Publication Information

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'CRPC': [335, 859, 960], 'growth.': [336, 1543], 'discovery': [338], 'castration-resistant': [340, 1540, 1581], '(CRPC)': [343], 'often': [345, 511], 'remains': [346], 'fueled': [347], 'ushered': [353], 'development': [356, 1320], 'clinical': [358, 435, 457, 562, 1126], 'integration': [359], 'highly': [361, 1661], 'potent': [362, 518], 'inhibitors.': [365, 423], 'These': [366, 456, 864], 'agents': [367], 'have': [368], 'undoubtedly': [369], 'benefited': [370], 'patients': [371, 580], 'CRPC,': [373], 'but': [374], 'merely': [376], 'palliative': [377], 'resistance': [379, 599, 698], 'inevitably': [380], 'emerges.': [381], 'There': [382], 'is': [383, 787, 1012, 1113, 1222, 1669], 'need': [385], 'develop': [387], 'active': [389], 'regimens,': [390, 444], 'either': [391, 784], 'currently': [394], 'approved': [395, 1143], 'drugs,': [396], 'via': [398, 725, 752, 1272, 1458], 'design': [399], 'novel': [401], 'biologically': [402], 'rational': [403], 'regimens': [404, 500], 'create': [406], 'contextual': [407], 'based': [409], 'on': [410, 892, 1188, 1229, 1791], 'genomic': [411, 646, 1305], 'biomarker': [412, 1150], 'enrichment,': [413], 'and/or': [414, 1154], 'co-targeting': [415, 886], 'adaptive': [416, 1497], 'activated': [419, 515, 626, 896, 1103], 'Indeed,': [424, 538], 'impressive': [425], 'results': [426, 589], 'from': [427, 1754], 'CHAARTED': [428], '(NCT00309985),': [429], 'STAMPEDE': [430], '(NCT00268476),': [431], 'LATITUDE': [433], '(NCT01715285)': [434], 'trials': [436, 458], 'highlight': [437], 'significant': [438], 'benefits': [439], 'combination': [441, 499, 875, 1139], 'versus': [442, 449], 'well': [446, 1148], 'early': [448, 636], 'late': [450], 'intervention': [451], 'advanced': [453, 476], 'cancer.': [455, 688, 1360, 1725], 'combined': [459, 690, 789, 1174], 'androgen-deprived': [460], 'therapy': [461], '(ADT)': [462, 1177], 'chemotherapy': [464, 1207], '(for': [465, 472], 'CHAARTED,': [466], 'STAMPEDE),': [467], 'ADT': [469], 'abiraterone': [471], 'LATITUDE,': [473], 'STAMPEDE)': [474], 'castrate-sensitive': [477], 'patients.': [480], 'studies': [482], 'all': [483], 'report': [484], 'remarkably': [486], 'similar': [487], '40%': [488], 'reduction': [489], 'death': [491], 'rate': [492], 'provide': [494, 1312], 'precedent': [495], 'future': [497], 'effective': [498], 'across': [501], 'treatment': [505, 697, 1394], 'landscape.': [506], 'Castrate-resistant': [507], 'progress': [512], 'despite': [517, 631], 'suppression,': [521], 'supported': [522], 'vast': [525], 'network': [526], 'pro-survival': [528], 'growth': [531, 861], 'factor': [532], 'including': [534], 'pathway.': [537, 650], '(via': [541, 547], 'amplification,': [542], 'mutation,': [543], 'variants)': [544], 'Pten': [548], 'loss)': [549], 'genomically': [556], 'CRPC.': [560, 582, 657], 'While': [561, 776], 'responses': [563, 570], 'inhibitors,': [569, 900], 'using': [571, 796, 832, 1250, 1769, 1776, 1804], 'PI3K': [572, 720, 741, 1352], 'rare': [575], 'preclinical': [577, 867, 1109, 1313, 1622], 'models': [578], 'Monotherapy': [583], 'reciprocal': [591, 726], 'crosstalk': [592], 'supports': [595], 'emergence': [596], 'acquired': [598], '(Carver': [600], 'al,': [602, 606, 968, 1019, 1183, 1204, 1210], '2011;': [603], 'Mulholland': [604, 1510], '2011).': [607], 'Genomically,': [608], '70%': [609], 'cancers': [612], 'harbor': [613, 618], 'PTEN': [614, 1083, 1153, 1537], '10%': [617], 'SPOP': [619, 640, 661, 1086, 1155], 'mutations.': [620], 'Both': [621], 'phenotypes': [622], 'associated': [624, 1670], 'fact': [633], 'that,': [634], 'treatment-naïve': [637], 'localized': [638], 'disease,': [639], 'mutations': [641], 'mutually': [643], 'exclusive': [644], 'Interestingly,': [651], 'these': [652, 693, 984, 1096], 'can': [654, 779], 'co-occur': [655], 'Expression': [658], 'mutant': [660, 1087], 'activates': [662, 734], 'upregulates': [666], 'maintaining': [669], 'activity': [672, 830, 945, 1198], 'against': [673, 1405], 'PI3K/AKT-mediated': [674], 'feedback,': [676, 728], 'effectively': [677, 1001], 'activating': [678], 'critical': [685, 1783], 'blockade': [691], 'may': [695, 1195], 'delay': [696], 'significantly': [700, 807, 1579, 1616], 'patient': [702], 'outcome.': [703], 'Carver': [707, 1325], '(2011)': [710, 1347, 1532], 'was': [711, 839, 1170, 1752, 1789], 'first': [713], 'demonstrate': [715], 'co-regulate': [722], 'another': [724], 'other.': [736], 'Mechanistically,': [737], 'PTEN-deficient': [747, 1358], 'part': [751, 1136], 'relief': [753], 'HER': [758], 'kinases;': [759], 'conversely,': [760], 'antagonism': [762], 'relieves': [763], 'reducing': [769], 'FKBP5-mediated': [770], 'stability': [771], 'phosphatase': [774], 'PHLPP.': [775], 'cells': [778], 'adapt': [780], 'survive': [782], 'when': [783, 1173, 1220], 'single': [785], 'inhibited,': [788], 'PI3K/mTOR': [798], 'inhibitor': [799, 837, 1092, 1124, 1227, 1253, 1319, 1393, 1402], 'BEZ235': [800], 'antagonist': [804], 'enzalutamide': [805, 1615], '(ENZ)': [806], 'delayed': [808, 858, 959], 'LNCaP': [810, 961], 'progression.': [812], 'Similar': [813], 'data': [814, 865, 971, 1288], 'were': [815, 1774, 1802], 'reported': [816], 'Thomas': [818, 1551], '(2013)': [821, 1484, 1571], 'Toren': [823, 1595], '(2015);': [826], 'observed': [831], 'AZD5363': [838, 843, 876, 1613], 'overcome': [840], 'ENZ,': [845], 'resulting': [846], 'synergistic': [848, 1398], 'cell': [851], 'proliferation': [852], 'induction': [854, 913], 'apoptosis,': [856], 'vivo.': [863, 1586], 'provided': [866], 'proof': [868, 1110, 1314], 'principle': [870, 1112, 1316], 'support': [872], 'evaluation': [873, 1131], 'ENZ': [878], 'clinic': [881], '(NCT02525068).': [882], 'Another': [883], 'approach': [884, 981], 'focussed': [891], 'stress': [893, 1498], 'chaperone': [894, 926], 'proteins': [895], 'coordinated': [901], 'feed-forward': [904], 'loop': [905], 'involving': [906, 948], 'p90rsk-mediated': [907], 'phospho-activation': [908], 'YB-1': [910], 'subsequent': [912], 'CLU': [915, 927], 'AKT/MAPK': [917], '(with': [922, 928], 'ENZ)': [923], 'molecular': [925], 'OGX-011)': [929], 'repressed': [930, 942], 'ENZ-induced': [931], 'MAPK': [936], 'accelerated': [938], 'degradation': [940], 'through': [946], 'mechanisms': [947], 'decreased': [949], 'YB-1-regulated': [950], 'expression': [951, 1668], 'co-chaperone,': [955], 'FKBP52,': [956], 'which': [957, 1011], 'synergistically': [958], 'progression': [963, 1494, 1584], 'vivo': [965], '(Matsumoto': [966], '2013).': [969], 'presented': [972, 1289], 'describe': [978], 'inhibiting': [987, 1066, 1496], '(HDAC3),': [991], 'regulator': [994], 'eliminating': [1002], '(Fig': [1008], '1).': [1009], 'HDAC3,': [1010, 1442], 'upregulated': [1013], '(Weichert': [1017], '2008),': [1020], 'facilitates': [1021], 'lysine-63-chain': [1022], 'polyubiquitination': [1023], 'phosphorylation': [1025, 1258], 'cells,': [1031], 'non-nuclear': [1033], 'effect': [1034], 'mediated': [1035], 'deacetylation': [1038, 1274], 'at': [1039, 1811], 'lysine': [1040], '14': [1041], '20': [1043], 'residues': [1044], 'interaction': [1047, 1058], 'scaffold': [1050], 'protein': [1051, 1446], 'APPL1.': [1052], 'Targeted': [1053], 'blocks': [1057], 'APPL1,': [1060], 'decreasing': [1061], 'acetylation': [1063], 'thereby': [1065], 'phosphorylation.': [1068], 'addition,': [1070], 'HDAC': [1071], 'decreases': [1073], 'full-length': [1075], 'splice': [1077], 'variant': [1078], 'mRNA': [1079], 'levels': [1080], 'loss': [1084], 'models.': [1090, 1623], 'shows': [1093], 'efficacy': [1094], 'subtypes': [1100], 'share': [1102], 'pathways.': [1107, 1247], 'This': [1108], 'encouraging': [1114], 'will': [1116], 'help': [1117], 'guide': [1118, 1318], 'bench-to-bedside': [1119], 'translation': [1120], 'integrate': [1122], 'into': [1125], 'trials.': [1127], 'Key': [1128], 'issues': [1129], 'include': [1130, 1160], 'regimen': [1140], 'inhibitor,': [1146], 'enrichment': [1151], '(e.g.,': [1152], 'mutated,': [1156], 'amplified)': [1158], 'those': [1161], 'likely': [1163], 'respond.': [1165], 'Targeting': [1166, 1248, 1441], 'profound': [1172], 'castration': [1176], '(Toren': [1181], '2015).': [1184], 'Beyond': [1185], 'focus': [1187], 'also': [1196], 'enhance': [1197], 'PARP': [1200, 1401], '(Ha': [1202], '2014)': [1205], '(Long': [1208], '2017),': [1211], 'supporting': [1212], 'potential': [1213, 1832], 'combinations': [1214], 'DNA': [1216, 1459], 'repair-deficient': [1217], 'cancers,': [1218], 'docetaxel': [1221], 'indicated.': [1223], 'Figure': [1224], '1.': [1225], 'effects': [1228, 1826], 'pathwaysHDAC3': [1233], 'integrates': [1234], 'small-molecule': [1252], 'siRNA': [1255], 'inhibits': [1256], 'binding': [1261], 'APPL1': [1263], 'cytoplasm,': [1266], 'it': [1268], 'represses': [1269], 'transcription': [1271], 'condensed': [1276], 'chromatin': [1277], 'nucleus.': [1280], 'Download': [1281, 1283], 'figure': [1282], 'PowerPoint': [1284], 'summary,': [1286], 'define': [1295], 'mechanism-based': [1297], 'key': [1304], 'toward': [1321], 'clinic.': [1323], 'References': [1324], 'BS,': [1326], 'Chapinski': [1327], 'C,': [1328, 1340, 1552, 1556, 1602, 1640, 1648], 'Wongvipat': [1329], 'J,': [1330, 1342, 1419, 1527, 1690, 1702], 'Hieronymus': [1331], 'H,': [1332, 1469, 1475, 1479, 1517], 'Chen': [1333, 1701], 'Y,': [1334, 1427, 1433, 1471, 1515, 1688, 1692, 1696], 'Chandarlapaty': [1335], 'S,': [1336, 1375, 1383, 1521, 1523, 1564, 1598, 1646], 'Arora': [1337], 'VK,': [1338], 'Le': [1339], 'Koutcher': [1341], 'Scher': [1343], 'H': [1344], 'Reciprocal': [1348], 'regulation': [1350], 'Cancer': [1361, 1544, 1588, 1681], 'Cell': [1362, 1533, 1545], '19:': [1363, 1546], '575–586CrossrefCASPubMedWeb': [1364], 'Science®Google': [1366, 1416, 1466, 1508, 1549, 1593, 1629, 1685, 1734], 'Scholar': [1367, 1417, 1467, 1509, 1550, 1594, 1630, 1686, 1735], 'Ha': [1368], 'K,': [1369, 1642], 'Fiskus': [1370], 'W,': [1371, 1632, 1698], 'Choi': [1372], 'DS,': [1373], 'Bhaskara': [1374], 'Cerchietti': [1376], 'L,': [1377, 1423, 1562, 1606, 1700], 'Devaraj': [1378], 'SG,': [1379], 'Shah': [1380], 'B,': [1381], 'Sharma': [1382], 'Chang': [1384, 1422], 'JC,': [1385], 'Melnick': [1386], 'AM': [1387], '(2014)': [1390], 'Histone': [1391, 1654], 'induces': [1395], "'BRCAness'": [1396], 'cisplatin': [1404], 'human': [1406], 'triple': [1407], 'breast': [1409], 'Oncotarget': [1412], '5:': [1413], '5637–5650CrossrefPubMedWeb': [1414], 'Long': [1418], 'Fang': [1420], 'WY,': [1421], 'Gao': [1424], 'WH,': [1425], 'Shen': [1426], 'Jia': [1428], 'MY,': [1429], 'Zhang': [1430, 1436], 'YX,': [1431], 'Wang': [1432, 1520], 'Dou': [1434], 'HB,': [1435], 'WJ': [1437], '(2017)': [1440], 'new': [1444], 'partner': [1445], 'reversal': [1451], 'chemoresistance': [1453], 'acute': [1455], 'myeloid': [1456], 'leukemia': [1457], 'damage': [1460], 'response.': [1461], 'Leukemia': [1462], '31:': [1463], '2761–2770CrossrefCASPubMedWeb': [1464], 'Matsumoto': [1468], 'Yamamoto': [1470], 'Shiota': [1472], 'M,': [1473], 'Kuruma': [1474], 'Beraldi': [1476], 'E,': [1477, 1560], 'Matsuyama': [1478], 'A,': [1481, 1519, 1634], 'M': [1483, 1650], 'Cotargeting': [1485], 'clusterin': [1489], 'delays': [1490, 1580, 1617], 'response': [1499], 'stability.': [1502], 'Can': [1503], 'Res': [1504], '73:': [1505], '5206–5217CrossrefCASPubMedWeb': [1506], 'DJ,': [1511], 'Tran': [1512], 'LM,': [1513], 'Li': [1514], 'Cai': [1516], 'Morim': [1518], 'Plaisier': [1522], 'Garraway': [1524], 'IP,': [1525], 'Huang': [1526], 'Graeber': [1528], 'TG': [1529], 'autonomous': [1534], 'role': [1535], 'regulating': [1539], '792–804CrossrefCASPubMedWeb': [1547], 'Lamoureux': [1553], 'F,': [1554], 'Crafter': [1555, 1601], 'Davies': [1557, 1603], 'BR,': [1558, 1604], 'Beralidi': [1559], 'Fazli': [1561, 1605], 'Kim': [1563, 1597], 'Thaper': [1565], 'D,': [1566, 1694], 'ME,': [1568, 1608], 'A': [1570, 1610], 'Synergistic': [1572], 'PI3K/AKT-pathway': [1575], 'androgen-receptor': [1577], 'axis': [1578], 'Ther': [1589], '12:': [1590], '2342–2355CrossrefCASPubMedWeb': [1591], 'P,': [1596], 'Cordonnier': [1599], 'T,': [1600, 1638], '(2015)': [1611], 'Combination': [1612], 'enzalutamide-resistant': [1618], 'Eur': [1624], 'Urol': [1625], '67:': [1626], '986–990CrossrefCASPubMedWeb': [1627], 'Weichert': [1631], 'Roske': [1633], 'Gekeler': [1635], 'V,': [1636], 'Beckers': [1637], 'Stephan': [1639], 'Jung': [1641], 'Fritzsche': [1643], 'FR,': [1644], 'Niesporek': [1645], 'Denkert': [1647], 'Dietel': [1649], '(2008)': [1653], 'deacetylases': [1655], '1,': [1656], '2': [1657], 'expressed': [1662], 'HDAC2': [1667], 'shorter': [1672], 'PSA': [1673], 'relapse': [1674], 'time': [1675], 'after': [1676, 1782], 'radical': [1677], 'prostatectomy.': [1678], 'Br': [1679], 'J': [1680], '98:': [1682], '604–610CrossrefCASPubMedWeb': [1683], 'An': [1689], 'Yang': [1691], 'Wu': [1693], 'Bai': [1695], 'Cao': [1697], 'Ma': [1699], 'Yu': [1703], 'Z,': [1704], 'He': [1705], 'Dual': [1710], 'AKT-mTOR': [1713], 'PTEN-': [1721], 'SPOP-mutated': [1723], '10:': [1729], 'e8478Wiley': [1730], 'Online': [1731], 'LibraryPubMedWeb': [1732], 'Previous': [1736], 'ArticleNext': [1737], 'Article': [1738], 'Read': [1739], 'MoreAbout': [1740], 'coverClose': [1742], 'modalView': [1743], 'large': [1744], 'imageVolume': [1745], '10,Issue': [1746], '4,April': [1747], '2018Cover:': [1748], 'Mouse': [1749], 'choroid': [1750, 1786], 'plexus': [1751, 1787], 'isolated': [1753], '7‐weeks‐old': [1756], 'mouse': [1757], 'fixed': [1759], '2%': [1761, 1770], 'paraformaldehyde': [1762], '2.5%': [1764], 'gluteraldehyde,': [1765], 'followed': [1766], 'postfixation': [1768], 'Osminumtetroxide.': [1771], 'Next,': [1772], 'samples': [1773], 'dehydrated': [1775], 'graded': [1777], 'series': [1778], 'ethanol': [1780], 'point': [1784], 'drying,': [1785], 'tissue': [1788], 'mounted': [1790], 'stub': [1793], 'coated': [1795], 'layer': [1798], 'platinum.': [1800], 'Images': [1801], 'obtained': [1803], 'Zeiss': [1806], 'Crossbeam': [1807], '540': [1808], 'Electron': [1809], 'Microscope': [1810], '1.5kV.': [1812], 'By': [1813], 'Sophie': [1814], 'Steeland,': [1815], 'Nina': [1816], 'Gorlé,': [1817], 'Charysse': [1818], 'Vandendriessche,': [1819], 'Roosmarijn': [1820, 1845], 'Vandenbroucke': [1821, 1847], 'colleagues:': [1823], 'Counteracting': [1824], 'TNF': [1828], 'receptor‐1': [1829], 'has': [1830], "Alzheimer's": [1834], 'disease.': [1835], 'Scientific': [1836], 'image': [1837], 'Peter': [1839], 'Borghgraef': [1840], '(VIB': [1841], 'BioImaging': [1842], 'Core)': [1843], 'E.': [1846], '(VIB‐UGent': [1848], 'Center': [1849], 'Inflammation': [1851], 'Research).': [1852], 'Volume': [1853], '10Issue': [1854], '41': [1855], 'April': [1856], '2018In': [1857], 'FiguresReferencesRelatedDetailsLoading': [1860], '...': [1861]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2790859354', 'counts_by_year': [{'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-14T20:48:32.244652', 'created_date': '2018-03-29'}