Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2792179957', 'doi': 'https://doi.org/10.1016/j.phymed.2018.01.012', 'title': 'Piscroside C inhibits TNF-α/NF-κB pathway by the suppression of PKCδ activity for TNF-RSC formation in human airway epithelial cells', 'display_name': 'Piscroside C inhibits TNF-α/NF-κB pathway by the suppression of PKCδ activity for TNF-RSC formation in human airway epithelial cells', 'publication_year': 2018, 'publication_date': '2018-02-01', 'ids': {'openalex': 'https://openalex.org/W2792179957', 'doi': 'https://doi.org/10.1016/j.phymed.2018.01.012', 'mag': '2792179957', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29496167'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.phymed.2018.01.012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S180051340', 'display_name': 'Phytomedicine', 'issn_l': '0944-7113', 'issn': ['0944-7113', '1618-095X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5032246267', 'display_name': 'Su Ui Lee', 'orcid': 'https://orcid.org/0000-0002-6455-5414'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Su Ui Lee', 'raw_affiliation_strings': ['Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea', 'institution_ids': ['https://openalex.org/I73616290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075188010', 'display_name': 'Seoghyun Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}, {'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Seoghyun Lee', 'raw_affiliation_strings': ['Department of Biological Sciences, College of Bioscience and Biotechnology, Chungnam National University, Daejeon, Republic of Korea', 'Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea', 'institution_ids': ['https://openalex.org/I73616290']}, {'raw_affiliation_string': 'Department of Biological Sciences, College of Bioscience and Biotechnology, Chungnam National University, Daejeon, Republic of Korea', 'institution_ids': ['https://openalex.org/I196345858']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072687839', 'display_name': 'Hyunju Ro', 'orcid': 'https://orcid.org/0000-0002-0829-9639'}, 'institutions': [{'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyunju Ro', 'raw_affiliation_strings': ['Department of Biological Sciences, College of Bioscience and Biotechnology, Chungnam National University, Daejeon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Sciences, College of Bioscience and Biotechnology, Chungnam National University, Daejeon, Republic of Korea', 'institution_ids': ['https://openalex.org/I196345858']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048965180', 'display_name': 'Jihee Choi', 'orcid': 'https://orcid.org/0000-0001-7801-7513'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ji-Hee Choi', 'raw_affiliation_strings': ['Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea', 'institution_ids': ['https://openalex.org/I73616290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003301259', 'display_name': 'Hyung Won Ryu', 'orcid': 'https://orcid.org/0000-0001-5291-3942'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Hyung Won Ryu', 'raw_affiliation_strings': ['Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea', 'institution_ids': ['https://openalex.org/I73616290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071763411', 'display_name': 'Mun-Ock Kim', 'orcid': 'https://orcid.org/0000-0003-3722-5724'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Mun-Ock Kim', 'raw_affiliation_strings': ['Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea', 'institution_ids': ['https://openalex.org/I73616290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079982482', 'display_name': 'Heung Joo Yuk', 'orcid': 'https://orcid.org/0000-0002-4705-4538'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Heung Joo Yuk', 'raw_affiliation_strings': ['Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea', 'institution_ids': ['https://openalex.org/I73616290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101413439', 'display_name': 'Jinhyuk Lee', 'orcid': 'https://orcid.org/0000-0002-7437-1846'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jinhyuk Lee', 'raw_affiliation_strings': ['Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea', 'institution_ids': ['https://openalex.org/I73616290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063851163', 'display_name': 'Sung-Tae Hong', 'orcid': 'https://orcid.org/0000-0001-5981-4859'}, 'institutions': [{'id': 'https://openalex.org/I196345858', 'display_name': 'Chungnam National University', 'ror': 'https://ror.org/0227as991', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I196345858']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Sung-Tae Hong', 'raw_affiliation_strings': ['Department of Anatomy & Cell biology, College of Medicine, Chungnam National University, 266, Munhwa-Ro, Daejeon 35015, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy & Cell biology, College of Medicine, Chungnam National University, 266, Munhwa-Ro, Daejeon 35015, Republic of Korea', 'institution_ids': ['https://openalex.org/I196345858']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5003821248', 'display_name': 'Sei‐Ryang Oh', 'orcid': 'https://orcid.org/0000-0002-9769-4779'}, 'institutions': [{'id': 'https://openalex.org/I73616290', 'display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'ror': 'https://ror.org/03ep23f07', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I73616290']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Sei-Ryang Oh', 'raw_affiliation_strings': ['Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea'], 'affiliations': [{'raw_affiliation_string': 'Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Cheongju-si 28116, Republic of Korea', 'institution_ids': ['https://openalex.org/I73616290']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5063851163', 'https://openalex.org/A5003821248'], 'corresponding_institution_ids': ['https://openalex.org/I196345858', 'https://openalex.org/I73616290'], 'apc_list': {'value': 3390, 'currency': 'USD', 'value_usd': 3390, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.237, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.8813, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '40', 'issue': None, 'first_page': '148', 'last_page': '157'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11613', 'display_name': 'Medicinal Plants: Chemical Constituents and Biological Activities', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11613', 'display_name': 'Medicinal Plants: Chemical Constituents and Biological Activities', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10371', 'display_name': 'Innate Immune Recognition and Signaling Pathways', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11385', 'display_name': 'Biological Activities of Triterpenoids and Saponins', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chromatin-immunoprecipitation', 'display_name': 'Chromatin immunoprecipitation', 'score': 0.60563827}, {'id': 'https://openalex.org/keywords/adaptive-immunity-regulation', 'display_name': 'Adaptive Immunity Regulation', 'score': 0.433642}, {'id': 'https://openalex.org/keywords/immunoprecipitation', 'display_name': 'Immunoprecipitation', 'score': 0.41564566}], 'concepts': [{'id': 'https://openalex.org/C134320426', 'wikidata': 'https://www.wikidata.org/wiki/Q901026', 'display_name': 'Chromatin immunoprecipitation', 'level': 5, 'score': 0.60563827}, {'id': 'https://openalex.org/C14519417', 'wikidata': 'https://www.wikidata.org/wiki/Q5113740', 'display_name': 'Chromatin structure remodeling (RSC) complex', 'level': 5, 'score': 0.57973087}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.54432315}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.5362152}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.53194433}, {'id': 'https://openalex.org/C2777730290', 'wikidata': 'https://www.wikidata.org/wiki/Q411114', 'display_name': 'NF-κB', 'level': 3, 'score': 0.52552384}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.51223034}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5079239}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.50249577}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.41816315}, {'id': 'https://openalex.org/C71829478', 'wikidata': 'https://www.wikidata.org/wiki/Q901305', 'display_name': 'Immunoprecipitation', 'level': 3, 'score': 0.41564566}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4121752}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36008638}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.27349916}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.18767849}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.16065994}, {'id': 'https://openalex.org/C167227067', 'wikidata': 'https://www.wikidata.org/wiki/Q5113739', 'display_name': 'Chromatin remodeling', 'level': 4, 'score': 0.11428052}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.112160444}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07326195}], 'mesh': [{'descriptor_ui': 'D057889', 'descriptor_name': 'Iridoid Glycosides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D051745', 'descriptor_name': 'Protein Kinase C-delta', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001980', 'descriptor_name': 'Bronchi', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001980', 'descriptor_name': 'Bronchi', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057889', 'descriptor_name': 'Iridoid Glycosides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055271', 'descriptor_name': 'Mucin 5AC', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055271', 'descriptor_name': 'Mucin 5AC', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D055271', 'descriptor_name': 'Mucin 5AC', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051745', 'descriptor_name': 'Protein Kinase C-delta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051745', 'descriptor_name': 'Protein Kinase C-delta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047888', 'descriptor_name': 'Receptors, Tumor Necrosis Factor, Type I', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047888', 'descriptor_name': 'Receptors, Tumor Necrosis Factor, Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D047992', 'descriptor_name': 'TNF Receptor-Associated Factor 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047992', 'descriptor_name': 'TNF Receptor-Associated Factor 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.phymed.2018.01.012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S180051340', 'display_name': 'Phytomedicine', 'issn_l': '0944-7113', 'issn': ['0944-7113', '1618-095X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29496167', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.63, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320322110', 'funder_display_name': 'Korea Research Institute of Bioscience and Biotechnology', 'award_id': 'KGM1221713'}], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1562080471', 'https://openalex.org/W1596545550', 'https://openalex.org/W1666565505', 'https://openalex.org/W1981681632', 'https://openalex.org/W1984790811', 'https://openalex.org/W1996933769', 'https://openalex.org/W2002463981', 'https://openalex.org/W2008646773', 'https://openalex.org/W2022188895', 'https://openalex.org/W2031695399', 'https://openalex.org/W2032399860', 'https://openalex.org/W2045991166', 'https://openalex.org/W2049667551', 'https://openalex.org/W2050254726', 'https://openalex.org/W2050824478', 'https://openalex.org/W2054931962', 'https://openalex.org/W2056402897', 'https://openalex.org/W2061658204', 'https://openalex.org/W2061689949', 'https://openalex.org/W2067901209', 'https://openalex.org/W2075355273', 'https://openalex.org/W2075895904', 'https://openalex.org/W2076649145', 'https://openalex.org/W2078901357', 'https://openalex.org/W2080244069', 'https://openalex.org/W2091092534', 'https://openalex.org/W2104333455', 'https://openalex.org/W2108079017', 'https://openalex.org/W2126224367', 'https://openalex.org/W2145933752', 'https://openalex.org/W2161893481', 'https://openalex.org/W2166793740', 'https://openalex.org/W2184248465', 'https://openalex.org/W2408558163', 'https://openalex.org/W4254648271', 'https://openalex.org/W4292166591', 'https://openalex.org/W625513488'], 'related_works': ['https://openalex.org/W4319350362', 'https://openalex.org/W4239724675', 'https://openalex.org/W2899211828', 'https://openalex.org/W2564946823', 'https://openalex.org/W2471443024', 'https://openalex.org/W2351542508', 'https://openalex.org/W2135353249', 'https://openalex.org/W2036891548', 'https://openalex.org/W1560235021', 'https://openalex.org/W10839406'], 'abstract_inverted_index': {'Piscroside': [0, 26, 94], 'C,': [1], 'isolated': [2], 'from': [3], 'Pseudolysimachion': [4], 'rotundum': [5], 'var.': [6], 'subintegrum,': [7], 'is': [8, 151, 196], 'a': [9, 17, 32, 177, 197], 'novel': [10], 'iridoid': [11], 'glycoside': [12], 'with': [13, 141], 'therapeutic': [14, 50, 199], 'efficacy': [15], 'in': [16, 54, 73, 112, 172, 188, 209], 'mouse': [18], 'model': [19], 'of': [20, 34, 100, 110, 122, 132, 156, 164, 180, 201, 206], 'chronic': [21], 'obstructive': [22], 'pulmonary': [23], 'disease': [24], '(COPD).': [25], 'C': [27, 49, 64, 95, 117, 150, 159, 170, 195], 'has': [28], 'been': [29], 'reported': [30], 'as': [31], 'constituent': [33, 200], 'YPL-001': [35, 202], '(under': [36], 'Phase': [37], '2a': [38], 'study,': [39], 'ClinicalTrials.gov': [40], 'identifier': [41], 'NCT02272634).': [42], 'To': [43], 'investigate': [44], 'the': [45, 98, 107, 120, 133, 142, 154, 210], 'mechanisms': [46], 'behind': [47], 'piscroside': [48, 63, 116, 149, 169, 194], 'effects': [51], 'on': [52], 'COPD': [53], 'human': [55], 'airway': [56], 'epithelial': [57], 'NCI-H292': [58, 75, 113], 'cells.': [59, 114], 'We': [60, 191], 'tested': [61], 'if': [62], 'effectively': [65], 'suppresses': [66], 'MUC5AC': [67, 102], 'gene': [68], 'expression': [69, 99], 'and': [70, 92, 182], 'TNF-RSC/IKK/NF-κB': [71], 'cascades': [72], 'TNF-α-stimulated': [74], 'cells': [76], 'by': [77, 105, 148, 153, 168], 'employing,': [78], 'reverse': [79], 'transcription-polymerase': [80], 'chain': [81], 'reaction,': [82], 'enzyme-linked': [83], 'immunosorbent': [84], 'assay,': [85], 'luciferase': [86], 'reporter': [87], 'assays,': [88], 'chromatin': [89], 'immunoprecipitation': [90], 'assays': [91], 'immunoprecipitation.': [93], 'markedly': [96], 'suppressed': [97], 'TNF-α-induced': [101], 'mucus': [103], 'protein': [104, 157], 'inhibiting': [106], 'transcriptional': [108], 'activity': [109, 208], 'NF-κB': [111, 134, 189], 'Indeed,': [115], 'negatively': [118], 'regulated': [119], 'function': [121], 'TNF': [123], 'receptor': [124], '1': [125], 'signaling': [126, 212], 'complex': [127], '(TNF-RSC,': [128], 'an': [129, 161], 'upstream': [130], 'regulator': [131, 163], 'pathway)': [135], 'without': [136], 'affecting': [137], 'its': [138, 204], 'extracellular': [139], 'interaction': [140], 'TNF-α': [143], 'ligand.': [144], 'This': [145], 'inhibitory': [146], 'effect': [147], 'mediated': [152], 'inactivation': [155, 167], 'kinase': [158], '(PKC),': [160], 'essential': [162], 'TNF-RSC.': [165], 'PKC': [166], 'results': [171], 'decreased': [173], 'PKCδ': [174, 207], 'binding': [175], 'to': [176], 'TRAF2': [178], 'subunit': [179], 'TNF-RSC': [181], 'subsequent': [183], 'reduced': [184], 'IKK': [185], 'phosphorylation,': [186], 'resulting': [187], 'inactivation.': [190], 'propose': [192], 'that': [193], 'promising': [198], 'through': [203], 'inhibition': [205], 'TNF-RSC/IKK/NF-κB/MUC5AC': [211], 'cascade.': [213]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2792179957', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-09-14T11:22:57.157606', 'created_date': '2018-03-29'}