Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2791611748', 'doi': 'https://doi.org/10.1128/aac.02258-17', 'title': 'The Novel Fungal Cyp51 Inhibitor VT-1598 Is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis', 'display_name': 'The Novel Fungal Cyp51 Inhibitor VT-1598 Is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis', 'publication_year': 2018, 'publication_date': '2018-01-31', 'ids': {'openalex': 'https://openalex.org/W2791611748', 'doi': 'https://doi.org/10.1128/aac.02258-17', 'mag': '2791611748', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29437615', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5913997'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.02258-17', 'pdf_url': 'https://aac.asm.org/content/aac/62/4/e02258-17.full.pdf', 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://aac.asm.org/content/aac/62/4/e02258-17.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089012738', 'display_name': 'Nathan P. Wiederhold', 'orcid': 'https://orcid.org/0000-0002-2225-5122'}, 'institutions': [{'id': 'https://openalex.org/I165951966', 'display_name': 'The University of Texas Health Science Center at San Antonio', 'ror': 'https://ror.org/02f6dcw23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165951966']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nathan P. Wiederhold', 'raw_affiliation_strings': ['University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA', 'institution_ids': ['https://openalex.org/I165951966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047691004', 'display_name': 'Lisa F. Shubitz', 'orcid': 'https://orcid.org/0000-0003-1011-0708'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lisa F. Shubitz', 'raw_affiliation_strings': ['Valley Fever Center for Excellence, University of Arizona, Tucson, Arizona, USA'], 'affiliations': [{'raw_affiliation_string': 'Valley Fever Center for Excellence, University of Arizona, Tucson, Arizona, USA', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030092946', 'display_name': 'Laura K. Najvar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165951966', 'display_name': 'The University of Texas Health Science Center at San Antonio', 'ror': 'https://ror.org/02f6dcw23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165951966']}, {'id': 'https://openalex.org/I4210144081', 'display_name': 'South Texas Veterans Health Care System', 'ror': 'https://ror.org/03n2ay196', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210144023', 'https://openalex.org/I4210144081']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laura K. Najvar', 'raw_affiliation_strings': ['South Texas Veterans Health Care System, San Antonio, Texas, USA', 'University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA', 'institution_ids': ['https://openalex.org/I165951966']}, {'raw_affiliation_string': 'South Texas Veterans Health Care System, San Antonio, Texas, USA', 'institution_ids': ['https://openalex.org/I4210144081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073705434', 'display_name': 'Rosie Jaramillo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165951966', 'display_name': 'The University of Texas Health Science Center at San Antonio', 'ror': 'https://ror.org/02f6dcw23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165951966']}, {'id': 'https://openalex.org/I4210144081', 'display_name': 'South Texas Veterans Health Care System', 'ror': 'https://ror.org/03n2ay196', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210144023', 'https://openalex.org/I4210144081']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rosie Jaramillo', 'raw_affiliation_strings': ['South Texas Veterans Health Care System, San Antonio, Texas, USA', 'University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA', 'institution_ids': ['https://openalex.org/I165951966']}, {'raw_affiliation_string': 'South Texas Veterans Health Care System, San Antonio, Texas, USA', 'institution_ids': ['https://openalex.org/I4210144081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079147043', 'display_name': 'Marcos Olivo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165951966', 'display_name': 'The University of Texas Health Science Center at San Antonio', 'ror': 'https://ror.org/02f6dcw23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165951966']}, {'id': 'https://openalex.org/I4210144081', 'display_name': 'South Texas Veterans Health Care System', 'ror': 'https://ror.org/03n2ay196', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210144023', 'https://openalex.org/I4210144081']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marcos Olivo', 'raw_affiliation_strings': ['South Texas Veterans Health Care System, San Antonio, Texas, USA', 'University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA', 'institution_ids': ['https://openalex.org/I165951966']}, {'raw_affiliation_string': 'South Texas Veterans Health Care System, San Antonio, Texas, USA', 'institution_ids': ['https://openalex.org/I4210144081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052350642', 'display_name': 'Gabriel Catano', 'orcid': 'https://orcid.org/0000-0001-6047-2286'}, 'institutions': [{'id': 'https://openalex.org/I165951966', 'display_name': 'The University of Texas Health Science Center at San Antonio', 'ror': 'https://ror.org/02f6dcw23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165951966']}, {'id': 'https://openalex.org/I4210144081', 'display_name': 'South Texas Veterans Health Care System', 'ror': 'https://ror.org/03n2ay196', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210144023', 'https://openalex.org/I4210144081']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gabriel Catano', 'raw_affiliation_strings': ['South Texas Veterans Health Care System, San Antonio, Texas, USA', 'University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA', 'institution_ids': ['https://openalex.org/I165951966']}, {'raw_affiliation_string': 'South Texas Veterans Health Care System, San Antonio, Texas, USA', 'institution_ids': ['https://openalex.org/I4210144081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050715257', 'display_name': 'Hien T. Trinh', 'orcid': 'https://orcid.org/0000-0002-7744-799X'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hien T. Trinh', 'raw_affiliation_strings': ['Valley Fever Center for Excellence, University of Arizona, Tucson, Arizona, USA'], 'affiliations': [{'raw_affiliation_string': 'Valley Fever Center for Excellence, University of Arizona, Tucson, Arizona, USA', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083348242', 'display_name': 'Christopher M. Yates', 'orcid': 'https://orcid.org/0000-0003-0884-1122'}, 'institutions': [{'id': 'https://openalex.org/I4210151457', 'display_name': 'Viamet Pharmaceuticals (United States)', 'ror': 'https://ror.org/0511egv62', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210151457']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher M. Yates', 'raw_affiliation_strings': ['Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA'], 'affiliations': [{'raw_affiliation_string': 'Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA', 'institution_ids': ['https://openalex.org/I4210151457']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073464082', 'display_name': 'Robert J. Schotzinger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210151457', 'display_name': 'Viamet Pharmaceuticals (United States)', 'ror': 'https://ror.org/0511egv62', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210151457']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert J. Schotzinger', 'raw_affiliation_strings': ['Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA'], 'affiliations': [{'raw_affiliation_string': 'Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA', 'institution_ids': ['https://openalex.org/I4210151457']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045688250', 'display_name': 'Edward P. Garvey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210151457', 'display_name': 'Viamet Pharmaceuticals (United States)', 'ror': 'https://ror.org/0511egv62', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210151457']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edward P. Garvey', 'raw_affiliation_strings': ['Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA'], 'affiliations': [{'raw_affiliation_string': 'Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA', 'institution_ids': ['https://openalex.org/I4210151457']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5021310794', 'display_name': 'Thomas F. Patterson', 'orcid': 'https://orcid.org/0000-0002-9513-7127'}, 'institutions': [{'id': 'https://openalex.org/I4210144081', 'display_name': 'South Texas Veterans Health Care System', 'ror': 'https://ror.org/03n2ay196', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210144023', 'https://openalex.org/I4210144081']}, {'id': 'https://openalex.org/I165951966', 'display_name': 'The University of Texas Health Science Center at San Antonio', 'ror': 'https://ror.org/02f6dcw23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165951966']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas F. Patterson', 'raw_affiliation_strings': ['South Texas Veterans Health Care System, San Antonio, Texas, USA', 'University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'South Texas Veterans Health Care System, San Antonio, Texas, USA', 'institution_ids': ['https://openalex.org/I4210144081']}, {'raw_affiliation_string': 'University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA', 'institution_ids': ['https://openalex.org/I165951966']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.072, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 40, 'citation_normalized_percentile': {'value': 0.999972, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '62', 'issue': '4', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11037', 'display_name': 'Epidemiology and Management of Fungal Infections', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11037', 'display_name': 'Epidemiology and Management of Fungal Infections', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10150', 'display_name': 'Diagnosis and Management of Fungal Infections', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13385', 'display_name': 'Emerging Animal Pathogens and Diseases', 'score': 0.9845, 'subfield': {'id': 'https://openalex.org/subfields/3404', 'display_name': 'Small Animals'}, 'field': {'id': 'https://openalex.org/fields/34', 'display_name': 'Veterinary'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/coccidioides-immitis', 'display_name': 'Coccidioides immitis', 'score': 0.9773423}, {'id': 'https://openalex.org/keywords/coccidioides', 'display_name': 'Coccidioides', 'score': 0.9424253}, {'id': 'https://openalex.org/keywords/coccidioidomycosis', 'display_name': 'Coccidioidomycosis', 'score': 0.547182}, {'id': 'https://openalex.org/keywords/antifungal-therapy', 'display_name': 'Antifungal Therapy', 'score': 0.502275}], 'concepts': [{'id': 'https://openalex.org/C2778439347', 'wikidata': 'https://www.wikidata.org/wiki/Q5139154', 'display_name': 'Coccidioides immitis', 'level': 2, 'score': 0.9773423}, {'id': 'https://openalex.org/C2781030883', 'wikidata': 'https://www.wikidata.org/wiki/Q142764', 'display_name': 'Coccidioides', 'level': 2, 'score': 0.9424253}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.57502717}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.55384326}], 'mesh': [{'descriptor_ui': 'D058888', 'descriptor_name': '14-alpha Demethylase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D003045', 'descriptor_name': 'Coccidioides', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D003045', 'descriptor_name': 'Coccidioides', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': True}, {'descriptor_ui': 'D003047', 'descriptor_name': 'Coccidioidomycosis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D058888', 'descriptor_name': '14-alpha Demethylase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003045', 'descriptor_name': 'Coccidioides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003047', 'descriptor_name': 'Coccidioidomycosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015725', 'descriptor_name': 'Fluconazole', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015725', 'descriptor_name': 'Fluconazole', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008813', 'descriptor_name': 'Mice, Inbred ICR', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008962', 'descriptor_name': 'Models, Theoretical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.02258-17', 'pdf_url': 'https://aac.asm.org/content/aac/62/4/e02258-17.full.pdf', 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5913997', 'pdf_url': 'https://europepmc.org/articles/pmc5913997?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913997', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29437615', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/aac.02258-17', 'pdf_url': 'https://aac.asm.org/content/aac/62/4/e02258-17.full.pdf', 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'score': 0.51, 'display_name': 'Life on land'}], 'grants': [{'funder': 'https://openalex.org/F4320337355', 'funder_display_name': 'National Institute of Allergy and Infectious Diseases', 'award_id': 'AI101497'}], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1978261301', 'https://openalex.org/W1984227450', 'https://openalex.org/W1991563265', 'https://openalex.org/W2006658793', 'https://openalex.org/W2030503504', 'https://openalex.org/W2036323185', 'https://openalex.org/W2039603262', 'https://openalex.org/W2065870824', 'https://openalex.org/W2106324628', 'https://openalex.org/W2109014098', 'https://openalex.org/W2127422954', 'https://openalex.org/W2145950720', 'https://openalex.org/W2152323457', 'https://openalex.org/W2162857158', 'https://openalex.org/W2166675124', 'https://openalex.org/W2173088729', 'https://openalex.org/W2316054119', 'https://openalex.org/W2346007779', 'https://openalex.org/W2414343169', 'https://openalex.org/W2479157738', 'https://openalex.org/W2514632012', 'https://openalex.org/W2575268702', 'https://openalex.org/W2625315574', 'https://openalex.org/W2924845564', 'https://openalex.org/W2940902180', 'https://openalex.org/W2966463840', 'https://openalex.org/W391620583', 'https://openalex.org/W4206301643', 'https://openalex.org/W4242945259', 'https://openalex.org/W4251007507', 'https://openalex.org/W42545706'], 'related_works': ['https://openalex.org/W4241153332', 'https://openalex.org/W2900130757', 'https://openalex.org/W2738762771', 'https://openalex.org/W2484779862', 'https://openalex.org/W2427774695', 'https://openalex.org/W2147134731', 'https://openalex.org/W2137643336', 'https://openalex.org/W2099295865', 'https://openalex.org/W1997519264', 'https://openalex.org/W1965081240'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Coccidioidal': [1], 'meningitis': [2], 'can': [3], 'cause': [4], 'significant': [5, 150], 'morbidity,': [6], 'and': [7, 49, 59, 72, 82, 93, 99], 'lifelong': [8], 'antifungal': [9], 'therapy': [10, 60], 'is': [11, 15], 'often': [12], 'required.': [13], 'VT-1598': [14, 36, 136, 147, 182, 242], 'a': [16, 198, 207, 215], 'fungus-specific': [17], 'Cyp51': [18], 'inhibitor': [19], 'that': [20], 'has': [21], 'potent': [22], 'in': [23, 32, 37, 77, 84, 96, 107, 116, 132, 142, 149, 152, 154, 168, 193, 210, 221, 231], 'vitro': [24], 'activity': [25], 'against': [26, 184], 'Coccidioides': [27], 'species.': [28, 159], 'We': [29], 'evaluated': [30], 'the': [31, 78, 85, 97, 117, 121, 123, 133, 143, 162, 169, 181, 185, 194, 211, 222, 226, 239, 244], 'vivo': [33, 232], 'efficacy': [34, 233], 'of': [35, 40, 68, 75, 225, 241, 246], 'murine': [38], 'models': [39], 'central': [41], 'nervous': [42], 'system': [43], 'coccidioidomycosis': [44], 'caused': [45], 'by': [46], 'C.': [47, 50, 79, 86, 144, 186, 212, 227], 'posadasii': [48, 87, 145, 187, 228], 'immitis': [51, 80, 213], '.': [52], 'Infection': [53], 'was': [54, 105, 165, 219], 'introduced': [55], 'via': [56], 'intracranial': [57], 'inoculation,': [58], 'began': [61], '48': [62, 113, 174], 'h': [63, 114, 175], 'postinoculation.': [64], 'Oral': [65], 'treatments': [66], 'consisted': [67], 'vehicle': [69], 'control,': [70], 'VT-1598,': [71], 'positive': [73], 'controls': [74], 'fluconazole': [76], 'study': [81, 196], 'VT-1161': [83], 'study.': [88, 146], 'Treatment': [89], 'continued': [90], 'for': [91, 243], '7': [92], '14': [94], 'days': [95, 122], 'fungal-burden': [98, 118, 170], 'survival': [100, 134, 153, 195, 223], 'studies,': [101, 119], 'respectively.': [102], 'Fungal': [103], 'burden': [104, 164, 203, 218], 'assessed': [106], 'brain': [108], 'tissue': [109], 'collected': [110], '24': [111], 'to': [112, 126, 237], 'posttreatment': [115], 'on': [120], 'mice': [124, 155], 'succumbed': [125], 'infection,': [127], 'or': [128], 'at': [129], 'prespecified': [130], 'endpoints': [131], 'studies.': [135, 171], 'plasma': [137], 'concentrations': [138, 173], 'were': [139, 191], 'also': [140], 'measured': [141], 'resulted': [148], 'improvements': [151], 'infected': [156], 'with': [157], 'either': [158], 'In': [160], 'addition,': [161], 'fungal': [163, 202, 217], 'significantly': [166], 'reduced': [167], 'Plasma': [172], 'after': [176, 197, 206], 'dosing': [177], 'stopped': [178], 'remained': [179, 204], 'above': [180], 'MIC': [183], 'isolate,': [188], 'although': [189], 'levels': [190], 'undetectable': [192], '4-week': [199], 'washout.': [200], 'Whereas': [201], 'suppressed': [205], '2-week': [208], 'washout': [209], 'model,': [214], 'higher': [216], 'observed': [220], 'arm': [224], 'model.': [229], 'This': [230], 'supports': [234], 'human': [235], 'studies': [236], 'establish': [238], 'utility': [240], 'treatment': [245], 'coccidioidomycosis.': [247]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2791611748', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 5}], 'updated_date': '2024-09-18T19:37:15.045685', 'created_date': '2018-03-29'}