Comparison of Platelet Function Guided Versus Unguided Treatment With P2Y12 Inhibitors in Patients With Acute Myocardial Infarction (from the Hungarian Myocardial Infarction Registry)

Name: Work Video:
Duration: 3 min 30 s
András Komócsi; Dániel Aradi; Tibor Szűk; Gergely Nagy; Ebrahim Noori; Zoltán Ruzsa; Róbert Gábor Kiss; Péter Andrássy; Lajos Nagy; Ferenc Nagy; Géza Lupkovics; Zsolt Kõszegi; Csaba András Dézsi; Elõd Papp; Zsolt Molnár; Péter Kupó; Péter Ofner; Béla Merkely; András Jánosi
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4131], 'intervention': [93, 360, 1543, 1633, 1721, 1766, 1881, 2792, 3704], 'registered.': [95, 362], 'After': [96, 363, 1787, 2821], 'exclusion': [97, 364], 'cases': [99, 366, 1410, 2797, 2817, 2839], 'contraindication': [101, 368, 1644], 'to': [102, 148, 151, 178, 201, 220, 238, 369, 415, 418, 445, 468, 487, 505, 710, 1150, 1161, 1336, 1645, 1740, 1758, 1780, 1824, 1832, 2028, 2034, 2137, 2146, 2160, 2216, 2223, 2227, 2374, 2414, 2662, 2721, 2760, 2831, 2894, 2961, 3012, 3107, 3120, 3437, 3477, 3493, 3706, 3765], 'prasugrel,': [103, 370, 2035, 2832, 2895, 3976], 'resulted': [106, 373, 1324, 2866], 'sample': [109, 376], '2,104': [111, 378, 2872], 'well-adjusted': [114, 381], 'characteristics.': [115, 382, 2257], 'Clopidogrel': [116, 383], 'dominant': [119, 386], 'inhibitor': [121, 388, 771, 1650, 1890, 2020, 4043], 'both': [123, 390, 1789, 3825, 3959], 'groups': [124, 391, 2226], '(unguided:': [125, 392], '96%': [126, 393], 'vs': [127, 394, 3074, 3419], 'PFT': [128, 395, 1311, 1330, 1342, 1816, 1834, 1841, 1850, 1872, 2290, 2806, 2811, 2931, 3517, 3564, 3732, 3745], 'guided:': [129, 396], '85%,': [130, 397], 'p': [131, 180, 222, 398, 447, 489, 2403, 2408, 2696, 3076, 3109, 3122, 3286, 3329, 3439], '<0.001).': [132, 181, 399, 448], 'In': [133, 224, 400, 491, 2123, 2302, 2795, 2906, 3026, 3442, 3532], 'group,': [136, 403, 2883], '19%': [137, 404], 'had': [140, 203, 407, 470, 1707, 2886, 2996, 3299, 3342, 3733], 'HPRoC': [141, 198, 258, 408, 465, 525, 1949, 2024, 2909, 2911, 2966, 3375, 3450, 3760], '77%': [143, 410, 2959], 'them': [145, 412, 2891], 'switched': [147, 200, 414, 467, 2893, 3763], 'prasugrel.': [149, 416, 3766], 'According': [150, 417], 'adjusted': [153, 420], 'analysis,': [154, 421, 3353], 'significantly': [161, 204, 428, 471, 3389], 'lower': [162, 189, 205, 244, 253, 429, 456, 472, 511, 520, 3001, 3097, 3411, 3572, 3775], 'group': [170, 437, 2315, 2327, 2819, 3072, 3380, 3445, 3758], '(hazard': [171, 213, 438, 480], 'ratio': [172, 214, 439, 481, 3278, 3321], '0.57': [173, 440], '[95%': [174, 216, 441, 483, 3145, 3221, 3279, 3322, 3434, 3608, 3612], 'confidence': [175, 217, 442, 484, 2354], 'interval': [176, 218, 443, 485], '0.43': [177, 444], '0.77],': [179, 446], 'Although': [182, 449], 'prasugrel': [183, 202, 239, 450, 469, 506, 557, 720, 1315, 1717, 1790, 1809, 2915, 2936, 2962, 3062, 3358, 3394, 3455, 3576, 3768, 3807, 4173], 'treatment': [184, 231, 451, 498, 785, 793, 1646, 1764, 1891, 2233, 2452, 2460, 2801, 3150, 3154, 3212, 3216, 3719, 3803, 4057, 4065], 'not': [186, 260, 453, 527, 724, 1803, 2213, 2813, 3094, 3425, 3460, 3579, 3771, 3806], 'associated': [187, 241, 454, 508, 2231, 2661, 2720, 3095, 3387, 3407, 3580, 3784, 3964], 'overall': [194, 263, 461, 530, 2922, 3087, 3584, 3779, 3828], 'cohort,': [195, 462, 2979, 3454, 3780], 'who': [199, 466, 1353, 1691, 1698, 1705, 2125], 'when': [207, 474], 'those': [210, 477, 3754], 'continuing': [211, 478, 2927], '0.33': [215, 482], '0.12': [219, 486], '0.92],': [221, 488], '<0.05).': [223, 490], 'conclusion,': [225, 492], 'AMI,': [229, 496, 2150], 'high': [234, 501, 1032, 1327, 2037, 2923, 3550], 'rate': [235, 502, 2568, 2986, 3552, 3629], 'switchover': [237, 504, 2960], 'mortality.': [247, 514, 2380], 'Prasugrel': [248, 515, 3090, 3834], 'predictor': [251, 518, 941, 3463, 3570, 3773, 3813], 'but': [259, 526, 1778, 3421, 3781, 3805], 'cohort': [264, 531, 2244, 2440, 2445, 2955, 3030, 3137, 3206, 3475], 'AMI.': [266, 533], 'Inhibition': [534], 'aggregation': [537], 'one': [539, 3302, 3345, 3597], 'major': [542, 3970], 'therapeutic': [543], 'targets': [544], 'an': [548, 939, 1377, 1676, 1708, 1734, 1953, 2774, 2833, 2921, 3582, 3707, 3722, 3734, 3811, 4136], '(AMI).': [552], 'Among': [553, 2876, 2933, 3399], 'P2Y12-receptor': [555, 4007], 'inhibitors,': [556], 'ticagrelor': [559, 722, 3836], 'are': [560, 1692, 2174, 2405, 2648, 2707, 3274, 3317], 'preferred': [562], 'choices': [563], 'for': [564, 675, 1120, 1271, 1318, 1376, 1630, 1651, 1795, 1860, 2149, 2151, 2156, 2190, 2248, 2253, 2267, 2773, 2858, 3003, 3038, 4118, 4126], 'AMI.1Windecker': [567], 'S.': [568, 665, 875, 1164, 1261, 1905, 1972, 3861, 3868, 3916, 3918, 4103], 'Kolh': [569, 650, 1165, 1246], 'P.': [570, 586, 602, 647, 651, 1077, 1166, 1182, 1198, 1243, 1247, 1415, 1454, 1458, 1529, 1537, 4093], 'Alfonso': [571, 1167], 'F.': [572, 643, 869, 912, 1087, 1168, 1239, 1484, 1486, 4115], 'Collet': [573, 640, 1169, 1236, 1910, 1977], 'J.-P.': [574, 641, 1170, 1237, 1911, 1978], 'Cremer': [575, 1171], 'J.': [576, 592, 625, 699, 804, 829, 1045, 1075, 1128, 1172, 1188, 1221, 1295, 1474, 1480, 1940, 2007, 3872, 3914, 4076, 4101, 4105, 4165], 'Falk': [577, 1173], 'V.': [578, 1174], 'Filippatos': [579, 1175], 'G.': [580, 596, 655, 831, 910, 952, 1085, 1176, 1192, 1251, 1470, 1533, 3857, 3874], 'Hamm': [581, 1177], 'C.': [582, 1178, 3912], 'Head': [583, 1179], 'S.J.': [584, 1180], 'Jüni': [585, 646, 1181, 1242], 'Kappetein': [587, 1183], 'A.P.': [588, 1184], 'Kastrati': [589, 648, 1098, 1185, 1244], 'A.': [590, 617, 645, 649, 740, 821, 825, 827, 837, 1016, 1018, 1062, 1099, 1186, 1213, 1241, 1245, 1413, 1452, 1478, 1482, 1515, 1539, 1897, 1964, 3906, 3926, 3934, 4012], 'Knuuti': [591, 1187], 'Landmesser': [593, 1189], 'U.': [594, 1190, 4111], 'Laufer': [595, 1191], 'Neumann': [597, 656, 955, 1193, 1252, 3862], 'F.-J.': [598, 657, 956, 1194, 1253, 3863], 'Richter': [599, 1195], 'D.J.': [600, 754, 867, 877, 1079, 1196, 4026], 'Schauerte': [601, 1197], 'Sousa': [603, 1199], 'Uva': [604, 1200], 'M.': [605, 613, 635, 659, 661, 904, 1022, 1089, 1201, 1209, 1231, 1255, 1257, 1517, 3936, 4099], 'Stefanini': [606, 1202], 'G.G.': [607, 1203], 'Taggart': [608, 1204], 'D.P.': [609, 1205], 'Torracca': [610, 1206], 'L.': [611, 653, 892, 894, 1064, 1207, 1249, 1468, 1531, 1907, 1974, 3902, 4095], 'Valgimigli': [612, 903, 1088, 1208], 'Wijns': [614, 1210], 'W.': [615, 889, 1211, 3859], 'Witkowski': [616, 1212], '2014': [618, 1214], 'ESC/EACTS': [619, 1215], 'guidelines': [620, 1139, 1216], 'revascularization.Eur': [623, 1219], 'Heart': [624, 698, 803, 1044, 1127, 1220, 1294, 1939, 2006, 4075, 4143, 4192], '2014;': [626, 858, 1222, 1444, 1941, 2008, 4194], '35:': [627, 1223, 1942, 2009], '2541-2619Crossref': [628, 1224], 'PubMed': [629, 813, 861, 927, 1008, 1054, 1132, 1225, 1509, 1574, 1944, 2011, 3896, 3953, 4085, 4151, 4197], 'Scopus': [630, 705, 814, 862, 928, 1009, 1055, 1133, 1226, 1301, 1447, 1510, 1575, 1945, 2012, 3897, 3954, 4086, 4152, 4198], '(3891)': [631, 1227], 'Google': [632, 707, 816, 864, 930, 1011, 1057, 1135, 1228, 1303, 1449, 1512, 1577, 1947, 2014, 3899, 3956, 4088, 4154, 4200], 'Scholar,': [633, 817, 865, 1012, 1058, 1229, 1450, 1513, 3900, 4089, 4155], '2Valgimigli': [634, 1230], 'Bueno': [636, 1232], 'H.': [637, 972, 1233, 3910, 3920, 4091], 'Byrne': [638, 1234], 'R.A.': [639, 1235, 3932], 'Costa': [642, 1238], 'Jeppsson': [644, 1240], 'Mauri': [652, 1248], 'Montalescot': [654, 909, 1250, 3856], 'Petricevic': [658, 1254], 'Roffi': [660, 1256], 'Steg': [662, 1258, 3927], 'P.G.': [663, 1259, 3928], 'Windecker': [664, 1260], 'Zamorano': [666, 1262], 'J.L.': [667, 1263], 'Levine': [668, 1264], 'G.N.': [669, 1265], 'ESC': [670, 682, 1266, 1278], 'Scientific': [671, 1267], 'Document': [672, 1268], 'GroupESC': [673, 1269], 'Committee': [674, 1270], 'Practice': [676, 1272], 'Guidelines': [677, 1273], '(CPG)ESC': [678, 1274], 'National': [679, 1275, 2111, 2169, 4187], 'Cardiac': [680, 1276], 'Societies2017': [681, 1277], 'focused': [683, 1279], 'update': [684, 1280], 'dual': [686, 1282], 'antiplatelet': [687, 1283, 3718], 'therapy': [688, 772, 1160, 1284, 2665, 2724, 3458, 3577, 3741, 3769, 4044, 4122], 'artery': [691, 989, 1287, 2540, 2562, 3546, 3617], 'disease': [692, 1288, 2541], 'developed': [693, 1289], 'collaboration': [695, 1291], 'EACTS.Eur': [697, 1293], '2017;': [700, 805, 924, 1296, 4077], '([Epub': [701, 1297], 'ahead': [702, 1298], 'print])https://doi.org/10.1093/eurheartj/ehx503Crossref': [704, 1300], '(17)': [706, 1302], 'Scholar': [708, 931, 1136, 1304, 1578, 1948, 2015, 3957, 4201], 'Due': [709], 'contraindications,': [711], 'financial': [712], 'restrictions,': [713], 'regulatory': [715], 'reasons,': [716], 'availability': [718], 'uniform': [725], 'across': [726, 1331, 3374], 'countries,': [727], 'whereas': [728, 2810, 2896, 2942, 3575, 3753], 'use': [730, 1143, 1744, 1801, 2913, 3060, 3385, 4174], 'switching': [734, 919], 'frequent.3Bagai': [739], 'Peterson': [741, 4013, 4166], 'E.D.': [742, 4014, 4167], 'McCoy': [743, 4015], 'L.A.': [744, 4016], 'Effron': [745, 4017], 'M.B.': [746, 4018], 'Zettler': [747, 4019], 'M.E.': [748, 4020], 'Stone': [749, 1100, 4021], 'G.W.': [750, 948, 1101, 4022], 'Henry': [751, 959, 4023], 'T.D.': [752, 960, 980, 4024], 'Cohen': [753, 4025], 'Schulte': [755, 4027], 'P.J.': [756, 4028], 'Anstrom': [757, 4029], 'K.J.': [758, 4030], 'Wang': [759, 901, 4031, 4168], 'T.Y.': [760, 902, 4032, 4169], 'Association': [761, 4033], 'measured': [763, 4035], 'changes': [767, 4039], 'receptor': [770, 788, 840, 4042, 4060], 'outcomes': [774, 986, 3126, 4046], 'infarction:': [777, 1436, 4049], 'insights': [778, 4050, 4133, 4184], 'into': [779, 4051], 'routine': [780, 1142, 4052], 'practice': [782, 4054, 4141], 'ADP': [787, 4059], 'inhibitors:': [789, 4061], 'longitudinal': [790, 4062], 'assessment': [791, 4063], 'patterns': [794, 2951, 4066], 'events': [796, 3188, 3254, 4068], 'syndrome': [800, 847, 4072], '(TRANSLATE-ACS)': [801, 4073], 'study.Am': [802, 4074], '187:': [806, 4078], '19-28Abstract': [807, 4079], 'Full': [808, 810, 1003, 1005, 1049, 1051, 1569, 1571, 4080, 4082], 'Text': [809, 811, 1004, 1006, 1050, 1052, 1570, 1572, 4081, 4083], 'PDF': [812, 1007, 1053, 1573, 4084], '(11)': [815, 4087], '4Aradi': [818], 'D.': [819, 879, 883, 885, 896, 1014, 1060, 1103, 1525, 1893, 1899, 1901, 1909, 1960, 1966, 1968, 1976, 3865], 'Tornyos': [820], 'Pintér': [822], 'T.': [823, 898, 1024, 1093, 1097, 1417, 1521], 'Vorobcsuk': [824, 1017], 'Kónyi': [826], 'Faluközy': [828], 'Veress': [830], 'Magyari': [832], 'B.': [833, 950, 1423, 1456, 1472, 1519], 'Horváth': [834, 1025], 'I.G.': [835, 1026], 'Komócsi': [836, 1015, 1896, 1963], 'Optimizing': [838], 'inhibition': [841], 'basis': [850], 'testing.J': [854], 'Am': [855, 4191], 'Coll': [856], 'Cardiol.': [857, 1565], '63:': [859], '1061-1070Crossref': [860], '(77)': [863], '5Angiolillo': [866], 'Rollini': [868], 'Storey': [870, 1894, 1961, 3929, 4106], 'R.F.': [871, 1895, 1962, 3930, 4107], 'Bhatt': [872], 'D.L.': [873], 'James': [874, 3917], 'Schneider': [876], 'Sibbing': [878, 1102, 1908, 1975], 'So': [880], 'D.Y.F.': [881], 'Trenk': [882, 1898, 1965], 'Alexopoulos': [884], 'Gurbel': [886, 967, 1065], 'P.A.': [887, 968, 1066], 'Hochholzer': [888], 'De': [890, 3866], 'Luca': [891], 'Bonello': [893, 1063, 1906, 1973], 'Aradi': [895, 1524], 'Cuisset': [897, 1096], 'Tantry': [899, 1067], 'U.S.': [900, 1068], 'Waksman': [905], 'R.': [906, 908, 978, 1083], 'Mehran': [907, 977], 'Franchi': [911], 'Price': [913, 1094], 'M.J.': [914, 954, 1095], 'International': [915], 'expert': [916], 'consensus': [917], 'receptor–inhibiting': [922], 'therapies.Circulation.': [923], '136:': [925], '1955-1975Crossref': [926], '(248)': [929], 'independent': [940, 2376, 3569, 3812], 'stent': [943, 1106, 1638], 'thrombosis': [944, 1107], 'infarction.6Stone': [947], 'Witzenbichler': [949], 'Weisz': [951], 'Rinaldi': [953], 'Metzger': [957], 'D.C.': [958], 'Cox': [961, 2361, 2368, 2398, 3599, 3603], 'D.A.': [962], 'Duffy': [963], 'P.L.': [964], 'Mazzaferri': [965], 'E.': [966, 1490, 3853], 'Xu': [969], 'K.': [970, 1070, 1421, 1460, 1466, 1913, 1980], 'Parise': [971], 'Kirtane': [973, 1061], 'A.J.': [974], 'Brodie': [975], 'B.R.': [976], 'Stuckey': [979], 'ADAPT-DES': [981], 'InvestigatorsPlatelet': [982], 'implantation': [990, 1639], 'drug-eluting': [992], 'stents': [993], '(ADAPT-DES):': [994], 'prospective': [996], 'multicentre': [997], 'study.Lancet.': [999], '2013;': [1000, 1506], '382:': [1001], '614-623Abstract': [1002], '(666)': [1010], '7Aradi': [1013], 'Rideg': [1019], 'O.': [1020, 1091], 'Tőkés-Füzesi': [1021], 'Magyarlaki': [1023], 'Serebruany': [1027], 'V.L.': [1028], 'Prognostic': [1029], 'significance': [1030, 3431], 'on-clopidogrel': [1033], 'percutaneous': [1037, 1124, 1936, 2003], 'intervention:': [1039], 'systematic': [1040], 'review': [1041], 'meta-analysis.Am': [1043], '2010;': [1046], '160:': [1047], '543-551Abstract': [1048], '(180)': [1056], '8Aradi': [1059], 'Huber': [1069, 1912, 1979], 'Freynhofer': [1071], 'M.K.': [1072], 'ten': [1073], 'Berg': [1074], 'Janssen': [1076], 'Angiolillo': [1078], 'Siller-Matula': [1080], 'J.M.': [1081], 'Marcucci': [1082], 'Patti': [1084], 'Mangiacapra': [1086], 'Morel': [1090], 'Palmerini': [1092], 'Bleeding': [1104], 'P2Y': [1109], '12': [1110], '-inhibitors:': [1111], 'collaborative': [1112], 'analysis': [1113, 1557, 2339, 2419, 3088, 3692], 'role': [1116, 1928, 1995, 3515], 'stratification': [1122], 'intervention.Eur': [1126, 1938, 2005], '2015;': [1129], '36:': [1130], '1762-1771Crossref': [1131], '(266)': [1134], 'However,': [1137, 1798, 3958], 'current': [1138, 4140], 'discourage': [1140], '(PFT)': [1148], 'due': [1149, 3705], 'lack': [1151], 'evidence': [1153], 'ability': [1156], 'PFT-based': [1158], 'improve': [1162], 'outcomes.1Windecker': [1163], 'Local': [1305], 'reimbursement': [1306, 1807], 'regulations': [1307], 'Hungary': [1309], 'mandate': [1310], 'clopidogrel,': [1313, 1768, 3752], 'reimbursed': [1317, 1811], 'HPRoC.': [1321, 1819, 2887, 3398, 3795], 'This': [1322, 2418], 'policy': [1323], 'penetration': [1328], 'invasive': [1332, 1662, 2664, 2723], 'centers.': [1333], 'We': [1334, 2334], 'sought': [1335], 'evaluate': [1337], 'impact': [1340, 1546, 3080, 3356, 3736], 'guidance': [1343, 3565, 3746], 'treated': [1355, 1375, 1411, 1657, 2789, 3701], 'intervention.': [1358], 'Hungarian': [1360, 1437, 1501, 1560, 2105], 'Myocardial': [1361, 1502, 1561], 'Infarction': [1362, 1503, 1562], 'Registry': [1363], 'prospective,': [1366, 3696], 'Internet-based': [1367], 'collecting': [1369], 'consecutive': [1373], 'event': [1378, 2158, 2775, 3708], 'Hungary,': [1382], 'country': [1384], '9.8': [1386], 'million': [1387], 'residents.': [1388], 'At': [1389], 'time': [1391], 'conduction': [1394], 'present': [1397], 'study,': [1398], 'operated': [1401], 'voluntary': [1404], 'basis,': [1405], 'capturing': [1406], '51%': [1407], 'countrywide.9Janosi': [1412], 'Ofner': [1414, 1453, 1536], 'Forster': [1416], 'Edes': [1418], 'I.': [1419, 1464, 1488], 'Toth': [1420], 'Merkely': [1422, 1455, 1518], 'Clinical': [1424], 'characteristics,': [1425], 'hospital': [1426], 'care,': [1427], 'prognosis': [1429, 1495], 'ST': [1433, 1623], 'elevation': [1434, 1625, 2551, 3679], 'registry.Eur': [1440], 'Hear': [1441], 'J': [1442, 1564, 3891, 3948, 4144], 'Suppl.': [1443], '16:': [1445], 'A12-A15Crossref': [1446], '(15)': [1448], '10Jánosi': [1451], 'Polgár': [1457], 'Zámolyi': [1459], 'Kiss': [1461, 1522, 1902, 1969], 'R.G.': [1462, 1523, 1903, 1970], 'Édes': [1463], 'Csapó': [1465], 'Nagy': [1467, 1530], 'Lupkovics': [1469, 1532], 'Herceg': [1471], 'Tomcsányi': [1473], 'László': [1475], 'Z.': [1476, 1527, 1535], 'Vértes': [1477], 'Simon': [1479, 1516], 'Katona': [1481], 'Juhász': [1483], 'Bajkó': [1485], 'Varjú': [1487], 'Dinya': [1489], 'Short': [1491], 'long': [1493], 'term': [1494], 'infarction.': [1500, 1554], 'Registry.Orv': [1504], 'Hetil.': [1505], '154:': [1507], '1297-1302Crossref': [1508], '(19)': [1511], '11Komócsi': [1514], 'Szűk': [1520], 'Ruzsa': [1526], 'Andrássy': [1528], 'Kőszegi': [1534], 'Jánosi': [1538], 'Underuse': [1540], 'its': [1545, 3078], 'elderly': [1551], 'propensity-matched': [1556, 3474], 'Registry.Int': [1563], '2016;': [1566, 4148], '214:': [1567], '485-490Abstract': [1568], '(7)': [1576], 'protocol': [1580], 'study': [1583, 2395, 4138], 'accordance': [1586], 'Declaration': [1589], 'Helsinki': [1591], 'reviewed': [1594], 'by': [1595, 1805, 2133, 2251, 2261, 3019], 'ethical': [1597], 'board.': [1598], 'All': [1599, 1853, 2401], 'recorded': [1601], 'gave': [1605], 'written': [1606], 'informed': [1607], 'consent.': [1608], 'all': [1617], '(both': [1621], 'segment': [1624, 2550, 3678], 'without)': [1627], 'eligible': [1629, 2210], 'enrollment': [1631], 'if': [1632, 1815], 'performed': [1635, 1874, 2335, 2814, 2864], 'successfully': [1636], 'there': [1641, 2846], 'no': [1643, 3977], 'year.': [1653], 'Data': [1654, 2144, 2706, 3313, 4189], 'collaborating': [1664], 'providing': [1666], 'monitoring': [1668], 'analyzed.': [1673], 'Patients': [1674, 3296, 3339], 'indication': [1677], 'chronic': [1679], 'oral': [1680], 'anticoagulation,': [1681], 'history': [1684, 2282, 3543], 'stroke': [1686, 2077, 3051], 'or': [1687, 1704, 1716, 1719, 1844, 1882, 2036, 2040, 2180, 2203, 2218, 2319, 2652, 2711, 2828, 3052, 3112, 3193, 3259, 3553, 3987], 'transient': [1688], 'ischemic': [1689, 3845], 'attack,': [1690], 'aged': [1693], 'older': [1694], 'than': [1695, 1701, 1714, 3068, 3301, 3344, 3415], '75': [1696, 2618, 3983], 'years,': [1697], 'weigh': [1699], 'less': [1700], '60': [1702], 'kg,': [1703], 'have': [1706, 3298, 3341], 'administration': [1709, 1750], 'other': [1713, 3522, 4124], 'before': [1718, 1765, 2433], 'during': [1720], 'excluded.': [1723], 'Thienopyridins': [1724], 'supplemented': [1726], 'low-dose': [1728, 2943], 'aspirin,': [1729], 'typically': [1730], '100': [1731], 'mg': [1732, 1777, 2619, 2626], 'optional': [1735], 'loading': [1736, 1773], 'dose': [1737, 1774], '300': [1739], '500': [1741], 'mg.': [1742], 'perioperative': [1746], 'anticoagulation': [1747], 'IIb/IIIa': [1753, 1889], 'allowed': [1756], 'according': [1757, 3476, 3492], 'local': [1760], 'protocols.': [1761], 'Generally,': [1762], 'comprised': [1767], 'usually': [1769], 'given': [1770], '600': [1776], 'left': [1779, 1823, 2027, 2671, 2677, 2683, 2731, 2737, 2743, 3560, 3653], 'decision': [1782, 1848, 2288], 'treating': [1785, 1829, 2030], 'physicians.': [1786], 'intervention,': [1788], 'available': [1794], 'long-term': [1796, 2799], 'treatment.': [1797], 'although': [1799], 'restricted': [1804], 'any': [1806, 3159, 3225], 'rule,': [1808], '70%': [1813], 'only': [1814, 2939, 3791], 'results': [1817, 2807, 3035, 3730, 3822], 'confirmed': [1818, 3824], 'Importantly,': [1820, 3767], 'it': [1821, 3782], 'discretion': [1826], 'physicians': [1830], 'whether': [1831], 'perform': [1833], 'make': [1836, 1845], 'choice': [1838, 2017], '(PFT-guided': [1842, 2808], 'group)': [1843], 'without': [1849, 2340, 2908, 3043, 3449, 3744], '(unguided': [1851, 2818], 'group).': [1852], 'participating': [1854, 2771], 'used': [1856, 2189, 2296, 2373, 3495], 'homogeneous': [1858], 'method': [1859], 'PFT,': [1861], 'which': [1862], 'analyzer': [1866], '(Roche': [1867], 'Diagnostics': [1868], 'GmbH,': [1869], 'Rotkreuz,': [1870], 'Switzerland).': [1871], 'least': [1876, 1884], '6': [1877], 'hours': [1878, 1886], '24': [1885], 'cessation.12Aradi': [1892], 'Gulba': [1900, 1967], 'Husted': [1904, 1971, 3915], 'Working': [1914, 1981], 'Group': [1915, 1982], 'Thrombosis': [1917, 1984], 'European': [1920, 1987], 'Society': [1921, 1988], 'CardiologyExpert': [1923, 1990], 'position': [1924, 1991], 'paper': [1925, 1992], 'undergoing': [1935, 2002], '209-215Crossref': [1943, 2010], '(212)': [1946, 2013], 'as': [1952, 2078, 2080, 2142, 2153, 2155, 2176, 2181, 2207, 2297, 2650, 2653, 2709, 2712, 3276, 3319, 3742, 3810], 'adenosine': [1954], 'diphosphate': [1955, 2608], 'test': [1956, 2206, 3130, 3480, 3644], 'level': [1957, 3428], '>46': [1958], 'U.12Aradi': [1959], 'also': [2026, 2391, 3017], 'physician:': [2031], 'either': [2032, 2249], 'switch': [2033], '(150': [2038], 'mg/day)': [2039], 'conventional': [2041], 'doses': [2042], '(75': [2043], 'mg)': [2044], 'allowed.': [2048], 'primary': [2050], 'efficacy': [2051], 'end': [2052, 2065, 2089, 3305, 3348, 3846], 'point': [2053], 'within': [2057, 3366, 3472], 'index': [2062], 'procedure.': [2063], 'Secondary': [2064], 'points': [2066, 3847], 'included': [2067], 'composite': [2069, 2088], 'cardiovascular': [2071, 3014, 3041, 3167, 3233], 'death,': [2072, 3190, 3256], 'recurrent': [2073, 2147], 'infarction,': [2075, 3192, 3258], 'well': [2079, 2154], 'transfusion': [2081, 2161], 'individual': [2084], 'elements': [2085], 'point.': [2090, 3306, 3349], 'Overall': [2091], 'obtained': [2094, 2841], 'patient': [2097, 2311, 2323, 2431, 2835], 'vital': [2098], 'status': [2099], 'database': [2102, 2166, 3698], 'Central': [2106], 'Statistical': [2107], 'Office': [2108], 'Health': [2112, 2170], 'Insurance': [2113, 2171], 'Fund,': [2114], 'including': [2115, 3031, 3540], 'date': [2117], 'cause': [2120, 2128], 'death.': [2122], 'died,': [2126], 'death': [2130, 3595, 3790], 'assessed': [2132], 'qualifying': [2134], 'deaths': [2135], 'related': [2136, 2145], 'infection,': [2138], 'malignancy,': [2139], 'trauma': [2141], 'noncardiovascular.': [2143], 'hospitalization': [2148], 'stroke,': [2152], 'bleeding': [2157], 'leading': [2159], 'extracted': [2163], 'Fund.': [2172], 'Variables': [2173], 'presented': [2175, 2649, 2708, 3275, 3318], 'means': [2177], '±': [2178, 2470, 2472, 2474, 2476, 2570, 2572, 2574, 2576, 2585, 2587, 2589, 2591, 2600, 2602, 2604, 2606, 2610, 2612, 2655, 2714], 'SD': [2179], 'frequencies': [2182], 'percentages.': [2184], 'Unpaired': [2185], 't': [2186], 'tests': [2187], 'comparisons': [2191, 3284, 3327], 'continuous': [2193], 'variables': [2194, 2198], 'groups.': [2196, 2271, 2855, 3376], 'Categorical': [2197], 'using': [2201, 2262, 2422], 'chi-square': [2202], "Fisher's": [2204], 'exact': [2205], 'appropriate.': [2208], 'As': [2209, 2381, 2844, 3058, 3350], 'randomly': [2214, 2308], 'assigned': [2215], 'treatments,': [2220], 'intended': [2222], 'balance': [2224], 'reduce': [2228], 'potential': [2229, 2284, 3079, 3514], 'bias': [2230], 'selection.': [2234], 'For': [2235], 'this': [2236, 2990, 3422], 'aim': [2237], 'built': [2239], '(PS)–matched': [2243], 'comparable': [2246], 'chance': [2247], 'strategy': [2250], 'adjusting': [2252], 'differences': [2254, 2849], 'baseline': [2256, 2851], 'PS': [2258, 2332, 2861], 'computed': [2260], 'logistic': [2264, 2668, 2727], 'regression': [2265, 2399], 'model': [2266, 2371], 'versus': [2269, 3132, 3456, 3882, 3939, 4172], 'Patient': [2272], 'presentation': [2275], 'factors': [2278, 3539], 'medical': [2281], 'influence': [2285], '(listed': [2291], 'Table': [2293, 3024], '1)': [2294], 'predictors': [2298, 2377, 3592], 'calculating': [2300], 'PS.': [2301], 'PS-matching': [2304], 'procedure,': [2305], 'first': [2307], 'selected': [2309, 3739], 'matched': [2317, 2338, 2444, 2869, 3136], 'him': [2318], 'her': [2320], 'closest': [2330], 'estimated': [2331], 'value.': [2333], '1-to-1': [2337], 'replacement': [2341], 'match': [2344], 'tolerance': [2345], '<0.01.': [2347], 'Unadjusted': [2348], 'hazard': [2349, 3002, 3277, 3320, 3601, 3605], 'ratios': [2350], '(HRs)': [2351], '95%': [2353, 3487], 'intervals': [2355], '(CIs)': [2356], 'determined': [2358], 'univariate': [2360, 3526], 'proportional': [2362, 2369, 3600, 3604], 'models,': [2363], 'then': [2365], 'multivariable': [2367], 'hazards': [2370], 'determine': [2375], 'sensitivity': [2383], 'exercise,': [2384], 'PS-unmatched': [2394], 'population': [2396, 2432, 2870], 'analyses.': [2400], 'reported': [2402], 'values': [2404, 2409], '2-sided,': [2406], '<0.05': [2411], 'considered': [2413], 'indicate': [2415], 'statistical': [2416, 2426, 3430], 'significance.': [2417], 'conducted': [2421], 'SPSS': [2424], '22': [2425], 'package.Table': [2427], '1Characteristics': [2428], 'matchingClinical': [2438], 'characteristicsEntire': [2439], '(n': [2441, 2446, 2449, 2453, 2457, 2461, 3138, 3151, 3155, 3207, 3213, 3217], '=': [2442, 2447, 2450, 2454, 2458, 2462, 2670, 2676, 2682, 2687, 2692, 2730, 2736, 2742, 2747, 2752, 3110, 3123, 3139, 3152, 3156, 3208, 3214, 3218, 3440, 3499], '3974)Propensity': [2443], '2104)PFT-guided': [2448], '2901)Unguided': [2451, 3215], '1073)p': [2455], 'valuePFT-guided': [2456], '1052)Unguided': [2459, 3153], '1052)p': [2463], 'valueAge,': [2464], '(years)': [2465], '*p': [2466, 2478, 2501, 2532, 2542, 2554], 'value': [2467, 2479, 2502, 2521, 2533, 2543, 2555, 2582, 2597, 2697, 3287, 3330], '<': [2468, 2480, 2503, 2522, 2534, 2544, 2556, 2583, 2598, 2698, 3289, 3332], '0.1.58.9': [2469], '9.660.5': [2471], '9.2<0.00160.5': [2473], '9.060.5': [2475], '9.10.926Men': [2477], '0.1.69.3': [2481], '%65.7': [2482], '%0.03565.3': [2483], '%66.1': [2484], '%0.748Medical': [2485], 'historyHypertension64.6': [2486], '%71.2': [2487], '%<0.00168.41': [2488], '%70.6': [2489], '%0.297Diabetes': [2490], 'mellitus24.8': [2491], '%29.2': [2492], '%0.00627.8': [2493], '%28.4': [2494], '%0.734-': [2495], 'insulin1.6': [2496], '%1.6': [2497], '%1.0001.0': [2498], '%1.5': [2499], '%0.324Hyperlipidemia': [2500], '0.1.11.1': [2504], '%5.1': [2505], '%<0.0013.7': [2506], '%5.2': [2507], '%0.113Smoker(current/past/never)35.2/1.6/63.3': [2508], '%36.1/2.1/61.9': [2509], '%0.45836.2/1.8/62.0': [2510], '%36.2/1.9/61.8': [2511], '%0.950Prior': [2512], 'infarction15.8': [2514], '%27.4': [2515], '%<0.00126.6': [2516], '%26.0': [2517], '%0.771Prior': [2518], 'intervention*p': [2520], '0.1.4.6': [2523], '%7.3': [2524], '%0.0017.1': [2525], '%7.4': [2526], '%0.867Prior': [2527], 'bypass': [2530, 3675], 'operation': [2531], '0.1.1.8': [2535], '%1.0': [2536, 2538], '%0.1130.8': [2537], '%0.646Peripheral': [2539], '0.1.5.3': [2545], '%11.6': [2546], '%<0.00110.2': [2547], '%10.4': [2548], '%0.943PresentationST': [2549], '0.1.64.1': [2557], '%51.0': [2558], '%<0.00155.1': [2559], '%51.7': [2560], '%0.126Culprit': [2561], '(LM/LAD/Cx/RCA/VSG2.8/46.7/23.0/35.8/1.2': [2563], '%3.3/44.1/25.9/35.8/1.1': [2564], '%0.34612.9/46.7/24.4/34.3/1.2': [2565], '%2.9/44.2/25.5/36.0/1.0': [2566], '%0.734Heart': [2567], '(bpm)79.8': [2569], '17.180.6': [2571], '18.10.23681.4': [2573], '18.080.5': [2575], '18.10.250Systolic': [2577], 'blood': [2578, 2593, 3635, 3658], 'pressure': [2579, 2594, 3636, 3659], '(mm': [2580, 2595], 'Hg)*p': [2581, 2596], '0.1.137.9': [2584], '24.2136.6': [2586], '25.70.191138.6': [2588], '24.8136.5': [2590], '25.70.054Diastolic': [2592], '0.1.70.0': [2599], '24.768.7': [2601], '25.00.16867.9': [2603], '26.168.8': [2605], '25.10.440Adenosin': [2607], 'reactivity32.5': [2609], '19.5-NA32.5': [2611], '19.9-NAHigh': [2613], 'reactivity19.1': [2615], '%-NA18.6': [2616], '%-NAMedicationsClopidogrel': [2617], 'daily50.6': [2620], '%74.3': [2621], '%<0.00143.6': [2622], '%74.2': [2623], '%<0.001Clopidogrel': [2624], '150': [2625], 'daily34.4': [2627], '%21.6': [2628], '%40.2': [2629], '%21.8': [2630], '%Prasugrel15.0': [2631], '%4.1': [2632], '%16.2': [2633], '%4.0': [2634], '%Aspirin71.1': [2635], '%81.0': [2636], '%<0.00180.9': [2637], '%79': [2638], '%0.547ß-blocker84.1': [2639], '%90.6': [2640], '%<0.00188.5': [2641], '%90.4': [2642], '%0.176Statin81.0': [2643], '%91.8': [2644], '%<0.00191.6': [2645], '%91.7': [2646], '%0.579Data': [2647], 'percentages': [2651, 2710], 'mean': [2654, 2713], 'standard': [2656, 2715], 'deviation.': [2657, 2716], 'Asterisk': [2658, 2717], 'marks': [2659, 2718, 3283, 3326], 'parameters': [2660, 2719], 'binary': [2667, 2726], 'model.LM': [2669], 'main': [2672, 2732, 3561, 3654], 'artery;': [2674, 2680, 2685, 2690, 2734, 2740, 2745, 2750], 'LAD': [2675, 2735], 'anterior': [2678, 2738], 'descending': [2679, 2739], 'Cx': [2681, 2741], 'circumflex': [2684, 2744], 'RCA': [2686, 2746], 'right': [2688, 2748], 'SVG': [2691, 2751], 'saphenous': [2693, 2753], 'vein': [2694, 2754], 'graft.*': [2695], '0.1.': [2699], 'Open': [2700, 3307, 3685], 'table': [2701, 3308, 3686], 'new': [2704, 3311, 3689], 'tab': [2705, 3312, 3690], 'model.': [2728], 'LM': [2729], 'graft.': [2755], 'From': [2756], '6,795': [2766], 'hospitalized': [2768], 'entered': [2779], 'registry.': [2782], 'Of': [2783], 'these,': [2784], '(82.2%)': [2787], 'stenting.': [2794], '3,715': [2796], '(66.5%),': [2798], 'chosen': [2803], 'group),': [2809, 2912], '1,868': [2816], '33.5%).': [2820], 'excluding': [2822], '29%': [2823], 'absolute': [2827], 'relative': [2829], 'contraindications': [2830], 'unmatched': [2834, 3028, 3115], 'pool': [2836], '3,974': [2838, 3032], '(Figure': [2842, 2967, 3021, 3466], '1).': [2843, 2875], 'expected,': [2845], 'numerous': [2848], 'To': [2856, 3509], 'adjust': [2857], 'these': [2859], 'differences,': [2860], 'that': [2865, 3728], '(Table': [2874, 3056, 3586], '2,901': [2878], 'subjects': [2879, 2995], '554': [2884], '(19%)': [2885], 'Seventy': [2888], 'percent': [2889], '30%': [2897], 'continued': [2898], '(14%': [2900], 'high-dose': [2901, 3404], '16%': [2903], 'standard-dose': [2904, 3416], 'clopidogrel).': [2905], '(no': [2910], 'low': [2917, 3554, 3989], '(2%),': [2918], 'resulting': [2919, 2980], 'proportion': [2924], 'guidance.': [2932], 'patients,': [2935, 3033, 3383], 'prescribed': [2938], '4%,': [2941, 3075], 'quite': [2946], 'frequent': [2947], '(74%).': [2948], 'Treatment': [2949], 'allocation': [2950], 'PS-matched': [2954, 2978, 3103, 3382, 3832], 'remained': [2956, 3566], 'similar': [2957, 3034], '2).': [2968, 3025, 3057], 'During': [2969], 'follow-up': [2971], 'period,': [2972], '200': [2973], 'died': [2975], '1-year': [2983, 3490], '9.5%,': [2988], 'unselected,': [2991], 'high-risk': [2992], 'cohort.': [2993], 'highly': [2998], 'significant,': [2999, 3568], '43%': [3000], 'group.': [3010], 'Similar': [3011], 'this,': [3013], 'reduced': [3018], '39%': [3020], '3': [3022], 'observed': [3037], 'significant': [3045, 3462, 3839], 'difference': [3046, 3423], 'repeat': [3053], 'higher': [3064, 3967], '(16%': [3073], '<0.001),': [3077], 'survival': [3082, 3391, 3465, 3585, 3713, 3816], 'calculated': [3084], 'populations.': [3089], 'treatment,': [3091], 'however,': [3092], '(HR': [3104, 3117, 3432], '0.65': [3105], '[0.38': [3106], '1.11],': [3108, 3121], '0.116)': [3111], 'cohorts': [3116], '0.75': [3118], '[0.51': [3119], '0.145).Table': [3124], '2Clinical': [3125], 'guided': [3131, 3149, 3211, 3453], 'patientsA.': [3134], 'Propensity': [3135], '2104)Nr.': [3140], '(%)Hazard': [3143], 'Ratio': [3144, 3220, 3607, 3611], 'Confidence': [3146, 3222, 3280, 3323, 3609, 3613], 'interval]Platelet': [3147], '1052)Death': [3157], 'cause75': [3160], '(7.1': [3161], '%)125': [3162], '(11.9': [3163], '%)0.57': [3164], '[0.43–0.77]***Death': [3165], 'causes66': [3168], '(6.3': [3169], '%)104': [3170], '(9.9': [3171], '%)0.61': [3172], '[0.45–0.83]**Repeated': [3173], 'infarction29': [3175], '(2.8': [3176], '%)20': [3177, 3243], '(1.9': [3178, 3244], '%)1.38': [3179], '[0.78–2.44]Stroke8': [3180], '(0.8': [3181, 3183, 3247], '%)8': [3182, 3248], '%)0.95': [3184], '[0.36–2.54]Major': [3185], 'adverse': [3186, 3252], 'cardiac': [3187, 3253], '(cardiovascular': [3189, 3255], 'stroke)97': [3194], '(9.2': [3195], '%)126': [3196], '(12.0': [3197, 3229, 3263], '%)0.74': [3198], '[0.57–0.96]*Transfusion74': [3199], '(7.0': [3200], '%)67': [3201], '(6.4': [3202], '%)1.01': [3203], '[0.73–1.41]B.': [3204], 'Unmatched': [3205], '3974)Platelet': [3209], '1073)Hazard': [3219], 'interval]Death': [3223], 'cause163': [3226], '(5.6': [3227], '%)129': [3228, 3262], '%)0.44': [3230], '[0.35–0.56]***Death': [3231], 'causes139': [3234], '(4.8': [3235], '%)107': [3236], '(10.0': [3237], '%)0.45': [3238], '[0.35–0.58]***Repeated': [3239], 'infarction71': [3241], '(2.4': [3242], '%)1.22': [3245], '[0.74–2.01]Stroke23': [3246], '(0.7': [3249], '%)0.99': [3250], '[0.44–2.21]Major': [3251], 'stroke)218': [3260], '(7.5': [3261], '%)0.59': [3264], '[0.47–0.73]***Transfusion131': [3265], '(4.5': [3266], '%)70': [3267], '(6.5': [3268], '%)1.03': [3269], '[0.92–1.64]Data': [3270], 'Cox-regression': [3272, 3315], 'analyses': [3273, 3316, 3471, 3726], 'interval],': [3281, 3324], 'asterisks': [3282, 3325], '*': [3288, 3331], '0.05,': [3290, 3333], 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[3524], 'determinants,': [3525], 'multivariate': [3528, 3534, 3819], 'models': [3529], 'generated.': [3531], 'model,': [3535], 'beyond': [3536], 'known': [3537], 'age,': [3541], 'smoking,': [3542], 'peripheral': [3545, 3616], 'disease,': [3547], 'hypertension,': [3548], 'diabetes,': [3549], 'heart': [3551], 'arterial': [3555], 'pressures': [3556], 'presentation,': [3558], 'involvement,': [3563], 'mortality,': [3574], 'improved': [3583, 3712, 3815], '3).Table': [3587], '3Clinical,': [3588], 'procedural,': [3589], 'pharmacological': [3591], 'yearVariableUnivariate': [3598], 'modelp-valueMultivariate': [3602], 'modelp-valueHazard': [3606], 'Interval]Hazard': [3610], 'Interval]History': [3614], 'disease2.79': [3618], '[2.01–3.88]<0.0012.97': [3619], '[2.11–4.18]0.001Smoker1.59': [3620], '[1.17–2.17]0.0031.74': [3621], '[1.27–2.38]0.001Age': [3622], '(per': [3623, 3630, 3637, 3660], '10': [3624, 3638, 3661], 'yrs': [3625], 'increase)1.56': [3626], '[1.34–1.82]<0.0011.62': [3627], '[1.38–1.90]<0.001Heart': [3628], '10/min': [3631], 'increase)1.26': [3632], '[1.18–1.34]<0.0011.25': [3633], '[1.17–1.33]<0.001Systolic': [3634], 'Hgmm': [3639], 'increase)0.85': [3640], '[0.80–0.90]<0.0010.83': [3641], '[0.78–0.88]<0.001Platelet': [3642], 'guidance0.57': [3645], '[0.43–0.77]<0.0010.52': [3646], '[0.39–0.69]<0.001Hypertension1.24': [3647], '[0.93–1.66]0.1491.56': [3648], '[1.14–2.10]0.005Diabetes1.57': [3649], '[1.18–2.08]0.0021.55': [3650], '[1.11–2.03]0.005Culprit': [3651], 'artery:': [3652], 'coronary3.01': [3655], '[1.80–5.02]<0.0012.01': [3656], '[1.18–3.39]<0.009Diastolic': [3657], 'mm': [3662], 'Hg': [3663], 'increase)0.98': [3664], '[0.93–1.03]0.4220.94': [3665], '[0.88–1.00]0.036Male': [3666], 'gender0.92': [3667], '[067-1.22]0.545Hyperlipidaemia0.83': [3668], '[0.39–1.76]0.626Prior': [3669], 'infarction0.98': [3671], '[0.72–1.35]0.910Prior': [3672], 'operation1.09': [3676], '[0.27–4.39]0.905ST': [3677], 'infarction1.27': [3681], '[0.96–1.68]0.102Prasugrel': 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