Repurposing Metformin for Cardiovascular Disease

Name: Work Video:
Duration: 3 min 30 s
Graham Rena; Chim C. Lang
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'University': [55, 78, 1629], 'Dundee,': [57, 80, 1631, 1632], 'Scotland,': [58, 81, 1633], 'United': [59, 82, 123, 167, 1634], 'Kingdom.': [60, 83], 'LangChim': [64], 'Lang': [66, 1556, 1700, 2906, 3415, 3852, 4059], 'Originally': [84, 4378], 'published30': [85], 'Jan': [86], '2018https://doi.org/10.1161/CIRCULATIONAHA.117.031735Circulation.': [87], '2018;137:422–424Although': [88], 'introduced': [89], 'use': [91, 116, 2523], 'as': [92, 469, 579, 587, 1003, 1005, 1337, 1344, 1361, 1433, 1450, 2193, 2410], 'a': [93, 184, 348, 382, 503, 696, 708, 842, 1276, 1434, 1441, 1451, 1656, 1769, 1831, 1883, 1887, 2160, 2194, 2482, 2693, 2849, 3218, 3266, 3337, 3352, 3560, 3966, 4013, 4259], 'diabetic': [94, 103], 'medication': [95], 'in': [96, 106, 135, 140, 219, 280, 286, 347, 359, 364, 399, 456, 475, 497, 536, 554, 576, 595, 601, 607, 617, 663, 673, 683, 775, 812, 854, 877, 901, 932, 1007, 1087, 1139, 1214, 1234, 1245, 1269, 1285, 1341, 1353, 1425, 1437, 1467, 1582, 1589, 1767, 1823, 1878, 2001, 2116, 2202, 2237, 2357, 2373, 2378, 2489, 2535, 2545, 2562, 2636, 2647, 2743, 2783, 2853, 2885, 2891, 2912, 2920, 3009, 3052, 3094, 3129, 3180, 3217, 3264, 3348, 3403, 3426, 3430, 3456, 3467, 3470, 3475, 3490, 3515, 3564, 3611, 3690, 3930, 3958, 4007, 4072, 4120, 4161, 4261, 4272, 4344, 4351], '1957,': [97], 'metformin': [98, 139, 159, 221, 263, 371, 395, 440, 651, 700, 750, 774, 859, 1268, 1284, 1447, 1502, 1508, 1652, 1707, 1816, 2007, 2066, 2235, 2582, 2699, 3004, 3786, 3822, 4001, 4067, 4119, 4341], 'remains': [99], 'the': [100, 122, 155, 230, 252, 284, 309, 313, 318, 373, 377, 409, 436, 518, 715, 758, 794, 822, 846, 866, 889, 921, 1054, 1075, 1088, 1286, 1393, 1399, 1426, 1465, 1499, 1539, 1546, 1560, 1570, 1574, 1597, 1601, 1773, 2111, 2122, 2307, 2607, 2648, 2688, 2701, 2731, 2740, 2974, 3124, 3214, 3332, 3349, 3420, 3491, 3517, 3551, 3662, 3725, 3754, 3882, 4080, 4262], 'cornerstone': [101], 'drug': [104, 234, 285, 314, 847, 1332, 1466, 2161, 2780, 3300, 4340], 'management': [105, 2608], 'patients': [107, 136, 192, 400, 684, 730, 776, 902, 2003, 2538, 2611, 3959, 4008, 4073, 4162], 'with': [108, 138, 142, 177, 198, 335, 366, 562, 636, 665, 731, 799, 841, 858, 903, 905, 925, 980, 1018, 1112, 1223, 1415, 1663, 1825, 2004, 2262, 2335, 2526, 2539, 2612, 3146, 3960, 3965, 4009, 4074, 4163, 4258, 4274, 4300], 'type': [109, 813, 1664, 1879, 2540, 4164, 4384], '2': [110, 641, 879, 892, 1155, 1665, 1880, 2115, 2541, 2978, 4165], 'diabetes': [111, 214, 227, 351, 402, 629, 686, 736, 783, 815, 1044, 1065, 1289, 1457, 1470, 1710, 1881, 2005, 3961, 4166], 'mellitus': [112, 352, 403, 630, 687, 737, 784, 816, 1471, 3962], '(T2D).': [113], 'Its': [114, 2265, 2640], 'widespread': [115], 'has': [117, 181, 216, 1273, 1430, 1448], 'largely': [118, 912, 1476], 'been': [119, 183, 307, 624, 1475], 'underpinned': [120], 'by': [121, 166, 262, 292, 361, 582, 2120, 2234, 2492, 2881, 3305, 3685, 3856], 'Kingdom': [124, 168], 'Prospective': [125, 169], 'Diabetes': [126, 170, 880, 1547, 1577, 1579, 2578, 2583, 2839, 2979, 3870, 4172], 'Study': [127, 534, 1575], 'that': [128, 154, 164, 394, 507, 559, 848, 888, 1446], 'reported': [129, 165], 'lower': [130], 'cardiovascular': [131, 156, 195, 210, 389, 843, 908, 1151, 1279, 1654, 2614, 2806, 3271, 3344, 3972, 4005, 4150], 'mortality': [132, 387, 900, 3973, 4006, 4160], 'morbidity': [134], 'treated': [137], 'comparison': [141, 365, 664], 'alternative': [143], 'glucose-lowering': [144], 'drugs,': [145], 'despite': [146, 833], 'similar': [147, 919], 'glycemic': [148], 'control.': [149], 'A': [150, 470, 1389, 1789, 1864, 2062, 2223, 2323, 2328, 2349, 2404, 2602, 2832, 2915, 2996, 3011, 3568, 3596, 3602, 3707, 3759, 4062, 4142, 4198, 4333], 'recent': [151, 301, 519, 609, 795], 'meta-analysis': [152, 1657], 'suggests': [153, 1445], 'effects': [157, 276, 311, 329, 438, 916, 1705, 3002, 3057], 'could': [160], 'be': [161, 175, 290, 452, 551, 569, 913, 1305, 1350, 1378], 'smaller': [162], 'than': [163], 'Study;': [171, 724, 1191], 'however,': [172, 268, 506], 'this': [173, 357, 465, 1396, 1428, 1527, 1590], 'should': [174, 1321], 'interpreted': [176], 'caution': [178], 'because': [179], 'there': [180], 'only': [182, 1412], 'small': [185], 'number': [186, 1565], 'randomized': [188, 1301, 1461, 1482, 1888, 4063], 'controlled': [189, 1302, 1483, 1889, 4064, 4388], 'trials.1': [190], 'Although': [191], 'who': [193, 404, 631, 688, 738, 777], 'have': [194, 306, 493, 621, 632, 689, 778, 1422, 1472], 'disease': [196, 742, 1017, 2231, 3304, 4077, 4151, 4155], '(CVD)': [197], 'T2D': [199, 369, 620, 896, 904, 1272], 'comorbidity': [200, 3268], 'are': [201, 510, 517, 860, 1310, 1363, 1592], 'likely': [202, 245, 558], 'benefit': [204, 211, 613], 'most': [205, 244], 'from': [206, 295, 462, 614, 865, 1559, 1772, 2070], 'metformin,': [207, 583, 1317, 3340], 'indications': [208], 'over': [212, 1510], 'other': [213, 336, 467, 560, 1511], 'treatments': [215], 'driven': [217], 'interest': [218], 'repurposing': [220, 1299, 1509], 'treat': [223], 'CVD,': [224, 482, 555], 'irrespective': [225, 1455, 1708], 'status.Identified': [228], 'before': [229, 1384], 'era': [231, 2804], 'target-driven': [233], 'discovery': [235], 'programs,': [236], "metformin's": [237], 'cellular': [238, 246, 426], 'mechanism': [239, 2417], 'is': [240, 251, 381, 431, 448, 477, 501, 549, 557, 580, 584, 849, 1293, 1398, 1605, 2232, 2481, 2524, 3963, 4256], 'poorly': [241], 'established.': [242], 'The': [243, 668, 1536, 2416, 2800, 3168, 4338], 'effect': [247, 358, 698, 748, 789, 820, 836, 844, 989, 1029, 1052, 1073, 3216], 'underlying': [248], 'antihyperglycemic': [249], 'responses': [250], 'inhibition': [253, 2300], 'mitochondrial': [255, 332, 339], 'enzymes,': [256], 'including': [257, 408], 'complex': [258], 'I.': [259], 'Mitochondrial': [260, 1762, 3681], 'suppression': [261, 316, 445, 463], 'activates': [264], 'AMP-activated': [265, 269], 'protein': [266, 270], 'kinase;': [267], 'kinase–independent': [271], 'targets': [272], 'also': [273, 289, 392, 449], 'contribute': [274, 480], 'on': [277, 441, 611, 701, 729, 751, 773, 821, 837, 917, 990, 1030, 1053, 1074, 1210, 1247, 1478, 1526, 1653, 1746, 1751, 1756, 1817, 2038, 2067, 2618, 3005, 3173, 3341, 3605, 4002, 4068], 'glycemia,': [278, 838, 918], 'and,': [279], 'addition,': [281, 757], 'benefits': [282, 460], 'CVD': [287, 498, 612, 899, 1270, 1454, 1513], 'may': [288, 911, 1374], 'exerted': [291], 'mechanisms': [293], 'distinct': [294], 'its': [296, 702, 1208, 4174], 'metabolic': [297], 'actions.': [298], 'In': [299, 626, 756, 792], 'our': [300], 'work,': [302], 'example,': [304, 1490], 'we': [305, 355], 'studying': [308], 'anti-inflammatory': [310, 486, 508, 564], 'through': [315, 574, 1535, 2738, 3655], 'NF-κB': [319, 447], '(nuclear': [320], 'factor': [321, 491, 3269, 4206], 'κB)': [322], 'inflammatory': [323, 1345, 1418, 3827], 'signaling': [324], 'pathway.2': [325], 'We': [326, 391], 'traced': [327], 'these': [328, 345, 1372], 'back': [330], 'inhibition,': [333], 'consistent': [334, 840], 'evidence': [337, 864, 1444], 'regulation': [340], 'inflammation.3': [342], 'Following': [343], 'up': [344, 956, 1153], 'studies': [346, 616, 857], 'large,': [349], 'treatment-naive': [350], 'population': [353], 'cohort,': [354], 'confirmed': [356], 'humans': [360], 'observing': [362], 'that,': [363], 'sulfonylureas': [367], '(another': [368], 'drug),': [370], 'suppressed': [372, 396], 'systemic': [374, 3824], 'inflammation': [375, 548, 1432], 'marker,': [376], 'neutrophil-to-lymphocyte': [378], 'ratio,': [379], 'which': [380, 516, 1408], 'known': [383], 'predictor': [384], 'all-cause': [386, 4003], 'events.': [390], 'found': [393, 695], 'plasma': [397, 1329], 'cytokines': [398], 'without': [401, 619, 628, 685, 735, 782, 1043, 1271, 1469, 4078], 'had': [405, 739], 'heart': [406, 690, 978, 3975], 'failure,': [407], 'aging-associated': [410], 'cytokine': [411], 'CCL11': [412, 420], '(C-C': [413], 'motif': [414], 'chemokine': [415], 'ligand': [416], '11).': [417], 'Blockade': [418], 'can': [421, 451], 'suppress': [422], 'aspects': [423], 'age-related': [425, 597], 'dysfunction,': [427, 3834], 'further': [429], 'investigation': [430, 3752], 'required': [432], 'determine': [434], 'whether': [435, 2698], 'observed': [437], 'mammalian': [442], 'longevity,': [443], 'where': [444, 1356], 'observed,': [450], 'attributed,': [453], 'at': [454, 1607], 'least': [455], 'part,': [457], 'cardioprotective': [459], 'arising': [461], 'cytokines.Immunometabolism': [468], 'Drug': [471, 2034, 2564, 2566], 'Target': [472, 2637, 2916], 'CVDInflammation': [476], 'understood': [478], 'but': [483, 640, 734, 1459], 'existing': [484], 'nonsteroidal': [485], 'drugs': [487, 492, 2775], 'anti–tumor': [489], 'necrosis': [490], 'shown': [494], 'limited': [495], 'utility': [496, 1336, 1500], 'treatment.': [499], 'There': [500], 'still': [502, 3419], 'strong': [504], 'belief,': [505], 'strategies': [509], 'worth': [511], 'pursuing,': [512], 'key': [513], 'exemplars': [514], 'CIRT': [520], '(Cardiovascular': [521, 531], 'Inflammation': [522, 2372], 'Reduction': [523, 533, 3563, 4260], 'Trial;': [524], 'ClinicalTrials.gov.': [525, 542, 679, 725, 769, 808, 883], 'Unique': [526, 543, 680, 726, 770, 809, 884], 'identifier:': [527, 544, 681, 727, 771, 810, 885], 'NCT01594333)': [528], 'CANTOS': [530, 1402], 'Risk': [532, 3397], '[Reduction': [535], 'Recurrent': [537], 'Major': [538], 'VC': [539], 'Events];': [541], 'NCT01327846)': [545], 'trials.': [546, 1388], 'If': [547], 'targeted': [552], 'successfully': [553], 'it': [556, 1292, 2159], 'agents,': [561], 'different': [563], 'mechanisms,': [565], 'will': [566], 'need': [567], 'studied.': [570], 'Control': [571], 'immunity': [573], 'changes': [575, 853], 'metabolism-immunometabolism,4': [577], 'such': [578, 1343, 1360], 'exhibited': [581], 'becoming': [585], 'recognized': [586], 'an': [588, 647, 819, 1366, 1405, 2411, 2744, 3095, 3306, 4017], 'additional': [589], 'potential': [590, 1449, 3059, 3267], 'site': [591], 'therapy': [593, 3957], 'even': [594, 1367], 'nondiabetic': [596], 'disease.Randomized': [598], 'Controlled': [599], 'Trials': [600, 935], 'Patients': [602, 1216, 3868, 4273], 'Without': [603, 3874], 'T2DDespite': [604], 'encouraging': [605], 'data': [606], 'T2D,': [608], 'findings': [610], 'prospective': [615, 1460], 'groups': [618], 'so': [622, 1473], 'far': [623, 1474], 'mixed.': [625], 'subjects': [627], 'cardiac': [633, 1872, 3832, 4212], 'syndrome': [634, 954], 'X': [635, 2475, 2517, 3385, 3388, 3994], 'normal': [637, 1828], 'coronary': [638, 740, 1116, 1173, 1829, 4010, 4075], 'arteriography,': [639], 'consecutive': [642], 'positive': [643], 'exercise': [644, 712, 1821], 'tolerance': [645, 1822], 'tests,': [646], '8-week': [648], 'period': [649], 'treatment': [652, 1452, 2236], 'improved': [653, 997], 'maximal': [654, 828, 968, 1102], 'ST-segment': [655, 969], 'depression,': [656, 970], 'Duke': [657, 971], 'score,': [658], 'chest': [660, 974], 'pain': [661, 975], 'incidence': [662, 1176], 'placebo5': [666], '(Table).': [667, 862], 'proof-of-concept': [669], 'TAYSIDE': [670], 'trial': [671, 717, 760, 797, 869, 1403, 1411, 2696, 4065], '(Metformin': [672, 761], 'Insulin': [674, 722, 1189, 1235], 'Resistant': [675, 1236], 'Left': [676, 1211, 1237, 2909, 3471], 'Ventricular': [677, 1212, 1238, 2910], 'Dysfunction;': [678, 1239], 'NCT00473876)': [682], 'failure': [691, 979], 'insulin': [693, 732, 981, 1009, 1113, 1129], 'resistance': [694, 733, 1010, 1114, 1130], 'beneficial': [697], 'secondary': [703, 999], 'outcome': [704], 'Ve/Vco2': [706], 'slope,': [707], 'prognostic': [709], 'measure': [710], 'capacity.': [713], 'However,': [714], 'CAMERA': [716], '(Carotid': [718], 'Atherosclerosis:': [719, 1186], 'Resistance': [723, 1190], 'NCT00723307)': [728], 'artery': [741, 753, 830, 1016, 1117, 4011, 4076], 'already': [743, 1021], 'taking': [744, 1022], 'statins,': [745], 'showed': [746, 785, 887], 'no': [747, 788, 834], 'carotid': [752, 829, 1037, 1082, 1103], 'intima-media': [754, 831], 'thickness.': [755], 'GIPS-III': [759], 'Reduce': [763, 1199], 'Heart': [764, 1200, 1562, 1603, 1743, 1775, 3472, 3875, 4084, 4374, 4393], 'Failure': [765, 1201, 3876], 'After': [766, 1202], 'Myocardial': [767, 1203], 'Infarction;': [768, 1204], 'NCT01217307)': [772], 'ST-segment–elevation': [779, 1193], 'myocardial': [780, 1164, 1194], 'infarction': [781], 'little': [786], 'or': [787, 1171, 1599, 1613, 1641, 2631, 3873, 3877], 'metformin.': [791, 3758], 'contrast,': [793], 'REMOVAL': [796], '(Reducing': [798], 'Vascular': [801, 1225, 3600, 3793, 4281], 'Adverse': [802, 1226, 2834], 'Lesions': [803, 1227], 'Type': [805, 878, 1229, 2333, 2977], '1': [806, 814, 1064, 1122, 1230, 2334, 4204], 'Diabetes;': [807, 1231], 'NCT01483560)': [811], 'did': [817], 'show': [818], 'prespecified': [823], 'tertiary': [824], 'end': [825, 992, 1032, 1056, 1077, 1090, 1109, 1145, 1179, 1280, 1339, 1358], 'point': [826, 993, 1033, 1057, 1078, 1281], 'thickness,': [832], 'sustained': [835], 'possibly': [839], 'not': [850, 1423, 1593], 'attributable': [851], 'glycemia.': [855], 'Further': [856], 'ongoing': [861], 'Recent': [863, 2938], 'EMPA-REG': [867], 'OUTCOME': [868], '(BI': [870], '10773': [871], '[Empagliflozin]': [872], 'Outcome': [874, 950], 'Event': [875], 'Trial': [876, 2691], 'Mellitus': [881, 3871], 'Patients;': [882, 944], 'NCT01131676)': [886], 'sodium-glucose': [890], 'cotransporter': [891], 'inhibitor,': [893], 'empagliflozin,': [894], 'another': [895], 'drug,': [897], 'lowered': [898], 'prevalent': [906], 'atherosclerotic': [907, 1150], 'disease.': [909], 'This': [910], 'independent': [914], 'multifactorial': [922], 'picture': [923], 'emerging': [924, 1512], 'metformin.Table.': [926], 'Summary': [927], 'Outcomes': [931, 3866], 'Selected': [933], 'Repurposing': [934, 2567, 3449], 'MetforminTrial': [937], '(NCT': [938], 'Number)Publication': [939], 'DatePatient': [940], 'GroupNo.': [941], 'Enrolled': [943], 'Duration': [945], 'Dose': [947], 'MetforminSelected': [949], 'MeasuresJadhav': [951], 'colleagues52006Cardiac': [953], 'X33;': [955], '500': [958, 1046], 'mg': [959, 984, 1025, 1047, 1068], 'BID': [960, 985, 1026, 1048, 1069], '8': [962, 2924], 'wkImproved': [963], 'endothelium-dependent': [964], 'microvascular': [965, 1818], 'responsesStress': [966], 'Test:': [967], 'score': [972], 'incidenceTAYSIDE(clinicaltrials.gov;': [976], 'NCT00473876)2012Chronic': [977], 'resistance62;': [982], '1000': [983, 1067], '4': [987, 1050], 'moNo': [988, 1028, 1051], 'primary': [991, 1031, 1055, 1076, 1178], 'peak': [995], 'Vo2;': [996], 'predetermined': [998], 'endpoint': [1000], 'Ve/Vco2,': [1002, 1251], 'well': [1004], 'improvements': [1006], 'fasting': [1008], 'index': [1011], 'body': [1013], 'weightCAMERA(clinicaltrials.gov;': [1014], 'NCT00723307)2014Coronary': [1015], 'central': [1019], 'obesity': [1020], 'statins173;': [1023], '850': [1024], 'for18': [1027], 'mean': [1035, 1080], 'distal': [1036], 'intimal': [1038, 1083, 1104], 'media': [1039, 1084, 1105], 'thicknessGIPS': [1040], 'III(clinicaltrials.gov;': [1041], 'NCT01217307)2014STEMI': [1042], 'mellitus380;': [1045], 'left': [1059, 1124, 1133, 4069], 'ventricular': [1060, 4070], 'ejection': [1061], 'fractionREMOVAL(clinicaltrials.gov;': [1062], 'NCT01483560)2017Type': [1063], 'mellitus428;': [1066], '3': [1071, 2205], 'yNo': [1072], 'far-wall': [1081], 'thickness;': [1085], 'improvement': [1086, 1138], 'secondary/tertiary': [1089], 'points': [1091, 1340], 'glycohemoglobin;': [1093], 'low-density': [1094], 'lipoprotein': [1095], 'cholesterol;': [1096], 'estimated': [1097], 'glomerular': [1098], 'filtration': [1099], 'rate': [1100], 'thicknessMET-REMODEL(clinicaltrials.gov;': [1106], 'NCT02226510)2018': [1107], '(expected': [1108, 1144], 'study)Normotensive': [1111], 'disease64;': [1118], '2g': [1119], 'daily': [1120, 1157], 'yPrimary:': [1123, 1160], 'ventricle': [1125, 1134], 'mass': [1126], 'indexSecondary:': [1127], 'Fasting': [1128], 'index;': [1131], 'obesity;': [1132], 'size,': [1135], 'function': [1136, 1819], 'endothelial': [1140, 2487, 3088], 'functionVA': [1141], 'IMPACT(clinicaltrials.gov;': [1142], 'NCT02915198)2024': [1143], 'study)Prediabetes': [1147], 'established': [1149, 1431, 2227], 'disease7868;': [1152], 'g': [1156], '4.5': [1159], 'Time': [1161], 'nonfatal': [1163], 'infarction;': [1165, 1195], 'stroke;': [1166], 'hospitalization': [1167], 'unstable': [1169], 'angina;': [1170], 'symptom-driven': [1172], 'revascularizationSecondary:': [1174], 'Cumulative/recurrent': [1175], 'pointsBID': [1180], 'indicates': [1181], 'twice': [1182], 'daily;': [1183], 'CAMERA,': [1184], 'Carotid': [1185], 'STEMI,': [1192], 'GIPS-III,': [1196], 'MET-REMODEL,': [1205], 'Effects': [1209, 1814, 2112, 2352, 2835, 2880], 'Hypertrophy': [1213, 2911], 'Normotensive': [1215], 'With': [1217, 2887, 3869, 3872], 'Coronary': [1218, 2374], 'Artery': [1219, 2375], 'Disease;': [1220], 'REMOVAL,': [1221], 'Reducing': [1222], 'TAYSIDE,': [1232], 'VA': [1240], 'IMPACT,': [1241], 'Investigation': [1242], 'Pre-Diabetes': [1246], 'Atherosclerotic': [1248], 'Outcomes;': [1250], 'minute': [1252], 'ventilation': [1253], 'carbon': [1255], 'dioxide': [1256], 'production': [1257], 'ratio;': [1258], 'Vo2,': [1260], 'oxygen': [1261, 3090], 'consumption.Future': [1262], 'ProspectsThe': [1263], 'present': [1264], 'clinical': [1265], 'equipoise': [1266], 'led': [1274], 'call': [1277], 'trials': [1282, 1303, 1315, 1355, 1462, 1660], 'absence': [1287], 'mellitus1': [1290], 'timely': [1294], 'consider': [1296], 'how': [1297], 'future': [1298, 2942, 4157], 'might': [1304, 1334, 1349, 1497], 'designed.': [1306], 'Because': [1307], 'pharmaceutical': [1308], 'companies': [1309], 'unlikely': [1311], 'fund': [1313], 'large-scale': [1314], 'public': [1318], 'funding': [1319], 'agencies': [1320], 'give': [1322], 'consideration': [1323], 'supporting': [1325], 'these.': [1326], 'New': [1327, 2644, 3903], 'diabetes-independent': [1328, 1495], 'markers': [1330, 1493], 'response': [1333], 'find': [1335], 'surrogate': [1338], 'trials,': [1342, 1484], 'biomarkers.': [1346], 'Such': [1347], 'biomarkers': [1348, 1373, 4350], 'especially': [1351], 'useful': [1352], 'short-term': [1354], 'hard': [1357], 'points,': [1359], 'mortality,': [1362], 'delayed.': [1364], 'Arguably,': [1365], 'more': [1368], 'critical': [1369], 'role': [1370, 1766], 'ultimately': [1375], 'prove': [1376], 'better': [1379, 1486], 'stratification': [1380], 'patient': [1382], 'groups,': [1383], 'their': [1385], 'entry': [1386], 'into': [1387, 3753, 3905], 'compelling': [1390], 'exemplar': [1391], 'power': [1394], 'approach': [1397], 'recently': [1400], 'completed': [1401], 'interleukin-1β': [1406], 'antibody,': [1407], 'selected': [1409], 'those': [1413, 1595], 'individuals': [1414, 1468], 'persistently': [1416], 'high': [1417, 3086], 'burden.': [1419], 'Where': [1420], 'others': [1421], 'succeeded': [1424], 'past,': [1427], 'study': [1429], 'viable': [1435], 'target': [1436, 2413, 3338], 'CVD.Concluding': [1438], 'RemarksIn': [1439], 'conclusion,': [1440], 'variety': [1442], 'status,': [1458], 'repurpose': [1464], 'neutral': [1477], 'cardiovascular-related': [1479], 'outcomes.': [1480], 'Future': [1481, 3495], 'incorporating': [1485], 'stratification/targeting,': [1487], 'using,': [1488], 'novel': [1491, 2483, 3060, 3299], 'preclinical': [1492], 'inflammation,': [1496], 'establish': [1498], 'therefore': [1504], 'help': [1505], 'prioritize': [1507], 'treatments.AcknowledgmentsThe': [1514], 'authors': [1515], 'thank': [1516], 'Professor': [1517], 'Allan': [1518], 'Struthers': [1519, 4054], 'his': [1521], 'careful': [1522], 'reading': [1523], 'comments': [1525], 'article.Sources': [1528], 'FundingDr': [1530], 'acknowledges': [1532, 1557], 'laboratory': [1533], 'support': [1534, 1558], 'Cunningham': [1537], 'Trust,': [1538], 'UK': [1540, 1548, 3350], 'Research': [1542, 1580, 3575], 'Council': [1543, 1745, 1750, 1755], '(MR/K012924/1)': [1544], 'RW': [1549], 'JM': [1551], 'Collins': [1552], 'studentship': [1553], '(12/0004625).': [1554], 'Dr': [1555], 'British': [1561], 'Foundation': [1563, 1572], '(grant': [1564], 'PG/06/143/21897': [1566], 'PG/14/4/30539)': [1568], 'European': [1571, 2076, 3063, 3763, 4083, 4126, 4278], 'Program': [1581], 'Macrovascular': [1583], 'Complications': [1584], 'Diabetes.DisclosuresNone.FootnotesThe': [1586], 'opinions': [1587], 'expressed': [1588], 'article': [1591], 'necessarily': [1594], 'editors': [1598], 'American': [1602, 1742, 1774, 3726, 4373], 'Association.Circulation': [1604], 'available': [1606], 'http://circ.ahajournals.org.Correspondence': [1608], 'to:': [1609], 'PhD,': [1612], 'MD,': [1617], 'Kingdom,': [1635], 'DD1': [1636], '9SY.': [1637], 'E-mail': [1638], '[email': [1639, 1642], 'protected]': [1640], 'protected]References1.': [1643], 'Griffin': [1644], 'SJ,': [1645], 'Leaver': [1646], 'JK,': [1647], 'Irving': [1648], 'GJ.': [1649], 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'M': [2152, 2155, 2182, 2254, 2407, 2681, 2829, 2999, 3139, 3464, 3484, 3850, 4293], 'Hill': [2154], 'Metformin:': [2157, 3418, 3686, 3926], 'Is': [2158, 2847], 'all': [2163], 'reasons': [2164], 'diseases?,': [2166], 'Metabolism,': [2167, 3522, 3693], '10.1016/j.metabol.2022.155223,': [2168], '133,': [2169], '(155223),': [2170], '1-Aug-2022.': [2174], 'Thomas': [2175], 'Wurzer': [2177], 'Malle': [2179], 'Ristow': [2181], 'Madreiter-Sokolowski': [2184], 'C': [2185, 2576, 2795, 2907, 3416, 3853, 4060], 'Modulation': [2187], 'Reactive': [2189], 'Oxygen': [2190], 'Species': [2191], 'Homeostasis': [2192], 'Pleiotropic': [2195], 'Commonly': [2198], 'Used': [2199], 'Drugs,': [2200], 'Frontiers': [2201, 2852, 2890, 2919, 3179, 3402, 3455, 3474, 3610, 3929], 'Aging,': [2203, 3154, 3520, 4308], '10.3389/fragi.2022.905261,': [2204], 'Corremans': [2206], 'Neven': [2208], 'Maudsley': [2210], 'Leysen': [2212], 'De': [2214, 3703], 'Broe': [2215], "D'Haese": [2217], 'Vervaet': [2219], 'B': [2220, 2346, 2559, 2684, 3118, 3923], 'Verhulst': [2222], 'Progression': [2225], 'non-diabetic': [2228], 'chronic': [2229, 3222, 4153], 'kidney': [2230, 4154], 'halted': [2233], 'rats,': [2238], 'Kidney': [2239, 2580, 2585, 3878], 'International,': [2240], '10.1016/j.kint.2022.01.037,': [2241], '101:5,': [2242], '(929-944),': [2243], '1-May-2022.': [2247], 'Rusanov': [2248], 'Zou': [2250], 'J': [2251, 3079, 3166, 3293, 3296, 3444, 3487, 3548, 3679, 3710, 3749, 4057, 4145, 4249], 'Babak': [2253], 'Biological': [2256], 'Properties': [2257], 'Transition': [2259], 'Metal': [2260], 'Complexes': [2261], 'Analogues,': [2266], 'Pharmaceuticals,': [2267, 2981], '10.3390/ph15040453,': [2268], '15:4,': [2269], '(453)': [2270], 'Xie': [2271, 3987], 'Chen': [2273, 2870, 3646], 'Song': [2279], 'Chaudhari': [2281], 'Yang': [2283, 2558, 3382, 3993], 'G,': [2286, 2593, 2677, 2986, 3237, 3411, 3636, 3640, 3806, 4098, 4327], 'Taylor': [2289], 'Li': [2291, 2674, 2859, 2863, 3196, 3198, 3368, 3615], 'Huang': [2294, 2453, 2477, 2797, 3631], 'Y': [2295, 2478, 2798, 2871, 3954], 'Let-7': [2297], 'underlies': [2298], 'metformin-induced': [2299], 'hepatic': [2302], 'glucose': [2303], 'production,': [2304], 'Proceedings': [2305], 'National': [2308], 'Academy': [2309], '10.1073/pnas.2122217119,': [2312], '119:14,': [2313], '5-Apr-2022.': [2317], 'García-Puga': [2318], 'Saenz-Antoñanzas': [2320], 'Matheu': [2322], 'López': [2325], 'de': [2326, 3674, 3804, 3811, 3814, 4329], 'Munain': [2327], 'Targeting': [2330, 3144, 4298], 'Myotonic': [2331], 'Dystrophy': [2332], 'Metformin,': [2336, 2354], 'International': [2337, 2654, 3571], '10.3390/ijms23052901,': [2342], '23:5,': [2343], '(2901)': [2344], 'Kurmanbekova': [2345], 'Noruizbaeva': [2348], 'Rational': [2355], 'Pharmacotherapy': [2356], '10.20996/1819-6446-2022-02-12,': [2359], '18:1,': [2360, 3980, 4023], '(97-102)': [2361], 'Hemenway': [2362], 'G': [2363, 2628, 2768, 2904, 3816, 3920, 4336], 'Frishman': [2365], 'W': [2366, 2724, 2727, 3901], '(2021)': [2367, 2603, 2629, 2685, 2728, 2769, 2799, 2833, 2872, 2908, 2933, 2966, 3000, 3048, 3083, 3119, 3143], 'Therapeutic': [2368, 2543, 2971], 'Implications': [2369], 'NLRP3-Mediated': [2371], 'Disease,': [2376, 2547, 2586, 3395, 3454, 3473], 'Cardiology': [2377], 'Review,': [2379, 2809], '10.1097/CRD.0000000000000391,': [2380], '30:2,': [2381, 3841], '(90-99),': [2382], '1-Mar-2022.': [2386, 2436, 2503], 'Feng': [2387, 3590, 3643], 'Ares': [2393], 'Lopez-Torres': [2395], 'Martínez': [2397, 2406], 'Martínez-Larrañaga': [2399], 'Anadón': [2403], 'Mitochondria': [2409], 'important': [2412], 'metformin:': [2415], 'action,': [2419], 'toxic': [2420], 'side': [2422], 'effects,': [2423], 'new': [2425, 2803], 'therapeutic': [2426, 3061], 'applications,': [2427, 3062], 'Pharmacological': [2428], '10.1016/j.phrs.2022.106114,': [2430], '177,': [2431], '(106114),': [2432], 'Cheng': [2437, 2794], 'Lin': [2439], 'Pu': [2441], 'Tse': [2443], 'Cao': [2449, 2514], 'Lau': [2451], 'He': [2455], 'Luo': [2457, 3320], 'Shih': [2459], 'Wan': [2461], 'Ng': [2463], 'Ma': [2467, 2512, 3200], 'Chiu': [2469], 'Chan': [2471], 'Yu': [2473], 'Tian': [2474, 3366], 'SOX4': [2480], 'phenotypic': [2484], 'regulator': [2485], 'cells': [2488, 2737], 'atherosclerosis': [2490], 'revealed': [2491], 'single-cell': [2493], 'analysis,': [2494, 3311], 'Advanced': [2497], '10.1016/j.jare.2022.02.017,': [2499], 'Tu': [2504, 3194], 'Z,': [2507, 2864, 2988, 3381, 3539], 'Chao': [2508], 'Yan': [2510, 3893], 'Ji': [2516], 'L': [2520, 2573, 3593, 3951], 'associated': [2525, 3964], 'low': [2527], 'risk': [2528, 2702, 3342, 3968, 4148], 'case': [2530], 'fatality': [2531], 'disability': [2533], 'rates': [2534], 'first-ever': [2536], 'stroke': [2537], 'diabetes,': [2542], 'Advances': [2544], 'Chronic': [2546, 3821], '10.1177/20406223221076894,': [2548], '13,': [2549], '(204062232210768),': [2550], '1-Jan-2022.': [2554], 'Z': [2556, 3082, 3997], 'Polypharmacology': [2561], 'Old': [2563], 'Rediscovery:': [2565], 'Polypharmacology,': [2568], '10.1007/978-3-031-04998-9_13,': [2569], '(535-592),': [2570], '.': [2571, 2589, 3157, 4311], 'Gnudi': [2572], 'Ricciardi': [2575], '10.1007/978-3-030-86020-2_24,': [2587], '(521-531),': [2588], 'Khan': [2590, 4046], 'Singh': [2592, 4036], 'Abrar': [2594], 'Ganeshan': [2596], 'Morgan': [2598], 'K': [2599, 3447, 3897], 'Harky': [2601], 'Pharmacotherapeutic': [2604], 'agents': [2605], 'COVID-19': [2610], 'preexisting': [2613], 'disease,': [2615, 3272], 'Expert': [2616], 'Opinion': [2617, 3429], 'Pharmacotherapy,': [2619], '10.1080/14656566.2021.1960311,': [2620], '22:18,': [2621], '(2455-2474),': [2622], '12-Dec-2021.': [2626], 'Tulipano': [2627], 'Integrated': [2630], 'Independent': [2632], 'Actions': [2633], 'Tissues': [2638], 'Underlying': [2639], 'Current': [2641, 3127, 3428], 'Use': [2642, 3863], 'Possible': [2645], 'Applications': [2646], 'Endocrine': [2649], 'Metabolic': [2651, 3394, 3565], 'Disorder': [2652], 'Area,': [2653], '10.3390/ijms222313068,': [2659], '22:23,': [2660], '(13068)': [2661], 'Golledge': [2662, 4229], 'Arnott': [2664], 'Moxon': [2666, 4248], 'Monaghan': [2668], 'Norman': [2670, 4243], 'Morris': [2672, 4231], 'Q,': [2675, 2718, 3365], 'Jones': [2676, 4245], 'Roake': [2678], 'Bown': [2680], 'Neal': [2683], 'Protocol': [2686], 'Aneurysm': [2690], '(MAT):': [2692], 'testing': [2697], 'reduces': [2700, 3823, 4347], 'serious': [2704], 'complications': [2705], 'abdominal': [2707, 3788], 'aortic': [2708, 2734, 3789], 'aneurysm,': [2709, 3790], 'Trials,': [2710], '10.1186/s13063-021-05915-0,': [2711], '22:1,': [2712], '1-Dec-2021.': [2716, 2755], 'En': [2717], 'Zeping': [2719], 'Yuetang': [2721], 'Xu': [2723, 3295, 3586], 'Wei': [2726, 3374], 'alleviates': [2730], 'calcification': [2732], 'valve': [2735], 'interstitial': [2736], 'activating': [2739], 'PI3K/AKT': [2741], 'pathway': [2742], 'AMPK': [2745, 3335, 3658], 'dependent': [2746, 3097], 'way,': [2747], '10.1186/s10020-021-00416-x,': [2750], '27:1,': [2751], 'Madugula': [2756], 'John': [2758], 'Nagamani': [2760], 'Gaur': [2762], 'Poroikov': [2764], 'V': [2765, 2962, 3461], 'Sastry': [2767], 'descriptor': [2771], 'approved': [2774], 'using': [2776], 'unsupervised': [2777], 'learning': [2778], 'repurposing,': [2781], 'Computers': [2782], 'Biology': [2784], '10.1016/j.compbiomed.2021.104856,': [2787], '138,': [2788], '(104856),': [2789], '1-Nov-2021.': [2793], 'gut-cardiovascular': [2801], 'connection:': [2802], 'therapy,': [2807], '10.1515/mr-2021-0002,': [2810], '1:1,': [2811], '(23-46),': [2812], '26-Oct-2021.,': [2816], '1-Oct-2021.': [2820], 'Shoshan-Barmatz': [2821], 'V,': [2822, 2960, 3253, 4315], 'Anand': [2823], 'U,': [2824, 2927, 4045], 'Nahon-Crystal': [2825], 'Di': [2827], 'Carlo': [2828], 'Shteinfer-Kuzmine': [2831], 'From': [2838, 3714, 3881], 'COVID-19,': [2841], 'Cancer,': [2842], 'Neurodegenerative': [2843], 'Diseases,': [2844, 3664, 3839], 'Aging:': [2846], 'VDAC1': [2848], 'Common': [2850], 'Target?,': [2851], 'Physiology,': [2854, 3181, 3457], '10.3389/fphys.2021.730048,': [2855], '12': [2856, 2894], 'Ke': [2857], 'Deng': [2861, 3582], 'Lv': [2867], 'P': [2868, 3047, 3260, 3676], 'Exerts': [2874], 'Mucus': [2877], 'Barrier': [2878], 'Protective': [2879], 'Enriching': [2882], 'Akkermansia': [2883], 'muciniphila': [2884], 'Mice': [2886], 'Ulcerative': [2888], 'Colitis,': [2889], '10.3389/fphar.2021.726707,': [2893], 'Dihoum': [2897], 'Mordi': [2899, 3412, 3847, 3857, 4034], 'Choy': [2901, 4048], 'Diabetic': [2913, 3177, 3712], 'Cardiomyopathy:': [2914], 'Intervention,': [2918], '10.3389/fcvm.2021.746382,': [2923], 'Mrudulakumari': [2925], 'Vasudevan': [2926], 'Lee': [2928, 2931, 3538], 'E': [2932, 3044, 3746, 3779], 'Alginate': [2934], 'derived': [2935], 'functional': [2936], 'oligosaccharides:': [2937], 'developments,': [2939], 'barriers,': [2940], 'outlooks,': [2943], 'Carbohydrate': [2944], 'Polymers,': [2945], '10.1016/j.carbpol.2021.118158,': [2946], '267,': [2947], '(118158),': [2948], '1-Sep-2021.': [2952], 'Blahova': [2953], 'Martiniakova': [2955], 'Babikova': [2957], 'Kovacova': [2959], 'Mondockova': [2961], 'Omelka': [2964], 'R': [2965, 3163, 3545, 4246], 'Pharmaceutical': [2967], 'Drugs': [2968, 3451], 'Natural': [2970], 'Products': [2972], 'Treatment': [2975], 'Mellitus,': [2980], '10.3390/ph14080806,': [2982], '14:8,': [2983], '(806)': [2984], 'Jîtcă': [2985], 'Gáll': [2987], 'Vari': [2989], 'Ősz': [2991], 'Tero-Vescan': [2993], 'Groșan': [2995], 'Dogaru': [2998], 'Beneficial': [3001], 'haloperidol-induced': [3006], 'motor': [3007], 'deficits': [3008], 'rats.': [3010], 'behavioral': [3012], 'assessment,': [3013], 'Acta': [3014, 4353], 'Marisiensis': [3015], '-': [3016], 'Seria': [3017], 'Medica,': [3018], '10.2478/amma-2021-0017,': [3019], '67:2,': [3020], '(115-121),': [3021], '1-Jun-2021.,': [3025], '1-Jun-2021.': [3029], 'Mbara': [3030], 'Mofo': [3032], 'Mato': [3033], 'Driver': [3035], 'Nzuza': [3037], 'Mkhombo': [3039], 'N,': [3040, 3189], 'Gcwensa': [3041], 'Mcobothi': [3043], 'Owira': [3046], 'turns': [3050], '62': [3051], 'pharmacotherapy:': [3053], 'Emergence': [3054], 'non-glycaemic': [3056], '10.1016/j.ejphar.2021.173934,': [3067], '898,': [3068], '(173934),': [3069], '1-May-2021.': [3073], 'Tao': [3074], 'Fan': [3076], 'prevented': [3085], 'glucose-induced': [3087], 'reactive': [3089], 'species': [3091], 'via': [3092], 'OGG1': [3093], 'AMPKα-Lin-28': [3096], 'pathway,': [3098], 'Life': [3099], '10.1016/j.lfs.2020.119015,': [3101], '268,': [3102], '(119015),': [3103], '1-Mar-2021.': [3107, 3137], 'Breite': [3108], 'Steck': [3110], 'Cutshall': [3112], 'Shah': [3114], 'Cave': [3117], 'Changing': [3120], 'Fields-Diabetes': [3121], 'Medications': [3122], 'Invading': [3123], 'Space,': [3126], 'Problems': [3128], '10.1016/j.cpcardiol.2020.100736,': [3131], '46:3,': [3132], '(100736),': [3133], 'Padki': [3138, 4292], 'Stambler': [3141, 4295], 'Aging': [3145, 4299], '(TAME)': [3148, 4302], 'Encyclopedia': [3149, 4303], 'Gerontology': [3151, 4305], 'Population': [3153, 4307], '10.1007/978-3-030-22009-9_400,': [3155], '(4908-4910),': [3156], 'Gopal': [3158], 'Chahade': [3160], 'Kim': [3162], 'Ussher': [3165], '(2020)': [3167, 3207, 3261, 3297, 3330, 3389, 3417, 3448, 3465, 3488, 3511, 3549, 3597, 3648, 3680, 3711, 3750, 3783, 3820, 3854, 3902], 'Antidiabetic': [3171, 3450], 'Therapies': [3172], 'Diastolic': [3174], 'Dysfunction': [3175], 'Cardiomyopathy,': [3178], '10.3389/fphys.2020.603247,': [3182], '11': [3183, 3459, 3614], 'Bai': [3186], 'Qin': [3192], 'Ouyang': [3202], 'Q': [3206], 'improves': [3209, 3830], 'lipid': [3210], 'metabolism': [3211], 'reverses': [3213], 'Warburg': [3215], 'canine': [3219], 'model': [3220], 'atrial': [3223], 'fibrillation,': [3224], 'BMC': [3225], 'Disorders,': [3227], '10.1186/s12872-020-01359-7,': [3228], '20:1,': [3229], '1-Dec-2020.': [3233], 'Alderawi': [3234], 'Caramori': [3236], 'Baker': [3238], 'Hitchings': [3240], 'Rahman': [3242], 'Rossios': [3244], 'Adcock': [3246], 'Cassolari': [3248], 'Papi': [3250], 'Ortega': [3252], 'Curtis': [3254], 'Dunmore': [3256], 'Kirkham': [3259], 'FN3K': [3262], 'expression': [3263, 4209], 'COPD:': [3265], 'BMJ': [3273], 'Open': [3274], 'Respiratory': [3275], '10.1136/bmjresp-2020-000714,': [3277], '7:1,': [3278], '(e000714),': [3279], '1-Nov-2020.': [3283, 3319, 3363], 'Peng': [3284], 'Yuan': [3286], 'Xin': [3288], 'Screening': [3298], 'candidates': [3301], "Alzheimer's": [3303], 'integrated': [3307], 'network': [3308], 'transcriptome': [3310], 'Bioinformatics,': [3312], '10.1093/bioinformatics/btaa563,': [3313], '36:17,': [3314], '(4626-4632),': [3315], 'Schooling': [3322], 'Au': [3327], 'Yeung': [3328], 'Evaluating': [3331], 'impact': [3333], 'activation,': [3336], 'diseases': [3345], 'cancer': [3347], 'Biobank:': [3351], 'Mendelian': [3353], 'randomisation': [3354], 'study,': [3355], 'Diabetologia,': [3356], '10.1007/s00125-020-05243-z,': [3357], '63:11,': [3358], '(2349-2358),': [3359], 'Lian': [3370], 'Zhao': [3372, 3633], 'Han': [3376, 3985], 'Zheng': [3378], 'Gao': [3380, 3991], 'Fang': [3384], 'Tong': [3387], 'Interactions': [3390], 'Between': [3391], 'Therapeutics': [3392], 'Factors,': [3398], 'Gut': [3400], 'Microbiota,': [3401], 'Cellular': [3404, 4220], 'Infection': [3406], 'Microbiology,': [3407, 3496], '10.3389/fcimb.2020.530160,': [3408], '10': [3409, 3933], 'sweet': [3421], 'spot': [3422], 'CV': [3424], 'protection': [3425], 'diabetes?,': [3427], '10.1016/j.coph.2020.10.018,': [3432], '54,': [3433], '(202-208),': [3434], '1-Oct-2020.': [3438], 'Schubert': [3439], 'Hansen': [3441], 'Leefmann': [3443], 'Guan': [3446], '10.3389/fphys.2020.568632,': [3458], 'Mulkareddy': [3460], 'Simon': [3463], 'Pulmonary': [3468], 'Hypertension': [3469], '10.3389/fmed.2020.00425,': [3477], '7': [3478], 'Górski': [3479], 'Międzybrodzki': [3481], 'Żaczek': [3483], 'Borysowski': [3486], 'Phages': [3489], 'fight': [3492], 'against': [3493], 'COVID-19?,': [3494], '10.2217/fmb-2020-0082,': [3497], '15:12,': [3498], '(1095-1100),': [3499], '1-Aug-2020.': [3503], 'Kulkarni': [3504], 'Gubbi': [3506], 'Barzilai': [3509], 'N': [3510, 3819], 'Benefits': [3512], 'Attenuating': [3516], 'Hallmarks': [3518], 'Cell': [3521, 3608], '10.1016/j.cmet.2020.04.001,': [3523], '32:1,': [3524], '(15-30),': [3525], '1-Jul-2020.': [3529], 'Ramos': [3530], 'Dalleck': [3532], 'Keith': [3534], 'Fennell': [3536], 'Drummond': [3540], 'Keating': [3542], 'Fassett': [3544], 'Coombes': [3547], 'Optimizing': [3550], 'Interaction': [3552], 'Exercise': [3554], 'Volume': [3555], 'Induce': [3559], 'Clinically': [3561], 'Significant': [3562], 'Syndrome': [3566, 4395], 'Severity:': [3567], 'Randomised': [3569], 'Trial,': [3570], 'Environmental': [3574], 'Public': [3577], 'Health,': [3578], '10.3390/ijerph17103695,': [3579], '17:10,': [3580], '(3695)': [3581], 'Su': [3584], 'Little': [3588], 'Tang': [3592], 'Shen': [3595, 3996], 'Diseases:': [3601], 'Focused': [3603], 'Review': [3604], 'Smooth': [3606], 'Muscle': [3607], 'Function,': [3609], '10.3389/fphar.2020.00635,': [3613], 'Lu': [3621], 'Pan': [3623], 'Oh': [3627], 'Yi': [3629], 'Ning': [3635], 'Xing': [3637], 'Xiao': [3639], 'Liu-Bryan': [3641], 'limits': [3650], 'osteoarthritis': [3651], 'development': [3652], 'progression': [3654], 'activation': [3656], 'signalling,': [3659], 'Annals': [3660], 'Rheumatic': [3663], '10.1136/annrheumdis-2019-216713,': [3665], '79:5,': [3666], '(635-645),': [3667], '1-May-2020.': [3671], 'Martín-Rodríguez': [3672], 'Pablos-Velasco': [3675], 'Calbet': [3678], 'Complex': [3682], 'Inhibition': [3684], 'Drug–Exercise': [3687], 'Interactions,': [3688], 'Trends': [3689], 'Endocrinology': [3691], '&': [3692], '10.1016/j.tem.2020.02.003,': [3694], '31:4,': [3695], '(269-271),': [3696], '1-Apr-2020.': [3700, 3736, 3773], 'Wilcox': [3701], 'Block': [3704], 'Schwartzbard': [3706], 'Newman': [3709], 'Agents,': [3713], 'SGLT2': [3717], 'Inhibitors': [3718], 'GLP1': [3720], 'Receptor': [3721], 'Agonists,': [3722], 'College': [3727], '10.1016/j.jacc.2020.02.056,': [3730], '75:16,': [3731], '(1956-1974),': [3732], 'Markowicz-Piasecka': [3737], 'Sadkowska': [3739], 'Huttunen': [3741], 'Podsiedlik': [3743], 'Mikiciuk-Olasik': [3745], 'Sikora': [3748], 'An': [3751], 'pleiotropic': [3755], 'activity': [3756], 'glimpse': [3760], 'haemostasis,': [3762], '10.1016/j.ejphar.2020.172984,': [3767], '872,': [3768], '(172984),': [3769], 'Raffort': [3774], 'Hassen-Khodja': [3776], 'Jean-Baptiste': [3778], 'Lareyre': [3781], 'Relationship': [3784], 'between': [3785], 'Surgery,': [3794, 4284], '10.1016/j.jvs.2019.08.270,': [3795], '71:3,': [3796], '(1056-1062),': [3797], '1-Mar-2020.': [3801], 'Oliveira': [3802], 'Sousa': [3805], 'Birocale': [3807], 'Gouvêa': [3809], 'Figueiredo': [3812], 'Abreu': [3815], 'Bissoli': [3818], 'local': [3826], 'proteins': [3828], 'hypertension-related': [3831], 'autonomic': [3833], 'Nutrition,': [3835], 'Metabolism': [3836], '10.1016/j.numecd.2019.09.005,': [3840], '(274-281),': 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'after': [3974], 'transplantation,': [3976], '10.1186/s12933-019-0925-y,': [3979], '1-Dec-2019.': [3984, 4027], 'diseases:': [4012], 'systematic': [4014], 'review': [4015], 'updated': [4018], 'meta-analysis,': [4019], '10.1186/s12933-019-0900-7,': [4022], 'Al-Talabany': [4030], 'McKinnie': [4032], 'Gandy': [4038], 'Baig': [4040], 'Hussain': [4042], 'Bhalraam': [4044], 'Matthew': [4050], 'Houston': [4052], 'George': [4056], 'hypertrophy': [4071], 'diabetes:': [4079], 'MET-REMODEL': [4081], 'Journal,': [4085], '10.1093/eurheartj/ehz203,': [4086], '40:41,': [4087], '(3409-3417),': [4088], '1-Nov-2019.': [4092], 'Álvarez-Cámara': [4093], 'Ramírez-Rosas': [4095], 'Medina-Terol': [4097], 'Silva-Velasco': [4099], 'Velazco-Paz': [4101], 'Sánchez-López': [4103], 'Guzman-Priego': [4105], 'Osuna-Martínez': [4107], 'U': [4108], 'Centurión': [4110], 'Potential': [4113], 'vascular': [4114], 'α1-adrenoceptor': [4115], 'blocking': [4116], 'properties': [4117], 'rat': [4121], 'aorta': [4122], 'tail': 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