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693, 702, 710, 776, 802, 1528, 1533, 1591, 1735, 1760, 1969, 2026, 2062, 2132, 2163, 2166, 2172, 2204, 2310, 2378, 2414, 2423, 2490, 2523, 2528, 2562], 'diameter': [214, 731], '≥50%': [216], '70%': [218], 'should': [219, 396, 647, 1318], 'considered': [221, 336], 'bypass': [226, 243, 259, 1764], 'grafting': [227, 244, 260, 1765], 'at': [228, 387, 889, 1172], 'time': [230], 'surgical': [232, 304, 1854], 'replacement': [235, 286, 1489, 1727, 1773, 1856, 1937, 1979], '(SAVR).4,6–8': [236], 'However,': [237, 541, 604], 'combined': [238, 2022], 'SAVR': [239, 254], 'carries': [245], 'higher': [247, 545, 900, 914, 922, 1290], 'than': [249, 2171], 'isolated': [250, 2016], 'SAVR.': [251], 'Vice': [252], 'versa,': [253], 'late': [255, 1769], 'after': [256, 581, 839, 853, 875, 896, 928, 1019, 1177, 1300, 1771, 2526], 'is': [261, 324, 335, 371, 490, 497, 997, 1227, 1295, 2168], 'associated': [263, 892], 'significantly': [265], 'increased': [266, 552, 1173, 1194], 'so': [268], 'it': [270, 1262], 'has': [271, 288, 349, 442, 763, 1408], 'been': [272, 351, 748, 764, 1070, 1249], 'consensus': [274], 'treat': [276], 'simultaneously': [279], 'avoid': [281], 'repeated': [282], 'sternotomy.4,7,8Transcatheter': [283], '(TAVR)': [287], 'become': [289], 'treatment': [291, 1362, 1400, 1610], 'choice': [293], 'severe': [298, 417, 716, 793, 1034, 1163, 1491, 1540, 2067], 'AS': [299, 321, 683, 717, 1035], 'high': [301, 1083, 1238], 'intermediate': [303, 595, 786], 'showing': [306], 'noninferior': [308], 'outcome': [309, 424, 895, 927, 989, 1145, 1299], 'compared': [310, 1146, 1358], 'SAVR.9,10': [312], 'this': [314, 520, 605, 964, 1114, 1346, 1425], 'patient': [315, 526, 652], 'population,': [316, 1207], 'occurrence': [319], 'CAD': [323, 410, 419, 787, 862, 901, 918, 1005, 1017, 1038, 1164, 1198, 1232, 1272, 1327, 1384], 'even': [325, 1141], 'more': [326, 358, 612, 904, 1182, 1281, 1394, 2169], 'frequent.4,11': [327], 'Therefore,': [328, 809], 'vast': [330], 'majority': [331], 'TAVR': [333, 426, 440, 505, 753, 840, 876, 1186, 1205, 1357, 1405], 'percutaneous': [338, 673, 701, 1532, 2025, 2527, 2561], 'intervention': [340, 675, 1534, 2063, 2563], '(PCI).': [341], 'Combined': [342], 'PCI': [343, 402, 437, 503, 580, 2442, 2535], 'transcatheter': [345, 623, 679, 706, 1137, 1544, 1935, 1976, 2017, 2072, 2139, 2210, 2279, 2317, 2385, 2427, 2566], 'implantation': [348, 1140, 2020, 2569], 'already': [350], 'shown': [352, 765], 'feasible': [355], 'but': [356], 'requires': [357], 'data': [359, 639, 1101, 1158], 'before': [360, 438, 493, 1136, 1185, 1356], 'firm': [362], 'recommendation': [363], 'can': [364, 407, 429, 1022], 'made.5,11–13': [366], 'chronology': [368], 'interventions': [370], 'subject': [372], 'individualized': [374, 649], 'discussion': [375], 'based': [376], 'on': [377, 565, 620, 640, 654, 869, 988, 1535, 1766, 2131, 2218, 2418], "patient's": [379], 'condition,': [381], 'extent': [382, 1013, 1382], 'CAD,': [384, 692, 1079], 'myocardium': [386], 'and,': [389], 'therefore,': [390], 'following': [392], 'questions': [393], 'remain': [394, 850], 'unanswered:What': [395], 'preferred': [399], 'timing': [400, 643], 'undergoing': [405, 961, 992, 1039, 1133, 1149, 1201, 1543, 1632, 2209, 2278, 2315, 2384, 2426], 'TAVR?How': [406], 'prognostically': [408], 'relevant': [409], 'lesions': [411, 596, 711, 2222], 'identified': [413, 720], 'AS?Does': [418], 'have': [420, 500, 746, 877, 1069, 1248], 'an': [421, 551, 1000, 1143, 1210, 2483], 'impact': [422, 859, 934, 984, 1353, 2520], 'complete': [430, 1183, 1216], 'revascularization': [431, 782, 936, 962, 986, 1030, 1088, 1135, 1184, 1208, 1218, 1355, 2416], 'improve': [432], 'outcome?A': [433], 'staged': [434], 'approach': [435], 'procedure': [441, 559], 'potential': [444, 2094], 'prevent': [446], 'hemodynamic': [447], 'instability': [448], 'because': [449], 'PCI-related': [451], 'complications': [452, 535], 'reduce': [455], 'ischemia': [459, 745], 'during': [460, 466, 506], 'rapid': [461], 'pacing': [462], 'balloon': [464], 'inflation': [465], 'subsequent': [467], 'TAVR,': [468, 705], 'especially': [469, 510], 'distal': [473], 'left': [474], 'main': [475], 'complex': [478], 'bifurcation': [479], 'lesions.11–13': [480], 'technical': [483], 'standpoint,': [484], 'access': [485, 614], 'arteries': [489, 618], 'less': [491], 'challenging': [492, 613], 'prosthesis': [496], 'implanted.4,13Some': [498], 'authors': [499, 1122, 1153], 'proposed': [501, 1609], 'performing': [502, 579], 'procedure,': [509], 'single': [511], 'type': [512], 'A': [513, 899, 1602, 2641, 2646], 'B': [515, 2601], 'lesions.2,11': [516], 'Potential': [517], 'advantages': [518, 2090], 'strategy': [521, 584, 606, 1401], 'enhanced': [523], 'resource': [524], 'utilization,': [525], 'convenience,': [527], 'reduction': [530], 'vascular': [532, 539], 'bleeding': [534], 'avoiding': [537], 'separate': [538], 'access.11': [540], 'disadvantages': [542], 'amount': [546], 'contrast': [548], 'dye': [549], 'acute': [555], 'kidney': [556], 'injury,': [557], 'longer': [558], 'reimbursement': [562], 'issues': [563], 'depending': [564], 'health': [567], 'system': [568], 'specific': [571, 1404], 'country.But': [572], 'third': [575], 'option': [576], 'remains': [577, 820, 1264], 'TAVR.': [582, 929, 993, 1040, 1178, 1202, 1301], 'This': [583, 1348], 'preferable': [587], 'critical': [591], 'would': [598], 'prone': [600], 'stress': [602], 'testing.': [603], 'will': [607, 1350], 'confront': [608], 'interventionalist': [610], '(depending': [619], 'used': [622, 1024, 1250], 'heart': [624, 1697, 1736], 'type)': [626], 'catheter': [629], 'manipulation': [630], 'may': [631], 'potentially': [632], 'dislodge': [633], 'prosthetic': [635], 'valve.13': [636], 'Because': [637], 'evidence-based': [638], 'optimal': [642], 'missing,': [645], 'decision-making': [646], 'focusing': [653], 'paramount': [656], 'pathology—CAD': [657], 'AS—to': [659], 'minimize': [660], 'periprocedural': [662], 'much': [665], 'possible': [667], '(Figure).Download': [668], 'figureDownload': [669], 'PowerPointFigure.': [670], 'Timing': [671], 'relation': [677], 'replacement.': [682], 'indicates': [684], 'stenosis;': [687], 'AVA,': [688], 'area;': [691], 'disease;': [695], 'CTO,': [696], 'total': [698, 1046], 'occlusion;': [699], 'PCI,': [700], 'intervention;': [703], 'replacement.Significant': [709], 'basically': [719], 'visual': [722], 'estimation': [723], 'assessment': [725, 1379, 2202], 'vessel': [727], 'size': [728], 'lesion': [730], 'according': [732, 1102, 2272], 'SYNTAX': [735, 867, 885, 940, 995, 1107, 1169, 1286, 1307, 1314, 2274, 2438, 2481, 2532], 'score.': [736], 'Noninvasive': [737], 'invasive': [739], 'methods': [740], 'functional': [742, 773, 806], 'evaluation': [743, 2220], 'not': [747, 951, 1111, 1428], 'validated': [749], 'properly': [750], 'date.': [756], 'measurement': [758, 816], 'fractional': [760, 813, 835], 'flow': [761, 814, 836, 2086, 2167], 'reserve': [762, 815, 837], 'useful': [769], 'tool': [770, 1002, 2485], 'determining': [772], 'significance': [774], 'stenoses': [777], 'need': [780], 'lesions.14–16': [788], 'coincidence': [790], 'these': [797, 805, 818], 'patients,': [798], 'influence': [801, 1758, 2214], 'hemodynamics': [803, 2133], 'indexes': [807], 'consistently.15,16': [808], 'applicability': [811], 'under': [817], 'conditions': [819], 'elucidated': [823, 1267], 'larger': [825], 'studies:': [826], 'Pesarini': [827, 2181], 'al17': [829], 'were': [830, 841, 1055, 1110], 'able': [831], 'confirm': [833], 'variations': [838], 'minor': [842], 'measured': [846], 'values': [847, 1064, 1246], 'seemed': [848], 'stable': [851], 'directly': [852], 'procedure.Published': [855], 'studies': [856, 946, 977, 1043, 1068, 1253, 2434], 'evaluating': [857], 'assessed': [864, 1188], 'Score': [868, 886, 1108], 'procedural': [870], 'outcomes': [871, 1075, 1485, 1536, 2012, 2271, 2419], 'long-term': [873, 1222], 'survival': [874, 958, 1770], 'yielded': [878], 'conflicting': [879], 'results.5': [880], 'most': [882, 1398], 'studies,': [883, 1304], '>22': [888], 'baseline': [890, 1106, 1285, 1313], 'was': [891, 903, 1213], 'worse': [894, 1298], 'procedure.': [898], 'burden': [902, 924, 1328], 'found': [906, 1123], 'comorbidities': [911], 'resulting': [912], 'scores.18,19Taken': [916], 'together,': [917, 1151], 'reflect': [920], 'comorbidity': [923, 1291], 'Trying': [930], 'assess': [932, 1351], 'using': [937, 978, 2435], 'residual': [939, 2437, 2531], 'score': [941, 996, 1315, 2275, 2439], '(rSS),': [942], 'several': [944], 'individual': [945, 1067, 1378], 'different': [948, 1105, 1242], 'centers': [949], 'could': [950], 'find': [952, 1396], 'significant': [954, 1125], 'improvement': [955], 'post-TAVR': [957], 'completeness.12,19,20In': [963], 'issue': [965], 'Circulation:': [967], 'Interventions,': [969], 'al21': [972], 'performed': [973], 'meta-analysis': [975, 2432], 'rSS': [980, 1010, 1061, 1084, 1095, 1211, 1243, 1317], 'evaluate': [982], 'completeness': [987, 2417], 'known': [998, 1228], 'angiographic': [1001, 2484], 'quantify': [1004], 'severity': [1006, 1273, 2266], 'complexity.22': [1008], 'quantifies': [1011], 'complexity': [1015, 1278, 1390, 2488], 'remaining': [1018], 'PCI23': [1020], 'describe': [1026], 'degree': [1028, 1387], 'Six': [1041], 'observational': [1042], '3110': [1048], 'met': [1050], 'inclusion': [1052], 'criteria': [1053], 'included': [1056], 'their': [1058, 1117, 1180, 1204], 'analysis.': [1059], 'cut': [1062, 1244], 'off': [1063, 1245], 'retained': [1071], 'compare': [1073], 'between': [1076, 1127, 1312], 'without': [1078, 1733], '(considered': [1085, 1096], 'incomplete': [1087], '[ICR]),': [1089], 'low': [1094], 'reasonable': [1098, 1134], 'revascularization).': [1099], 'Outcome': [1100], 'levels': [1109], 'reported': [1112], 'meta-analysis.': [1115, 1259], 'carefully': [1118], 'conducted': [1119], 'analysis,': [1120, 1181], 'association': [1126], 'ICR': [1128, 1236, 1269], 'mortality.': [1130], 'Importantly,': [1131], 'had': [1142], 'improved': [1144], 'ICR.21Taken': [1150], 'elegantly': [1154], 'show': [1155], 'current': [1157], '(as': [1165, 1187], 'defined': [1166], 'score)': [1170, 1287], 'mortality': [1176, 1223], 'rSS),': [1191], 'mitigated': [1192], 'exerted': [1196], 'study': [1206, 2572], 'achieving': [1209], '<8,': [1212], 'equivalent': [1214], 'anatomic': [1217, 1277, 1389], 'terms': [1220], '(similar': [1224], 'what': [1226, 1594], 'overall': [1231], 'population).Inhomogeneous': [1233], 'definition': [1234], '(eg,': [1237], 'rSS)': [1239], 'which': [1247], 'important': [1255, 2170], 'limitations': [1256], 'addition,': [1261], 'still': [1263], 'whether': [1268], '(rSS)': [1270], 'itself': [1274], '(degree': [1275], 'reflecting': [1279, 1288, 1309], 'advanced': [1282], 'state;': [1284], 'burden,': [1292], 'general,': [1294], 'driving': [1296], 'future': [1303], 'delta': [1306], 'score,': [1308], 'difference': [1311], 'assessed,': [1320], 'marker': [1323], 'real': [1326], 'treated': [1329], 'PCI.Large': [1331], 'prospective': [1332], 'randomized': [1334, 2576], 'trials': [1335], 'ongoing': [1339], 'ACTIVATION': [1340], 'trial': [1341, 1349], 'needed': [1343], 'address': [1345], 'question.': [1347], 'best': [1360], 'medical': [1361], 'TAVR.24': [1366], 'Until': [1367], 'then,': [1368], 'key': [1370], 'institutional': [1374], 'Heart': [1375, 1438, 1449, 1612, 1741, 2174, 2283, 2750], 'Team': [1376], 'cannot': [1391], 'emphasized': [1393], 'appropriate': [1399], 'patient.DisclosuresDr': [1406], 'received': [1409], 'speaker': [1410], 'honoraria': [1411], 'research': [1413], 'grants': [1414], 'Medtronic,': [1416], 'Edwards': [1417], 'Lifesciences,': [1418], 'Boston': [1420], 'Scientific.FootnotesThe': [1421], 'opinions': [1422], 'expressed': [1423], 'article': [1426], 'necessarily': [1429], 'those': [1430], 'editors': [1433], 'American': [1437, 2749], 'Association.Correspondence': [1439], 'PhD,': [1444], 'Center': [1450], 'Sigmund-Freud-Str.': [1455], '25,': [1456], 'Bonn': [1457], 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