Publication Information

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1237], 'Lee': [239, 242, 315, 318, 835, 838, 911, 914], 'Masaki': [256, 258, 852, 854, 1239], 'Shiota': [257, 259, 853, 855], 'Daksh': [285, 287, 881, 883, 1241], 'Thaper': [286, 288, 882, 884], 'Wilson': [313, 316, 909, 912, 1243], 'CW': [314, 317, 910, 913, 1244], 'Daniel': [332, 335, 928, 931, 1246], 'HF': [333, 336, 929, 932, 1247], 'Hui': [334, 337, 930, 933], 'Hidetoshi': [351, 353, 947, 949, 1249], 'Kuruma': [352, 354, 948, 950], 'Larissa': [368, 370, 964, 966, 1251], 'Ivanova': [369, 371, 965, 967], 'Parvin': [385, 387, 981, 983, 1253], 'Yenki': [386, 388, 982, 984], 'Ivy': [413, 416, 1009, 1012, 1255], 'ZF': [414, 417, 1010, 1013, 1256], 'Jiao': [415, 418, 1011, 1014], 'Shahram': [432, 434, 1028, 1030, 1258], 'Khosravi': [433, 435, 1029, 1031], 'Alice': [449, 452, 1045, 1048, 1260], 'L-F': [450, 453, 1046, 1049, 1261], 'Mui': [451, 454, 1047, 1050], 'Surgery,': [457, 1053, 1320], 'Ladan': [472, 474, 1068, 1070, 1263], 'Fazli': [473, 475, 1069, 1071], 'Amina': [489, 491, 1085, 1087, 1265], 'Zoubeidi': [490, 492, 1086, 1088], 'Mads': [517, 519, 1113, 1115, 1267], 'Daugaard': [518, 520, 1114, 1116], 'Martin': [545, 550, 1141, 1146, 1269], 'E': [546, 551, 1142, 1147, 1270], 'Gleave': [547, 552, 1143, 1148, 1271], 'Corresponding': [548, 583, 1144, 1179], 'Author': [549, 584, 1145, 1180, 1213], '[email': [553, 588, 590, 1149, 1184, 1186, 1335, 1346, 1349], 'protected]': [554, 589, 591, 1150, 1185, 1187, 1336, 1347, 1350], 'orcid.org/0000-0003-4235-0167': [555, 1151], 'Christopher': [580, 585, 1176, 1181, 1274], 'Ong': [582, 587, 1178, 1183, 1276], 'orcid.org/0000-0002-0175-8724': [592, 1188], 'Information': [1214], 'Peacock1,2,': [1217], 'Takeuchi1,3,': [1219], 'Hayashi1,4,': [1221], 'Liu1,': [1223], 'Tam1,2,': [1226], 'Nakouzi1,': [1229], 'Khazamipour1,': [1231], 'Tombe1,': [1233], 'Dejima1,3,': [1235], 'Lee1,': [1238, 1245], 'Shiota1,3,': [1240], 'Thaper1,2,': [1242], 'Hui1,': [1248], 'Kuruma1,': [1250], 'Ivanova1,': [1252], 'Yenki1,2,': [1254], 'Jiao1,': [1257], 'Khosravi1,': [1259], 'Mui5,': [1262], 'Fazli1,': [1264], 'Zoubeidi1,2,': [1266], 'Daugaard1,2,': [1268], '*,1,2': [1272], 'and': [1273, 1360, 1378, 1411, 1440, 1467, 1478, 1490, 1493, 1527, 1553, 1560, 1578, 1590, 1655, 1686, 1720, 1847, 1886, 1903, 1912, 1920, 1943, 1954, 1974, 2014, 2022, 2025, 2031, 2061, 2064, 2093, 2097, 2143, 2196, 2206, 2223, 2229, 2286, 2292, 2310, 2316, 2338, 2340, 2380, 2412, 2433, 2523, 2585, 2602, 2607, 2611, 2617, 2629, 2668, 2718, 2742, 2754, 2834, 2889, 2900, 2918, 2948, 2962, 2970, 2972, 2978, 3025, 3035, 3042, 3091, 3097, 3103, 3121, 3129, 3136, 3175, 3189, 3194, 3246, 3289, 3336, 3371, 3397, 3414, 3429, 3457, 3471, 3480, 3495, 3519, 3539, 3551, 3556, 3559, 3580, 3600, 3616, 3649, 3654, 3664, 3667, 3695, 3698, 3701, 3709, 3726, 3729, 3763, 3765, 3821, 3858, 3898, 3941, 3966, 3971, 4061, 4068, 4113, 4120, 4164, 4171, 4179, 4204, 4211], '*,*,1,2': [1277], '1Vancouver': [1278], '2Department': [1284], '3Department': [1295], '4Department': [1307], '5Department': [1318], '*Corresponding': [1328, 1337], 'author.': [1329, 1338], 'Tel:': [1330, 1339], '+1': [1331, 1340], '6046': [1332], '752568;': [1333], 'E-mail:': [1334, 1345], '6048': [1341], '754111': [1342], 'ext.': [1343], '63120;': [1344], 'or': [1348, 1421, 1834, 1914, 2256, 3755, 3840, 3869, 3879, 3903, 3911, 3926, 3981, 4034, 4215, 4227], 'EMBO': [1351], 'Mol': [1352], 'Med': [1353], '(2018)10:219-238https://doi.org/10.15252/emmm.201707689': [1354], 'PDFDownload': [1355], 'PDF': [1356], 'article': [1358], 'text': [1359], 'main': [1361], 'figures.': [1362], 'Peer': [1363], 'ReviewDownload': [1364], 'a': [1365, 1403, 1443, 1506, 1519, 1540, 1568, 1635, 1643, 1705, 1714, 1729, 1753, 1803, 1823, 1827, 1875, 1978, 2035, 2053, 2069, 2114, 2180, 2317, 2516, 2569, 2654, 2684, 2774, 2804, 2937, 3019, 3036, 3357, 3442, 3499, 3534, 3543, 4107, 4156, 4189], 'summary': [1366], 'the': [1368, 1611, 1650, 1708, 1768, 1851, 1866, 1900, 1929, 2102, 2185, 2240, 2357, 2477, 2483, 2486, 2493, 2496, 2499, 2507, 2529, 2646, 2665, 2669, 2677, 2693, 2809, 2857, 2933, 2981, 2995, 3069, 3170, 3778, 3805, 3828, 3850, 3890, 3921, 3955, 3986, 3991, 3998, 4007, 4049, 4059, 4062, 4066, 4168, 4197], 'editorial': [1369, 1373], 'decision': [1370, 1374], 'including': [1372, 1437, 1647, 1881, 1950, 2574, 2871, 2957], 'letters,': [1375], 'reviewer': [1376], 'comments': [1377], 'responses': [1380], 'to': [1381, 1384, 1462, 1469, 1642, 1790, 2067, 2190, 2246, 2271, 2498, 2622, 2675, 2699, 2744, 2789, 2824, 2913, 2926, 3305, 3426, 3584, 3609, 3676, 3712, 4111, 4144, 4195], 'feedback.': [1382], 'ToolsAdd': [1383], 'favoritesDownload': [1385], 'CitationsTrack': [1386], 'CitationsPermissions': [1387], 'ShareFacebookTwitterLinked': [1388], 'InMendeleyWechatReddit': [1389], 'Figures': [1390], '&': [1391, 1856, 1889, 1925, 1962, 1987, 1997, 2019, 3574], 'Info': [1392], 'Abstract': [1393], 'Growth': [1394], 'factor': [1395, 1522, 1659, 1669, 1681, 1795, 2056, 3056], 'kinase': [1398, 2295, 3312], '(RTK)': [1399, 3313], 'pathway': [1400, 1472, 1722, 2967, 2983, 3161], 'activation': [1401, 1433, 1656, 1691, 3060, 3157, 3337, 3368, 3492, 3587], 'is': [1402, 1518, 1567, 1599, 1616, 1634, 1756, 1934, 1969, 2034, 2080, 2442, 2652, 3052, 3770, 4073, 4106], 'key': [1404, 2054, 2940, 3535], 'mechanism': [1405, 2823], 'mediating': [1407, 4182], 'growth,': [1409], 'survival,': [1410], 'treatment': [1412, 1511, 1528, 1579, 1808, 2062, 2266, 3110, 4148, 4251], 'resistance.': [1413, 1580, 2827], 'Cognate': [1414], 'ligands': [1415, 1688], 'play': [1416], 'crucial': [1417], 'roles': [1418], 'in': [1419, 1442, 1454, 1501, 1539, 1551, 1554, 1674, 1718, 1737, 1759, 1816, 1850, 1865, 1874, 1896, 1977, 2016, 2091, 2203, 2249, 2367, 2415, 2455, 2515, 2568, 2596, 2710, 2747, 2782, 2847, 2909, 2919, 2921, 2984, 3022, 3039, 3045, 3114, 3124, 3147, 3162, 3178, 3196, 3227, 3260, 3354, 3356, 3374, 3409, 3498, 3515, 3542, 3623, 3634, 3734, 3833, 3861, 3900, 3974, 3990, 3997, 4020, 4213], 'autocrine': [1420, 1521, 3054], 'paracrine': [1422], 'stimulation': [1423, 3353], 'these': [1425, 1693, 2770, 3720], 'RTK': [1426, 1488, 3586, 4186], 'pathways.': [1427], 'Here,': [1428], 'we': [1429, 2047, 2100, 2564, 2772, 2850, 2999, 3182, 3378, 3440, 3606, 3629, 4142, 4192, 4255], 'show': [1430], 'RTKs': [1436, 2960], 'EGFR,': [1438, 1558, 2289, 2410, 2832, 3023, 3040, 3094, 3117, 3187, 3464, 3707, 4177], 'ErbB2,': [1439, 1559, 2290, 3118, 3188], 'MET': [1441, 1561, 2514, 2537, 2835, 3309, 3324, 3339, 3347, 3372, 3494, 3540, 3601, 3967], 'cognate': [1444, 1541], 'ligand-independent': [1445, 1542], 'manner': [1446, 3359, 3501], 'B1.': [1449], 'expression': [1451, 1700, 1750, 1966, 2033, 2079, 2089, 2210, 2282, 2567, 2706, 2727, 2741, 3174, 3396, 3402, 3461], 'levels': [1452, 2090, 2103, 2366, 2454, 2467, 2593, 2778, 2903, 3140, 3233, 3238, 3259, 3487, 3511, 3953], 'increase': [1453, 3021, 3113], 'castration-resistant': [1455, 2375, 2755, 2783], 'prostate': [1456, 1514, 1548, 1575, 1591, 1607, 2095, 2470, 2576, 2647, 2700, 2713, 3210, 3283, 3735], '(CRPC),': [1458], 'where': [1459], 'it': [1460, 1734], 'functions': [1461], 'promote': [1463, 1910, 3427], 'cell': [1465, 1491, 1835, 1845, 2012, 2389, 2572, 2588, 2649, 2702, 2715, 2892, 2897, 2965, 2973, 3376, 3412, 3521, 3562, 4169], 'resistance': [1468, 1529, 2743], 'androgen': [1470, 1651, 2372, 2381, 2586], 'inhibition.': [1473], 'inhibition': [1475, 1504], 'delays': [1476], 'CRPC': [1477, 1495, 1622, 1633, 1719, 1731, 1817, 2059, 2083, 2155, 2230, 2285, 2319, 2810], 'enzalutamide-resistant': [1479, 2378, 2604], 'progression.': [1480], 'sema': [1483], 'domain-containing:Fc': [1484], 'fusion': [1485, 3083, 4225], 'proteins': [1486, 1838, 2435, 2894, 2906, 2968, 2976, 3100, 3192, 3514, 3957, 4130], 'suppress': [1487, 1915], 'signaling': [1489, 1546, 1562, 1589, 1660, 1837, 2296, 2414, 2830, 2842, 2893, 2905, 2997, 3099, 3160, 3177, 3191, 3307, 3340, 3373, 3497, 3541, 3550, 3733], 'inhibit': [1494], 'progression': [1496, 1676, 1942, 1976, 2060], 'LNCaP': [1498, 2416, 2613, 2784, 2848, 2911, 2916, 2930, 3001, 3072, 3125, 3148], 'xenografts': [1499], 'post-castration': [1500], 'vivo.': [1502, 1555], 'represents': [1505, 2485, 2664, 2692, 4048, 4065], 'novel': [1507, 1746], 'therapeutic': [1508, 2070], 'strategy': [1509], 'advanced': [1513, 1760, 2214], 'cancer.': [1515, 1897], 'Synopsis': [1516], 'secreted': [1520, 1709, 1833, 2591, 2642, 2704, 2991, 3567], 'that': [1523, 1638, 1689, 1755, 2057, 2216, 2656, 2662, 2686, 2691, 2803, 2817, 2895, 2942, 3012, 3050, 3057, 3389, 3530, 3723, 4245], 'manner.': [1543, 2518], 'Antagonizing': [1544], 'inhibits': [1547], 'vitro': [1552, 2017], 'cascades.': [1563], '(PLXNB1)': [1566], 'SEMA3C.': [1571, 3016], 'Autocrine': [1572], 'promotes': [1574, 2011], 'A': [1581], 'recombinant': [1582, 3081, 3489, 4222], 'PLEXIN': [1583, 3938], 'decoy': [1585], 'protein': [1586, 2071, 2667, 2885, 3084, 3253], 'attenuates': [1587], 'growth.': [1593], 'Introduction': [1594], 'Androgen': [1595], 'deprivation': [1596], 'therapy': [1597, 1602, 2137, 2307, 2746], '(ADT)': [1598], 'first-line': [1600], 'systemic': [1601], 'men': [1604], 'with': [1605, 1749, 1807, 1940, 1971, 2082, 2213, 2221, 2253, 2284, 2395, 2419, 2526, 2542, 2769, 3003, 3028, 3076, 3236, 3268, 3331, 3405, 3488, 3638, 3752, 3837, 3865, 3876, 3908, 3934, 3947, 3978, 4162, 4176, 4220, 4240, 4261], 'metastatic': [1606], '(PCa).': [1609], 'Unfortunately,': [1610], 'survival': [1612, 1794, 2966, 3408, 3430], 'benefit': [1613], 'from': [1614, 2187, 2333, 2371, 2468, 2495, 2643, 2730, 2791, 2863, 3008, 3203, 3281, 3294, 4078], 'ADT': [1615], 'limited': [1617], 'emergence': [1619], 'lethal': [1621], '(Bruchovsky': [1623], 'et': [1624, 1628, 1663, 1782, 1800, 1819, 1983, 1993, 2001, 2005, 2028, 2043, 2173, 2732, 2762, 3218, 3222, 3315, 3436, 3592, 3597, 3603, 4137], 'al,': [1625, 1629, 1664, 1783, 1801, 1820, 1984, 1994, 2002, 2006, 2029, 2044, 2174, 2763, 3219, 3223, 3316, 3437, 3593, 3598, 3604, 4138], '1989;': [1626], 'Goldenberg': [1627], '1988).': [1630], 'Development': [1631], 'complex': [1636, 4158], 'has': [1639, 3422], 'been': [1640, 1862, 1872, 2218, 3424], 'attributed': [1641], 'variety': [1644, 1876], 'mechanisms': [1646], 'reactivation': [1648], '(AR)': [1653], 'axis': [1654], 'pathways': [1661, 1671, 1694, 2843], '(Yap': [1662], '2011).': [1665], 'While': [1666, 1859], 'many': [1667], 'are': [1672, 1826, 2402, 2547, 3302, 3561, 3582, 3619, 3958, 4016, 4085], 'activated': [1673], 'PCa': [1675, 2119, 2150, 2215, 2314, 2384, 3180, 3624], '(such': [1677], 'as': [1678, 1713, 1728, 1733, 1841, 1957, 1959, 2152, 2154, 2398, 2444, 2579, 2581, 2676, 2787, 2876, 2878, 3141, 3143, 3249, 3299, 3589, 3772, 3825, 3928, 4231], 'epidermal': [1679], '(EGFR),': [1683], 'ErbB2': [1684, 3095], '(HER2/neu),': [1685], 'MET),': [1687], 'drive': [1690, 3367], 'remain': [1695], 'poorly': [1696], 'defined.': [1697], 'Our': [1698], 'gene': [1699, 1717, 1754, 2726], 'profiling': [1701, 1741, 1764, 2728], 'data': [1702, 2401, 2473, 2546, 2729, 3212, 3286, 3385, 3527, 3721, 4084], 'identified': [1703, 1736, 1765], 'SEMA3C,': [1704, 2814, 3463], 'member': [1706], 'class': [1710, 1906, 1930, 3568], '3': [1711, 1907, 1931, 3569], 'semaphorins,': [1712, 1932], 'highly': [1715], 'expressed': [1716, 1773, 3771], 'AR': [1721], 'inhibitor-recurrent': [1723], 'tumors.': [1724], 'was': [1726, 1735, 1788, 2211, 2354, 2504, 2538, 2707, 3105, 3341, 3349, 3403, 3802, 3847, 3887, 3918, 3945, 4246], 'prioritized': [1727], 'putative': [1730, 4206], 'driver': [1732, 3536], 'two': [1738, 2623, 4128], 'independent': [1739, 2406], 'genomewide': [1740], 'studies.': [1742], 'In': [1743, 1785, 2008], 'search': [1744], 'targets': [1747], 'associated': [1748, 1806, 1970, 2081, 2212, 3235, 3404], 'PTEN,': [1752], 'frequently': [1757], 'mutated': [1758], 'PCa,': [1761, 2009], 'DNA': [1762], 'microarray': [1763, 2108, 2861], 'among': [1767], 'top': [1769], 'three': [1770, 2405], 'most': [1771], 'differentially': [1772], 'genes': [1774], 'between': [1775, 2738, 3172, 3856, 4202], 'PTEN+': [1776], 'vs.': [1777], 'PTEN−/−': [1778], 'cells': [1780, 2251, 2274, 2385, 2417, 2520, 2578, 2610, 2614, 2631, 2912, 3002, 3011, 3073, 3126, 3149, 3164, 3328, 3434, 3445, 3482, 3636, 3674, 3750, 3835, 3864, 3906, 3976, 4015, 4151, 4218], '(Peacock': [1781], '2009).': [1784], 'addition,': [1786], 'found': [1789, 2595, 2773, 4234, 4256], 'be': [1791, 1813, 2052, 3533], 'an': [1792, 2736, 2852, 3053, 3391], 'NFκB-regulated': [1793], 'induced': [1796, 3155, 3350], 'CLU': [1798], '(Zoubeidi': [1799, 1818], '2010b),': [1802], 'molecular': [1804], 'chaperone': [1805], 'resistance,': [1809, 2063], 'suggesting': [1810, 3049], 'may': [1812, 2820, 3532], 'functionally': [1814], 'relevant': [1815], '2010a).': [1821], 'As': [1822, 2201, 2697, 3225, 4188], 'whole,': [1824], 'semaphorins': [1825, 1860, 1908], 'large': [1828], 'family': [1829, 2959], 'evolutionarily': [1831], 'conserved': [1832], 'surface': [1836, 3563, 4170], 'originally': [1839], 'discovered': [1840], 'important': [1842], 'mediators': [1843], 'migration': [1846, 2013], 'axon': [1848], 'guidance': [1849], 'developing': [1852], 'nervous': [1853, 1867], 'system': [1854], '(Cagnoni': [1855, 1888], 'Tamagnone,': [1857, 1890, 1926, 1963, 3575], '2014).': [1858, 1891, 3438], 'have': [1861, 1870, 2217, 2636], 'best': [1863], 'characterized': [1864], 'system,': [1868], 'they': [1869], 'also': [1871, 2681, 3303], 'implicated': [1873], 'dynamic': [1878], 'physiological': [1879], 'processes': [1880], 'angiogenesis,': [1882], 'tissue': [1883, 2107], 'morphogenesis,': [1884], 'immunity,': [1885], 'Semaphorins': [1892], 'exhibit': [1893], 'diverse': [1894], 'activities': [1895], 'Depending': [1898], 'on': [1899, 2179, 4167], 'tumor': [1901, 1941, 1948, 1975, 2458, 3262, 3279, 3387], 'type': [1902], 'context,': [1904], 'various': [1905], 'either': [1909, 3838, 3866, 3877, 3909, 3979, 4221], '(SEMA3C': [1911, 3272, 3277], '3E)': [1913], '(SEMA3A,': [1916], '3B,': [1917], '3D,': [1918], '3E,': [1919], '3F)': [1921], '(Rehman': [1924, 1961, 3573], '2013).': [1927, 1964, 2045, 3224, 3576], 'Among': [1928], 'notable': [1935], 'its': [1937, 4205], 'frequent': [1938], 'association': [1939, 2737, 3392, 3855, 3962, 4126], 'poor': [1944, 1972, 3398, 3406], 'prognosis': [1945, 1973], 'across': [1946], 'types': [1949, 3388], 'lung,': [1951], 'breast,': [1952], 'gastric,': [1953], 'ovarian': [1955], 'cancers': [1956, 1981], 'well': [1958, 2153, 2580, 2877], 'glioblastoma': [1960, 3458], 'Increased': [1965, 2077, 2280], 'number': [1979, 2938], '(Yamada': [1982], '1997;': [1985], 'Martin-Satue': [1986], 'Blanco,': [1988], '1999;': [1989], 'Konno,': [1990], '2001;': [1991], 'Galani': [1992], '2002;': [1995], 'Herman': [1996], 'Meadows,': [1998, 2020], '2007;': [1999], 'Miyato': [2000], '2012;': [2003, 3220], 'Xu': [2004], '2017).': [2007], 'invasion': [2015], '(Herman': [2018], '2007)': [2021], 'EMT': [2024], 'stemness': [2026], '(Tam': [2027], '2017)': [2030], 'predictive': [2036], 'marker': [2037], 'biochemical': [2039], 'recurrence': [2040], '(BCR)': [2041], '(Li': [2042], 'Therefore,': [2046], 'investigated': [2048], 'whether': [2049, 2989, 3066, 3320, 3364, 3611, 4146, 4172], 'could': [2051, 2993, 4152], 'set': [2065, 3213], 'out': [2066, 2749], 'develop': [2068], 'inhibitor': [2072], 'signaling.': [2075, 2986, 4187], 'Results': [2076], 'bone': [2084, 2098, 2156, 2231, 2318, 2341], 'metastases': [2085, 2157, 2232], 'To': [2086, 2839, 2987, 3064, 3168, 3318, 3362, 3626], 'define': [2087], 'benign': [2092, 2122, 2575, 2624, 2712], 'cancerous': [2094], 'specimens': [2096, 2120], 'metastases,': [2099], 'assessed': [2101, 2437], '(TMA)': [2109], 'immunohistochemical': [2110], '(IHC)': [2111], 'staining': [2112, 2189, 2192, 2269, 2332, 2397, 3988, 4019, 4047], 'panel': [2115, 2570, 3443], '280': [2117], 'human': [2118, 4228], 'representing': [2121, 2184, 3447], 'prostatic': [2123, 2626], 'hyperplasia': [2124], '(BPH,': [2125], 'n': [2126], '=': [2127, 2133, 2140, 2146, 2159, 2227, 2234, 2347, 2350, 2796, 3787, 3791, 3795, 3815, 4023], '12),': [2128], 'untreated': [2129, 2302], 'hormone': [2130, 2136, 2303, 2306], 'naive': [2131], '(n': [2132, 2139, 2145, 2158, 3814], '114),': [2134], 'neo-adjuvant': [2135, 2305], '(NHT)-treated': [2138], '87),': [2141], 'NHT-': [2142, 2309, 2337], 'docetaxel-treated': [2144, 2311], '53)': [2147], 'radical': [2148, 2312], 'prostatectomy': [2149, 2313], 'specimens,': [2151, 2315], '30)': [2160], 'collected': [2161], 'immediately': [2162], 'after': [2163, 3811], 'death': [2164], 'Washington': [2168], 'Rapid': [2169], 'Autopsy': [2170], 'program': [2171], '(Rocchi': [2172], '2005).': [2175], 'Specimens': [2176], 'were': [2177, 2393, 2436, 2521, 2594, 2907, 2943, 3074, 3234, 3292, 3329, 3874, 3932, 4029], 'graded': [2178], '0–3,': [2181], 'intensity': [2182, 2327], 'scale': [2183], 'range': [2186, 2494, 4064], 'no': [2188], 'high': [2191, 2462, 2813, 3197, 3230, 3394, 3516], 'visual': [2194], 'scoring': [2195], 'automated': [2197], 'quantitative': [2198], 'image': [2199], 'analysis.': [2200], 'shown': [2202, 2443, 3226, 3425], 'Fig': [2204, 2236, 2276, 2619, 2633, 2722, 2766, 2799, 3062, 3131, 3151, 3166, 3228, 3418, 3474, 3503, 3524, 3656, 3716], '1A': [2205], 'B,': [2207], 'increased': [2208, 2739, 3237, 3265], 'heavily': [2219], 'treated': [2220, 2418, 3000, 3075, 3637, 3751, 3836, 3875, 3977], 'NHT': [2222], 'docetaxel': [2224], '(DTXL)': [2225], '(*P': [2226], '0.02),': [2228], '(**P': [2233], '0.0075;': [2235], '1B).': [2237], 'We': [2238, 2635, 2680, 2801, 3017, 4233], 'validated': [2239], 'specificity': [2241], '(N20)': [2244, 2331], 'antibodies': [2245, 2875, 2879, 3935], 'detect': [2247], 'DU145': [2250, 2519, 2609, 3163, 3327, 3355, 3635, 3673, 3749, 3834, 3862, 3905, 3930, 3975, 4014, 4150, 4217], 'transfected': [2252, 3907], 'scramble': [2254, 3753], '(siScr)': [2255, 3678, 3754, 3868], 'siRNA': [2258, 3639], '(siSEMA3C-1)': [2259], 'using': [2260, 2356, 2506, 2856, 3214, 3777, 3804, 3849, 3889, 3920, 4032], 'confocal': [2261], 'immunofluorescent': [2262], 'microscopy.': [2263], 'siSEMA3C': [2265], 'reduced': [2267, 3510], 'compared': [2270, 2621, 2698, 2788, 2908, 2925, 3675, 3711], 'siScr': [2272, 3713, 4214], 'control': [2273, 3714, 3775, 3880, 3901, 3929], '(Appendix': [2275, 2632, 2721, 2765, 2798, 2954, 3061, 3150, 3165, 3417, 3473, 3502, 3523, 3715], 'S1A).': [2277], 'Figure': [2278, 2556, 3738, 4094], '1.': [2279], 'correlates': [2283], 'activates': [2288, 2513, 2829, 3068], 'MET,': [2291, 3465, 4180], 'SRC': [2293, 3193], 'Representative': [2297, 4001], 'immunostaining': [2299], 'BPH,': [2301, 2334], 'naïve,': [2304], '(NHT)-treated,': [2308], 'metastasis': [2320], 'specimen.': [2321], 'Scale': [2322, 4039], 'bar:': [2323], '100': [2324], 'μm.': [2325, 4042], 'IHC': [2326], 'scores': [2328], 'untreated,': [2335], 'NHT-treated,': [2336], 'docetaxel-treated,': [2339], 'metastasis.': [2342], 'Mean': [2343, 3783, 4060], '±': [2344, 3784], 'SEM;': [2345, 3785], '*P': [2346, 3786, 3790], '0.02,': [2348], '**P': [2349, 4022], '0.0075.': [2351], 'Statistical': [2352, 2502, 3800, 3845, 3885, 3916], 'analysis': [2353, 2503, 3801, 3846, 3886, 3917], 'performed': [2355, 2505, 2851, 3631, 3803, 3848, 3888, 3919], 'unpaired': [2358, 2508], 'two-tailed': [2359, 2509], "Student's": [2360, 2510], 't-test.': [2361, 2511], 'Immunoblot': [2362], 'analyses': [2363], 'conditioned': [2368, 2597, 3004], 'media': [2369, 2598], 'produced': [2370], 'dependent': [2373], '(LNCaP),': [2374], '(C4-2,': [2376], '22Rv1),': [2377], '(MR49F),': [2379], 'receptor-negative': [2382, 2587], '(DU145)': [2383], 'seeded': [2386], 'at': [2387, 2528, 2658, 3139], 'equivalent': [2388], 'density.': [2390], 'Whole-cell': [2391], 'lysates': [2392, 3931], 'immunoblotted': [2394], 'Ponceau': [2396], 'control.': [2399, 2446, 4232], 'representative': [2403, 4074], 'experiments.': [2407], 'Activation': [2408, 2535], 'HER2/ErbB2,': [2411, 3708, 3940], 'downstream': [2413, 3098, 3190, 4185], 'varying': [2420, 3332], 'concentrations': [2421, 3078, 3333], 'SEMA3C:Fc': [2423, 3335, 3490, 4239], '(0–2': [2424, 3086], 'μM)': [2425, 3087], '10': [2427, 2533, 3089, 4041], 'min.': [2428, 2534], 'Levels': [2429], 'indicated': [2431, 2452, 2530], 'phosphoproteins': [2432, 2941], 'total': [2434], 'immunoblot': [2439, 3944], 'analyses.': [2440], 'Vinculin': [2441], 'loading': [2445], 'Boxplots': [2447], 'RPPA': [2449], 'measurements': [2450, 3256], 'phosphoprotein': [2453, 2488, 3258], '498': [2456], 'patient': [2457, 3261], 'samples': [2459, 3202, 3263, 3280], 'expressing': [2460, 3264], 'versus': [2463, 3199, 3274, 4012], 'low': [2465, 2709, 3142, 3200], 'mRNA': [2466, 2781, 3232, 3267], 'TCGA': [2469, 3282], 'adenocarcinoma': [2471, 3211, 3284], 'provisional': [2472, 3285], 'set.': [2474, 3287], 'Boxes': [2475], 'span': [2476], 'interquartile': [2478], 'range.': [2479], 'Horizontal': [2480, 4056], 'line': [2481], 'within': [2482], 'box': [2484, 4063], 'median': [2487], 'levels.': [2489], 'Error': [2490], 'bars': [2491], 'represent': [2492, 2821, 3985, 4058], 'highest': [2497], 'lowest': [2500], 'observations.': [2501], 'dose-dependent': [2517, 3112, 3156, 3358, 3500], 'serum-starved': [2522], 'then': [2524], 'stimulated': [2525, 3134, 3330, 4219], 'doses': [2531], 'determined': [2539, 3250], 'immunoblotting': [2541, 3344], 'phospho-MET': [2543], 'Abs.': [2544], 'available': [2548, 4086], 'online': [2549, 4087], 'figure.': [2552, 4090], 'Data': [2554, 4028, 4037, 4072, 4092], '1': [2557], '[emmm201707689-sup-0002-SDataFig1.pdf]': [2558], 'Download': [2559, 2561, 4097, 4099], 'figure': [2560, 4098], 'PowerPoint': [2562, 4100], 'Next,': [2563], 'examined': [2565, 3342], 'lines': [2573, 3446, 3522, 4057], 'epithelial': [2577, 2714], 'androgen-sensitive,': [2582], 'castrate-resistant,': [2583], 'enzalutamide-resistant,': [2584], 'lines.': [2589, 2650], 'Elevated': [2590], 'castrate-resistant': [2600], 'C4-2': [2601], '22Rv1,': [2603], 'MR49F': [2605], 'cells,': [2606, 2627, 2849, 2917], 'androgen-independent': [2608], 'androgen-sensitive': [2612], '(Fig': [2615, 3127, 3360, 3652, 3688, 4243, 4252], '1C': [2616], 'Appendix': [2618, 3130, 3655, 4118], 'S1B)': [2620], 'immortalized': [2625, 2711], 'RWPE-1': [2628, 2717], 'BPH-1': [2630], 'S1B).': [2634, 2723], 'observed': [2637, 3018, 3989], 'all': [2638, 2644], 'forms': [2639], 'There': [2651], 'typically': [2653, 2682], 'doublet': [2655], 'runs': [2657, 2687], 'about': [2659], '83': [2660], 'kDa': [2661, 2690], 'likely': [2663], 'full-length': [2666, 3014, 3080, 4223], 'C-terminal': [2670], 'cleavage': [2671, 2695], 'product': [2672], 'often': [2673], 'referred': [2674], '∆13,': [2678], 'respectively.': [2679], 'see': [2683], 'band': [2685], 'below': [2688], '70': [2689], 'p65': [2694], 'product.': [2696], 'lines,': [2703, 2716], 'very': [2708], 'BPH-1,': [2719], 'respectively': [2720], 'Mining': [2724], 'Chen': [2731], 'al': [2733], '(2004)': [2734], 'revealed': [2735, 2936], 'anti-androgen': [2745], 'six': [2748], 'seven': [2751], 'isogenic': [2752], 'hormone-sensitive': [2753], 'xenograft': [2756, 2785], 'pairs': [2757], '[NCBI': [2758], 'GEO': [2759], 'GDS535': [2760], '(Barrett': [2761], '2007)]': [2764], 'S1C).': [2767], 'Consistent': [2768], 'findings,': [2771], 'trend': [2775], 'higher': [2777], 'tumors': [2786, 2790, 2811], 'non-castrate': [2792], 'male': [2793], 'mice': [2794], '(P': [2795], '0.075)': [2797], 'S1D).': [2800], 'noted': [2802], 'subgroup': [2805], '(approx.': [2806], '50%)': [2807], 'had': [2812], 'which': [2815, 3483], 'suggests': [2816], 'overexpression': [2819, 2947], 'one': [2822], 'achieve': [2825], 'castration': [2826], 'through': [2831, 3308, 3742], 'HER2,': [2833, 4178], 'identify': [2840], 'potential': [2841], 'regulated': [2844], 'unbiased': [2853], 'proteomic': [2854], 'screen': [2855, 2935], 'Kinex': [2858, 2934], 'KAM-1.1': [2859], 'antibody': [2860, 3995], 'chip': [2862], 'Kinexus': [2864], 'Biosciences': [2865], 'Corp.,': [2866], 'containing': [2867, 3033], 'over': [2868], '650': [2869], 'antibodies,': [2870], '>': [2872, 2883], '270': [2873], 'phospho-site-specific': [2874], 'detection': [2881], '240': [2884], 'kinases,': [2886], '28': [2887], 'phosphatases,': [2888], '90': [2890], 'other': [2891, 3375], 'regulate': [2896], 'proliferation,': [2898], 'stress,': [2899], 'apoptosis.': [2901], 'SEMA3C-overexpressing': [2910], 'empty': [2914], 'vector-transduced': [2915], 'parallel': [2920], 'antisense': [2923], 'knockdown': [2924, 3691], 'scrambled': [2927], 'oligonucleotide': [2928], 'control-treated': [2929], 'cells.': [2931, 3625, 3737], 'Intriguingly,': [2932], 'upregulated': [2944], 'correspondingly,': [2949], 'downregulated': [2950], 'silencing': [2953, 3507, 3682], 'Table': [2955], 'S1),': [2956], 'Erb': [2958], '(ErbB2': [2961], 'EGFR),': [2963], 'PI3K/PTEN': [2964], '(Akt1': [2969], '4EBP1),': [2971], 'cycle': [2974], 'regulatory': [2975], '(Rb': [2977], 'CDK1/2),': [2979], 'implicating': [2980], 'EGFR/ErbB2': [2982, 2996, 3070, 3176], 'investigate': [2988, 3169], 'naturally': [2990], 'activate': [2994], 'pathway,': [2998, 3071], 'medium': [3005], '(CM)': [3006], 'harvested': [3007], 'HEK': [3009], '293T': [3010], 'overexpress': [3013], 'wild-type': [3015], 'dosage-dependent': [3020], 'SHC,': [3024, 3041, 3102, 3120], 'MAPK': [3026, 3043, 3123, 3137], 'phosphorylation': [3027, 3044, 3092, 3115, 3138, 3184, 3348, 3705], 'increasing': [3029, 3077], 'concentration': [3030], 'CM': [3034], 'corresponding': [3037, 3956, 4002, 4051], 'decrease': [3038], 'immuno-depleted': [3047], 'CM,': [3048], 'EGFR': [3059, 3135, 3159, 3370, 3496, 3538, 3969], 'S1E).': [3063], 'validate': [3065], 'SEMA3C-Fc': [3082, 4224], '(SEMA3C:Fc)': [3085, 4226], 'min': [3090], '(HER2),': [3096], '(SRC,': [3101], 'MAPK)': [3104], 'analyzed': [3106, 3183], 'immunoblotting.': [3108], 'triggered': [3111], 'SRC,': [3119], 'p44/42': [3122], '1D': [3128], 'S2A).': [3132], '1.6': [3144], 'nM': [3145], 'S2B).': [3152], 'Similarly,': [3153], 'S2C).': [3167], 'relationship': [3171], 'clinical': [3179], 'samples,': [3181], 'status': [3185], 'SHC': [3195, 3710], 'SEMA3C-expressing': [3201, 3517], 'Cancer': [3205, 3383], 'Genome': [3206], 'Atlas': [3207], '(TCGA,': [3208], 'http://cancergenome.nih.gov/)': [3209], 'cBioPortal': [3215, 3381], 'tools': [3216], '(Cerami': [3217], 'Gao': [3221], '1E,': [3229], 'phospho-EGFR': [3240, 3513], '(Y1068),': [3241], 'phospho-ErbB2': [3242], '(Y1248),': [3243], 'phospho-SRC': [3244], '(Y416),': [3245], 'phospho-SHC': [3247], '(Y317)': [3248], 'reverse-phase': [3252], 'array': [3254], '(RPPA)': [3255], 'z-score': [3269], 'threshold': [3270], '>1.0': [3271], 'high)': [3273], 'unaltered': [3275], 'low)': [3278], 'Plot': [3288], 'P': [3290], 'value': [3291], 'generated': [3293], 'cBioPortal.': [3295], 'Semaphorin': [3296], 'receptors': [3297, 3564, 3620], 'such': [3298, 3588], 'known': [3304, 3583], 'mediate': [3306, 3585, 3731], '(Giordano': [3314, 3602], '2002).': [3317, 4139], 'examine': [3319, 3610], 'can': [3322, 3366], 'trigger': [3323], 'signaling,': [3325], 'MET-expressing': [3326], 'phospho-MET.': [3346], '1F).': [3361], 'determine': [3363, 4145], 'types,': [3377], 'first': [3379, 3630, 4190], 'screened': [3380, 3441], 'Genomics': [3384], 'showed': [3390, 3491], 'prognosis.': [3399], 'High': [3400], 'overall': [3407], 'renal': [3410, 3448], 'clear': [3411], 'carcinoma': [3413, 3416], 'bladder': [3415, 3453], 'S2D).': [3419], 'Furthermore,': [3420, 4254], 'recently': [3423], 'tumorigenicity': [3428], 'glioma': [3432], 'stem': [3433], '(Man': [3435], 'Hence,': [3439], '(CAKI-1,': [3450], 'CAKI-2,': [3451, 3478], 'ACHN),': [3452], '(UC13,': [3455], 'T24),': [3456], '(U87MG),': [3459], 'B1,': [3467, 3615, 3661, 3939], 'D1,': [3469], 'NRP1,': [3470, 3612, 3662, 3761], 'NRP2': [3472, 3650, 3668, 3699, 3766], 'S2E).': [3475], 'Treatment': [3476], 'T24,': [3479], 'U87MG': [3481], 'express': [3484], 'lower': [3485], 'S2F).': [3504], 'Conversely,': [3505], 'siRNA-mediated': [3506, 3681], 'CAKI-1': [3518], 'ACHN': [3520], 'S2G).': [3525], 'These': [3526], 'collectively': [3528], 'suggest': [3529, 3722], 'broad': [3544], 'spectrum': [3545], 'cancers.': [3547], 'NRP1/2': [3557], 'Plexins': [3558], 'neuropilins': [3560], 'responsible': [3565], 'semaphorin': [3570], 'signal': [3571], 'transduction': [3572, 4183], 'Since': [3577], 'D1': [3581, 3618, 3642, 3685], 'HER2/ErbB2': [3590], '(Swiercz': [3591], '2004,': [3594], '2008;': [3595], 'Casazza': [3596], '2010)': [3599], '2002),': [3605], 'therefore': [3607], 'sought': [3608, 4143], 'NRP2,': [3613, 3663, 3730, 3762], 'end,': [3628], 'proliferation': [3632, 3781], 'assays': [3633], 'targeting': [3640], '(siPLXND1),': [3643], '(siPLXNB1),': [3646], 'NRP1': [3647, 3666, 3697, 3728, 3764, 3899, 4163, 4212, 4262], '(siNRP1),': [3648], '(siNRP2)': [3651], '2A': [3653], 'S2H).': [3657], 'Knockdown': [3658], 'both': [3665], 'inhibited': [3669, 3703, 4248], 'SEMA3C-induced': [3670, 3768], 'siScramble': [3677], 'controls,': [3679], 'whereas': [3680], 'did': [3686], 'not': [3687], '2A).': [3689], 'Moreover,': [3690], 'individually': [3700], 'combined': [3702], 'SEMA3C-activated': [3704], 'S2I–K).': [3717], 'Taken': [3718], 'together,': [3719], 'coreceptors,': [3727], '2.': [3739], 'acts': [3741], 'A.': [3745], 'Proliferation': [3746], 'assay': [3747, 3831, 4104, 4123], 'siRNAs': [3756], 'specific': [3757, 4050], 'PLXND1,': [3759], 'PLXNB1,': [3760], 'together.': [3767], 'percent': [3773], '(siScramble)': [3776], 'crystal': [3779], 'violet': [3780], 'assay.': [3782], '0.025': [3788], '(NRP1),': [3789], '0.031': [3792], '(NRP2),': [3793], '***P': [3794], '0.0005,': [3796], '****P': [3797, 3842, 3882, 3913, 4025], '<': [3798, 3843, 3883, 3914, 4026], '0.0001.': [3799, 3844, 3884, 3915, 4027], 'Holm–Sidak': [3806], 'post': [3807], 'hoc': [3808], 'comparison': [3809], 'test': [3810], 'one-way': [3812], 'ANOVA': [3813], '6).': [3816], 'B.': [3817], 'Association': [3818], '(Interactions/cell)': [3824], 'detected': [3826], 'proximity': [3829, 4102], 'ligation': [3830, 4103], '(PLA)': [3832, 4105], 'rhIgG1Fc': [3839, 3927, 3980], 'SEMA3C:Fc,': [3841], 'Mann–Whitney': [3851, 3891, 3922, 4035], 'test.': [3852, 3892, 3923, 4036], 'C.': [3853], 'PLA': [3854, 3894, 3961, 3999, 4008, 4052, 4076, 4194], 'KD': [3863], 'siScrambled': [3867], 'si-Plexin': [3870], 'siRNAs.': [3872], 'Cells': [3873], '(rhIgG1Fc),': [3881], 'D.': [3893], 'interactions': [3895, 4009, 4053, 4070, 4077, 4116], '(rhIgG1Fc)': [3902], 'SEMA3C:Fc-treated': [3904, 4013], 'siPLXNB1': [3910, 4250], 'siScr,': [3912], 'E.': [3924], 'immunoprecipitated': [3933], 'against': [3936], 'NRP-1,': [3937], 'MET.': [3942], 'probed': [3946], 'C-terminal-specific': [3948], 'antibodies.': [3951], 'Input': [3952], 'shown.': [3959, 4017], 'F–H.': [3960], '(F),': [3968], '(G),': [3970], 'HER2': [3972], '(H)': [3973], 'SEMA3C:Fc.': [3982], 'Negative': [3983], 'controls': [3984], 'background': [3987], 'absence': [3992], 'primary': [3994], 'added': [3996], 'reaction.': [4000], 'fluorescence': [4003, 4046], 'micrographic': [4004], 'images': [4005], 'rIgG1Fc': [4011], 'DAPI': [4018], 'blue.': [4021], '0.005,': [4024], 'statistically': [4030], 'tested': [4031], 'Kruskal–Wallis': [4033], 'information:': [4038], 'bars:': [4040], 'punctate': [4044], 'red': [4045], '(B–D,': [4054], 'F–H).': [4055], 'minimum': [4067], 'maximum': [4069], '/cell.': [4071], '5': [4079], 'fields': [4080], 'view.': [4082], '2': [4095], '[emmm201707689-sup-0003-SDataFig2.pdf]': [4096], 'powerful': [4108], 'technique': [4109], 'used': [4110, 4193], 'visualize': [4112], 'quantitate': [4114], 'protein–protein': [4115], '(see': [4117], 'Materials': [4119], 'Methods).': [4121], 'reports': [4124], 'proximal': [4125], 'target': [4129], 'less': [4131], 'than': [4132], '40': [4133], 'nm': [4134], 'apart': [4135], '(Fredriksson': [4136], 'Using': [4140], 'PLA,': [4141], 'induce': [4153], 'formation': [4154, 4198], 'ligand–receptor': [4157, 4200], 'comprised': [4159], 'associates': [4175], 'thereby': [4181], 'step,': [4191], 'characterize': [4196], 'complexes': [4201], 'candidate': [4207], 'receptors,': [4208], 'siPLXNB1-treated': [4216], 'IgGFc': [4229], '(rhIgGFc)': [4230], 'significant': [4235, 4257], 'direct': [4236], 'binding': [4237, 4258], '2B)': [4244], 'significantly': [4247], '2C).': [4253], '(F': [4263]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2782790872', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 5}], 'updated_date': '2024-12-14T20:50:30.467351', 'created_date': '2018-01-26'}