Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2792835060', 'doi': 'https://doi.org/10.1016/j.ejphar.2018.03.022', 'title': 'Mechanism of cardiovascular toxicity by proteasome inhibitors: New paradigm derived from clinical and pre-clinical evidence', 'display_name': 'Mechanism of cardiovascular toxicity by proteasome inhibitors: New paradigm derived from clinical and pre-clinical evidence', 'publication_year': 2018, 'publication_date': '2018-06-01', 'ids': {'openalex': 'https://openalex.org/W2792835060', 'doi': 'https://doi.org/10.1016/j.ejphar.2018.03.022', 'mag': '2792835060', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29550338'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejphar.2018.03.022', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064517994', 'display_name': 'Mara Gavazzoni', 'orcid': 'https://orcid.org/0000-0001-9516-8188'}, 'institutions': [{'id': 'https://openalex.org/I79940851', 'display_name': 'University of Brescia', 'ror': 'https://ror.org/02q2d2610', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I79940851']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Mara Gavazzoni', 'raw_affiliation_strings': ['Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy', 'institution_ids': ['https://openalex.org/I79940851']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061512474', 'display_name': 'Enrico Vizzardi', 'orcid': 'https://orcid.org/0000-0002-3544-6104'}, 'institutions': [{'id': 'https://openalex.org/I79940851', 'display_name': 'University of Brescia', 'ror': 'https://ror.org/02q2d2610', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I79940851']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Enrico Vizzardi', 'raw_affiliation_strings': ['Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy', 'institution_ids': ['https://openalex.org/I79940851']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054225519', 'display_name': 'Elio Gorga', 'orcid': 'https://orcid.org/0000-0003-1582-5403'}, 'institutions': [{'id': 'https://openalex.org/I79940851', 'display_name': 'University of Brescia', 'ror': 'https://ror.org/02q2d2610', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I79940851']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Elio Gorga', 'raw_affiliation_strings': ['Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy', 'institution_ids': ['https://openalex.org/I79940851']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077709879', 'display_name': 'Ivano Bonadei', 'orcid': 'https://orcid.org/0000-0001-6275-608X'}, 'institutions': [{'id': 'https://openalex.org/I79940851', 'display_name': 'University of Brescia', 'ror': 'https://ror.org/02q2d2610', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I79940851']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Ivano Bonadei', 'raw_affiliation_strings': ['Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy', 'institution_ids': ['https://openalex.org/I79940851']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061709114', 'display_name': 'Laura Rossi', 'orcid': 'https://orcid.org/0000-0001-9976-9394'}, 'institutions': [{'id': 'https://openalex.org/I79940851', 'display_name': 'University of Brescia', 'ror': 'https://ror.org/02q2d2610', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I79940851']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Laura Rossi', 'raw_affiliation_strings': ['Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy', 'institution_ids': ['https://openalex.org/I79940851']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072928867', 'display_name': 'Angelo Belotti', 'orcid': 'https://orcid.org/0000-0002-0617-3127'}, 'institutions': [{'id': 'https://openalex.org/I4210103289', 'display_name': 'Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia', 'ror': 'https://ror.org/015rhss58', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103289']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Angelo Belotti', 'raw_affiliation_strings': ['Department of Hematology, Spedali Civili of Brescia, Brescia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, Spedali Civili of Brescia, Brescia, Italy', 'institution_ids': ['https://openalex.org/I4210103289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101631020', 'display_name': 'Giuseppe Rossi', 'orcid': 'https://orcid.org/0000-0001-8377-2898'}, 'institutions': [{'id': 'https://openalex.org/I4210103289', 'display_name': 'Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia', 'ror': 'https://ror.org/015rhss58', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103289']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppe Rossi', 'raw_affiliation_strings': ['Department of Hematology, Spedali Civili of Brescia, Brescia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, Spedali Civili of Brescia, Brescia, Italy', 'institution_ids': ['https://openalex.org/I4210103289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034395311', 'display_name': 'Rossella Ribolla', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210103289', 'display_name': 'Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia', 'ror': 'https://ror.org/015rhss58', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103289']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Rossella Ribolla', 'raw_affiliation_strings': ['Department of Hematology, Spedali Civili of Brescia, Brescia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Hematology, Spedali Civili of Brescia, Brescia, Italy', 'institution_ids': ['https://openalex.org/I4210103289']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053760015', 'display_name': 'Marco Metra', 'orcid': 'https://orcid.org/0000-0001-6691-8568'}, 'institutions': [{'id': 'https://openalex.org/I79940851', 'display_name': 'University of Brescia', 'ror': 'https://ror.org/02q2d2610', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I79940851']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Marco Metra', 'raw_affiliation_strings': ['Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy', 'institution_ids': ['https://openalex.org/I79940851']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5027401178', 'display_name': 'Riccardo Raddino', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I79940851', 'display_name': 'University of Brescia', 'ror': 'https://ror.org/02q2d2610', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I79940851']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Riccardo Raddino', 'raw_affiliation_strings': ['Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Cardiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health University, Cardiothoracic Department, Spedali Civili of Brescia, Italy', 'institution_ids': ['https://openalex.org/I79940851']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5064517994'], 'corresponding_institution_ids': ['https://openalex.org/I79940851'], 'apc_list': {'value': 2790, 'currency': 'USD', 'value_usd': 2790, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.362, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.998497, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '828', 'issue': None, 'first_page': '80', 'last_page': '88'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10649', 'display_name': 'Diagnosis and Treatment of Multiple Myeloma', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10649', 'display_name': 'Diagnosis and Treatment of Multiple Myeloma', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Role of Matrix Metalloproteinases in Cancer and Physiology', 'score': 0.9841, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proteasome-inhibitors', 'display_name': 'Proteasome Inhibitors', 'score': 0.553731}, {'id': 'https://openalex.org/keywords/proteasome', 'display_name': 'Proteasome', 'score': 0.524552}, {'id': 'https://openalex.org/keywords/protease-inhibition', 'display_name': 'Protease Inhibition', 'score': 0.515013}], 'concepts': [{'id': 'https://openalex.org/C2780108899', 'wikidata': 'https://www.wikidata.org/wiki/Q15366934', 'display_name': 'Carfilzomib', 'level': 4, 'score': 0.94249094}, {'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.7346471}, {'id': 'https://openalex.org/C89611455', 'wikidata': 'https://www.wikidata.org/wiki/Q6804646', 'display_name': 'Mechanism (biology)', 'level': 2, 'score': 0.6783823}, {'id': 'https://openalex.org/C2778367456', 'wikidata': 'https://www.wikidata.org/wiki/Q7251235', 'display_name': 'Proteasome inhibitor', 'level': 3, 'score': 0.65294605}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6264786}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.518329}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.46755302}, {'id': 'https://openalex.org/C2776364478', 'wikidata': 'https://www.wikidata.org/wiki/Q467635', 'display_name': 'Multiple myeloma', 'level': 2, 'score': 0.4578951}, {'id': 'https://openalex.org/C23131810', 'wikidata': 'https://www.wikidata.org/wiki/Q818574', 'display_name': 'Observational study', 'level': 2, 'score': 0.44139624}, {'id': 'https://openalex.org/C2778198053', 'wikidata': 'https://www.wikidata.org/wiki/Q181754', 'display_name': 'Heart failure', 'level': 2, 'score': 0.4394687}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.42688382}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.29974216}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.17795926}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.07096928}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C111472728', 'wikidata': 'https://www.wikidata.org/wiki/Q9471', 'display_name': 'Epistemology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002319', 'descriptor_name': 'Cardiovascular System', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D061988', 'descriptor_name': 'Proteasome Inhibitors', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002319', 'descriptor_name': 'Cardiovascular System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D061988', 'descriptor_name': 'Proteasome Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012449', 'descriptor_name': 'Safety', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.ejphar.2018.03.022', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S187816532', 'display_name': 'European Journal of Pharmacology', 'issn_l': '0014-2999', 'issn': ['0014-2999', '1879-0712'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29550338', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.84, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 86, 'referenced_works': ['https://openalex.org/W122349615', 'https://openalex.org/W1486234023', 'https://openalex.org/W1536763098', 'https://openalex.org/W1565076702', 'https://openalex.org/W1702221923', 'https://openalex.org/W1938445792', 'https://openalex.org/W1967234838', 'https://openalex.org/W1967767433', 'https://openalex.org/W1968769311', 'https://openalex.org/W1972774655', 'https://openalex.org/W1972958434', 'https://openalex.org/W1978726512', 'https://openalex.org/W1985864219', 'https://openalex.org/W2027152656', 'https://openalex.org/W2028031291', 'https://openalex.org/W2031173888', 'https://openalex.org/W2049374802', 'https://openalex.org/W2052735334', 'https://openalex.org/W2053303896', 'https://openalex.org/W2061032583', 'https://openalex.org/W2069866232', 'https://openalex.org/W2070485123', 'https://openalex.org/W2070607774', 'https://openalex.org/W2071814131', 'https://openalex.org/W2077548365', 'https://openalex.org/W2080136209', 'https://openalex.org/W2083365324', 'https://openalex.org/W2089865526', 'https://openalex.org/W2091378741', 'https://openalex.org/W2094231531', 'https://openalex.org/W2100940126', 'https://openalex.org/W2104507960', 'https://openalex.org/W2108747173', 'https://openalex.org/W2109371953', 'https://openalex.org/W2110277687', 'https://openalex.org/W2110935486', 'https://openalex.org/W2111480959', 'https://openalex.org/W2116007724', 'https://openalex.org/W2117960206', 'https://openalex.org/W2122891093', 'https://openalex.org/W2123775770', 'https://openalex.org/W2124007377', 'https://openalex.org/W2124704672', 'https://openalex.org/W2125939035', 'https://openalex.org/W2128863027', 'https://openalex.org/W2129080270', 'https://openalex.org/W2129163103', 'https://openalex.org/W2130105783', 'https://openalex.org/W2130794506', 'https://openalex.org/W2131755255', 'https://openalex.org/W2132145608', 'https://openalex.org/W2132392953', 'https://openalex.org/W2133304247', 'https://openalex.org/W2136355136', 'https://openalex.org/W2136671891', 'https://openalex.org/W2137146938', 'https://openalex.org/W2140493010', 'https://openalex.org/W2148597785', 'https://openalex.org/W2154104279', 'https://openalex.org/W2154343997', 'https://openalex.org/W2156302614', 'https://openalex.org/W2161407352', 'https://openalex.org/W2161569030', 'https://openalex.org/W2164706843', 'https://openalex.org/W2164710551', 'https://openalex.org/W2166661413', 'https://openalex.org/W2167799942', 'https://openalex.org/W2169054659', 'https://openalex.org/W2170552969', 'https://openalex.org/W2193716145', 'https://openalex.org/W2215693941', 'https://openalex.org/W2231156824', 'https://openalex.org/W2234403337', 'https://openalex.org/W2278481520', 'https://openalex.org/W2303653139', 'https://openalex.org/W2346132062', 'https://openalex.org/W2460673902', 'https://openalex.org/W2536208744', 'https://openalex.org/W2538533094', 'https://openalex.org/W2577999621', 'https://openalex.org/W2578172276', 'https://openalex.org/W2605384785', 'https://openalex.org/W2618223593', 'https://openalex.org/W2660722395', 'https://openalex.org/W2755916684', 'https://openalex.org/W342775215'], 'related_works': ['https://openalex.org/W366928778', 'https://openalex.org/W3083642093', 'https://openalex.org/W2887253292', 'https://openalex.org/W26359590', 'https://openalex.org/W2301933883', 'https://openalex.org/W2269989009', 'https://openalex.org/W2088635940', 'https://openalex.org/W2063424779', 'https://openalex.org/W2043887851', 'https://openalex.org/W1850271161'], 'abstract_inverted_index': {'Proteasome': [0], 'Inhibitors': [1], '(PI)': [2], 'have': [3, 35], 'now': [4], 'become': [5], 'the': [6, 37, 47, 51, 64, 79, 85, 91], 'cornerstone': [7], 'of': [8, 10, 39, 53, 94, 98, 123], 'treatment': [9], 'multiple': [11], 'myeloma': [12], '(MM).': [13], 'Carfilzomib': [14], 'has': [15], 'been': [16], 'demonstrated': [17], 'to': [18, 111, 120], 'cause': [19], 'more': [20], 'frequent': [21], 'cardiovascular': [22, 92, 105, 124], 'side': [23, 106], 'effects': [24, 38, 52], 'such': [25], 'as': [26], 'dyspnea,': [27], 'hypertension,': [28], 'and': [29, 43, 71, 77, 117], 'heart': [30], 'failure.': [31], 'Recent': [32], 'pre-clinical': [33], 'studies': [34, 74], 'investigated': [36], 'proteasome': [40, 54, 95], 'on': [41, 56, 84], 'myocardial': [42], 'vascular': [44], 'cells,': [45], 'but': [46], 'pathogenic': [48, 86], 'mechanism': [49], 'underlying': [50], 'inhibition': [55], 'these': [57], 'cells': [58], 'is': [59, 101], 'poorly': [60], 'understood.': [61], 'We': [62], 'reviewed': [63], 'evidence': [65], 'from': [66, 81], 'clinical': [67], 'trials,': [68], 'post-hoc': [69], 'analysis': [70], 'small': [72], 'observational': [73], 'currently': [75], 'available': [76], 'summarized': [78], 'data': [80], 'experimental,': [82], 'focusing': [83], 'mechanisms': [87], 'potentially': [88], 'implicated': [89], 'in': [90], 'toxicity': [93], 'inhibitor,': [96], 'particularly': [97], 'carfilzomib': [99], 'that': [100], 'most': [102], 'responsible': [103], 'for': [104, 115], 'effects.': [107], 'Finally,': [108], 'we': [109], 'tried': [110], 'suggest': [112], 'future': [113], 'perspectives': [114], 'diagnostic': [116], 'therapeutic': [118], 'approach': [119], 'this': [121], 'type': [122], 'damage.': [125]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2792835060', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 5}], 'updated_date': '2024-09-13T13:41:25.916679', 'created_date': '2018-03-29'}