486], 'UK': [34, 60, 86, 112, 138, 168, 194, 225, 249, 275, 301, 327, 353, 383, 409, 440, 487], 'Search': [35, 61, 87, 113, 139, 169, 195, 226, 250, 276, 302, 328, 354, 384, 410, 441], 'more': [37, 63, 89, 115, 141, 171, 197, 228, 252, 278, 304, 330, 356, 386, 412, 443, 617], 'papers': [38, 64, 90, 116, 142, 172, 198, 229, 253, 279, 305, 331, 357, 387, 413, 444], 'by': [39, 65, 91, 117, 143, 173, 199, 230, 254, 280, 306, 332, 358, 388, 414, 445, 548, 867, 920, 962, 1294, 1314, 1485, 1570, 1640, 1646, 1789, 1809, 1823, 1889, 2058, 2150, 2307, 2573, 2841, 2946, 3186, 3262, 3297, 3313, 3403, 3419, 3466, 3592, 3723, 3771, 3874, 4362], 'this': [40, 66, 92, 118, 144, 174, 200, 231, 255, 281, 307, 333, 359, 389, 415, 446, 699, 1177, 1268, 1436, 1890, 2564, 2778, 3371, 4016, 4049], 'author': [41, 67, 93, 119, 145, 175, 201, 232, 256, 282, 308, 334, 360, 390, 416, 447, 524], 'Anna': [42, 45, 257, 260, 452], 'S': [43, 46, 258, 261, 453], 'Dickson': [44, 47, 259, 262], 'Stephen': [68, 71, 283, 286, 455], 'P': [69, 72, 284, 287, 456], 'Burr': [70, 73, 285, 288], 'James': [94, 97, 202, 207, 309, 312, 417, 422, 458, 471], 'C': [95, 98, 310, 313, 459], 'Williamson': [96, 99, 311, 314], 'Ian': [120, 123, 335, 338, 461], 'T': [121, 124, 336, 339, 462], 'Lobb': [122, 125, 337, 340], 'Dick': [146, 151, 361, 366, 464], 'JH': [147, 152, 362, 367, 465], 'van': [148, 153, 363, 368], 'den': [149, 154, 364, 369], 'Boomen': [150, 155, 365, 370], 'Paul': [176, 179, 391, 394, 467], 'J': [177, 180, 392, 395, 468], 'Lehner': [178, 181, 393, 396], 'A': [203, 208, 418, 423, 472, 1320, 1499, 3134], 'Nathan': [204, 209, 419, 424, 473], 'Corresponding': [205, 420], 'Author': [206, 421, 448], '[email': [210, 425, 495], 'protected]': [211, 426, 496], 'orcid.org/0000-0002-0248-1632': [212, 427], 'Information': [449], 'Stefanovic-Barrett1,': [451], 'Dickson1,': [454], 'Burr1,': [457], 'Williamson1,': [460], 'Lobb1,': [463], 'Boomen1,': [466], 'Lehner1': [469], '*,1': [474], '1Department': [475], '*Corresponding': [488], 'author.': [489], 'Tel:': [490], '+44': [491], '1223': [492], '748483;': [493], 'E-mail:': [494], 'EMBO': [497], 'Reports': [498], '(2018)19:e45603https://doi.org/10.15252/embr.201745603': [499], 'PDFDownload': [500], 'PDF': [501], 'article': [503], 'text': [504], 'main': [506], 'figures.': [507], 'Peer': [508], 'ReviewDownload': [509], 'a': [510, 616, 778, 1022, 1103, 1212, 1272, 1341, 1364, 1378, 1421, 1488, 1531, 1584, 1594, 1624, 1798, 1833, 1917, 1989, 2025, 2165, 2216, 2268, 2366, 2370, 2385, 2486, 2557, 2594, 2700, 2742, 2810, 2828, 2838, 2869, 2898, 2904, 2985, 3190, 3499, 3956, 4169, 4229, 4251, 4320], 'summary': [511], 'editorial': [514, 518], 'decision': [515, 519], 'including': [517, 872, 1081, 1165, 1863], 'letters,': [520], 'reviewer': [521], 'comments': [522], 'responses': [525], 'to': [526, 529, 680, 793, 813, 826, 848, 893, 932, 1034, 1128, 1151, 1157, 1183, 1189, 1219, 1276, 1355, 1387, 1414, 1583, 1661, 1671, 1695, 1832, 1899, 1947, 1961, 2017, 2050, 2089, 2362, 2509, 2533, 2657, 2687, 2753, 2782, 2785, 2818, 2903, 2910, 3030, 3103, 3204, 3315, 3325, 3329, 3390, 3485, 3488, 3542, 3560, 3610, 3910, 3969, 3975, 4046, 4103, 4147, 4250, 4281], 'feedback.': [527], 'ToolsAdd': [528], 'favoritesDownload': [530], 'CitationsTrack': [531], 'CitationsPermissions': [532], 'ShareFacebookTwitterLinked': [533], 'InMendeleyWechatReddit': [534], 'Figures': [535], '&': [536], 'Info': [537], 'Abstract': [538], 'Misfolded': [539], 'or': [540, 1543, 1557, 1574, 1606, 2144, 2282, 2351, 2436, 2468, 2549, 2577, 2732, 2774, 2886, 2927, 2948, 3160, 3170, 3175, 3234, 3343, 3468, 3583, 3725, 3735, 3759, 3808, 3824, 3854, 3876, 3891, 3904, 3999, 4054, 4181, 4214, 4220, 4247, 4277, 4287, 4339, 4348, 4352], 'damaged': [541], 'are': [543, 865, 916, 1032, 1690, 1908, 2258, 2856, 3289, 3310, 3322, 3388, 3440], 'typically': [544, 842, 2982], 'targeted': [545, 857, 2190, 2340, 2400], 'destruction': [547, 1192], 'proteasome-mediated': [549, 572, 1458, 3443, 3712], 'degradation,': [550, 2424, 2506, 2799], 'but': [551, 674, 763, 1017, 1195, 2073, 2620, 2777, 2878, 2977, 3053, 3385, 3427, 3454, 3476, 3907, 4015], 'mammalian': [553, 889, 909, 1001, 1173], 'ubiquitin': [554, 890, 1222, 1238, 1329, 1865, 1872, 2803, 2805, 2820, 2832, 2852, 2855, 2870, 2900, 2921, 3492], 'machinery': [555, 891, 1198, 1223], 'involved': [556, 911, 1332, 1401, 2796], 'is': [557, 590, 741, 811, 898, 1202, 1589, 1669, 1693, 1774, 1886, 1896, 1971, 2122, 2320, 2814, 2950, 2981, 3362, 4133], 'incompletely': [558], 'understood.': [559], 'Here,': [560, 1205], 'using': [561, 1363, 1530, 2038, 2897, 3766, 3789], 'forward': [562, 1381, 1620, 1711], 'genetic': [563, 1322, 1382, 1501, 1621, 1785, 1981, 3383, 4201, 4294], 'screens': [564, 1218, 1706, 3387], 'in': [565, 609, 712, 908, 912, 917, 1060, 1102, 1133, 1215, 1230, 1307, 1333, 1345, 1402, 1492, 1511, 1656, 1681, 1702, 1722, 1739, 1762, 1826, 1955, 1959, 1964, 2000, 2005, 2033, 2093, 2177, 2229, 2236, 2252, 2260, 2277, 2471, 2523, 2575, 2589, 2611, 2655, 2691, 2730, 2745, 2748, 2766, 2797, 2849, 2866, 2882, 2925, 2990, 3045, 3064, 3076, 3096, 3155, 3171, 3189, 3238, 3253, 3277, 3364, 3381, 3480, 3528, 3628, 3651, 3883, 3955, 3986, 4073, 4178, 4199, 4216, 4273, 4355], 'human': [566, 1062, 1231, 1342, 1493, 1512, 1980, 2006, 2991], 'cells,': [567, 1002, 1174, 2619, 4075], 'we': [568, 620, 1206, 1270, 2566, 2651, 2714, 2800, 3025, 3878, 4033, 4209], 'find': [569, 1285], 'that': [570, 627, 817, 1117, 1235, 1286, 1290, 1308, 1470, 1684, 1840, 1919, 2343, 2519, 2708, 2813, 2845, 2965, 2996, 3552, 3632, 3944, 4077, 4186, 4297], 'degradation': [573, 589, 657, 760, 796, 938, 961, 1120, 1159, 1163, 1201, 1246, 1310, 1334, 1459, 1578, 1588, 1952, 1974, 2002, 2035, 2319, 2572, 2607, 2690, 2787, 2968, 3444, 3558, 3565, 4062, 4084, 4164, 4177, 4316], 'soluble': [576, 688, 718, 733, 1228, 1249, 2986, 3047, 3684], 'misfolded': [577, 734, 815, 840, 1093, 1227], 'reporter,': [578], 'mCherry-CL1,': [579, 762, 1581, 3446], 'involves': [580], 'two': [581, 1236, 1810, 1864, 1994, 4196], 'ER-resident': [582, 667, 706, 751, 1026, 1167, 1237, 1282, 1995], 'E3': [583, 643, 707, 752, 870, 926, 971, 988, 1027, 1168, 1330, 1770, 1866, 1996], 'ligases,': [584, 708, 753, 871, 1046, 1239, 1867], 'TRC8.': [587, 784, 4307], 'mCherry-CL1': [588, 1305, 1440, 1471, 1518, 1549, 1602, 1794, 1901, 2004, 2016, 2037, 2055, 2071, 2107, 2128, 2131, 2168, 2174, 2219, 2239, 2275, 2303, 2318, 2354, 2423, 2444, 2472, 2505, 2546, 2571, 2585, 2606, 2656, 2689, 2720, 2747, 2786, 2863, 2893, 2945, 2970, 2997, 3033, 3041, 3078, 3101, 3107, 3118, 3123, 3153, 3157, 3179, 3258, 3275, 3431, 3462, 3481, 3541, 3557, 3612, 3734, 3736, 3793, 3822, 3841, 3900, 3971, 4009, 4066, 4100, 4167, 4176, 4233, 4253, 4280, 4318, 4324], 'routed': [591], 'via': [592, 1160], 'ER': [594, 748, 950, 959, 983, 1260, 1764, 1924, 2090, 2100, 2975, 3018, 3141, 3331, 3451], 'membrane': [595, 997, 1925, 2956, 3068, 3098, 3210, 3224, 3452, 3465, 3671, 3709], 'dependent': [597, 742, 2951, 3448], 'on': [598, 743, 1130, 1930, 1933, 1936, 2061, 2106, 2443, 2952, 3449, 4005], 'hydrophobicity': [600, 2954, 3572, 3618, 3638, 3664, 3706, 3717, 3870, 4132], 'substrate,': [603], 'with': [604, 646, 746, 789, 1087, 1140, 1303, 1449, 1456, 1553, 1605, 1623, 1631, 1797, 2020, 2046, 2080, 2136, 2417, 2499, 2556, 2593, 2937, 3012, 3035, 3088, 3127, 3159, 3306, 3442, 3512, 3614, 3640, 3694, 3708, 3738, 3752, 3811, 3847, 3868, 3925, 3982, 4026, 4135, 4191, 4218, 4245, 4275, 4284, 4331], 'complete': [605, 3652, 4230, 4252], 'stabilisation': [606, 2126, 2169, 2220, 2380, 2670, 3460, 3482, 3653, 4098], 'only': [607, 2846, 3554, 3908, 4192], 'observed': [608, 1484, 2019, 2079, 2918, 3021, 3075, 3989, 4262], 'double': [610, 4225], 'knockout': [611], 'MARCH6/TRC8': [612, 2284, 2734, 3240, 3255, 3285, 3894, 3992, 4289], 'cells.': [613, 1232, 1666, 2007, 2207, 2286, 2992, 3242, 3257], 'To': [614, 1262, 2562, 2706, 2790, 3862, 4203], 'identify': [615, 1220, 1277, 1356], 'physiological': [618], 'correlate,': [619], 'used': [621, 1127, 2163, 2214, 2801, 2983, 3138, 3217], 'quantitative': [622, 1273, 2829], 'mass': [623, 770], 'spectrometry': [624, 771], 'found': [626, 1694], 'depletion': [631, 2009, 2097, 2373, 2551, 3412, 3470, 3895, 3906, 3964, 4001, 4088, 4270, 4290], 'altered': [632, 2711, 3936], 'turnover': [634], 'protein': [638, 683, 798, 808, 913, 945, 1075, 1142, 1360, 1443, 1491, 1508, 2251, 2357, 2478, 2625, 2673, 3634, 3681], 'heme': [639], 'oxygenase-1': [640], '(HO-1).': [641], 'These': [642, 2085, 3438, 4293], 'ligases': [644, 668, 878, 927, 972, 1331, 1997, 2091, 2647, 2710, 2939, 3293, 3497, 3806, 4197], 'associate': [645, 788], 'intramembrane': [648, 661, 804, 1292], 'cleaving': [649], 'signal': [650, 790, 1295], 'peptide': [651, 791, 1296], 'peptidase': [652, 792, 1297], '(SPP)': [653, 1298], 'HO-1': [659, 802], 'following': [660, 803, 1447, 1478, 2547, 2662, 2721, 3004, 3038, 3054, 3801, 3892, 3902, 3916, 3990], 'proteolysis.': [662, 805], 'Our': [663, 2962], 'results': [664], 'highlight': [665], 'how': [666], 'may': [669, 818, 2771], 'target': [670], 'same': [672, 3977, 4304], 'substrates,': [673], 'work': [675, 764], 'independently': [676, 765], 'each': [678, 767, 2066, 3889], 'other,': [679], 'optimise': [681], 'selected': [687, 717, 1287, 1845], 'proteins.': [691], 'Synopsis': [692], 'Using': [693], 'near-haploid': [694, 1321, 1346, 1500], 'CRISPR-Cas9': [696], 'mutagenesis': [697, 1217, 1343, 1791], 'screens,': [698], 'study': [700], 'identifies': [701, 772, 1324, 1503], 'overlapping': [702, 3474, 3514, 3581], 'functions': [703, 3475, 3582], 'TRC8,': [711, 756, 2029, 3877, 4148, 4340], 'at': [722, 948, 981, 993, 1254, 1743, 1922, 2299, 2973, 3050, 3198, 3463], 'face': [725, 1257], 'ER.': [728], 'Protein': [729], 'proteins,': [735, 1978], 'such': [736, 828, 1047, 3943], 'as': [737, 777, 829, 1012, 1048, 1112, 1211, 1328, 1368, 1420, 1483, 1593, 2096, 2164, 2215, 2267, 2984, 3139, 3218, 3341, 3417, 3495, 3637, 3662, 3832, 3856, 3979, 4019, 4255, 4306], 'CL1': [739, 1097, 1150, 1209, 1251, 1337, 1366, 1417, 1527, 1976, 2712, 2798, 2979, 3360, 3575, 3600, 3605, 3608, 3626, 3667, 3680, 3705, 3716, 3825, 3866, 3941, 3947, 4021, 4041, 4106, 4127, 4144, 4155], 'degron,': [740, 1306, 3942, 4128], 'their': [744, 934, 979, 1158, 1190, 1309, 2703, 3334, 3513, 3633, 3670, 3880], 'association': [745, 2957, 3453, 3672, 3710], 'membrane.': [749, 1261, 1765], 'The': [750, 888, 902, 1096, 1627, 1735, 1766, 1784, 1882, 2542, 2760, 3336, 3458, 3898, 4065, 4172], 'both': [757, 781, 1058, 1315, 1984, 2011, 2118, 2560, 2612, 2646, 2938, 3496, 3760, 3855, 3945, 4090, 4116], 'other.': [768], 'Quantitative': [769], 'protein,': [775, 1880], 'HO-1,': [776], 'substrate': [779, 1214, 1252, 2389], 'Introduction': [806], 'Intracellular': [807], 'essential': [812], 'remove': [814, 894], 'otherwise': [819], 'promote': [820, 973, 3319], 'aggregate': [821], 'formation': [822, 2397], 'toxicity,': [824], 'leading': [825], 'conditions': [827], "Alzheimer's": [830], 'disease,': [831], "Parkinson's": [832], 'disease': [833], 'cystic': [835], 'fibrosis': [836], '1,': [837], '2.': [838, 2115], 'Terminally': [839], 'have': [843, 1078, 3473], 'exposed': [844, 1088, 3307], 'hydrophobic': [845, 1089, 1371, 3308, 3596, 3646, 3687, 3745, 3934, 4122, 4140, 4154], 'domains': [846, 1090, 3309], 'prone': [847], 'aggregation': [849, 1143], '3': [850], 'can': [852, 1311, 4150], 'be': [853, 1312, 1696, 1948, 3486], 'ubiquitinated': [854, 866], 'selectively': [856], 'proteasomal': [859, 1191, 1245], 'degradation.': [860, 3320, 3713], 'In': [861, 968, 1000, 1146, 1172], 'yeast,': [862, 969, 1147], 'these': [863, 1031, 1281, 1703, 1993, 2491, 2920, 3386, 3624], 'Ubr1p': [875], 'San1p': [877], '4-6': [879], 'endoplasmic': [882], 'reticulum': [883], '(ER)-resident': [884], 'ligase': [885, 989, 1169, 1771, 2704, 3938], 'Doa10p': [886, 977, 1008, 1170], '7-9.': [887], 'required': [892, 1199, 1224, 1358, 1505, 1949, 2123, 3324, 4051, 4082, 4095], 'aberrantly': [895], 'folded': [896], 'less': [899, 4153], 'clearly': [900], 'defined.': [901], 'increased': [903, 1446, 2068, 2353, 2865, 3636, 3901, 4259], 'diversity': [904], 'complexity': [906], 'seen': [907, 2661, 4283], 'enzymes': [910, 2463], 'part': [918, 3347], 'driven': [919], 'an': [921, 1113, 1369, 1793, 1927, 2653, 3094, 3140], 'expansion': [922, 1024], 'E2': [924, 1873], '10,': [928], 'highlighting': [929], 'need': [931], 'elucidate': [933], 'detailed': [935], 'functions.': [936], 'ER-associated': [937], '(ERAD)': [939], 'provides': [940, 1377], 'major': [942], 'mechanism': [943], 'membrane,': [951, 2976], 'facilitating': [952], 'dislocation': [954], 'from': [957, 2187, 2296, 2337], 'proteasome': [964, 1110, 1131, 1372, 1451, 1479, 2021, 2081, 2663, 2722, 2988, 3005, 3039, 3055, 3162, 3914, 3980, 4285], 'within': [965, 1475, 2398, 3598, 4039, 4302], 'cytosol.': [967], 'three': [970], 'ERAD:': [974], 'Hrd1p': [975, 1005, 1035], 'recognise': [978, 4120], 'substrates': [980, 1086, 1111, 1279], '11,': [984], 'while': [985, 1039, 2425, 4115], 'Asi': [987], 'complex': [990, 1918, 3357], 'facilitates': [991], 'ERAD': [992, 1015, 1064, 1162, 1397], 'inner': [995], 'nuclear': [996], '12,': [998], '13.': [999], 'orthologues': [1003, 1909], '(HRD1)': [1006], '(MARCH6,': [1009], 'also': [1010, 1020, 1187, 2609, 3251, 3295, 3323, 3673], 'known': [1011, 3340], 'TEB4)': [1013], 'support': [1014, 2261], '14-17,': [1016], 'there': [1018], 'has': [1019, 1124, 1385], 'been': [1021, 1079, 1125, 1843], 'marked': [1023, 2743], 'ligases.': [1028, 1283, 2561, 3587], 'Some': [1029], 'homologous': [1033], '(e.g.': [1036, 1154], 'gp78)': [1037], '18,': [1038, 2632], 'others': [1040, 1486], 'do': [1041], 'not': [1042, 1203, 1709, 1842, 1897, 2503, 2780, 3429, 3686, 3698, 4081], 'resemble': [1043], 'yeast': [1045, 1911, 1956, 1965], 'RING-H2': [1050], 'containing': [1051], '19': [1053], 'TMEM129': [1055], '20,': [1056], '21,': [1057], 'implicated': [1059, 3363], 'cytomegalovirus-mediated': [1063], 'MHC': [1066], 'class': [1067], 'I': [1068], 'molecules.': [1069], 'Several': [1070, 3588], 'reporter': [1071, 1413, 1437, 1462, 1550, 2989, 3280, 3526, 3656, 4022, 4068], 'systems': [1072], 'investigating': [1074], 'developed,': [1080], 'generation': [1083], 'artificial': [1085], 'typical': [1091], '22.': [1095, 3015], 'degron': [1098, 1210, 1338, 1367, 2980, 3058, 3372], 'was': [1099, 1472, 1708, 1787, 2162, 2213, 2376, 2517, 2554, 2586, 2608, 2741, 2998, 3020, 3042, 3059, 3137, 3196, 3550, 3682, 3697, 3967, 4017, 4050, 4059, 4069, 4080, 4094, 4257], 'originally': [1100], 'identified': [1101, 1645, 1679, 1822, 1983, 2092, 3380, 4198], 'Saccharomyces': [1104], 'cerevisiae': [1105, 2536], '(S.': [1106], 'cerevisiae)': [1107], 'screen': [1108, 1323, 1344, 1502, 1622, 1786, 1982], 'unstable': [1114, 1370], 'C-terminal': [1115, 1422], 'extension': [1116, 1423], 'promotes': [1118, 1920], 'rapid': [1119, 3562], '7,': [1121], '23,': [1122], 'widely': [1126], 'report': [1129], 'activity': [1132], 'context': [1135], 'neurological': [1137], 'diseases': [1138], 'associated': [1139, 3034, 3693, 4025], '24,': [1144], '25.': [1145], 'attachment': [1148], 'Ura3p)': [1155], 'leads': [1156, 1188], 'machinery,': [1164], '23.': [1171, 1957], 'fusion': [1175, 1490, 1977, 2812], '16': [1178, 1524, 2160, 2211, 3132, 3167], 'amino': [1179, 1525], 'acid': [1180, 1526], 'amphipathic': [1181, 1418, 1528, 2960, 3576, 3601, 4042], 'helix': [1182, 1529, 2961, 3577, 4043, 4107], 'usually': [1184], 'stable': [1185], '22,': [1193, 1495], '26,': [1194], 'molecular': [1197], 'known.': [1204], 'use': [1207, 1271], 'model': [1213], 'unbiased': [1216, 1380], 'degrading': [1226], 'We': [1233, 1284, 1339, 1409, 2023, 3393, 3567], 'show': [1234], 'MARCH6,': [1242, 1987, 2028, 2145, 2280, 2347, 3757, 3852], 'fluorescent': [1250, 1365, 1412, 2477, 3525, 3625], '(mCherry-CL1)': [1253], 'establish': [1263], 'biological': [1265], 'significance': [1266], 'pathway,': [1269, 3416], 'proteomic': [1274], 'approach': [1275, 1894], 'potential': [1278], 'undergo': [1291], 'proteolysis': [1293], '27': [1299], 'share': [1300], 'some': [1301, 3017], 'properties': [1302], 'mediated': [1313], 'MARCH6.': [1318], 'Results': [1319], 'established': [1340], 'KBM7': [1347, 1430, 1541, 1619, 1665, 1795], 'cells': [1348, 1433, 1494, 1513, 1545, 1603, 1628, 1639, 1839, 2042, 2132, 2191, 2276, 2474, 2580, 2592, 2736, 2751, 2770, 2848, 2867, 2883, 3085, 3125, 3158, 3183, 3269, 3281, 3287, 3396, 3532, 3630, 3730, 3837, 4211, 4325], '(karyotype': [1349], '25,': [1350], 'XY,': [1351], '+8,': [1352], 'Ph+)': [1353], '28': [1354], 'genes': [1357, 1400, 1504, 1655, 1728, 1852, 2053, 4347], 'control,': [1362], 'substrate.': [1373], 'This': [1374], 'screening': [1375, 1893], 'methodology': [1376], 'powerful': [1379], 'approach,': [1383], 'which': [1384, 1445, 2792, 2850, 3345, 4149, 4224], 'led': [1386, 4249], 'identification': [1389], 'novel': [1391], 'pathogen': [1392], 'restriction': [1393], 'factors,': [1394], 'epigenetic': [1395], 'regulators,': [1396], 'components': [1398], 'regulation': [1403], 'hypoxia': [1406], 'response': [1407], '28-33.': [1408], 'designed': [1410], 'our': [1411, 3926], 'encode': [1415], 'sequence': [1419, 3602], 'mCherry': [1425, 1567, 1806, 2147, 2227, 2294, 3401, 3881, 3987, 4358], '(Fig': [1426, 1463, 1481, 1817, 1846, 1859, 1906, 1998, 2083, 2359, 2403, 2527, 2552, 2581, 2602, 2665, 2674, 2788, 3022, 3070, 3086, 3109, 3533, 3545, 3619, 3657, 3675, 3700, 3896, 3920, 3959, 3994, 4011, 4028, 4063, 4085, 4108, 4235, 4267, 4291], '1A': [1427], 'B).': [1429, 2113, 3410, 3437, 4238], 'HeLa': [1432, 1544, 1601, 2041, 2130, 2238, 2473, 2591, 2755, 3077, 3106, 3124, 3156, 3178, 3629, 3729, 3836, 4074, 4323], 'stably': [1434, 3731, 3838], 'expressing': [1435, 1547, 2884, 3732, 3839], 'showed': [1438, 2879, 3498, 3631], 'low': [1439, 2761], 'fluorescence': [1441, 1807, 2056, 2072, 2148, 2355, 4234, 4256], 'levels,': [1444], 'incubation': [1448], 'inhibitor,': [1452], 'bortezomib': [1453, 1561, 1610, 2159, 2210, 3130, 3166, 3812], '(Velcade),': [1454], 'consistent': [1455, 2555, 2936, 3011, 3441, 3511, 3924], 'constitutive': [1457], '1C': [1464], 'D).': [1466], 'Confocal': [1467, 1598, 2993, 3120], 'immunofluorescence': [1468], 'demonstrated': [1469], 'diffusely': [1473, 2999], 'distributed': [1474, 3000, 3063], 'cytosol': [1477, 3066, 3207], 'inhibition': [1480, 2022, 2082, 2664, 2723, 3006, 3163, 3915, 4286], '1E),': [1482], 'GFP-CL1': [1489], '26.': [1496], 'Figure': [1497, 2114, 3111, 3714, 4308], '1.': [1498], 'A.': [1514, 2129, 3119], 'Schematic': [1515, 1755], 'reporter.': [1519, 1902], 'B.': [1520, 2172, 3728], 'Diagram': [1521], 'helical': [1532], 'wheel': [1533, 3768, 3787], 'prediction': [1534], '(http://rzlab.ucr.edu/scripts/wheel/wheel.cgi).': [1535], 'C,': [1536], 'D.': [1537, 2223, 3835], 'Clonal': [1538], 'populations': [1539, 2195, 2341, 3887, 4344], '(left)': [1542], '(right)': [1546], 'were': [1551, 1629, 1685, 1821, 1853, 1945, 2043, 2087, 2133, 2288, 2305, 2648, 2795, 2895, 2917, 2923, 2971, 3074, 3184, 3216, 3250, 3260, 3294, 3379, 3483, 3590, 3749, 3799, 3844, 3871, 3952, 4328, 4360], 'incubated': [1552], '40': [1554], 'nM': [1555, 1559, 1609, 2158, 2209, 3129, 3165], '(KBM7)': [1556], '100': [1558, 1608], '(HeLa)': [1560], '(Btz)': [1562, 3813], '6': [1564, 1612], 'h': [1565, 2161, 2212, 3203], 'levels': [1568, 2018, 2069, 2078, 2108, 2175, 2228, 2257, 2304, 2358, 2445, 2826, 2864, 2894, 3154, 3259, 3276, 3402, 3422, 3432, 3527, 3544, 3635, 3797, 3882, 3988, 4007, 4282, 4359], 'measured': [1569, 2057, 2149, 2306, 2567, 2715, 3261, 3800, 3879, 4361], 'flow': [1571, 2059, 2151, 2842, 3263, 3404, 4363], 'cytometry': [1572, 2060, 2152, 3264, 3405], '(C)': [1573, 3208], 'immunoblot': [1575, 2225, 3298], '(D).': [1576], '*Presumed': [1577], 'product': [1579], 'present': [1582], 'variable': [1585], 'extent': [1586], 'when': [1587, 2645, 2919], 'impaired.': [1590], 'β-actin': [1591, 2265], 'served': [1592, 2266], 'loading': [1595, 2269], 'control.': [1596, 2270], 'E.': [1597], 'microscopy': [1599, 2994, 3121], 'treated': [1604, 3126], 'without': [1607, 3161], 'h.': [1613, 3133], 'Scale': [1614, 3143], 'bar,': [1615, 3144], '10': [1616, 2291, 3145], 'μm.': [1617, 3146], 'F.': [1618, 2272], 'mCherry-CL1-expressing': [1625], 'clone.': [1626, 2255], 'mutagenised': [1630, 1663, 1838], 'Z-loxP-GFP': [1633], 'gene-trap': [1634, 1677, 1700, 1720, 1837], 'retrovirus,': [1635, 1800], 'enriched': [1636, 1654, 1687, 1698, 1719, 1855, 1888], 'mCherryHIGH': [1638, 1658, 1828], 'FACS,': [1641], 'insertion': [1643], 'sites': [1644], 'MiSeq': [1647], 'Illumina': [1648, 1824], 'sequencing.': [1649], 'G.': [1650], 'Bubble': [1651, 1667], 'plot': [1652], 'population': [1659, 1829, 2200, 2840], 'compared': [1660, 1831, 2752, 2902, 3102, 4146], 'unsorted': [1662], 'size': [1668], 'proportional': [1670], 'number': [1673], 'independent': [1675, 3455], 'inactivating': [1676], 'integrations': [1678], '(shown': [1680], 'brackets).': [1682], 'Genes': [1683], 'significantly': [1686, 2783], '(>': [1688], '−log(p)5)': [1689], 'shown': [1691, 1946, 2259, 2321, 4354], '(SPEN': [1692], 'frequently': [1697, 1887], 'insertions': [1701, 1721, 1738, 1820, 1858], 'types': [1704], 'taken': [1710], 'further': [1713, 2449, 4260], 'validation).': [1714], 'H.': [1715], 'Location': [1716], 'AUP1,': [1723, 1757, 1934, 2182, 2231, 2244, 3079, 3172, 4158, 4337], 'UBE2G2,': [1724, 1758, 2142, 2183, 2232, 2411, 3080, 3173], '(red,': [1729], 'sense': [1730], 'insertion;': [1731], 'blue,': [1732], 'antisense': [1733], 'insertion).': [1734], 'predominance': [1736], 'correct': [1741, 4206], 'orientation': [1742], 'start': [1745], 'gene': [1748, 2067, 2455, 4226], 'indicates': [1749], 'enrichment': [1750, 1803], 'gene-trapping': [1752, 1799], 'mutations.': [1753], 'I.': [1754], 'position': [1767], 'RING': [1772], 'domain': [1773, 1929], 'shown.': [1775, 3290], 'SSC': [1776], '=': [1777, 2327], 'side': [1778], 'scatter.': [1779], 'Download': [1780, 1782, 2329, 2331, 3301, 3303, 3858, 3860], 'figure': [1781, 2330, 3302, 3859], 'PowerPoint': [1783, 2332, 3304, 3861], 'performed': [1788], 'insertional': [1790], 'clone': [1796], 'selective': [1802], 'high': [1805], '(mCherryHIGH)': [1808], 'rounds': [1811], 'fluorescence-activated': [1813], 'cell': [1814, 3003], 'sorting': [1815], '(FACS)': [1816], '1F).': [1818], 'Gene-trapping': [1819], 'sequencing': [1825], 'library': [1835], 'had': [1841, 2103, 2440, 4002], 'phenotypically': [1844], '1G': [1847, 1860], 'Dataset': [1849], 'EV1).': [1850], 'Five': [1851], 'highly': [1854], 'trapping': [1857], 'H),': [1862], 'MARCH6;': [1870], 'conjugating': [1874], 'enzyme,': [1875], 'UBE2G2;': [1876], 'ubiquitin-binding': [1879], 'AUP1.': [1881, 2514], 'fifth': [1883], 'gene,': [1884], 'SPEN,': [1885], 'type': [1891, 3490], 'specific': [1898, 2088, 2344], 'UBE2G2': [1903, 2030, 2245, 2350, 2430, 2526, 4159, 4182, 4189, 4215, 4248, 4278, 4298, 4311, 4338], 'AUP1': [1905, 1931, 2032, 2352, 2496, 2501, 2520, 4180, 4187, 4213, 4246, 4276, 4300], '1I)': [1907, 1999], 'Ubc7p': [1912, 1942, 2540], 'Cue1p': [1914, 1944, 2538], 'form': [1916], 'ubiquitination': [1921, 2765, 2966, 3369, 4053], 'through': [1926, 2378, 4168, 4319], 'E2-binding': [1928], '(G2BR': [1932], 'U7BR': [1935], 'Cue1p)': [1937], '8,': [1938], '34,': [1939], '35.': [1940], 'Interestingly,': [1941], 'Ura3p-CL1': [1954], 'However,': [1958, 2515, 3016, 3510, 3929, 4269], 'contrast': [1960], 'studies': [1963, 3151, 3820], 'where': [1966], 'homologue,': [1969], 'Doa10p,': [1970], 'sufficient': [1972, 3968], 'predicting': [1988], 'non-redundant': [1990], 'role': [1991, 2026], 'Combined': [2008], 'stabilises': [2015], 'validated': [2024, 2377], 'CRISPR/Cas9': [2039], 'depletion.': [2040], 'transiently': [2044, 2134, 3750, 3845, 4329], 'transfected': [2045, 2135, 3751, 3846, 4330], 'Cas9': [2047, 2137, 3753, 3848, 4332], 'sgRNA': [2049, 2139, 2189, 3755, 3802, 3850, 4242, 4335], 'all': [2051, 3089, 3643], 'four': [2052, 3090], 'day': [2062], '7.': [2063], 'Depletion': [2064, 2116], 'never': [2074, 4258], 'reached': [2075], '2A).': [2084], 'findings': [2086, 2916, 2963, 3073], 'screen,': [2095, 3384], 'another': [2099], 'ligase,': [2101, 3890], 'gp78,': [2102], 'no': [2104, 2441, 2880, 3691, 3983, 4003, 4023], 'effect': [2105, 2442, 2489, 4004], '(Appendix': [2109, 2446, 2479, 2696, 2737, 2757, 2858, 2889, 2931, 3406, 3424, 3433, 3505], 'Fig': [2110, 2406, 2447, 2480, 2530, 2640, 2697, 2738, 2758, 2859, 2890, 2913, 2932, 3407, 3425, 3434, 3506], 'S1A': [2111], 'targeting': [2140, 3756, 3851, 4243, 4336], 'AUP,': [2141, 4310], 'after': [2153, 3809], '7': [2154], 'days': [2155], '(blue).': [2156], '20': [2157, 2208, 3128], '(brown': [2170, 2221, 3814], 'line).': [2171, 2222], 'Representative': [2173, 2224], '(green)': [2176, 3288], 'isolated': [2178, 2336], 'KO': [2179, 2206, 2240, 2627, 2634, 3091, 3177, 3886, 4183, 4227, 4343], 'clones': [2180, 2335, 2416, 2498, 2695, 2930, 3180, 4184], '(A).': [2192, 3792], 'C.': [2193, 3148, 3817], 'Mixed': [2194], '(shaded': [2196, 2201, 4326], 'blue)': [2197], 'clonal': [2199, 2372], 'green)': [2202], 'combined': [2204, 2283, 2733, 2768, 3239, 3284, 3530, 3893, 3917, 3991, 4288], 'TRC8/MARCH6': [2205, 3918], 'clones.': [2241], 'Antibodies': [2242], 'confirmed': [2248, 2342, 2995], 'loss': [2249, 2345, 2521, 3919, 3993], 'relevant': [2254], 'SQLE': [2256], 'deficiency.': [2264], 'E,': [2271], '[35S]methionine/cysteine-radiolabelling': [2273, 2574], 'wild-type': [2278, 2420, 2500, 2590, 2731, 2802, 3105, 3733, 3794, 3823], '(WT),': [2279], 'null': [2285, 2415, 2497, 2579, 2615, 2618, 2694, 2735, 2769, 2929, 3084, 3241, 3256, 3286], 'Cells': [2287], 'pulse-radiolabelled': [2289], 'min,': [2292], 'immunoprecipitated': [2295], 'detergent': [2297], 'lysates': [2298, 3108], 'times': [2301], 'indicated.': [2302], 'autoradiography': [2308], '(E)': [2309], 'quantification': [2311], '(using': [2312], 'ImageJ': [2313], 'GraphPad': [2315], 'Prism)': [2316], '(F).': [2322], 'Mean': [2323], '±': [2324, 2631, 2638], 'SEM,': [2325], 'n': [2326], '3.': [2328, 3112], 'Knockout': [2333], '(KO)': [2334], 'CRISPR': [2339, 3885], 'E3,': [2349], '2B–D).': [2360], 'Due': [2361], 'lack': [2364], 'suitable': [2367], 'antibody,': [2369], 'functional': [2371], 'squalene': [2382], 'monooxygenase': [2383], '(SQLE),': [2384], 'previously': [2386, 3833], 'reported': [2387], '16,': [2390], '36,': [2391], 'presence': [2394], 'indel': [2396], 'locus': [2402], '2D,': [2404, 2528], 'Appendix': [2405, 2529, 2912], 'S2).': [2407], 'Reconstitution': [2408, 2493], 'respective': [2419, 2693], 'cDNA': [2421], 'restored': [2422, 3540, 3556], 'catalytically': [2426, 2461, 2683], 'inactive': [2427, 2462, 2684, 3244], 'forms': [2428, 3346], '(UBE2G2': [2431, 2464], 'C89A),': [2432], '(TRC8': [2434], 'ΔRING)': [2435], '(MARCH6': [2438, 2626, 3246], 'C9A)': [2439, 2470], 'S3A–F),': [2448], 'confirming': [2450], 'specificity': [2452, 3584, 3720, 3939], 'KOs.': [2456], 'Moreover,': [2457, 2892, 3661, 3963, 4087], 'overexpression': [2458, 3536], 'C89A,': [2465], 'ΔRING': [2467], 'stabilised': [2475, 2623, 3060, 3909], 'S3B,': [2481], 'D': [2482], 'F),': [2484], 'demonstrating': [2485, 2699], 'dominant': [2487], 'negative': [2488], 'mutants.': [2492], 'did': [2502, 2650, 2779, 3428], 'restore': [2504, 2688], 'principally': [2507], 'due': [2508, 3487, 3559], 'toxicity': [2511], 'ectopic': [2513, 3516], 'it': [2516, 3690], 'likely': [2518], 'resulted': [2522], 'destabilisation': [2524], 'S3G),': [2531], 'similar': [2532, 2817, 4102], 'S.': [2535], 'orthologues,': [2537], '37.': [2541], 'incomplete': [2543, 4173], 'rescue': [2544, 4174], '2A)': [2553], 'requirement': [2558, 2701, 3500], 'explore': [2563], 'further,': [2565], 'rate': [2569], '2E': [2582, 2603, 2641, 2675], 'F).': [2584, 2605, 2643, 2677, 3273], 'rapidly': [2587, 4071], 'degraded': [2588, 3699, 3873, 3953, 4072], 'half-life': [2595, 2628, 2635], '21': [2597], 'min': [2598, 2630, 2637], '(±': [2599], '5': [2600], 'min)': [2601], 'decreased': [2610, 3420, 3523, 3674, 3869], 'neither': [2621], 'completely': [2622, 3539], '42': [2629], '62': [2636], '20;': [2639], 'Only': [2644], 'depleted': [2649, 3395, 4210], 'observe': [2652], 'increase': [2654, 3095], 'equivalent': [2659], 'level': [2660, 2762, 3912, 3978], '2C': [2666], 'D)': [2668], 'Both': [2678], 'mutants': [2685, 2888, 2922, 3245, 3737, 3826, 3867], 'failed': [2686], 'S3),': [2698], 'activity.': [2705], 'confirm': [2707], 'ubiquitination,': [2713, 2776], 'accumulation': [2717], 'polyubiquitinated': [2719, 2746], '(MG132,': [2724], '50': [2725], 'μM': [2726], '2': [2728], 'h)': [2729, 3168], 'S4A).': [2739, 2759], 'There': [2740], 'reduction': [2744], 'MARCH6-/TRC8-deficient': [2750, 3531], 'controls': [2756], 'residual': [2764], 'reflect': [2772], 'MARCH6-': [2773], 'TRC8-independent': [2775], 'seem': [2781], 'contribute': [2784], '2F).': [2789], 'determine': [2791, 3031, 3863, 4047, 4204], 'polyubiquitin': [2793], 'linkages': [2794, 2876, 3504], 'lysine': [2806, 4037, 4079], '(K)': [2807], 'mutants,': [2808], 'encoding': [2809], 'GFP': [2811, 2825], 'co-translationally': [2815], 'cleaved,': [2816], 'endogenous': [2819, 2854], 'processing': [2821], '38,': [2822], '39.': [2823], 'Therefore,': [2824], 'provide': [2827], 'marker': [2830], 'expression': [2833, 3229, 3517, 3622], 'allow': [2835], 'gating': [2836], 'GFPHIGH': [2839], 'cytometry,': [2843], 'so': [2844], 'those': [2847], 'mutant': [2851, 2871, 2906, 3796, 3843, 4156], 'outcompetes': [2853], 'analysed': [2857], 'S4B': [2860, 2933, 3507], 'C).': [2862], 'overexpressing': [2868], 'incapable': [2872], 'forming': [2874, 2940, 3502], 'K48': [2875], '(Ub-K48R),': [2877], 'change': [2881, 3985], 'Ub-K63R': [2885], 'Ub-K11R': [2887], 'S4C).': [2891], 'rescued': [2896, 4279], 'K48-only': [2899], 'construct': [2901], 'Ub-K0': [2905], '(all': [2907], 'lysines': [2908], 'mutated': [2909, 4034], 'arginines;': [2911], 'S4B).': [2914], 'Similar': [2915, 3072], 'expressed': [2924], 'C),': [2935], 'K48-ubiquitin': [2941, 3503], 'linkages.': [2942], 'Degradation': [2943], 'its': [2959, 3450, 3561], 'suggested': [2964, 3471], 'initiated': [2972], 'throughout': [3001], '(Figs': [3007], '1E': [3008], '3A),': [3010], 'prior': [3013, 3927], 'reports': [3014], 'co-localisation': [3019], '3A)': [3023], 'therefore': [3026, 3394], 'probed': [3027], 'subcellular': [3028], 'fractionations': [3029], 'whether': [3032, 3570, 3864, 4048, 4055], 'membranous': [3036], 'compartments': [3037], 'inhibition.': [3040], 'predominantly': [3043], 'detected': [3044], '(cytosolic)': [3048], 'fraction': [3049, 3099], 'steady': [3051], 'state': [3052], 'inhibition,': [3056, 3981], 'equally': [3062], 'fractions': [3069], '3B).': [3071], '3C),': [3087], 'lines': [3092], 'showing': [3093], '3C).': [3110], 'degrade': [3116, 4151], 'membrane-associated': [3117, 4123], 'KDEL': [3135], 'antibody': [3136], 'marker.': [3142], 'B,': [3147], 'Membrane': [3149, 3818], 'fractionation': [3150, 3819], '(20': [3164], '(B),': [3169], '(C).': [3181], 'Briefly,': [3182], 'lysed': [3185], 'ball-bearing': [3187], 'homogenisation': [3188], 'sucrose': [3191], 'buffer,': [3192], 'supernatant': [3195], 'ultracentrifuged': [3197], '50,000': [3199], 'rpm': [3200], '1': [3202], 'obtain': [3205], '(M)': [3211], 'fractions.': [3212], 'Tubulin': [3213], 'calnexin': [3215], 'fractions,': [3225], 'respectively.': [3226], 'D–G.': [3227], 'Ectopic': [3228], '(D,': [3232, 3272], 'E)': [3233, 3548], '(F,': [3236], 'G)': [3237], 'Catalytically': [3243], 'C9A-HA': [3247], 'TRC8ΔRING-HA)': [3249], 'overexpressed': [3252, 3292], 'gated': [3266], 'HA-positive': [3268], '(black': [3270], 'line)': [3271, 3815], 'Basal': [3274], 'parent': [3279], '(red)': [3282, 3740, 3798], 'HA-tagged': [3291], 'visualised': [3296, 3400], '(E,': [3299], 'G).': [3300], 'Proteins': [3305], 'often': [3311], 'bound': [3312], 'chaperones': [3314, 3378], 'assist': [3316], 'folding': [3317], 'Chaperones': [3321], 'deliver': [3326], 'transmembrane': [3327], 'insertion.': [3335], 'chaperone': [3337], 'Bag6': [3338, 3375, 3398, 3411], '(also': [3339], 'BAT3': [3342], 'Scythe),': [3344], 'guided': [3350], 'entry': [3351], '(GET)/transmembrane': [3355], 'recognition': [3356, 3366, 3722], '(TRC),': [3358], 'binds': [3359], 'subsequent': [3368], '40.': [3373], 'Neither': [3374], 'nor': [3376], 'other': [3377], 'unlikely': [3389, 3484], 'reach': [3391], 'saturation.': [3392], 'S5A': [3408, 3435], 'destabilised': [3413], 'GET/TRC': [3415], 'evidenced': [3418], 'Ubl4A': [3421], '41': [3423], 'S5C),': [3426], 'affect': [3430], 'data': [3439, 4295], 'being': [3447], 'Bag6.': [3457], 'partial': [3459], 'they': [3472], 'act': [3477], 'independently.': [3478], 'Differences': [3479], 'chain': [3493], 'formed,': [3494], 'C)': [3509], 'functions,': [3515], 'either': [3519], '3D–G).': [3534], 'Indeed,': [3535, 3677], 'basal': [3543], '3D': [3546], '(it': [3549], 'possible': [3551], 'partially': [3555], 'autoubiquitination': [3563], '42).': [3566], 'next': [3568], 'explored': [3569], 'could': [3578], 'explain': [3579], 'mutations': [3589, 3641, 3741, 3930, 3951], 'introduced': [3591], 'substituting': [3593], 'alanine': [3594, 3739], 'residues': [3597, 3647, 3746, 3935], '(CL1': [3603, 3648, 3688, 3827, 4044], '2A,': [3604], '4A': [3606, 3950, 3974], '6A)': [3609, 3649, 3831], 'generate': [3611], 'constructs': [3613], 'varying': [3615], 'degrees': [3616], '4A).': [3620], 'Stable': [3621], 'reporters': [3627, 3668], 'decreased,': [3639, 3669], 'bulky': [3645, 3744, 3933], 'resulting': [3650], '4B,': [3658, 3921, 3960, 3995, 4012, 4109], 'bottom': [3659, 3702, 4013, 4030], 'panel).': [3660, 3703, 4031], '4C).': [3676], 'once': [3678], 'fully': [3683], '6A),': [3689], 'longer': [3692, 4024, 4139], 'membranes': [3695, 4027], '4C,': [3701, 4029], 'Thus,': [3704, 4114], 'correlated': [3707], '4.': [3715], 'determines': [3718], 'A,': [3727], '(blue)': [3747, 3807], '(A)': [3748], '(B).': [3761, 3816], 'Hydrophobicity': [3762], '(arbitrary': [3763], 'units)': [3764], 'generated': [3765, 3788], '"helical': [3767], 'projection"': [3769], 'created': [3770], 'Don': [3772], 'Armstrong': [3773], 'Raphael': [3775], 'Zidovetzki': [3776], '(Version': [3777], 'Id:': [3778], 'wheel.pl,': [3779], 'v': [3780], '1.4': [3781], '2009-10-20': [3782], '21:23:36': [3783], 'don': [3784], 'Exp.).': [3785], 'Helical': [3786], 'HeliQuest': [3790], '75': [3791], 'transfection': [3803], 'treatment': [3810], '4A,': [3828], '2A': [3829, 3948, 3972], 'described.': [3834, 3857], 'K3A': [3842, 4067], 'still': [3872, 4070], 'mixed': [3884, 4342], '4B).': [3897], 'unmodified': [3899, 4105], 'MARCH': [3905], 'top': [3922, 4110], 'panel),': [3923, 4014], 'results.': [3928], 'solely': [3954], 'TRC8-dependent': [3957], 'manner': [3958], 'middle': [3961, 3996], 'panels).': [3962, 3997], 'stabilise': [3970], 'additional': [3984], '6A': [4010], 'expected': [4018], 'Lastly,': [4032], 'single': [4036, 4346], 'residue': [4038, 4058], 'K3A)': [4045], 'charged': [4057], 'important': [4060], '4D).': [4064, 4086, 4113], 'indicating': [4076], 'full': [4097], 'K3A,': [4101], 'panel': [4111], 'region': [4124, 4141], 'degree': [4130], 'important,': [4134], 'requiring': [4137], 'sequence,': [4145], 'reporters.': [4157], 'shared': [4170, 4321], 'pathway': [4171, 4305, 4322], 'implied': [4185], 'functioned': [4190, 4301], 'one': [4193], 'screen.': [4202], 'E2/E3': [4207], 'pairing,': [4208], 'combination': [4217, 4240, 4274], 'determined': [4223], 'provided': [4228], 'recovery': [4231], '5A': [4236], 'No': [4239], 'recovery,': [4254], 'than': [4261], 'single-gene': [4265], 'knockouts': [4266], '5A).': [4268], '5B).': [4292], 'suggest': [4296], '5.': [4309], 'red)': [4327], 'combinations': [4334, 4349], 'generating': [4341], '(AUP1/UBE2G2,': [4350], 'TRC8/AUP1': [4351], 'TRC8/UBE2G2,': [4353], 'shaded': [4356], 'blue).': [4357]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2794441819', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 17}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 9}], 'updated_date': '2025-01-06T07:50:32.196593', 'created_date': '2018-03-29'}