Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2784137900', 'doi': 'https://doi.org/10.1021/acschembio.7b01016', 'title': 'A Cell-Permeable Stapled Peptide Inhibitor of the Estrogen Receptor/Coactivator Interaction', 'display_name': 'A Cell-Permeable Stapled Peptide Inhibitor of the Estrogen Receptor/Coactivator Interaction', 'publication_year': 2018, 'publication_date': '2018-01-08', 'ids': {'openalex': 'https://openalex.org/W2784137900', 'doi': 'https://doi.org/10.1021/acschembio.7b01016', 'mag': '2784137900', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29309722', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6057476'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acschembio.7b01016', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S118914585', 'display_name': 'ACS Chemical Biology', 'issn_l': '1554-8929', 'issn': ['1554-8929', '1554-8937'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc6057476?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5038694828', 'display_name': 'Thomas E. Speltz', 'orcid': 'https://orcid.org/0000-0001-9551-9080'}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois at Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas E. Speltz', 'raw_affiliation_strings': ['Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., Chicago, Illinois 60612, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., Chicago, Illinois 60612, United States', 'institution_ids': ['https://openalex.org/I39422238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105934212', 'display_name': 'Jeanne M. Danes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois at Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeanne M. Danes', 'raw_affiliation_strings': ['Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1835 W Polk St, Chicago, Illinois 60612, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1835 W Polk St, Chicago, Illinois 60612, United States', 'institution_ids': ['https://openalex.org/I39422238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042555469', 'display_name': 'Joshua D. Stender', 'orcid': 'https://orcid.org/0000-0002-2263-4595'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joshua D. Stender', 'raw_affiliation_strings': ['Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093, United States', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004867663', 'display_name': 'Jonna Frasor', 'orcid': 'https://orcid.org/0000-0002-6003-1867'}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois at Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jonna Frasor', 'raw_affiliation_strings': ['Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1835 W Polk St, Chicago, Illinois 60612, United States', 'University of Illinois Cancer Center, 1801 W Taylor St., Chicago, Illinois 60612, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 1835 W Polk St, Chicago, Illinois 60612, United States', 'institution_ids': ['https://openalex.org/I39422238']}, {'raw_affiliation_string': 'University of Illinois Cancer Center, 1801 W Taylor St., Chicago, Illinois 60612, United States', 'institution_ids': ['https://openalex.org/I39422238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048635691', 'display_name': 'Terry W. Moore', 'orcid': 'https://orcid.org/0000-0002-5410-306X'}, 'institutions': [{'id': 'https://openalex.org/I39422238', 'display_name': 'University of Illinois at Chicago', 'ror': 'https://ror.org/02mpq6x41', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I39422238']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Terry W. Moore', 'raw_affiliation_strings': ['Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., Chicago, Illinois 60612, United States', 'University of Illinois Cancer Center, 1801 W Taylor St., Chicago, Illinois 60612, United States'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., Chicago, Illinois 60612, United States', 'institution_ids': ['https://openalex.org/I39422238']}, {'raw_affiliation_string': 'University of Illinois Cancer Center, 1801 W Taylor St., Chicago, Illinois 60612, United States', 'institution_ids': ['https://openalex.org/I39422238']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5048635691'], 'corresponding_institution_ids': ['https://openalex.org/I39422238'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.305, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.999951, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '13', 'issue': '3', 'first_page': '676', 'last_page': '684'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10756', 'display_name': 'Mechanisms of Estrogen Receptor Signaling', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10756', 'display_name': 'Mechanisms of Estrogen Receptor Signaling', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10911', 'display_name': 'Peptide Synthesis and Drug Discovery', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11440', 'display_name': 'Click Chemistry in Chemical Biology and Drug Development', 'score': 0.9878, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/estrogen-related-receptor-alpha', 'display_name': 'Estrogen-related receptor alpha', 'score': 0.49492234}, {'id': 'https://openalex.org/keywords/g-protein-coupled-receptors', 'display_name': 'G Protein-Coupled Receptors', 'score': 0.487315}, {'id': 'https://openalex.org/keywords/estrogen-receptor-alpha', 'display_name': 'Estrogen receptor alpha', 'score': 0.42340004}], 'concepts': [{'id': 'https://openalex.org/C77445288', 'wikidata': 'https://www.wikidata.org/wiki/Q637488', 'display_name': 'Coactivator', 'level': 4, 'score': 0.9463}, {'id': 'https://openalex.org/C203966977', 'wikidata': 'https://www.wikidata.org/wiki/Q14914599', 'display_name': 'Nuclear receptor coactivator 3', 'level': 5, 'score': 0.8108735}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.685621}, {'id': 'https://openalex.org/C124170894', 'wikidata': 'https://www.wikidata.org/wiki/Q14914591', 'display_name': 'Nuclear receptor coactivator 2', 'level': 5, 'score': 0.66108876}, {'id': 'https://openalex.org/C195598365', 'wikidata': 'https://www.wikidata.org/wiki/Q14914583', 'display_name': 'Nuclear receptor coactivator 1', 'level': 5, 'score': 0.5503716}, {'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.5083737}, {'id': 'https://openalex.org/C201729690', 'wikidata': 'https://www.wikidata.org/wiki/Q5401841', 'display_name': 'Estrogen-related receptor alpha', 'level': 5, 'score': 0.49492234}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4587851}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4387401}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4340466}, {'id': 'https://openalex.org/C2777164284', 'wikidata': 'https://www.wikidata.org/wiki/Q277954', 'display_name': 'Estrogen', 'level': 2, 'score': 0.42959413}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.42432535}, {'id': 'https://openalex.org/C172313692', 'wikidata': 'https://www.wikidata.org/wiki/Q14902310', 'display_name': 'Estrogen receptor alpha', 'level': 5, 'score': 0.42340004}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41760358}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4009019}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35800713}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.168753}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.14340392}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11676428}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.10505617}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.06862801}], 'mesh': [{'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D057846', 'descriptor_name': 'Cell-Penetrating Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057846', 'descriptor_name': 'Cell-Penetrating Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056004', 'descriptor_name': 'Molecular Dynamics Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acschembio.7b01016', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S118914585', 'display_name': 'ACS Chemical Biology', 'issn_l': '1554-8929', 'issn': ['1554-8929', '1554-8937'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6057476', 'pdf_url': 'https://europepmc.org/articles/pmc6057476?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057476', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29309722', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6057476', 'pdf_url': 'https://europepmc.org/articles/pmc6057476?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.62, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320306278', 'funder_display_name': 'Chicago Community Trust', 'award_id': None}, {'funder': 'https://openalex.org/F4320337349', 'funder_display_name': 'NIH Office of the Director', 'award_id': None}, {'funder': 'https://openalex.org/F4320337593', 'funder_display_name': 'National Center for Complementary and Integrative Health', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1501286679', 'https://openalex.org/W1537737183', 'https://openalex.org/W1963505593', 'https://openalex.org/W1969973975', 'https://openalex.org/W1971463046', 'https://openalex.org/W1973253404', 'https://openalex.org/W1974468585', 'https://openalex.org/W1974762491', 'https://openalex.org/W1999122150', 'https://openalex.org/W2005374212', 'https://openalex.org/W2007836674', 'https://openalex.org/W2008845432', 'https://openalex.org/W2010136675', 'https://openalex.org/W2014677321', 'https://openalex.org/W2022467904', 'https://openalex.org/W2023604724', 'https://openalex.org/W2028138612', 'https://openalex.org/W2029595514', 'https://openalex.org/W2031713918', 'https://openalex.org/W2036016124', 'https://openalex.org/W2036487394', 'https://openalex.org/W2039216669', 'https://openalex.org/W2040576705', 'https://openalex.org/W2043701535', 'https://openalex.org/W2044568134', 'https://openalex.org/W2047307378', 'https://openalex.org/W2048172946', 'https://openalex.org/W2054731547', 'https://openalex.org/W2060128629', 'https://openalex.org/W2060158924', 'https://openalex.org/W2060996573', 'https://openalex.org/W2063125253', 'https://openalex.org/W2070440733', 'https://openalex.org/W2074465378', 'https://openalex.org/W2076083257', 'https://openalex.org/W2097134216', 'https://openalex.org/W2107922733', 'https://openalex.org/W2111650618', 'https://openalex.org/W2121454015', 'https://openalex.org/W2128681877', 'https://openalex.org/W2147037321', 'https://openalex.org/W2156763527', 'https://openalex.org/W2159686118', 'https://openalex.org/W2167739779', 'https://openalex.org/W2171538667', 'https://openalex.org/W2291624458', 'https://openalex.org/W2462949473', 'https://openalex.org/W2468731336', 'https://openalex.org/W2522094723', 'https://openalex.org/W2531723709', 'https://openalex.org/W2535959923', 'https://openalex.org/W2558962869', 'https://openalex.org/W2745290453', 'https://openalex.org/W2755015722', 'https://openalex.org/W2765125567', 'https://openalex.org/W4210611640'], 'related_works': ['https://openalex.org/W3177216449', 'https://openalex.org/W2599008170', 'https://openalex.org/W2157632679', 'https://openalex.org/W2124174146', 'https://openalex.org/W2098103041', 'https://openalex.org/W2077994082', 'https://openalex.org/W2050018101', 'https://openalex.org/W2048600164', 'https://openalex.org/W2030148320', 'https://openalex.org/W1969076105'], 'abstract_inverted_index': {'We': [0], 'and': [1, 16, 52, 120, 142], 'others': [2], 'have': [3], 'proposed': [4], 'that': [5, 153], 'coactivator': [6, 33, 70], 'binding': [7, 34, 71, 107], 'inhibitors,': [8], 'which': [9, 46], 'block': [10], 'the': [11, 43, 114, 123, 157, 181], 'interaction': [12], 'of': [13, 25, 32, 42, 77, 116, 129, 145, 156, 159, 180], 'estrogen': [14, 110, 117, 139, 182], 'receptor': [15, 18, 111, 140], 'steroid': [17], 'coactivators,': [19], 'may': [20], 'represent': [21], 'a': [22, 69, 90, 100, 126, 171], 'potential': [23], 'class': [24], 'new': [26], 'breast': [27, 78], 'cancer': [28], 'therapeutics.': [29], 'The': [30], 'development': [31], 'inhibitors': [35, 179], 'has': [36], 'been': [37], 'limited,': [38], 'however,': [39], 'because': [40], 'many': [41], 'current': [44], 'molecules': [45], 'are': [47, 55, 165], 'active': [48, 57, 73], 'in': [49, 50, 58, 63, 74], 'vitro': [51], 'biochemical': [53], 'assays': [54], 'not': [56], 'cell-based': [59], 'assays.': [60], 'Our': [61], 'goal': [62], 'this': [64], 'work': [65], 'was': [66], 'to': [67, 88], 'prepare': [68], 'inhibitor': [72], 'cellular': [75], 'models': [76], 'cancer.': [79], 'To': [80], 'accomplish': [81], 'this,': [82], 'we': [83, 151], 'used': [84], 'molecular': [85], 'dynamics': [86], 'simulations': [87], 'convert': [89], 'high-affinity': [91], 'stapled': [92, 102, 177], 'peptide': [93, 178], 'with': [94, 125], 'poor': [95], 'cell': [96, 124], 'permeability': [97], 'into': [98], 'R4K1,': [99], 'cell-penetrating': [101], 'peptide.': [103], 'R4K1': [104, 132, 160], 'displays': [105], 'high': [106, 127], 'affinity': [108], 'for': [109, 174], 'α,': [112], 'inhibits': [113, 143], 'formation': [115], 'receptor/coactivator': [118, 183], 'complexes,': [119], 'distributes': [121], 'throughout': [122], 'percentage': [128], 'nuclear': [130], 'localization.': [131], 'represses': [133], 'native': [134], 'gene': [135, 163], 'transcription': [136, 164], 'mediated': [137], 'by': [138], 'α': [141], 'proliferation': [144], 'estradiol-stimulated': [146], 'MCF-7': [147], 'cells.': [148], 'Using': [149], 'RNA-Seq,': [150], 'demonstrate': [152], 'almost': [154], 'all': [155], 'effects': [158], 'on': [161], 'global': [162], 'estrogen-receptor-associated.': [166], 'This': [167], 'chemical': [168], 'probe': [169], 'provides': [170], 'significant': [172], 'proof-of-concept': [173], 'preparing': [175], 'cell-permeable': [176], 'interaction.': [184]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2784137900', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 5}], 'updated_date': '2024-08-21T20:01:17.834659', 'created_date': '2018-01-26'}