Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2789977408', 'doi': 'https://doi.org/10.1016/j.toxicon.2018.03.004', 'title': 'Pros and cons of different therapeutic antibody formats for recombinant antivenom development', 'display_name': 'Pros and cons of different therapeutic antibody formats for recombinant antivenom development', 'publication_year': 2018, 'publication_date': '2018-05-01', 'ids': {'openalex': 'https://openalex.org/W2789977408', 'doi': 'https://doi.org/10.1016/j.toxicon.2018.03.004', 'mag': '2789977408', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29534892'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.toxicon.2018.03.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42803210', 'display_name': 'Toxicon', 'issn_l': '0041-0101', 'issn': ['0041-0101', '1879-3150'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.toxicon.2018.03.004', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047291517', 'display_name': 'Andreas H. Laustsen', 'orcid': 'https://orcid.org/0000-0001-6918-5574'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': True, 'raw_author_name': 'Andreas H. Laustsen', 'raw_affiliation_strings': ['Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079027751', 'display_name': 'José Marı́a Gutiérrez', 'orcid': 'https://orcid.org/0000-0001-8385-3081'}, 'institutions': [{'id': 'https://openalex.org/I31944674', 'display_name': 'Universidad de Costa Rica', 'ror': 'https://ror.org/02yzgww51', 'country_code': 'CR', 'type': 'education', 'lineage': ['https://openalex.org/I31944674']}], 'countries': ['CR'], 'is_corresponding': False, 'raw_author_name': 'José María Gutiérrez', 'raw_affiliation_strings': ['Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica'], 'affiliations': [{'raw_affiliation_string': 'Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica', 'institution_ids': ['https://openalex.org/I31944674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086469344', 'display_name': 'Cecilie Knudsen', 'orcid': 'https://orcid.org/0000-0002-6399-3009'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Cecilie Knudsen', 'raw_affiliation_strings': ['Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071574286', 'display_name': 'K. Johansen', 'orcid': 'https://orcid.org/0000-0002-7711-9451'}, 'institutions': [{'id': 'https://openalex.org/I4210090236', 'display_name': 'National Human Genome Research Institute', 'ror': 'https://ror.org/00baak391', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210090236']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kristoffer H. Johansen', 'raw_affiliation_strings': ['Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, USA'], 'affiliations': [{'raw_affiliation_string': 'Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, USA', 'institution_ids': ['https://openalex.org/I4210090236', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025770391', 'display_name': 'Erick Bermúdez-Méndez', 'orcid': 'https://orcid.org/0000-0001-9241-7898'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Erick Bermúdez-Méndez', 'raw_affiliation_strings': ['Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053596193', 'display_name': 'Felipe Augusto Cerni', 'orcid': 'https://orcid.org/0000-0002-3695-5971'}, 'institutions': [{'id': 'https://openalex.org/I17974374', 'display_name': 'Universidade de São Paulo', 'ror': 'https://ror.org/036rp1748', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I17974374']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Felipe A. Cerni', 'raw_affiliation_strings': ['School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil'], 'affiliations': [{'raw_affiliation_string': 'School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil', 'institution_ids': ['https://openalex.org/I17974374']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063496740', 'display_name': 'Jonas A. Jürgensen', 'orcid': 'https://orcid.org/0000-0002-8986-4483'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Jonas A. Jürgensen', 'raw_affiliation_strings': ['Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085174850', 'display_name': 'Line Ledsgaard', 'orcid': 'https://orcid.org/0000-0001-7380-8420'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Line Ledsgaard', 'raw_affiliation_strings': ['Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012148978', 'display_name': 'Andrea Martos-Esteban', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Andrea Martos-Esteban', 'raw_affiliation_strings': ['Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013128072', 'display_name': 'Mia Øhlenschlæger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Mia Øhlenschlæger', 'raw_affiliation_strings': ['Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011304227', 'display_name': 'Urška Puš', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Urska Pus', 'raw_affiliation_strings': ['Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033651373', 'display_name': 'Mikael Rørdam Andersen', 'orcid': 'https://orcid.org/0000-0003-4794-6808'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Mikael R. Andersen', 'raw_affiliation_strings': ['Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003513067', 'display_name': 'Bruno Lomonte', 'orcid': 'https://orcid.org/0000-0003-2419-6469'}, 'institutions': [{'id': 'https://openalex.org/I31944674', 'display_name': 'Universidad de Costa Rica', 'ror': 'https://ror.org/02yzgww51', 'country_code': 'CR', 'type': 'education', 'lineage': ['https://openalex.org/I31944674']}], 'countries': ['CR'], 'is_corresponding': False, 'raw_author_name': 'Bruno Lomonte', 'raw_affiliation_strings': ['Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica'], 'affiliations': [{'raw_affiliation_string': 'Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica', 'institution_ids': ['https://openalex.org/I31944674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042451239', 'display_name': 'Mikael Engmark', 'orcid': 'https://orcid.org/0000-0002-3918-2425'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'Mikael Engmark', 'raw_affiliation_strings': ['Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056516134', 'display_name': 'Manuela Berto Pucca', 'orcid': 'https://orcid.org/0000-0003-2594-7068'}, 'institutions': [{'id': 'https://openalex.org/I4210144834', 'display_name': 'Universidade Federal de Roraima', 'ror': 'https://ror.org/03ehp1h78', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I4210144834']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Manuela B. Pucca', 'raw_affiliation_strings': ['Medical School, Federal University of Roraima, Boa Vista, Brazil'], 'affiliations': [{'raw_affiliation_string': 'Medical School, Federal University of Roraima, Boa Vista, Brazil', 'institution_ids': ['https://openalex.org/I4210144834']}]}], 'countries_distinct_count': 4, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5047291517'], 'corresponding_institution_ids': ['https://openalex.org/I96673099'], 'apc_list': {'value': 3090, 'currency': 'USD', 'value_usd': 3090, 'provenance': 'doaj'}, 'apc_paid': {'value': 3090, 'currency': 'USD', 'value_usd': 3090, 'provenance': 'doaj'}, 'fwci': 2.138, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 137, 'citation_normalized_percentile': {'value': 0.99901, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '146', 'issue': None, 'first_page': '151', 'last_page': '175'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12477', 'display_name': 'Immunotoxin Therapy for Cancer Treatment', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12477', 'display_name': 'Immunotoxin Therapy for Cancer Treatment', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11353', 'display_name': 'Snake Venom Evolution and Toxinology', 'score': 0.9916, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/antibody-engineering', 'display_name': 'Antibody Engineering', 'score': 0.535394}, {'id': 'https://openalex.org/keywords/antibody-pharmacokinetics', 'display_name': 'Antibody Pharmacokinetics', 'score': 0.507116}, {'id': 'https://openalex.org/keywords/basic-research', 'display_name': 'Basic research', 'score': 0.43904755}, {'id': 'https://openalex.org/keywords/antivenom', 'display_name': 'Antivenom', 'score': 0.42898571}], 'concepts': [{'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.5854361}, {'id': 'https://openalex.org/C2986762682', 'wikidata': 'https://www.wikidata.org/wiki/Q964754', 'display_name': 'Basic research', 'level': 2, 'score': 0.43904755}, {'id': 'https://openalex.org/C117287731', 'wikidata': 'https://www.wikidata.org/wiki/Q424427', 'display_name': 'Antivenom', 'level': 3, 'score': 0.42898571}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.38979533}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3455503}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.3370874}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.22771493}, {'id': 'https://openalex.org/C2779448229', 'wikidata': 'https://www.wikidata.org/wiki/Q3386847', 'display_name': 'Venom', 'level': 2, 'score': 0.2247647}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C161191863', 'wikidata': 'https://www.wikidata.org/wiki/Q199655', 'display_name': 'Library science', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000997', 'descriptor_name': 'Antivenins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D014688', 'descriptor_name': 'Venoms', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000997', 'descriptor_name': 'Antivenins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000997', 'descriptor_name': 'Antivenins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D002162', 'descriptor_name': 'Camelus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014688', 'descriptor_name': 'Venoms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.toxicon.2018.03.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42803210', 'display_name': 'Toxicon', 'issn_l': '0041-0101', 'issn': ['0041-0101', '1879-3150'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.repository.cam.ac.uk/handle/1810/277227', 'pdf_url': 'https://www.repository.cam.ac.uk/bitstreams/43416ad2-64e9-4990-9422-8356a0bb722f/download', 'source': {'id': 'https://openalex.org/S4306401776', 'display_name': 'Apollo (University of Cambridge)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I241749', 'host_organization_name': 'University of Cambridge', 'host_organization_lineage': ['https://openalex.org/I241749'], 'host_organization_lineage_names': ['University of Cambridge'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://backend.orbit.dtu.dk/ws/files/146599737/1_s2.0_S0041010118301144_main.pdf', 'pdf_url': 'https://backend.orbit.dtu.dk/ws/files/146599737/1_s2.0_S0041010118301144_main.pdf', 'source': {'id': 'https://openalex.org/S4306400705', 'display_name': 'Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I96673099', 'host_organization_name': 'Technical University of Denmark', 'host_organization_lineage': ['https://openalex.org/I96673099'], 'host_organization_lineage_names': ['Technical University of Denmark'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://backend.orbit.dtu.dk/ws/files/146599734/taja_1_s2.0_S0041010118301144_main_sara.pdf', 'pdf_url': 'https://backend.orbit.dtu.dk/ws/files/146599734/taja_1_s2.0_S0041010118301144_main_sara.pdf', 'source': {'id': 'https://openalex.org/S4306400705', 'display_name': 'Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I96673099', 'host_organization_name': 'Technical University of Denmark', 'host_organization_lineage': ['https://openalex.org/I96673099'], 'host_organization_lineage_names': ['Technical University of Denmark'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://orbit.dtu.dk/en/publications/4d85d4d6-d3ac-47f7-8fce-b9a3aa8ee9c8', 'pdf_url': 'https://orbit.dtu.dk/files/146599734/taja_1_s2.0_S0041010118301144_main_sara.pdf', 'source': {'id': 'https://openalex.org/S4306400705', 'display_name': 'Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I96673099', 'host_organization_name': 'Technical University of Denmark', 'host_organization_lineage': ['https://openalex.org/I96673099'], 'host_organization_lineage_names': ['Technical University of Denmark'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29534892', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.toxicon.2018.03.004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S42803210', 'display_name': 'Toxicon', 'issn_l': '0041-0101', 'issn': ['0041-0101', '1879-3150'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.47, 'id': 'https://metadata.un.org/sdg/9', 'display_name': 'Industry, innovation and infrastructure'}], 'grants': [{'funder': 'https://openalex.org/F4320322025', 'funder_display_name': 'Conselho Nacional de Desenvolvimento Científico e Tecnológico', 'award_id': '150749/2017-1'}, {'funder': 'https://openalex.org/F4320323217', 'funder_display_name': 'Universidad de Costa Rica', 'award_id': 'OAICE-CAB-05-56-2016'}, {'funder': 'https://openalex.org/F4320323896', 'funder_display_name': 'Ministerio de Ciencia Tecnología y Telecomunicaciones', 'award_id': 'PEM-066-2015-II'}, {'funder': 'https://openalex.org/F4320325957', 'funder_display_name': 'Novo Nordisk Fonden', 'award_id': 'NNF16OC0019248'}, {'funder': 'https://openalex.org/F4320325957', 'funder_display_name': 'Novo Nordisk Fonden', 'award_id': 'NNF13OC0005613'}], 'datasets': [], 'versions': [], 'referenced_works_count': 229, 'referenced_works': ['https://openalex.org/W137907460', 'https://openalex.org/W141261962', 'https://openalex.org/W1458979797', 'https://openalex.org/W1505676752', 'https://openalex.org/W1507835484', 'https://openalex.org/W1564028741', 'https://openalex.org/W1565588554', 'https://openalex.org/W1569892463', 'https://openalex.org/W1572912927', 'https://openalex.org/W1578375703', 'https://openalex.org/W1601489911', 'https://openalex.org/W1775429285', 'https://openalex.org/W1788565548', 'https://openalex.org/W1864783240', 'https://openalex.org/W1894196248', 'https://openalex.org/W1922320648', 'https://openalex.org/W1963522035', 'https://openalex.org/W1964774201', 'https://openalex.org/W1965745529', 'https://openalex.org/W1966727536', 'https://openalex.org/W1967210387', 'https://openalex.org/W1969493759', 'https://openalex.org/W1969671154', 'https://openalex.org/W1970301951', 'https://openalex.org/W1970442415', 'https://openalex.org/W1970875728', 'https://openalex.org/W1970942128', 'https://openalex.org/W1971121100', 'https://openalex.org/W1971147824', 'https://openalex.org/W1971255832', 'https://openalex.org/W1971550487', 'https://openalex.org/W1971727851', 'https://openalex.org/W1972018125', 'https://openalex.org/W1972165200', 'https://openalex.org/W1972610146', 'https://openalex.org/W1973204761', 'https://openalex.org/W1973978463', 'https://openalex.org/W1975248826', 'https://openalex.org/W1976598911', 'https://openalex.org/W1979103616', 'https://openalex.org/W1980387413', 'https://openalex.org/W1980655108', 'https://openalex.org/W1980990335', 'https://openalex.org/W1981607206', 'https://openalex.org/W1982501635', 'https://openalex.org/W1982622656', 'https://openalex.org/W1982690535', 'https://openalex.org/W1983204053', 'https://openalex.org/W1984527299', 'https://openalex.org/W1985912468', 'https://openalex.org/W1989037087', 'https://openalex.org/W1990111072', 'https://openalex.org/W1991332802', 'https://openalex.org/W1991669097', 'https://openalex.org/W1991817598', 'https://openalex.org/W1992204938', 'https://openalex.org/W1992333130', 'https://openalex.org/W1993558161', 'https://openalex.org/W1996045402', 'https://openalex.org/W1999733098', 'https://openalex.org/W2000373530', 'https://openalex.org/W2001062098', 'https://openalex.org/W2001588096', 'https://openalex.org/W2004509052', 'https://openalex.org/W2004703200', 'https://openalex.org/W2006968970', 'https://openalex.org/W2007504861', 'https://openalex.org/W2008316222', 'https://openalex.org/W2008487520', 'https://openalex.org/W2009201102', 'https://openalex.org/W2010914111', 'https://openalex.org/W2015168762', 'https://openalex.org/W2015478876', 'https://openalex.org/W2015718953', 'https://openalex.org/W2016371994', 'https://openalex.org/W2016507471', 'https://openalex.org/W2018540366', 'https://openalex.org/W2020356184', 'https://openalex.org/W2020494888', 'https://openalex.org/W2020522769', 'https://openalex.org/W2027268124', 'https://openalex.org/W2027344849', 'https://openalex.org/W2027446763', 'https://openalex.org/W2029621048', 'https://openalex.org/W2031346366', 'https://openalex.org/W2031692341', 'https://openalex.org/W2031804837', 'https://openalex.org/W2032160423', 'https://openalex.org/W2032233026', 'https://openalex.org/W2033111976', 'https://openalex.org/W2034842370', 'https://openalex.org/W2035025581', 'https://openalex.org/W2035074554', 'https://openalex.org/W2035611301', 'https://openalex.org/W2035776098', 'https://openalex.org/W2036181958', 'https://openalex.org/W2039037695', 'https://openalex.org/W2039144093', 'https://openalex.org/W2039232895', 'https://openalex.org/W2042078619', 'https://openalex.org/W2042733618', 'https://openalex.org/W2043001568', 'https://openalex.org/W2043032712', 'https://openalex.org/W2044181031', 'https://openalex.org/W2045213075', 'https://openalex.org/W2045742996', 'https://openalex.org/W2047499811', 'https://openalex.org/W2048849328', 'https://openalex.org/W2049361760', 'https://openalex.org/W2049994871', 'https://openalex.org/W2051350778', 'https://openalex.org/W2051639276', 'https://openalex.org/W2053031581', 'https://openalex.org/W2054433424', 'https://openalex.org/W2054615802', 'https://openalex.org/W2059050919', 'https://openalex.org/W2059304691', 'https://openalex.org/W2061946307', 'https://openalex.org/W2062826169', 'https://openalex.org/W2063840206', 'https://openalex.org/W2065219066', 'https://openalex.org/W2065750080', 'https://openalex.org/W2066427586', 'https://openalex.org/W2066511622', 'https://openalex.org/W2066960839', 'https://openalex.org/W2067430399', 'https://openalex.org/W2067446557', 'https://openalex.org/W2068578775', 'https://openalex.org/W2070194399', 'https://openalex.org/W2070556216', 'https://openalex.org/W2071095038', 'https://openalex.org/W2071123897', 'https://openalex.org/W2071299216', 'https://openalex.org/W2073624663', 'https://openalex.org/W2074013699', 'https://openalex.org/W2074872934', 'https://openalex.org/W2075298528', 'https://openalex.org/W2075312823', 'https://openalex.org/W2075901113', 'https://openalex.org/W2076179548', 'https://openalex.org/W2076312685', 'https://openalex.org/W2078317394', 'https://openalex.org/W2078624174', 'https://openalex.org/W2078864791', 'https://openalex.org/W2083571658', 'https://openalex.org/W2083764503', 'https://openalex.org/W2084418115', 'https://openalex.org/W2084750170', 'https://openalex.org/W2085900470', 'https://openalex.org/W2087439096', 'https://openalex.org/W2087865968', 'https://openalex.org/W2089937475', 'https://openalex.org/W2089999473', 'https://openalex.org/W2090657368', 'https://openalex.org/W2092075235', 'https://openalex.org/W2093702879', 'https://openalex.org/W2094052190', 'https://openalex.org/W2096899667', 'https://openalex.org/W2097129951', 'https://openalex.org/W2099141683', 'https://openalex.org/W2099965123', 'https://openalex.org/W2106481926', 'https://openalex.org/W21125662', 'https://openalex.org/W2118540273', 'https://openalex.org/W2119511077', 'https://openalex.org/W2119984695', 'https://openalex.org/W2125130429', 'https://openalex.org/W2125873511', 'https://openalex.org/W2129150005', 'https://openalex.org/W2133606090', 'https://openalex.org/W2134944663', 'https://openalex.org/W2135377366', 'https://openalex.org/W2135696719', 'https://openalex.org/W2138945197', 'https://openalex.org/W2141002805', 'https://openalex.org/W2142252167', 'https://openalex.org/W2143631600', 'https://openalex.org/W2147451568', 'https://openalex.org/W2154207356', 'https://openalex.org/W2154955381', 'https://openalex.org/W2159702923', 'https://openalex.org/W2161533704', 'https://openalex.org/W2162385837', 'https://openalex.org/W2165134271', 'https://openalex.org/W2170202130', 'https://openalex.org/W2179227226', 'https://openalex.org/W2186379853', 'https://openalex.org/W2216526400', 'https://openalex.org/W2232895560', 'https://openalex.org/W2266449668', 'https://openalex.org/W2273152113', 'https://openalex.org/W2273473415', 'https://openalex.org/W2276236854', 'https://openalex.org/W2278563853', 'https://openalex.org/W2323569276', 'https://openalex.org/W2332076457', 'https://openalex.org/W2402285784', 'https://openalex.org/W2468932669', 'https://openalex.org/W2471180956', 'https://openalex.org/W2480035861', 'https://openalex.org/W2486819405', 'https://openalex.org/W2510831965', 'https://openalex.org/W2514661967', 'https://openalex.org/W2529194043', 'https://openalex.org/W2532646138', 'https://openalex.org/W2556495444', 'https://openalex.org/W2572937551', 'https://openalex.org/W2580845483', 'https://openalex.org/W2584943228', 'https://openalex.org/W2589215160', 'https://openalex.org/W2593483585', 'https://openalex.org/W2606721249', 'https://openalex.org/W2611204710', 'https://openalex.org/W2613564777', 'https://openalex.org/W2618177156', 'https://openalex.org/W2623608647', 'https://openalex.org/W2734368618', 'https://openalex.org/W2743993644', 'https://openalex.org/W2750983690', 'https://openalex.org/W2753028423', 'https://openalex.org/W2766002859', 'https://openalex.org/W2905344637', 'https://openalex.org/W2917973694', 'https://openalex.org/W3214975867', 'https://openalex.org/W4211091111', 'https://openalex.org/W4231627661', 'https://openalex.org/W4321001023', 'https://openalex.org/W5767759', 'https://openalex.org/W99354103'], 'related_works': ['https://openalex.org/W4311143210', 'https://openalex.org/W4285393379', 'https://openalex.org/W3090801604', 'https://openalex.org/W2774495993', 'https://openalex.org/W2165414580', 'https://openalex.org/W2038383133', 'https://openalex.org/W2018897047', 'https://openalex.org/W2013238756', 'https://openalex.org/W2006260830', 'https://openalex.org/W147551516'], 'abstract_inverted_index': {'Antibody': [0], 'technologies': [1], 'are': [2, 28], 'being': [3, 29], 'increasingly': [4], 'applied': [5], 'in': [6, 16, 59, 75], 'the': [7, 13, 32, 56, 60, 67, 110, 128, 136], 'field': [8], 'of': [9, 55, 62, 71, 112], 'toxinology.': [10], 'Fuelled': [11], 'by': [12], 'many': [14], 'advances': [15, 57], 'immunology,': [17], 'synthetic': [18], 'biology,': [19], 'and': [20, 25, 65, 69, 91, 95, 99, 135], 'antibody': [21, 26, 73, 114, 121], 'research,': [22], 'different': [23, 39, 72], 'approaches': [24], 'formats': [27, 41, 74, 115], 'investigated': [30], 'for': [31, 93], 'ability': [33, 79, 137], 'to': [34, 77, 80, 86, 106, 124, 138], 'neutralize': [35, 81], 'animal': [36], 'toxins.': [37], 'These': [38], 'molecular': [40], 'each': [42], 'have': [43], 'their': [44, 78, 125], 'own': [45], 'therapeutic': [46, 133], 'characteristics.': [47], 'In': [48], 'this': [49], 'review,': [50], 'we': [51], 'provide': [52], 'an': [53], 'overview': [54], 'made': [58], 'development': [61, 96], 'toxin-targeting': [63], 'antibodies,': [64], 'discuss': [66], 'benefits': [68], 'drawbacks': [70], 'relation': [76], 'toxins,': [82], 'pharmacokinetic': [83], 'features,': [84], 'propensity': [85], 'cause': [87], 'adverse': [88], 'reactions,': [89], 'formulation,': [90], 'expression': [92], 'research': [94, 103], '(R&D)': [97], 'purposes': [98], 'large-scale': [100], 'manufacturing.': [101], 'A': [102], 'trend': [104], 'seems': [105], 'be': [107], 'emerging': [108], 'towards': [109], 'use': [111], 'human': [113, 129], 'as': [116, 118], 'well': [117], 'camelid': [119], 'heavy-domain': [120], 'fragments': [122], 'due': [123], 'compatibility': [126], 'with': [127], 'immune': [130], 'system,': [131], 'beneficial': [132], 'properties,': [134], 'manufacture': [139], 'these': [140], 'molecules': [141], 'cost-effectively.': [142]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2789977408', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 23}, {'year': 2022, 'cited_by_count': 26}, {'year': 2021, 'cited_by_count': 24}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 15}, {'year': 2018, 'cited_by_count': 13}], 'updated_date': '2024-09-13T13:38:27.448737', 'created_date': '2018-03-29'}