Title: Use of T<sub>1</sub> relaxation time in rotating frame (T<sub>1</sub>ρ) and apparent diffusion coefficient to estimate cerebral stroke evolution
Abstract: Background The major factor for the appropriate treatment strategies for ischemia patients is its onset timing. Purpose/Hypothesis To study to evaluate the diagnostic accuracy of T 1 relaxation time in a rotating frame (T 1 ρ) and apparent diffusion coefficient (ADC) from MRI to estimate ischemia stages. Study Type Prospective. Population/Subjects/Phantom/Specimen/Animal Model In all, 73 patients (49 males, aged 29–78 years and 24 females, aged 22–94 years) with ischemia were prospectively imaged with T 1 ρ and diffusion MRI during the postischemic period. Field Strength/Sequence 3T/T 1 ρ and diffusion‐weighted imaging (DWI). Assessment Ischemic parenchyma included tissue with elevated signal areas on DWI and correlative hypointense areas on ADC maps. Statistical Tests The sensitivity of variables to ischemia time was quantified by analyzing the respective correlations of these values with onset time. Results ΔT 1 ρ (ipsilateral‐contralateral differences in T 1 ρ) (R 2 = 0.956) and T 1 ρ ipsi (ipsilateral ischemia T 1 ρ values) (R 2 = 0.941) were elevated in all ischemic lesions; these values increased linearly as a function of time, unlike ΔADC (ipsilateral‐contralateral differences in ADC) (R 2 = –0.410) and ADC ipsi (ipsilateral ischemia ADC values) (R 2 = 0.550). ΔT 1 ρ and T 1 ρ ipsi were significantly different between all stages ( P < 0.01), except the acute and hyperacute stages ( P = 0.589 for ΔT 1 ρ, P = 0.290 for T 1 ρ ipsi , respectively), but ΔADC and ADC ipsi only between the late subacute and early subacute stages ( P < 0.01) and the late subacute and chronic stages ( P < 0.01). Data Conclusion These data suggest that T 1 ρ can provide estimates for the ischemic time in patients. T 1 ρ has the potential to outperform diffusion for single‐timepoint examination because the T 1 ρ change during strokes is positive and linear. If patients with suspected stroke are scanned by MRI within the appropriate timeframe, T 1 ρ may provide tools for evaluating stroke onset, potentially aiding in treatment strategies. Level of Evidence: 4 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:1247–1254.
Publication Year: 2018
Publication Date: 2018-02-15
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 10
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