2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke

Name: Work Video:
Duration: 3 min 30 s
Karen L. Furie; Mahesh Jayaraman
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'severity-based': [274], 'algorithm': [275], 'such': [276], 'as': [277, 337, 772, 817], 'Mission:': [279], 'Lifeline': [280], 'Severity-Based': [281], 'Triage': [283, 556], 'Algorithm': [284], '(http://www.heart.org/missionlifelinestroke)': [289], 'potential': [292, 535, 657, 3468], 'increase': [294], 'access': [295], 'thrombectomy.': [297], 'Hopefully,': [298], 'research': [300], 'determine': [302, 439], 'optimal': [304, 700], 'methods': [305], 'triaging': [307], 'appropriately': [309], 'from': [310, 448, 595, 628, 895, 1122], 'field.Imaging': [312], 'central': [314], 'management': [317, 883, 1994], 'patient.': [322], 'Historically,': [323], 'parenchymal': [324], 'imaging': [325, 350, 361, 457, 2983], 'with': [326, 351, 458, 777, 886, 955, 1360, 1399, 1646, 1844, 1918, 2207, 2340, 2612, 2817, 2821, 3029, 3179], 'noncontrast': [327, 431], 'CT': [328, 352, 432, 613, 1644, 2980], 'scan': [329], 'mainstay': [333], 'imaging.': [335], 'However,': [336], 'report,': [340, 2651], 'recently': [343], 'an': [345, 699, 3095], 'increasing': [346], 'use': [347, 358], 'vessel': [349, 360, 456, 491, 692, 2441, 3489], 'angiography': [353], '(CTA).': [354], 'Moving': [355], 'forward,': [356], 'should': [362, 526], 'become': [363], 'routine': [364], 'centers.': [367], 'new': [370, 732, 774, 3396], 'recommendation': [371], 'that': [373, 379, 520, 601, 652, 688], 'it': [374], 'reasonable': [376], 'expect': [378], 'all': [380], 'Primary': [381, 462, 638, 678], 'Centers': [383, 640], 'able': [385], 'perform': [387, 414], 'CTA': [388, 402, 415, 434, 459, 529, 675, 2976], 'on': [389, 580, 1397, 1479, 1642, 1796, 1884, 1913, 2372, 2481, 2815, 2862, 2886, 2898, 3251, 3337], 'patients,': [391, 2251], 'do': [393], 'so': [394], 'delaying': [396, 1429], 'alteplase': [397], 'administration.': [398], 'The': [399, 722, 731, 799, 910, 940, 1131, 2443, 2783, 3387], 'availability': [400], 'widespread,': [405], 'hospitals': [409], 'capability': [412], 'rapid': [418], 'fashion.': [419], 'cases,': [426], 'combination': [428], 'provides': [435], 'sufficient': [436], 'information': [437], 'eligibility': [440], 'first': [445], '6': [446, 593, 662], 'hours': [447, 594, 627, 663], 'onset.': [450, 597, 629], 'additional': [452], 'performing': [455], 'Center': [464, 680], 'would': [465, 533, 696], 'efficiently': [469], 'triage': [470], 'transfers': [471, 495], 'endovascular': [473, 1996, 3491], 'therapy.': [474], 'In': [475], 'some': [476], 'series,': [477], 'less': [478], 'than': [479], 'half': [480], 'transferred': [482], 'receive': [484], 'because': [486], 'lack': [488], 'intracranial': [490], 'occlusion.': [492], 'Such': [493], 'futile': [494, 705], 'resource': [497], 'intensive': [498, 1558], 'may': [500], 'overwhelm': [501], 'Centers.': [504], 'also': [506, 632], 'commend': [507], 'reaffirming': [511], 'low': [513], 'incidence': [514, 941], 'contrast-induced': [516], 'nephropathy,': [517], 'suggesting': [519], 'waiting': [521], 'serum': [524], 'creatinine': [525], 'not': [527, 728, 830], 'delay': [528], 'who': [532, 604], 'candidates.Two': [537], 'trials,': [539], 'DAWN': [540], '(Diffusion': [541], 'Weighted': [542], 'Imaging': [543, 571, 1000], '[DWI]': [544], 'or': [545, 615, 681, 836], 'Computerized': [546], 'Tomography': [547], 'Perfusion': [548], '[CTP]': [549], 'Assessment': [550, 2242], 'Clinical': [552, 998, 1113, 2252, 2655, 3131], 'Mismatch': [553], 'Wake': [558], 'Up': [559], 'Late': [561], 'Presenting': [562], 'Strokes': [563], 'Undergoing': [564], 'Neurointervention)': [565], 'DEFUSE-3': [567], '(Endovascular': [568], 'Therapy': [569, 3339], 'Following': [570], 'Evaluation': [572], '3),': [576], 'shed': [578], 'light': [579], 'anterior': [587], 'circulation': [588], 'large-vessel': [589], 'occlusion': [590, 693], 'beyond': [592, 661, 2708], 'symptom': [596], 'Both': [598], 'trials': [599], 'showed': [600], 'carefully': [606], 'using': [608, 611, 674, 1168, 2557, 2978], 'advanced': [609, 2982], 'either': [612], 'perfusion': [614], 'magnetic': [616], 'resonance': [617], 'dramatically': [620], 'improves': [621], 'outcomes': [622], 'even': [623], 'up': [624], '24': [626], 'These': [630, 646], 'results': [631], 'implications': [634], 'Ready': [644, 684], 'Hospitals.': [645], 'centers': [647], 'need': [649], 'ensure': [651, 687], 'their': [653], 'workflow': [654, 701], 'identify': [656], 'candidates': [658], 'rapidly': [665], 'transfer': [666, 695, 952], 'them': [667], 'Center.': [672], 'Again,': [673], 'Hospitals': [685], 'before': [694], 'likely': [697], 'could': [703], 'minimize': [704], 'transfers.There': [706], 'palpable': [710], 'shift': [711], 'toward': [712], 'focused': [714], 'cost-effective': [715], 'recommendations': [716, 3289], 'laboratory': [718], 'cardiac': [720, 2431], 'testing.': [721], 'message': [723], 'clear:': [725], 'necessarily': [729, 831], 'better.': [730], 'Guideline': [733, 813], 'emphasizes': [734], 'targeted': [736], 'approach': [737, 1876, 2884], 'diagnostic': [740], 'evaluation': [741, 1235, 2935], 'institution': [744], 'preventive': [748], 'interventions.': [749], 'Although': [750], 'role': [752, 3455], 'antiplatelet': [754, 767], 'agents': [755, 768], 'statins': [757], 'remains': [758], 'relatively': [759], 'unchanged': [760], 'this': [762, 812, 827], 'update,': [763], 'consideration': [764], 'dual': [766], 'added': [771], 'recommendation,': [775], 'albeit': [776], 'limited': [778], 'evidence.To': [779], 'quote': [780], 'Thoreau,': [781], '"When': [782], 'any': [783], 'real': [784], 'progress': [785, 805], 'made,': [787], 'unlearn': [789], 'learn': [791], 'anew': [792], 'what': [793], 'thought': [795], 'knew': [797], 'before."2': [798], 'made': [803], 'enormous': [804], 'elegantly': [815], 'serve': [816], 'primer': [819], 'updating': [821], 'our': [822], 'knowledge.DisclosuresNone.FootnotesThe': [823], 'opinions': [824], 'expressed': [825], 'article': [828], 'those': [832], 'editors': [835], 'American': [839, 897, 1132, 2784, 3627], 'Heart': [840, 898, 3583, 3628], 'Association.Correspondence': [841], 'MPH,': [847], 'Hospital,': [850], '593': [851], 'Eddy': [852], 'St,': [853], 'APC-5th': [854], 'Floor,': [855], 'Room': [856], '521,': [857], 'RI': [859], '02903.': [860], 'E-mail': [861], '[email': [862], 'protected]References1.': [863], 'Powers': [864], 'WJ,': [865], 'Rabinstein': [866], 'AA,': [867], 'Ackerson': [868], 'T,': [869, 1340, 1506, 3011, 3425], 'Adeoye': [870], 'OM,': [871], 'Bambakidis': [872], 'NC,': [873], 'Becker': [874], 'K,': [875, 1028, 1098, 1254, 1298, 1934, 2628, 2761, 2963, 3551], 'et': [876], 'al.': [877], 'guidelines': [879], 'early': [882, 1793], 'ischemic': [888, 1166, 1565, 1727, 1878, 1961, 2000, 2209, 2249, 2337, 2706, 2819, 2986, 3030, 3463], 'stroke:': [889, 1203, 1436, 1566, 2001, 2210, 2987, 3287], 'guideline': [891, 2371], 'healthcare': [893], 'professionals': [894], 'Association/American': [899], 'Association.Stroke.': [901], '2018;': [902], '49:e46–e110.': [903], 'doi:': [904], 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1501, 1669, 1675, 1903, 1983, 2184, 2355, 2689, 2734, 2804, 2807, 2844, 3049, 3432, 3478], 'Lou': [986], 'M,': [987, 1054, 1152, 1220, 1226, 1520, 1678, 2054, 2106, 2112, 2319, 2598, 2624, 2729, 2757, 2965, 3005, 3084, 3115, 3119, 3199, 3270, 3354, 3378, 3380, 3516, 3555, 3557], 'Yin': [988], 'C,': [989, 1188, 1717, 1746, 1750, 1825, 2017, 2048, 2068, 2118, 2122, 2151, 2155, 2264, 2291, 2392, 2533, 2535, 3117, 3419, 3431, 3433, 3435], 'Y,': [991, 1030, 1038, 1040, 1044, 1048, 1090, 1222, 1224, 1294, 1375, 1502, 1534, 1536, 1589, 1591, 1676, 1705, 1778, 2464, 2537, 2696, 2733, 2797, 2799, 2801, 2915, 2923, 3003, 3050, 3315, 3325, 3429, 3439], 'Lu': [992, 1020, 1211, 1374, 1539], 'J': [993, 996, 1302, 1383, 1632, 1722, 2327, 2426, 2808, 2877, 2967, 3518], 'Liu': [995, 1103, 1223, 1331, 1333, 1372, 1590, 1704, 1714, 2459, 2910, 3054, 3312, 3316, 3420], '(2021)': [997, 1232, 1266, 1306, 1346, 1387, 1472, 1554, 1599, 1636, 1684, 1756, 1790, 1871], 'Indicators': [1001], 'Hemorrhagic': [1003, 1274], 'Transformation': [1004, 1275], 'After': [1009, 1356, 2488], 'Endovascular': [1010, 2703, 3526, 3540], 'Thrombectomy,': [1011], 'Stroke,': [1012, 1080, 1363, 1617, 2144, 2282, 2490, 2525, 3100, 3226, 3343], '53:5,': [1013], '(1674-1681),': [1014], '1-May-2022.Bai': [1018], 'Pan': [1022, 1623], 'Q,': [1023, 1300, 1377, 1668, 1709, 3443], 'Wang': [1024, 1031, 1037, 1043, 1053, 1382, 1385, 1503, 1634, 1673, 1721, 1822, 1824, 1826, 2190, 3047, 3051, 3159, 3442, 3447], 'Pong': [1026], 'U': [1027], 'H,': [1032, 1218, 1256, 1338, 1524, 1546, 1583, 1670, 1713, 1859, 1863, 1896, 2187, 2191, 2229, 2354, 2356, 2466, 2497, 2503, 2694, 2839, 2871, 3321, 3360, 3376, 3441, 3506, 3553], 'Lin': [1033, 1041, 1143, 1155, 1943, 2353, 2627], 'Feng': [1035], 'L,': [1036, 1050, 1102, 1150, 1373, 1532, 1861, 1865, 1940, 2019, 2231, 2321, 2541, 2692, 2913, 3044, 3048, 3123, 3162, 3166], 'Lee': [1055, 2496, 2498, 2502, 2504, 3234, 3505, 3546, 3556, 3563], 'Jiang': [1057, 1860], 'X': [1058, 1345, 1904, 2701, 2805, 3330, 3448], 'G': [1061, 1109, 1190, 1949, 1986], 'Cranial': [1063], 'Bone': [1064], 'Transport': [1065], 'Promotes': [1066], 'Angiogenesis,': [1067], 'Neurogenesis,': [1068], 'Modulates': [1070], 'Meningeal': [1071], 'Lymphatic': [1072], 'Function': [1073], 'Middle': [1075, 1124, 3246], 'Cerebral': [1076, 3180, 3533], 'Artery': [1077, 3181, 3534], 'Occlusion': [1078], 'Rats,': [1079], '53:4,': [1081], '(1373-1385),': [1082], '1-Apr-2022.': [1086, 1142, 1186], 'Xie': [1087, 1667, 2693, 2800], 'Alsheikh-Ali': [1091], 'A,': [1092, 1096, 1419, 1460, 1780, 2072, 2116, 2266, 2289, 2390, 2669, 3268, 3272, 3277, 3366, 3592], 'AlMahmeed': [1093], 'Shehab': [1095], 'Sulaiman': [1097], 'Asaad': [1099], 'N,': [1100, 1510, 1542, 2108, 2727, 3160], 'Guo': [1101, 1261, 1293, 1295, 1335, 1671, 1939, 2461, 2730, 3318], 'Zubaid': [1105], 'M': [1106, 1305, 1468, 1789, 2195, 2423, 2605, 2671, 2768, 2845, 3055, 3210, 3382, 3561], 'Lip': [1108], 'Symptom': [1111], 'Status,': [1112], 'Subtypes,': [1114], 'Prognosis': [1116], 'Atrial': [1120, 3093, 3579], 'Fibrillation': [1121, 3580], 'East': [1125, 3247], 'Region': [1126], '(from': [1127], 'Gulf-SAFE': [1129], 'Registry),': [1130], 'Cardiology,': [1135, 3411], '10.1016/j.amjcard.2021.12.060,': [1136], '169,': [1137], '(57-63),': [1138], 'Chiang': [1145], 'Chen': [1147, 1151, 1158, 1230, 1588, 1866, 1869, 2363, 2726, 3161, 3438], 'Cheng': [1149, 1529, 3444], 'Chang': [1153], 'W': [1156, 1598, 1946, 2765], 'Toward': [1161], 'automated': [1162], 'segmentation': [1163], 'non-contrast': [1169], 'computed': [1170], 'tomography,': [1171], 'International': [1172, 1771, 2860, 2896, 3223, 3470], 'Computer': [1175], 'Assisted': [1176], 'Radiology': [1177], 'Surgery,': [1179, 2449], '10.1007/s11548-022-02570-x,': [1180], '17:4,': [1181], '(661-671),': [1182], 'Salgueiro': [1187], 'Urrútia': [1189], 'Cabanas-Valdés': [1192], 'R': [1193, 3090], 'Telerehabilitation': [1194], 'balance': [1196], 'rehabilitation': [1197, 3285], 'subacute': [1200], 'stage': [1201], 'A': [1204, 1321, 1403, 1481, 1553, 1806, 2002, 2211, 2649, 2712, 2850, 2882, 2973, 3071, 3130, 3479, 3482], 'pilot': [1205, 2773], 'controlled': [1206], 'trial,': [1207, 1571], 'NeuroRehabilitation,': [1208], '10.3233/NRE-210332,': [1209], '(1-9)': [1210], 'Luo': [1213, 1864, 1985, 2359, 2700, 2796], 'Ni': [1215, 1341, 2351], 'Meng': [1219], 'Cai': [1221, 1513, 1829, 2366], 'Ren': [1225, 1677], 'Sun': [1227, 1339, 1973, 2463, 2467, 2469, 3322, 3326], 'Reporting': [1233], 'quality': [1234], 'clinical': [1239, 1570, 1910, 2892], 'practice': [1240, 2370], 'guidelines:': [1241], 'systematic': [1243, 1438, 1807, 2212], 'review,': [1244], 'Systematic': [1245, 1322, 3216], 'Reviews,': [1246], '10.1186/s13643-021-01805-3,': [1247], '10:1,': [1248, 2042], '1-Dec-2021.': [1252], 'Jin': [1255, 1337, 2465, 3320], 'Xu': [1257, 1507, 1552, 1895, 2838, 2842, 2870, 2906, 3424], 'R,': [1258, 1458, 1666, 2102, 2124, 2421, 2600, 2909, 3013, 3113, 3356, 3362], 'Z': [1262, 1830, 1989, 3594], 'N-Terminal': [1267], 'Pro-brain': [1268], 'Natriuretic': [1269], 'Peptide': [1270], 'Is': [1271, 3177], 'Associated': [1272, 1610, 3178], 'Poor': [1277], 'Outcomes': [1278, 1310], 'Treated': [1283, 1317], 'Intravenous': [1285, 1319], 'Thrombolysis,': [1286], 'Frontiers': [1287, 1326, 1618, 1699, 2096, 2145, 2283, 2491, 3344], 'Molecular': [1289, 3473], 'Neuroscience,': [1290, 1774, 1964], '10.3389/fnmol.2021.758915,': [1291], '14': [1292], 'Zhao': [1297, 1906, 2847, 2879, 2912, 3314], 'Bao': [1299, 2695], 'Statin': [1307], 'Use': [1308], 'Thrombolysis:': [1320], 'Review': [1323], 'Meta-Analysis,': [1325, 3073], 'Neurology,': [1328, 1445, 1574, 1620, 2098, 2147, 2285, 2344, 2493, 2615, 3105, 3346], '10.3389/fneur.2021.734927,': [1329], '12': [1330, 1622, 1703], 'D,': [1334, 1508, 1540, 1544, 1630, 1982, 2235, 2362, 2759, 3001, 3205, 3275, 3317, 3358], 'C': [1342, 1426, 2023, 2543, 3022, 3170, 3207, 3282], 'Yan': [1344, 1519, 2457, 3329], 'Incidence': [1347], 'Risk': [1349, 2482], 'Factors': [1350, 1428, 2483], 'Lower-Extremity': [1352], 'Deep': [1353, 1648], 'Vein': [1354], 'Thrombosis': [1355], 'Thrombolysis': [1357], 'Among': [1358], 'Pharmacogenomics': [1364], 'Personalized': [1366], 'Medicine,': [1367, 1495, 2381, 2748, 2788, 3304, 3474, 3497], '10.2147/PGPM.S321084,': [1368], 'Volume': [1369], '14,': [1370], '(1107-1114)': [1371], 'Bi': [1376], 'Fu': [1378], 'Zhou': [1380, 1521, 2728, 3200], 'Q': [1386, 1550, 2630], 'Effects': [1388, 2740, 3332], 'Different': [1390], 'Intervention': [1391], 'Time': [1392], 'Points': [1393], 'Rehabilitation': [1396, 3303], 'Stroke:': [1402, 2092, 3070], 'Single-Center,': [1404], 'Randomized': [1405], 'Control': [1406, 2484], 'Study,': [1407, 2095], 'BioMed': [1408], 'Research': [1409, 3409], 'International,': [1410], '10.1155/2021/1940549,': [1411], '2021,': [1412], '(1-7),': [1413], '28-Aug-2021.': [1417], 'Sharobeam': [1418], 'Jones': [1420], 'Walton-Sonda': [1422], 'D': [1423, 1595, 1680, 1907, 2514, 2674, 2698, 2848, 2880, 2971, 3052, 3385, 3521], 'Lueck': [1425], '(2020)': [1427, 1723, 1908, 1950, 1990, 2027, 2080, 2132, 2164, 2199, 2241, 2272, 2299, 2331, 2368, 2400, 2427, 2474, 2515, 2547, 2578, 2606, 2634, 2739, 2769], 'thrombolytic': [1431, 2341], 'therapy': [1432, 1556, 1997], 'ischaemic': [1435, 3404], 'review': [1439, 1808, 2003, 2213, 3217], 'literature,': [1442, 2006], '10.1007/s00415-020-09803-6,': [1446], '268:8,': [1447], '(2723-2734),': [1448], '1-Aug-2021.': [1452], 'Savioli': [1453], 'G,': [1454, 1464, 1466, 1626, 1936, 1942, 2063, 2104, 2667, 2907, 3007, 3009, 3368], 'Ceresa': [1455], 'I,': [1456, 2065], 'Guarnone': [1457], 'Muzzi': [1459], 'Novelli': [1461], 'V,': [1462, 1784], 'Ricevuti': [1463], 'Iotti': [1465], 'Bressan': [1467], 'Oddone': [1470], 'E': [1471, 1786, 2577, 3128], 'Impact': [1473, 1791, 3242], 'Coronavirus': [1475], 'Disease': [1476], '2019': [1477, 2858, 2894], 'Pandemic': [1478], 'Crowding:': [1480], 'Call': [1482], 'Action': [1484], 'Effective': [1486], 'Solutions': [1487], '"Access': [1489], 'Block",': [1490], 'Western': [1491], '10.5811/westjem.2021.2.49611,': [1496], '22:4,': [1497], '(860-870)': [1498], 'Yu': [1505, 1627, 1712, 1901, 2876, 3426], 'Niu': [1511], 'Zhuo': [1515], 'Wu': [1517, 1527, 1592, 1625, 2361, 2691], 'J,': [1522, 1530, 1585, 1624, 1628, 1674, 1707, 1898, 1902, 1938, 1944, 2052, 2059, 2505, 2509, 2626, 2731, 2755, 2763, 2837, 2873, 2911, 2919, 2959, 3121, 3364, 3477, 3514, 3547, 3549], 'Liang': [1525, 1597], 'Huang': [1531, 2536, 2920, 3167], 'Guan': [1535], 'Tan': [1537, 2192], 'He': [1541, 1945, 2697, 2737], 'Dong': [1543, 1718, 2908, 3002], 'Zhu': [1545, 1858], 'Shen': [1549, 3165], 'Combined': [1555, 2635], 'statin': [1559], 'plus': [1560], 'rt-PA': [1562], 'INSPIRE': [1568], 'randomized': [1569], '10.1007/s00415-020-10388-3,': [1575], '268:7,': [1576], '(2560-2569),': [1577], '1-Jul-2021.': [1581], 'Zhong': [1582, 2922], 'Qu': [1584], 'Xiao': [1586, 2194, 2916], 'Qiu': [1594, 3045], 'Severity': [1600], 'Lesions': [1602], 'Involving': [1603], 'Cortical': [1605], 'Cholinergic': [1606], 'Pathways': [1607], 'May': [1608], 'Be': [1609], 'Cognitive': [1612], 'Impairment': [1613], 'Subacute': [1615], '10.3389/fneur.2021.606897,': [1621], 'Geng': [1629], 'Detecting': [1637], 'Infarct': [1640], 'Core': [1641], 'Non-Contrast': [1643], 'Images': [1645], 'Learning': [1649, 2082, 2517], 'Residual': [1650], 'Network,': [1651], 'Cerebrovascular': [1656, 2086, 2428, 3148, 3189, 3538], 'Diseases,': [1657, 3149, 3190], '10.1016/j.jstrokecerebrovasdis.2021.105752,': [1658], '30:6,': [1659], '(105752),': [1660], '1-Jun-2021.': [1664], 'Ma': [1665, 1706, 3418], 'Gong': [1679], 'Gao': [1682, 3428], 'T': [1683, 2268, 2330, 2602, 2928], 'l-Borneol': [1685], 'Exerted': [1686], 'Neuroprotective': [1688], 'Effect': [1689], 'by': [1690], 'Promoting': [1691], 'Angiogenesis': [1692], 'Coupled': [1693], 'Neurogenesis': [1695], 'via': [1696], 'Ang1-VEGF-BDNF': [1697], 'Pathway,': [1698], 'Pharmacology,': [1701], '10.3389/fphar.2021.641894,': [1702], 'Xin': [1710], 'Pang': [1716, 1897, 2836, 2872], 'F': [1719, 2159, 2198, 2295, 2396, 3445], 'Quantitatively': [1724], 'monitoring': [1725], 'post': [1730], 'recombinant': [1731], 'tissue': [1732], 'plasminogen': [1733], 'activator': [1734], 'treatment,': [1735], 'Health': [1736, 2479], 'Science': [1737], 'Reports,': [1738, 2040, 3609], '10.1002/hsr2.218,': [1739], '4:1,': [1740], '1-Mar-2021.': [1744], 'Chung': [1745, 2016, 2532, 3515], 'Bamodu': [1747, 2020], 'O,': [1748, 2021], 'Hong': [1749, 2022, 2534], 'Chan': [1751, 2018, 2540], 'L': [1752, 1827, 2574, 2633, 2738, 3279], 'Chiu': [1754, 2025, 2545], 'Application': [1757], 'machine': [1759, 1874], 'learning-based': [1760], 'models': [1761], 'boost': [1763], 'predictive': [1765], 'power': [1766], 'SPAN': [1769], 'index,': [1770], '10.1080/00207454.2021.1881092,': [1775], '(1-11)': [1776], 'Hourmant': [1777], 'Mailloux': [1779], 'Valade': [1781], 'Lemiale': [1783], 'Azoulay': [1785], 'Darmon': [1788], 'ICU': [1794], 'admission': [1795], 'outcome': [1797, 2554, 2776], 'critically': [1799, 1802], 'ill': [1800, 1803], 'cancer': [1804], 'patients:': [1805], 'meta-analysis.,': [1810], 'Critical': [1813], 'Care,': [1814], '10.1016/j.jcrc.2020.10.008,': [1815], '61,': [1816], '(82-88),': [1817], '1-Feb-2021.': [1821], 'Minocycline': [1831], 'Inhibits': [1832], 'mTOR': [1833], 'Signaling': [1834], 'Activation': [1835], 'Alleviates': [1837], 'Behavioral': [1838], 'Deficits': [1839, 2275], 'Wistar': [1842], 'Rats': [1843], 'Ischemia': [1846], 'stroke,': [1847, 1962, 3031, 3405], 'CNS': [1848], '&': [1849], 'Neurological': [1850, 2219, 2564], 'Disorders': [1851], '-': [1852, 2309, 2411, 2586, 3033], 'Drug': [1853, 3062], 'Targets,': [1854], '10.2174/1871527319999200831153748,': [1855], '19:10,': [1856], '(791-799)': [1857], 'automatic': [1873], 'learning': [1875], 'onset': [1880], 'time': [1881, 2435, 2710], 'identification': [1882], 'based': [1883, 1912, 2031, 2885], 'DWI': [1885], 'FLAIR': [1887], 'NeuroImage:': [1889], 'Clinical,': [1890], '10.1016/j.nicl.2021.102744,': [1891], '31,': [1892], '(102744),': [1893], '.': [1894, 3266, 3545], 'Modeling': [1909], 'activities': [1911], 'multi-perspective': [1914, 2887], 'declarative': [1915, 2888], 'process': [1916, 2889], 'mining': [1917, 2890], "openEHR's": [1919], 'characteristic,': [1920], 'BMC': [1921, 1963], 'Informatics': [1923], 'Decision': [1925], 'Making,': [1926], '10.1186/s12911-020-01323-7,': [1927], '20:S14,': [1928], '1-Dec-2020.': [1932, 1970, 2015, 2046], 'Rui': [1935], 'Ding': [1948], 'Cathodal': [1951], 'tDCS': [1952], 'exerts': [1953], 'neuroprotective': [1954], 'effect': [1955, 2811], 'rat': [1957], 'brain': [1958, 2943], 'after': [1959, 2172, 2430, 2555, 3286], '10.1186/s12868-020-00570-8,': [1965], '21:1,': [1966], 'Han': [1971], 'Tong': [1975], 'Raynald': [1977], ',': [1978], 'Jia': [1979], 'Mo': [1981], 'Miao': [1988], 'blood': [1992], 'pressure': [1993], 'Interventional': [2007, 2827], 'Neuroradiology,': [2008, 2828], '10.1177/1591019920931651,': [2009], '26:6,': [2010], '(785-792),': [2011], 'Artificial': [2028], 'neural': [2029, 2559], 'network': [2030], 'prediction': [2032], 'postthrombolysis': [2034], 'intracerebral': [2035], 'hemorrhage': [2036], 'death,': [2038], 'Scientific': [2039], '10.1038/s41598-020-77546-5,': [2041], 'Dargazanli': [2047], 'Zub': [2049], 'E,': [2050, 2499, 2539], 'Deverdun': [2051], 'Decourcelle': [2053], 'de': [2055, 2402, 2588, 3203], 'Bock': [2056], 'F,': [2057, 2070, 2110], 'Labreuche': [2058], 'Lefèvre': [2060], 'Gascou': [2062], 'Derraz': [2064], 'Riquelme': [2066], 'Bareiro': [2067], 'Cagnazzo': [2069], 'Bonafé': [2071], 'Marin': [2073], 'Costalat': [2075], 'V': [2076, 2298, 2399], 'Marchi': [2078], 'N': [2079, 2511], 'Machine': [2081, 2516], 'Analysis': [2083], 'Thrombi': [2087], 'Proteome': [2088], 'Human': [2090], 'Exploratory': [2094], '10.3389/fneur.2020.575376,': [2099], '11': [2100, 2149, 2287, 2495], 'Mendes': [2101], 'Martins': [2103], 'Oliveira': [2105], 'Rocha': [2107], 'Cruz': [2109], 'Antunes': [2111], 'Abreu': [2113], 'Silva': [2115, 2130], 'Takiya': [2117], 'Pimentel-Coelho': [2119], 'Robba': [2121], 'Mendez-Otero': [2123], 'Pelosi': [2125], 'Rocco': [2127], 'P': [2128, 2131, 2163, 2237], 'Iso-Oncotic': [2133], 'Albumin': [2134], 'Mitigates': [2135], 'Brain': [2136], 'Kidney': [2138], 'Injury': [2139], 'Experimental': [2141], 'Focal': [2142], '10.3389/fneur.2020.01001,': [2148], 'Tracol': [2150], 'Vannier': [2152], 'Hurel': [2154], 'Tuffier': [2156], 'Eugene': [2158], 'Le': [2161], 'Reste': [2162], 'Predictors': [2165], 'malignant': [2167], 'middle': [2168, 2645], 'cerebral': [2169, 2646], 'artery': [2170, 2643, 2647], 'infarction': [2171], 'thrombectomy,': [2174, 2747, 3492], 'Revue': [2175], 'Neurologique,': [2176], '10.1016/j.neurol.2020.01.352,': [2177], '176:7-8,': [2178], '(619-625),': [2179], '1-Sep-2020.': [2183, 2227], 'Du': [2186], 'Song': [2188], 'Efficacy': [2200], 'safety': [2202], 'sonothrombolysis': [2204], 'meta-analysis,': [2215], 'Sciences,': [2220, 2565, 2950], '10.1016/j.jns.2020.116998,': [2221], '416,': [2222], '(116998),': [2223], 'AlHarfany': [2228], 'Haidar': [2230], 'Cherri': [2232], 'Malaeb': [2234], 'Salameh': [2236], 'Hosseini': [2239], 'treatment': [2245, 2639, 2704], 'hypertension': [2247, 2742], 'Neurology': [2253, 3032], 'Neurosurgery,': [2255, 3075, 3541], '10.1016/j.clineuro.2020.105949,': [2256], '195,': [2257], '(105949),': [2258], '1-Aug-2020.': [2262], 'Wijesundera': [2263], 'Vingrys': [2265], 'Wijeratne': [2267], 'Crewther': [2270], 'S': [2271, 3019, 3125], 'Acquired': [2273], 'Visual': [2274, 3493], 'Independent': [2276], 'Lesion': [2278], 'Site': [2279], '10.3389/fneur.2020.00705,': [2286], 'Jacquens': [2288, 2389], 'Guidoux': [2290, 2391], 'Mathon': [2292, 2393], 'Clarençon': [2294, 2395], 'Degos': [2297, 2398], 'Gestione': [2300], 'degli': [2301], 'accidenti': [2302], 'vascolari': [2303], 'cerebrali': [2304], 'fase': [2306, 2408], 'acuta,': [2307], 'EMC': [2308, 2410, 2585], 'Anestesia-Rianimazione,': [2310], '10.1016/S1283-0771(20)43694-1,': [2311], '25:2,': [2312], '(1-20),': [2313], '1-Jun-2020.': [2317], 'Scalise': [2318], 'Brechtel': [2320], 'Conn': [2322], 'Bailes': [2324], 'Gainey': [2326], 'Nathaniel': [2329], 'Predicting': [2332, 2548], 'ambulatory': [2333], 'recovery': [2334], 'therapy,': [2342], 'Future': [2343], '10.2217/fnl-2020-0002,': [2345], '15:2,': [2346], '1-May-2020.': [2350, 2388, 2419], 'Liao': [2357], 'Evidence‐based': [2369], 'integrative': [2373], 'medicine': [2374], '2019,': [2377], 'Evidence-Based': [2380], '10.1111/jebm.12386,': [2382], '13:2,': [2383], '(137-152),': [2384], 'Tratamiento': [2401], 'los': [2403], 'accidentes': [2404], 'cerebrovasculares': [2405], 'en': [2406, 2581], 'la': [2407], 'aguda,': [2409], 'Anestesia-Reanimación,': [2412], '10.1016/S1280-4703(20)43647-3,': [2413], '46:2,': [2414], '(1-21),': [2415], 'Schweizer': [2420], 'Jacquet-Lagrèze': [2422], 'Fellahi': [2425], 'complications': [2429], 'surgery:': [2432], 'It': [2433], 'track': [2437], 'treat': [2439], 'large': [2440, 3488], 'occlusion,': [2442], 'Thoracic': [2446], 'Cardiovascular': [2448, 3391, 3572], '10.1016/j.jtcvs.2019.10.147,': [2450], '159:4,': [2451], '(e263-e264),': [2452], '1-Apr-2020.': [2456], 'Positive': [2475], 'Influence': [2476], 'Manager': [2480], 'Medication': [2486], 'Adherence': [2487], '10.3389/fneur.2020.00168,': [2494], 'Ham': [2500], 'Kwon': [2506, 3550], 'Kang': [2513], 'Approach': [2518], 'Identify': [2520], 'Within': [2522], '4.5': [2523], 'Hours,': [2524], '51:3,': [2526], '(860-866),': [2527], '1-Mar-2020.': [2531, 2572, 2596], 'Su': [2538], 'Hu': [2542], 'neurologic': [2550], 'improvement': [2551], 'long-term': [2553], 'thrombolysis': [2556, 3601], 'artificial': [2558], 'networks,': [2560], '10.1016/j.jns.2020.116667,': [2566], '410,': [2567], '(116667),': [2568], 'Puy': [2573], 'Jouvent': [2576], 'Accidente': [2579], 'cerebrovascular': [2580], 'el': [2582], 'paciente': [2583], 'anciano,': [2584], 'Tratado': [2587], 'Medicina,': [2589], '10.1016/S1636-5410(20)43329-X,': [2590], '24:1,': [2591], '(1-6),': [2592], 'Young': [2597], 'Regenhardt': [2599], 'Leslie-Mazwi': [2601], 'Stein': [2604], 'Disabling': [2607], 'persons': [2610], 'already': [2611], 'disability,': [2614], '10.1212/WNL.0000000000008964,': [2616], '94:7,': [2617], '(306-310),': [2618], '18-Feb-2020.': [2622], 'Hao': [2625], 'Cui': [2629], 'surgical': [2636], 'interventional': [2638], 'tandem': [2641], 'carotid': [2642], 'embolus:': [2648], 'case': [2650], 'World': [2652, 3074], 'Cases,': [2656], '10.12998/wjcc.v8.i3.630,': [2657], '8:3,': [2658], '(630-637),': [2659], '6-Feb-2020.': [2663], 'Ottolenghi': [2664], 'Sabbatini': [2666], 'Brizzolari': [2668], 'Samaja': [2670], 'Chiumello': [2673], 'Hyperoxia': [2675], 'oxidative': [2677], 'stress': [2678], 'anesthesia': [2680], 'critical': [2682], 'medicine,': [2684], 'Minerva': [2685], 'Anestesiologica,': [2686], '10.23736/S0375-9393.19.13906-5,': [2687], '86:1': [2688], '(2019)': [2702, 2809, 2849, 2881, 2929, 2972, 3023, 3056, 3091, 3129, 3174, 3241, 3283], 'window:': [2711], 'meta‐analysis,': [2713], 'Acta': [2714], 'Neurologica': [2715], 'Scandinavica,': [2716], '10.1111/ane.13161,': [2717], '141:1,': [2718], '(3-13),': [2719], '1-Jan-2020.': [2723, 2795], 'Yuan': [2724, 2802], 'receiving': [2745], '10.1097/MD.0000000000019803,': [2749], '99:16,': [2750], '(e19803)': [2751], 'Scheving': [2752], 'Ebersole': [2754], 'Froehler': [2756], 'Moore': [2758], 'Brown-Espaillat': [2760], 'Closser': [2762], 'Self': [2764], 'Ward': [2767], 'Implementation': [2770], 'electronic': [2774], 'reporting': [2777], 'system': [2778], 'emergency': [2780], 'providers,': [2782], '10.1016/j.ajem.2019.07.017,': [2789], '38:1,': [2790], '(114-117),': [2791], 'Therapeutic': [2810], 'pre-operative': [2813], 'tirofiban': [2814], 'within': [2824], '6–24': [2825], 'hours,': [2826], '10.1177/1591019919851167,': [2829], '25:6,': [2830], '(705-709),': [2831], '1-Dec-2019.': [2835], 'Nan': [2840], 'Mobile': [2851], 'Intelligent': [2852], 'Checklist': [2853], 'System': [2854], 'IEEE': [2859, 2895], 'Conference': [2861, 2897], 'Bioinformatics': [2863, 2899], 'Biomedicine': [2865, 2901], '(BIBM),': [2866, 2902], '10.1109/BIBM47256.2019.8983379,': [2867], '978-1-7281-1867-3,': [2868, 2904], '(1581-1584)': [2869], 'modeling': [2883], 'activity': [2893], '10.1109/BIBM47256.2019.8983089,': [2903], '(1688-1691)': [2905], 'Zeng': [2914], 'Guang': [2924], 'B': [2925, 3173], 'Synthesis,': [2930], 'characterization': [2931], 'vivo': [2934], 'honokiol': [2937], 'bisphosphate': [2938], 'prodrugs': [2939], 'protects': [2940], 'against': [2941], "rats'": [2942], 'ischemia-reperfusion': [2944], 'injury,': [2945], 'Asian': [2946], 'Pharmaceutical': [2949], '10.1016/j.ajps.2018.11.004,': [2951], '14:6,': [2952], '(640-648),': [2953], '1-Nov-2019.': [2957], 'Ognard': [2958], 'Dissaux': [2960], 'Haioun': [2962], 'Nonent': [2964], 'Gentric': [2966], 'Ben': [2969], 'Salem': [2970], '"one-stop-shop"': [2974], '4D': [2975], 'protocol': [2977], '320-row': [2979], 'technical': [2989], 'note,': [2990], 'European': [2991], 'Radiology,': [2992], '10.1007/s00330-019-06041-x,': [2993], '29:9,': [2994], '(4930-4936),': [2995], '1-Sep-2019.': [2999], 'Weisenburger-Lile': [3000], 'Yger': [3004], 'Weisenburger': [3006], 'Polara': [3008], 'Chaigneau': [3010], 'Ochoa': [3012], 'Marro': [3014], 'Lapergue': [3016], 'Alamowitch': [3018], 'Elbim': [3021], 'Harmful': [3024], 'neutrophil': [3025], 'subsets': [3026], 'Neuroimmunology': [3034], 'Neuroinflammation,': [3035], '10.1212/NXI.0000000000000571,': [3036], '6:4,': [3037], '(e571),': [3038], '1-Jul-2019.': [3042, 3082, 3111], 'Deng': [3043, 3172], 'Comparison': [3057], 'Four': [3059], 'Food': [3060], 'Administration–Approved': [3063], 'Mechanical': [3064, 3525], 'Thrombectomy': [3065, 3527], 'Devices': [3066], 'Network': [3072], '10.1016/j.wneu.2019.02.011,': [3076], '127,': [3077], '(e49-e57),': [3078], 'Johansen': [3083], 'De': [3085], 'Vasconcellos': [3086], 'Gottesman': [3089], 'Understanding': [3092], 'Cardiopathy:': [3094], 'Under-Recognized': [3096], 'Contributor': [3097], 'Cardioembolic': [3099], 'Current': [3101], 'Treatment': [3102], 'Options': [3103], '10.1007/s11940-019-0571-4,': [3106], '21:7,': [3107], 'Pollard': [3112], 'Leppert': [3114], 'Rawson': [3116], 'Boehnke': [3118], 'Honce': [3120], 'Nagae': [3122], 'Poisson': [3124], 'Nyberg': [3127], 'Paradigm': [3132], 'Classifying': [3134], 'Neurologic': [3135], 'Symptoms': [3136], 'Screen': [3138], 'Emergent': [3140], 'Large': [3141], 'Vessel': [3142], 'Occlusions,': [3143], '10.1016/j.jstrokecerebrovasdis.2018.12.010,': [3150], '28:4,': [3151], '(929-934),': [3152], '1-Apr-2019.': [3156], 'Serum': [3175], 'Aldosterone': [3176], 'Atherosclerosis': [3182], 'Calcification,': [3184], '10.1016/j.jstrokecerebrovasdis.2018.09.053,': [3191], '28:3,': [3192], '(523-530),': [3193], '1-Mar-2019.': [3197], 'Badve': [3198], 'van': [3202], 'Beek': [3204], 'Anderson': [3206], 'Hackett': [3209], '(2018)': [3211, 3331, 3386, 3449, 3483, 3522, 3565, 3598], 'Frequency': [3212], 'post-stroke': [3214], 'pneumonia:': [3215], 'meta-analysis': [3219], 'observational': [3221], 'studies,': [3222], '10.1177/1747493018806196,': [3227], '14:2,': [3228], '(125-136),': [3229], '1-Feb-2019.': [3233], 'Khang': [3236], 'Lim': [3239], '2015': [3245], 'Respiratory': [3248], 'Syndrome': [3249], 'Outbreak': [3250], 'Care': [3253], 'Utilization': [3254], 'Mortality': [3256, 3575], 'South': [3258], 'Korea,': [3259], 'Yonsei': [3260], 'Journal,': [3262, 3587], '10.3349/ymj.2019.60.8.796,': [3263], '60:8,': [3264], '(796),': [3265], 'Schnitzler': [3267], 'Erbault': [3269], 'Solomiac': [3271], 'Sainte': [3273], 'Croix': [3274], 'Fouchard': [3276], 'May-Michelangeli': [3278], 'Grenier': [3281], 'Strong': [3288], 'no': [3291], 'achievement': [3292], 'French': [3295], 'Healthcare': [3297], 'Facilities,': [3298], 'Annals': [3299], 'Physical': [3301], '10.1016/j.rehab.2018.07.001,': [3305], '62:1,': [3306], '(58-59),': [3307], '1-Jan-2019.': [3311], 'Nursing': [3334], 'Quality': [3335], 'Improvement': [3336], 'Thrombolytic': [3338], '10.3389/fneur.2018.01025,': [3347], '9': [3348], 'Davidson': [3349], 'Arjun': [3351], 'Basalay': [3353], 'Bell': [3355], 'Bromage': [3357], 'Bøtker': [3359], 'Carr': [3361], 'Cunningham': [3363], 'Ghosh': [3365], 'Heusch': [3367], 'Ibanez': [3369], 'Kleinbongard': [3371], 'Lecour': [3373], 'Maddock': [3375], 'Ovize': [3377], 'Walker': [3379], 'Wiart': [3381], 'Yellon': [3384], '10th': [3388], 'Biennial': [3389], 'Hatter': [3390], 'Institute': [3392], 'workshop:': [3393], 'cellular': [3394], 'protection—evaluating': [3395], 'directions': [3397], 'setting': [3400], 'myocardial': [3402], 'infarction,': [3403], 'cardio-oncology,': [3407], 'Basic': [3408], '10.1007/s00395-018-0704-z,': [3412], '113:6,': [3413], '1-Nov-2018.': [3417], 'Zhai': [3430], 'Lei': [3434], 'Fan': [3436], 'Evidence': [3450], 'perspective': [3452], 'NLRP3': [3458], 'inflammasome': [3459], 'signaling': [3460], 'pathway': [3461], 'therapeutic': [3467], '(Review),': [3469], '10.3892/ijmm.2018.3911': [3475], 'Fong': [3476], 'Vohra': [3481], 'requiring': [3490], '10.1016/j.visj.2018.06.022,': [3498], '13,': [3499], '(10-11),': [3500], '1-Oct-2018.': [3504], 'Im': [3509], 'Hwang': [3511], 'Jeong': [3513], 'Park': [3517, 3558], 'Shin': [3520], 'Implications': [3523], 'Basilar': [3530], 'Posterior': [3532], 'Occlusion,': [3535], '10.7461/jcen.2018.20.3.168,': [3542], '20:3,': [3543], '(168),': [3544], 'Sunwoo': [3548], 'Roh': [3552], 'Ahn': [3554], 'Hyon': [3560], 'K': [3564], 'Left': [3566], 'Ventricular': [3567], 'Ejection': [3568], 'Fraction': [3569], 'Predicts': [3570], 'Poststroke': [3571], 'Events': [3573], 'Coronary': [3582], 'Disease,': [3584], 'Korean': [3585], 'Circulation': [3586], '10.4070/kcj.2018.0115,': [3588], 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