Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2793600083', 'doi': 'https://doi.org/10.18632/oncotarget.24745', 'title': 'Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism', 'display_name': 'Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism', 'publication_year': 2018, 'publication_date': '2018-03-23', 'ids': {'openalex': 'https://openalex.org/W2793600083', 'doi': 'https://doi.org/10.18632/oncotarget.24745', 'mag': '2793600083', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29662610', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5882301'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.24745', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24745&path%5B%5D=77615', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24745&path%5B%5D=77615', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5080428202', 'display_name': 'Özgün Özer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Özgün Özer', 'raw_affiliation_strings': ['Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048597160', 'display_name': 'Rahul Bhowmick', 'orcid': 'https://orcid.org/0000-0002-5412-1209'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Rahul Bhowmick', 'raw_affiliation_strings': ['Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067876663', 'display_name': 'Ying Liu', 'orcid': 'https://orcid.org/0000-0003-3703-2498'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Ying Liu', 'raw_affiliation_strings': ['Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5085921889', 'display_name': 'Ian D. Hickson', 'orcid': 'https://orcid.org/0000-0002-0583-566X'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': True, 'raw_author_name': 'Ian D. Hickson', 'raw_affiliation_strings': ['Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark', 'institution_ids': ['https://openalex.org/I124055696']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5085921889'], 'corresponding_institution_ids': ['https://openalex.org/I124055696'], 'apc_list': None, 'apc_paid': None, 'fwci': 7.366, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 81, 'citation_normalized_percentile': {'value': 0.999954, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '9', 'issue': '22', 'first_page': '15836', 'last_page': '15846'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10937', 'display_name': 'Telomeres, Telomerase, and Senescence', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10937', 'display_name': 'Telomeres, Telomerase, and Senescence', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9684, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9579, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rad52', 'display_name': 'RAD52', 'score': 0.6664955}], 'concepts': [{'id': 'https://openalex.org/C177336024', 'wikidata': 'https://www.wikidata.org/wiki/Q14872779', 'display_name': 'Telomere', 'level': 3, 'score': 0.83679974}, {'id': 'https://openalex.org/C2776630724', 'wikidata': 'https://www.wikidata.org/wiki/Q18031020', 'display_name': 'RAD52', 'level': 5, 'score': 0.6664955}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.6321247}, {'id': 'https://openalex.org/C93304396', 'wikidata': 'https://www.wikidata.org/wiki/Q14763008', 'display_name': 'Mitosis', 'level': 2, 'score': 0.61325395}, {'id': 'https://openalex.org/C94581717', 'wikidata': 'https://www.wikidata.org/wiki/Q331839', 'display_name': 'Telomerase', 'level': 3, 'score': 0.5645681}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.51461256}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.47519696}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.41917747}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.35261834}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.3275503}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16043255}, {'id': 'https://openalex.org/C2779012473', 'wikidata': 'https://www.wikidata.org/wiki/Q3235015', 'display_name': 'RAD51', 'level': 4, 'score': 0.12207553}], 'mesh': [], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.24745', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24745&path%5B%5D=77615', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5882301', 'pdf_url': 'https://europepmc.org/articles/pmc5882301?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882301', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://curis.ku.dk/ws/files/217552523/24745_345905_4_PB.pdf', 'pdf_url': 'https://curis.ku.dk/ws/files/217552523/24745_345905_4_PB.pdf', 'source': {'id': 'https://openalex.org/S4306401983', 'display_name': 'Research at the University of Copenhagen (University of Copenhagen)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I124055696', 'host_organization_name': 'University of Copenhagen', 'host_organization_lineage': ['https://openalex.org/I124055696'], 'host_organization_lineage_names': ['University of Copenhagen'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29662610', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.24745', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=24745&path%5B%5D=77615', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1974993967', 'https://openalex.org/W1987369038', 'https://openalex.org/W2016357039', 'https://openalex.org/W2022529631', 'https://openalex.org/W2032097800', 'https://openalex.org/W2032407757', 'https://openalex.org/W2049576185', 'https://openalex.org/W2073031672', 'https://openalex.org/W2086333179', 'https://openalex.org/W2098085059', 'https://openalex.org/W2107632586', 'https://openalex.org/W2130272241', 'https://openalex.org/W2130937335', 'https://openalex.org/W2147259349', 'https://openalex.org/W2150490516', 'https://openalex.org/W2161232591', 'https://openalex.org/W2164580633', 'https://openalex.org/W2187574279', 'https://openalex.org/W2532728099', 'https://openalex.org/W2532734448', 'https://openalex.org/W2561547057', 'https://openalex.org/W2563646853', 'https://openalex.org/W2620853354', 'https://openalex.org/W2739167375', 'https://openalex.org/W2740697669'], 'related_works': ['https://openalex.org/W60632522', 'https://openalex.org/W4241189537', 'https://openalex.org/W2417511905', 'https://openalex.org/W2400859286', 'https://openalex.org/W2127443475', 'https://openalex.org/W2103156000', 'https://openalex.org/W2090447055', 'https://openalex.org/W2050296416', 'https://openalex.org/W2005903392', 'https://openalex.org/W1536144403'], 'abstract_inverted_index': {'//': [0], 'Özgün': [1], 'Özer': [2], '1': [3, 7, 11, 16, 17], ',': [4, 8], 'Rahul': [5], 'Bhowmick': [6], 'Ying': [9], 'Liu': [10], 'and': [12, 22, 30, 82, 151, 185], 'Ian': [13, 41], 'D.': [14, 42], 'Hickson': [15], 'Center': [18, 23], 'for': [19, 24, 223], 'Chromosome': [20, 57], 'Stability': [21], 'Healthy': [25], 'Aging,': [26], 'Department': [27], 'of': [28, 34, 49, 105, 121, 137, 155, 159, 163, 176, 216], 'Cellular': [29], 'Molecular': [31], 'Medicine,': [32], 'University': [33], 'Copenhagen,': [35, 37], '2200': [36], 'Denmark': [38], 'Correspondence': [39], 'to:': [40], 'Hickson,': [43], 'email:': [44], '[email protected]': [45], 'Keywords:': [46], 'alternative': [47, 174], 'lengthening': [48, 175], 'telomeres;': [50], 'common': [51, 73], 'fragile': [52, 74], 'sites;': [53], 'RAD52;': [54], 'MiDAS;': [55], 'MUS81;': [56], 'Received:': [58], 'November': [59], '02,': [60], '2017 ': [61], 'Accepted:': [62], 'February': [63], '25,': [64], '2018 ': [65], 'Published:': [66], 'March': [67], '23,': [68], '2018': [69], 'ABSTRACT': [70], 'Telomeres': [71], 'resemble': [72], 'sites': [75], '(CFSs)': [76], 'in': [77, 85, 87, 102, 229], 'that': [78, 127, 196, 219], 'they': [79], 'are': [80, 113, 167], 'difficult-to-replicate': [81], 'exhibit': [83], 'fragility': [84, 96], 'mitosis': [86], 'response': [88], 'to': [89, 115, 117, 145, 189, 225], 'DNA': [90, 106, 130, 227], 'replication': [91, 107, 210, 218], 'stress.': [92], 'At': [93], 'CFSs,': [94], 'this': [95, 128], 'is': [97, 133, 142, 152, 186], 'associated': [98], 'with': [99, 192], 'a': [100, 118, 135, 153, 156, 207, 213, 221], 'delay': [101], 'the': [103, 173, 193, 202], 'completion': [104], 'until': [108], 'early': [109], 'mitosis,': [110], 'whereupon': [111], 'cells': [112], 'proposed': [114], 'switch': [116], 'RAD52-dependent': [119, 214], 'form': [120, 215], 'break-induced': [122, 217], 'replication.': [123], 'Here,': [124], 'we': [125], 'show': [126], 'mitotic': [129], 'synthesis': [131, 228], '(MiDAS)': [132], 'also': [134], 'feature': [136, 154], 'human': [138], 'telomeres.': [139], 'Telomeric': [140], 'MiDAS': [141, 180, 198], 'not': [143, 200], 'restricted': [144], 'those': [146], 'telomeres': [147, 166, 177, 182], 'displaying': [148], 'overt': [149], 'fragility,': [150], 'wide': [157], 'range': [158], 'cell': [160], 'lines': [161], 'irrespective': [162], 'whether': [164], 'their': [165], 'maintained': [168], 'by': [169, 172], 'telomerase': [170], 'or': [171], '(ALT)': [178], 'mechanism.': [179], 'at': [181], 'requires': [183], 'RAD52,': [184], 'mechanistically': [187], 'similar': [188], 'CFS-associated': [190], 'MiDAS,': [191], 'notable': [194], 'exception': [195], 'telomeric': [197], 'does': [199], 'require': [201], 'MUS81-EME1': [203, 224], 'endonuclease.': [204], 'We': [205], 'propose': [206], 'model': [208], 'whereby': [209], 'stress': [211], 'initiates': [212], 'bypasses': [220], 'requirement': [222], 'complete': [226], 'mitosis.': [230]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2793600083', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 21}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 4}], 'updated_date': '2024-12-24T09:05:28.473236', 'created_date': '2018-03-29'}