Title: Gastro Retentive Drug Delivery System of Salbutamol Sulphate: Formulation and It’s in Vitro Evaluation
Abstract: Salbutamol sulphate is a short acting bronchodilators (β2 adrenergic agonist), which have short biological half -life about 2.7 - 5 hours. It is available as conventional
oral tablets, solution, inhalation (inhaler, nebulised solution). The recommended dose of
salbutamol in conventional dose 2 or 4 mg three or four times per day this project work is to develop the Salbutamol sulphate as Gastro Retentive Drug delivery System by Floating Matrix Tablets with extended drug
release, for administration as once daily dose. Floating matrix tablets were formulated
by different methods. Non-effervescent method- by using Hydrocolloids and Effervescent method - by using Gas-forming agents
Thus, it is an object of the present invention to provide a Salbutamol as floating
matrix tablets, which have gastro-retentive controlled oral drug delivery system. Several controlled oral drug delivery systems with prolonged gastric residence
time have been reported such as Floating system, Swelling system,
Mucoadhesive system, High density system and other gastric emptying systems
have been commonly used. Floating system has a lower density than the gastric
fluid and thus remains buoyancy in the stomach, which retain in the stomach for
a prolonged period of time. The objective of this thesis work was planned to formulate the floating matrix
tablet of Salbutamol sulphate by using different matrix forming material (like
hydrophilic, hydrophobic and combined matrix forming material) with an
extended drug release for administration as once daily dose. Hence this research work entitled “Gastro retentive Drug Delivery System of
Salbutamol sulphate: Formulation and its in vitro Evaluation” was under taken
with the above object to achieve. The hydrophilic floating matrix tablets were formulated by non-effervescent
method by using different hydrocolloids like methyl cellulose, HPMC K100M,
HPMC K4M and their floating properties and in vitro drug release were
evaluated. In addition to the polymer stearic acid was included in the
hydrophilic floating matrix tablet and the effects of stearic acid in the in vitro
drug release were evaluated. From this study it was concluded that “Gastro retentive Drug Delivery Systems
as Floating Matrix Tablets” designed as three different matrix tablet such as
Hydrophilic Floating Matrix tablets, Insoluble Floating Matrix Tablets and
Combined Floating Matrix Tablets among them the Hydrophilic Floating Matrix
Tablets with stearic acid of hardness about 5kg/cm2 and round shaped tablets
could be suitable for floating and controlled the drug release form the dosage
form for administration as once daily dose.
Publication Year: 2008
Publication Date: 2008-03-01
Language: en
Type: dissertation
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot