Publication Information

{'id': 'https://openalex.org/W2792211948', 'doi': 'https://doi.org/10.4103/ijc.ijc_510_17', 'title': 'Epidermal growth factor receptor T790M mutation: A major culprit in the progression of epidermal growth factor receptor-driven non-small cell lung cancer and the role of repeat biopsy', 'display_name': 'Epidermal growth factor receptor T790M mutation: A major culprit in the progression of epidermal growth factor receptor-driven non-small cell lung cancer and the role of repeat biopsy', 'publication_year': 2017, 'publication_date': '2017-01-01', 'ids': {'openalex': 'https://openalex.org/W2792211948', 'doi': 'https://doi.org/10.4103/ijc.ijc_510_17', 'mag': '2792211948', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29292704'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.4103/ijc.ijc_510_17', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S165423279', 'display_name': 'Indian Journal of Cancer', 'issn_l': '0019-509X', 'issn': ['0019-509X', '1998-4774'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320448', 'host_organization_name': 'Medknow', 'host_organization_lineage': ['https://openalex.org/P4310318547', 'https://openalex.org/P4310320448'], 'host_organization_lineage_names': ['Wolters Kluwer', 'Medknow'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5105461257', 'display_name': 'Shyam Aggarwal', 'orcid': 'https://orcid.org/0000-0003-1137-3120'}, 'institutions': [{'id': 'https://openalex.org/I4210113434', 'display_name': 'Sir Ganga Ram Hospital', 'ror': 'https://ror.org/01x18vk56', 'country_code': 'IN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210113434']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'S Aggarwal', 'raw_affiliation_strings': ['Department of Medical Oncology, Sir Ganga Ram Hospital, New Delhi, India.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Sir Ganga Ram Hospital, New Delhi, India.', 'institution_ids': ['https://openalex.org/I4210113434']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005319131', 'display_name': 'Sandeep R. Patil', 'orcid': 'https://orcid.org/0000-0003-0601-6559'}, 'institutions': [], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'S Patil', 'raw_affiliation_strings': ['Senior Consulting Medical Oncologist, HCG Bangalore Institute of Oncology, Bengaluru, Karnataka, India.'], 'affiliations': [{'raw_affiliation_string': 'Senior Consulting Medical Oncologist, HCG Bangalore Institute of Oncology, Bengaluru, Karnataka, India.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5004926114', 'display_name': 'Nitesh Rohtagi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802464703', 'display_name': 'Max Super Speciality Hospital', 'ror': 'https://ror.org/00e7r7m66', 'country_code': 'IN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802464703', 'https://openalex.org/I307255591']}], 'countries': ['IN'], 'is_corresponding': False, 'raw_author_name': 'N Rohtagi', 'raw_affiliation_strings': ['Consultant Medical Oncology, Max Super Speciality Hospital, New Delhi, India.'], 'affiliations': [{'raw_affiliation_string': 'Consultant Medical Oncology, Max Super Speciality Hospital, New Delhi, India.', 'institution_ids': ['https://openalex.org/I2802464703']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.117, 'has_fulltext': False, 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.465378, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '54', 'issue': '5', 'first_page': '15', 'last_page': '15'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11067', 'display_name': 'Colorectal Cancer Treatments and Studies', 'score': 0.995, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12334', 'display_name': 'Lung Cancer Research Studies', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/t790m', 'display_name': 'T790M', 'score': 0.9446763}, {'id': 'https://openalex.org/keywords/egfr-inhibitors', 'display_name': 'EGFR Inhibitors', 'score': 0.46092793}], 'concepts': [{'id': 'https://openalex.org/C2777930144', 'wikidata': 'https://www.wikidata.org/wiki/Q25100112', 'display_name': 'T790M', 'level': 5, 'score': 0.9446763}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8417901}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.83403736}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.7236075}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.54842174}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.49134532}, {'id': 'https://openalex.org/C2777506169', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'EGFR inhibitors', 'level': 4, 'score': 0.46092793}, {'id': 'https://openalex.org/C2780580887', 'wikidata': 'https://www.wikidata.org/wiki/Q417824', 'display_name': 'Gefitinib', 'level': 4, 'score': 0.43485522}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.42113283}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3812855}], 'mesh': [{'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001706', 'descriptor_name': 'Biopsy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.4103/ijc.ijc_510_17', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S165423279', 'display_name': 'Indian Journal of Cancer', 'issn_l': '0019-509X', 'issn': ['0019-509X', '1998-4774'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320448', 'host_organization_name': 'Medknow', 'host_organization_lineage': ['https://openalex.org/P4310318547', 'https://openalex.org/P4310320448'], 'host_organization_lineage_names': ['Wolters Kluwer', 'Medknow'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29292704', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.6, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W1801337950', 'https://openalex.org/W1967249248', 'https://openalex.org/W1974918522', 'https://openalex.org/W1980497534', 'https://openalex.org/W1983159571', 'https://openalex.org/W1985264867', 'https://openalex.org/W1988767929', 'https://openalex.org/W1988827171', 'https://openalex.org/W2000082608', 'https://openalex.org/W2002937040', 'https://openalex.org/W2011341487', 'https://openalex.org/W2027242209', 'https://openalex.org/W2063940168', 'https://openalex.org/W2066128027', 'https://openalex.org/W2072406319', 'https://openalex.org/W2079778947', 'https://openalex.org/W2095735298', 'https://openalex.org/W2096786080', 'https://openalex.org/W2099556905', 'https://openalex.org/W2111662961', 'https://openalex.org/W2112602910', 'https://openalex.org/W2124967121', 'https://openalex.org/W2128344699', 'https://openalex.org/W2129360604', 'https://openalex.org/W2132157071', 'https://openalex.org/W2132870547', 'https://openalex.org/W2133149289', 'https://openalex.org/W2138089710', 'https://openalex.org/W2144330816', 'https://openalex.org/W2160982674', 'https://openalex.org/W2163351155', 'https://openalex.org/W2171139285', 'https://openalex.org/W2269456081', 'https://openalex.org/W2292347930', 'https://openalex.org/W2296139876', 'https://openalex.org/W2304781427', 'https://openalex.org/W2325481887', 'https://openalex.org/W2337836619', 'https://openalex.org/W2339922740', 'https://openalex.org/W2340070077', 'https://openalex.org/W2343022817', 'https://openalex.org/W2346744024', 'https://openalex.org/W2352491315', 'https://openalex.org/W2392027550', 'https://openalex.org/W2404777164', 'https://openalex.org/W2462847503', 'https://openalex.org/W2464433500', 'https://openalex.org/W2468983064', 'https://openalex.org/W2469255185', 'https://openalex.org/W2554062134', 'https://openalex.org/W2554188839', 'https://openalex.org/W2559648825', 'https://openalex.org/W2569485476', 'https://openalex.org/W2571097605', 'https://openalex.org/W2700788761', 'https://openalex.org/W2921075544', 'https://openalex.org/W3149071155', 'https://openalex.org/W4299728204'], 'related_works': ['https://openalex.org/W3072989489', 'https://openalex.org/W2464702708', 'https://openalex.org/W2068244265', 'https://openalex.org/W2048662229', 'https://openalex.org/W2015000811', 'https://openalex.org/W1973817016', 'https://openalex.org/W1970538115', 'https://openalex.org/W1923844506', 'https://openalex.org/W1849518619', 'https://openalex.org/W140545899'], 'abstract_inverted_index': {'Non-small': [0], 'cell': [1], 'lung': [2, 11], 'cancer': [3, 12], '(NSCLC)': [4], 'accounts': [5], 'for': [6], 'the': [7, 30, 38, 42, 84, 95, 104, 121, 131, 138], 'majority': [8], 'of': [9, 18, 32, 76, 97, 123, 133, 141, 143], 'primary': [10], 'cases': [13], 'worldwide.': [14], 'The': [15], 'activating': [16, 58], 'mutations': [17, 60, 109], 'epidermal': [19], 'growth': [20, 96], 'factor': [21], 'receptor': [22], '(EGFR)': [23], 'have': [24, 88], 'been': [25], 'demonstrated': [26], 'to': [27, 51, 65, 93], 'associate': [28], 'with': [29, 34, 57, 125], 'development': [31], 'NSCLC,': [33], 'T790M': [35, 118], 'mutation': [36, 119], 'being': [37], 'most': [39], 'common.': [40], 'Over': [41], 'years,': [43], 'EGFR': [44, 59, 86, 98, 108, 117, 144], 'tyrosine': [45], 'kinase': [46], 'inhibitors': [47, 87], '(TKIs)': [48], 'were': [49], 'developed': [50], 'target': [52], 'EGFR-related': [53], 'mutations.': [54], 'However,': [55], 'patients': [56, 124], 'who': [61], 'are': [62], 'initially': [63], 'responsive': [64], 'EGFR-TKIs': [66], 'eventually': [67], 'develop': [68], 'acquired': [69], 'resistance': [70], 'after': [71], 'a': [72], 'median': [73], 'progression-free': [74], 'survival': [75], '10-16': [77], 'months,': [78], 'followed': [79], 'by': [80], 'disease': [81], 'progression.': [82], 'Recently,': [83], 'third-generation': [85, 114], 'emerged': [89], 'as': [90], 'potential': [91], 'therapeutics': [92], 'block': [94], 'T790M-positive': [99], 'tumors.': [100], 'This': [101], 'article': [102], 'reviews': [103, 130], 'emerging': [105], 'data': [106], 'regarding': [107], 'and': [110], 'clinical': [111], 'evidence': [112], 'on': [113], 'agents': [115], 'against': [116], 'in': [120, 136], 'treatment': [122, 142], 'advanced': [126], 'NSCLC.': [127, 147], 'It': [128], 'also': [129], 'role': [132], 'repeat': [134], 'biopsy': [135], 'improving': [137], 'success': [139], 'rates': [140], 'T790M-derived': [145], 'drug-resistant': [146]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2792211948', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-16T00:06:07.105133', 'created_date': '2018-03-29'}