Publication Information

{'id': 'https://openalex.org/W2782063681', 'doi': 'https://doi.org/10.1038/emm.2017.165', 'title': 'The significance of intertumor and intratumor heterogeneity in liver cancer', 'display_name': 'The significance of intertumor and intratumor heterogeneity in liver cancer', 'publication_year': 2018, 'publication_date': '2018-01-01', 'ids': {'openalex': 'https://openalex.org/W2782063681', 'doi': 'https://doi.org/10.1038/emm.2017.165', 'mag': '2782063681', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29303512', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5992990'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/emm.2017.165', 'pdf_url': 'https://www.nature.com/articles/emm2017165.pdf', 'source': {'id': 'https://openalex.org/S57588113', 'display_name': 'Experimental & Molecular Medicine', 'issn_l': '1226-3613', 'issn': ['1226-3613', '2092-6413'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/emm2017165.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047981422', 'display_name': 'Jinping Liu', 'orcid': 'https://orcid.org/0000-0003-4020-879X'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}, {'id': 'https://openalex.org/I4210108482', 'display_name': 'Genesis Foundation', 'ror': 'https://ror.org/01nz9qm02', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210108482']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jinping Liu', 'raw_affiliation_strings': ['Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA'], 'affiliations': [{'raw_affiliation_string': 'Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA', 'institution_ids': ['https://openalex.org/I4210140884', 'https://openalex.org/I4210149717', 'https://openalex.org/I4210108482']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070731845', 'display_name': 'Hien Dang', 'orcid': 'https://orcid.org/0000-0002-1007-4041'}, 'institutions': [{'id': 'https://openalex.org/I4210108482', 'display_name': 'Genesis Foundation', 'ror': 'https://ror.org/01nz9qm02', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210108482']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}, {'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hien Dang', 'raw_affiliation_strings': ['Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA'], 'affiliations': [{'raw_affiliation_string': 'Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA', 'institution_ids': ['https://openalex.org/I4210108482', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100765872', 'display_name': 'Xin Wei Wang', 'orcid': 'https://orcid.org/0000-0001-9735-606X'}, 'institutions': [{'id': 'https://openalex.org/I4210149717', 'display_name': 'Center for Cancer Research', 'ror': 'https://ror.org/05bjen692', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210149717']}, {'id': 'https://openalex.org/I4210108482', 'display_name': 'Genesis Foundation', 'ror': 'https://ror.org/01nz9qm02', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210108482']}, {'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xin Wei Wang', 'raw_affiliation_strings': ['Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA'], 'affiliations': [{'raw_affiliation_string': 'Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA', 'institution_ids': ['https://openalex.org/I4210149717', 'https://openalex.org/I4210108482', 'https://openalex.org/I4210140884']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2690, 'currency': 'GBP', 'value_usd': 3299, 'provenance': 'doaj'}, 'apc_paid': {'value': 2690, 'currency': 'GBP', 'value_usd': 3299, 'provenance': 'doaj'}, 'fwci': 2.563, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 190, 'citation_normalized_percentile': {'value': 0.998568, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '50', 'issue': '1', 'first_page': 'e416', 'last_page': 'e416'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10073', 'display_name': 'Hepatocellular Carcinoma Treatment and Prognosis', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10417', 'display_name': 'Lung Cancer Treatments and Mutations', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/liver-cancer', 'display_name': 'Liver Cancer', 'score': 0.63754994}, {'id': 'https://openalex.org/keywords/primary-tumor', 'display_name': 'Primary tumor', 'score': 0.4207223}], 'concepts': [{'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.662686}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.64697224}, {'id': 'https://openalex.org/C2776231280', 'wikidata': 'https://www.wikidata.org/wiki/Q623031', 'display_name': 'Liver cancer', 'level': 3, 'score': 0.63754994}, {'id': 'https://openalex.org/C64618202', 'wikidata': 'https://www.wikidata.org/wiki/Q3733697', 'display_name': 'Genetic heterogeneity', 'level': 4, 'score': 0.494411}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.49180534}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44666559}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.4430718}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.4263314}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.42603892}, {'id': 'https://openalex.org/C2780283643', 'wikidata': 'https://www.wikidata.org/wiki/Q2110267', 'display_name': 'Primary tumor', 'level': 4, 'score': 0.4207223}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.3679915}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.32614315}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.2737742}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.20296797}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.1596407}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11427659}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055106', 'descriptor_name': 'Genome-Wide Association Study', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009360', 'descriptor_name': 'Neoplastic Cells, Circulating', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D059010', 'descriptor_name': 'Single-Cell Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059016', 'descriptor_name': 'Tumor Microenvironment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/emm.2017.165', 'pdf_url': 'https://www.nature.com/articles/emm2017165.pdf', 'source': {'id': 'https://openalex.org/S57588113', 'display_name': 'Experimental & Molecular Medicine', 'issn_l': '1226-3613', 'issn': ['1226-3613', '2092-6413'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5992990', 'pdf_url': 'https://europepmc.org/articles/pmc5992990?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992990', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29303512', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/emm.2017.165', 'pdf_url': 'https://www.nature.com/articles/emm2017165.pdf', 'source': {'id': 'https://openalex.org/S57588113', 'display_name': 'Experimental & Molecular Medicine', 'issn_l': '1226-3613', 'issn': ['1226-3613', '2092-6413'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.43, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 105, 'referenced_works': ['https://openalex.org/W1544539327', 'https://openalex.org/W1701091641', 'https://openalex.org/W1757407923', 'https://openalex.org/W1763686333', 'https://openalex.org/W1792294722', 'https://openalex.org/W1903979702', 'https://openalex.org/W1963590109', 'https://openalex.org/W1967304777', 'https://openalex.org/W1968812902', 'https://openalex.org/W1969228079', 'https://openalex.org/W1969523501', 'https://openalex.org/W1979728979', 'https://openalex.org/W1987681742', 'https://openalex.org/W1988684186', 'https://openalex.org/W1988799190', 'https://openalex.org/W1990563353', 'https://openalex.org/W1992314595', 'https://openalex.org/W1992450231', 'https://openalex.org/W2001008402', 'https://openalex.org/W2002319294', 'https://openalex.org/W2004528113', 'https://openalex.org/W2004834404', 'https://openalex.org/W2004878973', 'https://openalex.org/W2005977856', 'https://openalex.org/W2007601283', 'https://openalex.org/W2015616444', 'https://openalex.org/W2018786027', 'https://openalex.org/W2018851752', 'https://openalex.org/W2020494144', 'https://openalex.org/W2032518018', 'https://openalex.org/W2033577259', 'https://openalex.org/W2035252444', 'https://openalex.org/W2035794058', 'https://openalex.org/W2042789810', 'https://openalex.org/W2046257690', 'https://openalex.org/W2048177238', 'https://openalex.org/W2049107238', 'https://openalex.org/W2049299149', 'https://openalex.org/W2050323239', 'https://openalex.org/W2051935450', 'https://openalex.org/W2059688175', 'https://openalex.org/W2060043441', 'https://openalex.org/W2060643602', 'https://openalex.org/W2068127752', 'https://openalex.org/W2070375208', 'https://openalex.org/W2076244071', 'https://openalex.org/W2077317303', 'https://openalex.org/W2080645865', 'https://openalex.org/W2085023377', 'https://openalex.org/W2085417547', 'https://openalex.org/W2093401218', 'https://openalex.org/W2094381610', 'https://openalex.org/W2098472545', 'https://openalex.org/W2099789788', 'https://openalex.org/W2100121019', 'https://openalex.org/W2101327682', 'https://openalex.org/W2103950437', 'https://openalex.org/W2107268345', 'https://openalex.org/W2107680358', 'https://openalex.org/W2117243662', 'https://openalex.org/W2117304513', 'https://openalex.org/W2121100040', 'https://openalex.org/W2124471593', 'https://openalex.org/W2125065061', 'https://openalex.org/W2128284007', 'https://openalex.org/W2134153682', 'https://openalex.org/W2136415416', 'https://openalex.org/W2139788242', 'https://openalex.org/W2148305615', 'https://openalex.org/W2150575159', 'https://openalex.org/W2154221980', 'https://openalex.org/W2158378236', 'https://openalex.org/W2162219788', 'https://openalex.org/W2162946128', 'https://openalex.org/W2168631000', 'https://openalex.org/W2170424652', 'https://openalex.org/W2170552969', 'https://openalex.org/W2170845559', 'https://openalex.org/W2177689130', 'https://openalex.org/W2194546364', 'https://openalex.org/W2197045356', 'https://openalex.org/W2227070988', 'https://openalex.org/W2269040222', 'https://openalex.org/W2286057510', 'https://openalex.org/W2286667211', 'https://openalex.org/W2306363300', 'https://openalex.org/W2317072491', 'https://openalex.org/W2402071659', 'https://openalex.org/W2411052804', 'https://openalex.org/W2419277740', 'https://openalex.org/W2518696212', 'https://openalex.org/W2520609209', 'https://openalex.org/W2520739069', 'https://openalex.org/W2520858613', 'https://openalex.org/W2548130694', 'https://openalex.org/W2558639270', 'https://openalex.org/W2563886529', 'https://openalex.org/W2572403213', 'https://openalex.org/W2586629973', 'https://openalex.org/W2587686129', 'https://openalex.org/W2614433098', 'https://openalex.org/W2916062160', 'https://openalex.org/W2917837889', 'https://openalex.org/W4211183069', 'https://openalex.org/W4234752386'], 'related_works': ['https://openalex.org/W3128070434', 'https://openalex.org/W3028946646', 'https://openalex.org/W2978433294', 'https://openalex.org/W2895620128', 'https://openalex.org/W2570780322', 'https://openalex.org/W2373209386', 'https://openalex.org/W2339474595', 'https://openalex.org/W2326081923', 'https://openalex.org/W2181038099', 'https://openalex.org/W2066869164'], 'abstract_inverted_index': {'Genomic': [0], 'analyses': [1], 'of': [2, 54, 70, 88, 92, 104, 110, 139, 206, 242], 'primary': [3, 19, 94, 140], 'liver': [4, 20, 57, 95, 141, 153, 170, 207, 253, 284], 'cancer': [5, 96, 111, 142, 154, 171, 177, 208, 243], 'samples': [6], 'reveal': [7], 'a': [8, 48], 'complex': [9], 'mutational': [10], 'landscape': [11], 'with': [12, 56, 143], 'vast': [13], 'intertumor': [14], 'and': [15, 22, 30, 41, 67, 79, 85, 102, 123, 130, 159, 165, 179, 187, 203, 212, 220, 233, 256], 'intratumor': [16, 105, 121], 'heterogeneity.': [17, 72], 'Different': [18], 'tumors': [21, 158, 162], 'subclones': [23], 'within': [24, 156], 'each': [25], 'tumor': [26, 34, 42, 71, 221, 254, 280], 'display': [27], 'striking': [28], 'molecular': [29, 35], 'biological': [31], 'variations.': [32], 'Consequently,': [33], 'heterogeneity': [36, 91, 106, 122, 138, 214, 226, 255, 282], 'contributes': [37, 215], 'to': [38, 51, 64, 119, 134, 146, 217, 239, 251, 257, 261, 276], 'drug': [39, 218], 'resistance': [40, 219], 'relapse': [43, 222], 'following': [44, 223], 'therapy,': [45], 'which': [46, 82, 236], 'poses': [47], 'substantial': [49], 'obstruction': [50], 'improving': [52], 'outcomes': [53], 'patients': [55], 'cancer.': [58, 285], 'There': [59], 'is': [60, 172, 182, 272], 'an': [61, 273], 'urgent': [62, 274], 'need': [63, 275], 'the': [65, 89, 93, 100, 108, 125, 136, 144, 173, 190, 201, 248, 259], 'compositional': [66], 'functional': [68, 90, 137], 'understanding': [69], 'In': [73], 'this': [74], 'review,': [75], 'we': [76], 'summarize': [77], 'genomic': [78], 'non-genomic': [80], 'diversities,': [81], 'include': [83], 'stemness': [84], 'microenvironmental': [86], 'causes': [87], 'ecosystem.': [97], 'We': [98, 114], 'discuss': [99, 116, 247], 'importance': [101], 'intricacy': [103], 'in': [107, 128, 131, 152, 194, 229, 283], 'context': [109], 'cell': [112, 231, 281], 'evolution.': [113], 'also': [115], 'methodologies': [117], 'applicable': [118], 'determine': [120], 'highlight': [124], 'best-fit': [126], 'patient-derived': [127], 'vivo': [129], 'vitro': [132], 'models': [133], 'recapture': [135], 'aim': [145], 'improve': [147], 'future': [148], 'therapeutic': [149], 'strategies.': [150], 'Differences': [151], 'cells': [155], 'individual': [157, 267], 'between': [160], 'different': [161, 240], 'obstruct': [163], 'treatment': [164], 'justify': [166], 'intensive': [167], 'research.': [168], 'Primary': [169], 'second': [174], 'most': [175], 'lethal': [176], 'worldwide': [178], 'its': [180], 'incidence': [181], 'increasing.': [183], 'Xin': [184], 'Wei': [185], 'Wang': [186], 'colleagues': [188], 'at': [189], 'National': [191], 'Cancer': [192], 'Institute': [193], 'Bethesda,': [195], 'Maryland,': [196], 'USA,': [197], 'reviewed': [198], 'research': [199], 'on': [200], 'genetic': [202], 'non-genetic': [204], 'diversity': [205], 'cells.': [209], 'Extensive': [210], 'intra-tumor': [211], 'inter-tumor': [213], 'significantly': [216], 'therapy.': [224], 'The': [225, 245], 'includes': [227], 'variations': [228], 'stem': [230], 'character': [232], 'other': [234], 'factors': [235], 'can': [237], 'lead': [238], 'pathways': [241], 'progression.': [244], 'authors': [246], 'methods': [249], 'available': [250], 'analyze': [252], 'use': [258], 'results': [260], 'devise': [262], 'optimum': [263], 'therapy': [264], 'strategies': [265], 'for': [266], 'patients.': [268], 'They': [269], 'conclude': [270], 'there': [271], 'learn': [277], 'more': [278], 'about': [279]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2782063681', 'counts_by_year': [{'year': 2024, 'cited_by_count': 25}, {'year': 2023, 'cited_by_count': 38}, {'year': 2022, 'cited_by_count': 37}, {'year': 2021, 'cited_by_count': 38}, {'year': 2020, 'cited_by_count': 32}, {'year': 2019, 'cited_by_count': 15}, {'year': 2018, 'cited_by_count': 3}], 'updated_date': '2024-12-22T16:27:34.686160', 'created_date': '2018-01-12'}