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[19, 79, 101, 124, 179, 830, 1121, 1481, 1611, 1658, 1672, 1704, 1745, 1868, 1925, 2022, 2040, 2061, 2110], 'Treated': [20, 1440], 'Radical': [22, 1437], 'Cystectomy': [23, 1438], 'Homayoun': [24, 48, 1995], 'Zargar,': [25], 'Jay': [26, 68, 2013], 'B.': [27, 69, 71, 2014], 'Shah,': [28], 'Bas': [29, 89, 2031], 'W.': [30, 90, 93, 2032], 'van': [31, 91, 94, 103, 1327, 1600, 1613, 2033, 2042], 'Rhijn,': [32], 'Siamak': [33, 115, 2053], 'Daneshmand,': [34], 'Trinity': [35, 139, 2075], 'J.': [36, 140, 142, 1731, 1819, 2076], 'Bivalacqua,': [37], 'Philippe': [38, 167, 2100], 'E.': [39, 168, 170, 1598, 1727, 2101], 'Spiess,': [40], 'Peter': [41, 192, 2122], 'C.': [42, 193, 195, 1807, 2123], 'Black,': [43], 'Wassim': [44, 214, 2141], 'Kassouf,': [45], 'Collaborators': [47, 237, 2161], 'ZargarHomayoun': [49], 'Zargar': [50, 1286, 1996], 'Vancouver': [51, 197, 1997, 2125], 'Prostate': [52, 198, 1998, 2126], 'Centre,': [53, 199, 1632, 1999, 2127], 'University': [54, 126, 200, 224, 956, 1651, 1688, 1716, 1757, 1795, 1859, 1894, 1912, 1927, 1933, 1957, 2000, 2063, 2128, 2150], 'British': [56, 59, 202, 205, 2002, 2005, 2130, 2133], 'Columbia,': [57, 60, 203, 206, 2003, 2006, 2131, 2134], 'Vancouver,': [58, 204, 2004, 2132], 'Canada': [61, 207, 229, 2007, 2135, 2155], 'More': [62, 83, 109, 133, 161, 186, 208, 230, 238, 2008, 2026, 2048, 2070, 2095, 2117, 2136, 2156, 2162], 'articles': [63, 84, 110, 134, 162, 187, 209, 231, 239, 2009, 2027, 2049, 2071, 2096, 2118, 2137, 2157, 2163], 'by': [64, 85, 111, 135, 163, 188, 210, 232, 240, 1274, 1585, 2010, 2028, 2050, 2072, 2097, 2119, 2138, 2158, 2164], 'this': [65, 86, 112, 136, 164, 189, 211, 233, 241, 351, 2011, 2029, 2051, 2073, 2098, 2120, 2139, 2159, 2165], 'author': [66, 87, 113, 137, 165, 190, 212, 234, 242, 2012, 2030, 2052, 2074, 2099, 2121, 2140, 2160, 2166], ',': [67, 88, 114, 138, 166, 191, 213, 235], 'ShahJay': [70], 'Shah': [72, 2015], 'Department': [73, 96, 144, 172, 220, 1606, 1665, 1685, 1698, 1713, 1741, 1754, 1768, 1792, 1809, 1825, 1849, 1856, 1875, 1891, 1907, 2016, 2035, 2078, 2103, 2146], 'Urology,': [75, 98, 120, 146, 219, 1354, 1413, 1445, 1467, 1495, 1546, 1564, 1608, 1687, 1700, 1715, 1756, 1770, 1794, 1811, 1827, 1858, 1877, 1893, 1922, 1944, 1970, 2018, 2037, 2057, 2080, 2145], 'M.': [76, 1680, 1701, 1790, 2019], 'D.': [77, 1702, 2020], 'Anderson': [78, 1521, 1703, 2021], 'Center,': [80, 125, 226, 1692, 1705, 1721, 1870, 1901, 1914, 1926, 2023, 2062, 2152], 'Houston,': [81, 2024], 'Texas': [82, 1718, 2025], 'RhijnBas': [92], 'Rhijn': [95, 1328, 2034], 'The': [99, 107, 147, 153, 353, 437, 459, 1609, 1617, 1771, 1777, 2038, 2046, 2081, 2087], 'Netherlands': [100, 108, 1610, 2039, 2047], 'Institute-Antoni': [102, 1612, 2041], 'Leeuwenhoek': [104, 1614, 2043], 'Hospital,': [105, 1615, 1645, 1813, 1883, 1950, 1962, 1972, 2044], 'Amsterdam,': [106, 1616, 2045], 'DaneshmandSiamak': [116], 'Daneshmand': [117, 1330, 2054], 'Institute': [118, 1737, 1920, 2055], 'USC': [121, 2058], 'Norris': [122, 2059], 'Comprehensive': [123, 1924, 2060], 'Southern': [128, 958, 1929, 2065], 'California,': [129, 1930, 1931, 2066], 'Los': [130, 2067], 'Angeles,': [131, 2068], 'California': [132, 1896, 2069], 'BivalacquaTrinity': [141], 'Bivalacqua': [143, 1315, 1387, 2077], 'James': [148, 1772, 2082], 'Buchanan': [149, 1773, 2083], 'Brady': [150, 1774, 2084], 'Urological': [151, 1276, 1587, 1734, 1775, 2085], 'Institute,': [152, 183, 1659, 1676, 1746, 1776, 2086, 2114], 'Johns': [154, 1778, 2088], 'Hopkins': [155, 1779, 2089], 'School': [156, 1780, 1862, 2090], 'Medicine,': [158, 1762, 1782, 2092], 'Baltimore,': [159, 1783, 2093], 'Maryland': [160, 2094], 'SpiessPhilippe': [169], 'Spiess': [171, 1332, 2102], 'Genitourinary': [174, 1667, 2105], 'Oncology,': [175, 1628, 1668, 1848, 2106], 'H.': [176, 1669, 2107], 'Lee': [177, 1670, 2108], 'Moffitt': [178, 1671, 2109], 'Center': [180, 1673, 2111], 'Research': [182, 826, 1675, 1832, 1869, 1981, 2113], 'Tampa,': [184, 1677, 2115], 'Florida': [185, 2116], 'BlackPeter': [194], 'Black': [196, 1284, 2124], 'KassoufWassim': [215], 'Kassouf': [216, 1296, 2142], 'Division': [217, 1625, 1846, 2143], 'Surgery,': [222, 1910, 2148], 'McGill': [223, 2149], 'Health': [225, 1630, 1798, 1830, 1979, 1988, 2151], 'Montreal,': [227, 2153], 'Quebec,': [228, 2154], 'View': [243], 'All': [244, 2168], 'Author': [245], 'Informationhttps://doi.org/10.1016/j.juro.2017.12.062AboutFull': [246], 'TextPDF': [247], 'ToolsAdd': [248], 'to': [249, 342, 450, 576, 585, 591, 1178, 1530], 'favoritesDownload': [250], 'CitationsTrack': [251], 'CitationsPermissionsReprints': [252], 'ShareFacebookLinked': [253], 'InTwitterEmail': [254], 'Abstract': [255], 'Purpose:': [256], 'Level': [257], 'I': [258], 'evidence': [259], 'supports': [260], 'the': [261, 319, 364, 392, 402, 419, 426, 467, 593, 619, 714, 861, 949, 955, 980, 1028, 1036, 1339], 'usefulness': [262], 'neoadjuvant': [264, 303, 328, 396, 596, 701, 782, 851, 881, 971, 998, 1058, 1148, 1241], 'cisplatin': [265, 422, 448, 499, 743, 806, 848, 875, 916, 974, 1020, 1026, 1050, 1056, 1162], 'based': [266, 490], 'chemotherapy': [267, 304, 329, 397, 631, 654, 672, 706, 763, 783, 808, 852, 939, 1180, 1242, 1256], 'for': [268, 350, 445, 452, 504, 638, 707, 764, 784, 825, 853, 883, 944, 970, 1001, 1060, 1075, 1163, 1204, 1240, 1257, 1402, 1407, 1430, 1489], 'muscle': [269, 1076], 'invasive': [270, 656, 674, 1077], 'bladder': [271, 299, 559, 605, 615, 641, 657, 675, 709, 747, 769, 786, 885, 1003, 1062, 1078, 1165, 1186, 1207, 1259, 1594], 'cancer.': [272, 606, 642, 748, 770, 787, 1004, 1063, 1166], 'Since': [273], 'dose': [274, 306, 369, 427, 453, 472, 510, 561, 597], 'dense': [275, 307, 370, 428, 454, 473, 511, 562, 598], '(methotrexate,': [277], 'vinblastine,': [278, 740, 803, 845, 872, 913, 1023, 1053], 'doxorubicin': [279], 'cisplatin)': [281], 'has': [282], 'mostly': [283], 'replaced': [284], 'traditional': [285], 'MVAC,': [286], 'we': [287], 'compared': [288, 362, 449, 575, 634, 1083], 'pathological': [289, 569], 'response': [290, 570, 898], 'survival': [292, 465, 573, 728], 'rates': [293, 354, 574], 'patients': [295, 322, 393, 494, 507, 555, 601, 745, 854, 1125], 'locally': [297, 557, 603, 639, 1031, 1205], 'advanced': [298, 558, 604, 640, 819, 1032, 1206], 'cancer': [300, 325, 560], 'who': [301, 326, 394, 495, 508], 'received': [302, 327, 496, 509], 'vs': [309, 432, 1428], 'gemcitabine': [310, 365, 420, 446, 468, 497, 577, 735, 972, 1018, 1048, 1160], 'cisplatin.': [312, 579], 'Materials': [313, 1579], 'Methods:': [315], 'We': [316], 'retrospectively': [317], 'reviewed': [318], 'records': [320], 'urothelial': [324, 768, 820, 922, 946, 977, 1033], 'underwent': [331, 395], 'cystectomy': [332, 400, 633, 636, 1102, 1145, 1216, 1221], 'at': [333, 501, 1100, 1436, 1897], 'a': [334, 659, 679, 731, 889, 951, 982, 1143, 1188, 1212, 1261, 1541], 'total': [335], '20': [337, 1119], 'contributing': [338], 'institutions': [339], 'from': [340, 954], '2000': [341], '2015.': [343], 'disease': [347, 1128], 'were': [348, 361, 383, 476, 500, 541], 'selected': [349], 'analysis.': [352], 'ypT0N0': [356, 415], 'ypT1N0': [358, 440], 'or': [359, 441], 'less': [360, 442], 'between': [363], 'cisplatin,': [367, 470, 702, 737], 'regimens.': [372], 'Two': [373], 'multivariable': [374, 486], 'Cox': [375], 'proportional': [376], 'hazards': [377], 'regression': [378, 488], 'models': [379], 'overall': [381, 464], 'mortality': [382], 'generated': [384], 'using': [385], 'preoperative': [386, 492, 1224], 'postoperative': [388, 1226], 'data.': [389, 687], 'Results:': [390], 'Of': [391], 'radical': [399, 1101, 1130, 1244], 'during': [401], 'study': [403, 893, 1108], 'period': [404], '319': [405], 'met': [406], 'our': [407, 551], 'inclusion': [408], 'criteria.': [409], 'A': [410, 580, 968], 'significantly': [411], 'lower': [412], 'rate': [413, 438], 'was': [416, 443, 564], 'observed': [417], 'arm': [423, 430], 'than': [424, 506], '(14.6%': [431], '28.0%,': [433], 'p': [434, 518, 529, 539], '=': [435, 457, 483, 519, 530], '0.005).': [436], '30.1%': [444], '41.0%': [451], '(p': [456, 482], '0.07).': [458], 'mean': [460], 'Kaplan-Meier': [461], 'estimates': [462], 'groups': [475], '4.2': [477], '7.0': [479], 'years,': [480], 'respectively': [481], '0.001).': [484], 'On': [485], 'cox': [487], 'analysis': [489, 953, 993], 'on': [491, 1150], 'data': [493], 'higher': [502, 545, 567], 'risk': [503, 546], 'death': [505], '(HR': [513, 524, 534], '2.07,': [514], '95%': [515, 526, 536], 'CI': [516, 527, 537], '1.25–3.42,': [517], '0.003).': [520], 'Lymph': [521], 'node': [522], 'invasion': [523], '1.97,': [525], '1.15–3.36,': [528], '0.01)': [531], 'hydronephrosis': [533], '2.18,': [535], '1.43–3.30,': [538], '<0.001)': [540], 'also': [542], 'associated': [543, 565], 'death.': [548], 'Conclusions:': [549], 'In': [550], 'retrospective': [552, 952, 983], 'cohort': [553], 'complete': [568], 'improved': [572, 1104], 'clinical': [581, 995], 'trial': [582, 699, 733, 799, 1214], 'is': [583, 876], 'warranted': [584], 'validate': [586], 'these': [587], 'hypothesis': [588], 'generating': [589], 'results': [590, 712, 729, 887], 'test': [592], 'superiority': [594], 'References': [607], '1': [608], ':': [609, 629, 652, 670, 695, 726, 757, 778, 795, 842, 869, 909, 937, 967, 991, 1013, 1044, 1070, 1097, 1120, 1140, 1158, 1176, 1201, 1236, 1254], 'Treatment': [610, 828], 'muscle-invasive': [612, 708, 785, 856, 884, 921, 945, 976, 1002, 1061, 1164, 1258], 'metastatic': [614], 'cancer:': [616, 658, 676, 710, 886, 923, 1079, 1187, 1208, 1260], 'update': [617, 677], 'EAU': [620], 'guidelines.': [621], 'Eur': [622, 688, 788, 1192], 'Urol2011;': [623], '59:': [624], '1009.': [625], 'Google': [626, 649, 667, 692, 723, 754, 775, 792, 839, 866, 906, 934, 964, 988, 1010, 1041, 1067, 1094, 1117, 1137, 1155, 1173, 1198, 1233, 1251, 1270], 'Scholar': [627, 650, 668, 693, 724, 755, 776, 793, 840, 867, 907, 935, 965, 989, 1011, 1042, 1068, 1095, 1118, 1138, 1156, 1174, 1199, 1234, 1252, 1271], '2': [628], 'Neoadjuvant': [630, 653, 671, 910, 938, 1071, 1159, 1255, 1343, 1400, 1442, 1487, 1531], 'plus': [632, 736, 742, 973, 1049, 1055, 1161, 1217], 'alone': [637], 'N': [643], 'Engl': [644], 'J': [645, 718, 749, 834, 901, 929, 1090, 1112, 1132, 1168, 1193, 1228, 1246, 1519, 1556], 'Med2003;': [646], '349:': [647], '859.': [648], '3': [651, 1397], 'systematic': [660, 680, 1262], 'review': [661, 681, 1263], 'meta-analysis.': [663, 1266], 'Lancet2003;': [664], '361:': [665], '1927.': [666], '4': [669], 'meta-analysis': [683], 'individual': [685], 'patient': [686, 1238], 'Urol2005;': [689], '48:': [690], '202.': [691], '5': [694], 'International': [696], 'phase': [697, 797, 891], 'III': [698, 798], 'assessing': [700], 'methotrexate,': [703, 739, 802, 844, 871, 912, 1022, 1052], 'vinblastine': [705], 'long-term': [711], 'BA06': [715], '30894': [716], 'trial.': [717], 'Clin': [719, 750, 835, 902, 930, 1005, 1169, 1229], 'Oncol2011;': [720, 772, 1170], '29:': [721, 773], '2171.': [722], '6': [725], 'Long-term': [727], 'randomized': [732, 1213], 'comparing': [734], 'doxorubicin,': [741, 804, 846, 873, 914, 1054], 'Oncol2005;': [751], '23:': [752], '4602.': [753], '7': [756], 'Patterns': [758, 1459], 'use': [760], 'systemic': [762], 'Medicare': [765], 'beneficiaries': [766], 'Urol': [771, 960], '252.': [774], '8': [777], 'Multicenter': [779], 'assessment': [780], 'Urol2015;': [789], '67:': [790], '241.': [791], '9': [794], 'Randomized': [796], 'high-dose-intensity': [801], '(MVAC)': [807], 'recombinant': [810], 'human': [811], 'granulocyte': [812], 'colony-stimulating': [813], 'factor': [814], 'classic': [816, 1085], 'tract': [821], 'tumors:': [822], 'European': [823], 'Organization': [824], 'Protocol': [831], 'no.': [832], '30924.': [833], 'Oncol2001;': [836, 1230], '19:': [837, 1231], '2638.': [838], '10': [841], 'Accelerated': [843, 870], '(AMVAC)': [849], 'as': [850, 1057], 'transitional': [857], 'cell': [858], 'carcinoma': [859, 947, 978, 1034], 'bladder.': [862, 1037], 'Cancer2012;': [863, 1007], '118:': [864], '3920.': [865], '11': [868], 'safe,': [877], 'effective,': [878], 'efficient': [880], 'treatment': [882], 'multicenter': [890], 'II': [892], 'molecular': [895], 'correlates': [896], 'toxicity.': [900], 'Oncol2014;': [903, 931], '32:': [904, 932], '1895.': [905], '12': [908], 'dose-dense': [911, 1073], 'pegfilgrastim': [918], 'support': [919], 'pathologic,': [924], 'radiologic,': [925], 'biomarker': [927], 'correlates.': [928], '1889.': [933], '13': [936], 'gemcitabine/cisplatin': [941], 'vs.': [942], 'methotrexate/vinblastine/doxorubicin/cisplatin': [943], 'bladder:': [950, 981], 'California.': [959], 'Oncol2013;': [961, 1195], '31:': [962], '1737.': [963], '14': [966], 'role': [969], 'experience.': [984, 1191], 'Cancer2008;': [985], '113:': [986], '2471.': [987], '15': [990], 'Retrospective': [992], 'outcomes': [996, 1123], 'cisplatin-based': [999], 'regimens': [1000], 'Genitourin': [1006], '10:': [1008], '246.': [1009], '16': [1012], 'Relative': [1014], 'efficacy': [1015, 1080], 'perioperative': [1017], 'adriamycin,': [1024], 'management': [1029], 'Urology2012;': [1038], '79:': [1039], '384.': [1040], '17': [1043], 'Comparative': [1045], 'effectiveness': [1046], 'therapy': [1059, 1149, 1203], 'Cancer2015;': [1064], '121:': [1065], '2586.': [1066], '18': [1069], 'induction': [1072, 1179], 'safety': [1082], 'gemcitabine/cisplatin.': [1088], 'World': [1089], 'Urol2016;': [1091], '34:': [1092], '157.': [1093], '19': [1096], 'Stage': [1098], 'pT0': [1099, 1127, 1144], 'confers': [1103], 'survival:': [1105], 'an': [1106], 'international': [1107], '4,430': [1110], 'patients.': [1111], 'Urol2010;': [1113], '184:': [1114], '888.': [1115], 'Link,': [1116, 1136, 1250], 'specific': [1122], 'following': [1129], 'cystectomy.': [1131, 1245], 'Urol2006;': [1133], '175:': [1134], '1645.': [1135], '21': [1139], 'Effect': [1141], 'specimen': [1146], 'without': [1147], 'survival.': [1151], 'Cancer2005;': [1152], 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