Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2777921000', 'doi': 'https://doi.org/10.1042/etls20170100', 'title': 'Genetic markers of artemisinin resistance in <i>Plasmodium</i> spp. parasites', 'display_name': 'Genetic markers of artemisinin resistance in <i>Plasmodium</i> spp. parasites', 'publication_year': 2017, 'publication_date': '2017-12-22', 'ids': {'openalex': 'https://openalex.org/W2777921000', 'doi': 'https://doi.org/10.1042/etls20170100', 'mag': '2777921000', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33525848', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7288991'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1042/etls20170100', 'pdf_url': 'https://portlandpress.com/emergtoplifesci/article-pdf/1/6/525/484067/etls-2017-0100c.pdf', 'source': {'id': 'https://openalex.org/S4210170546', 'display_name': 'Emerging Topics in Life Sciences', 'issn_l': '2397-8554', 'issn': ['2397-8554', '2397-8562'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://portlandpress.com/emergtoplifesci/article-pdf/1/6/525/484067/etls-2017-0100c.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5042257591', 'display_name': 'Colin J. Sutherland', 'orcid': 'https://orcid.org/0000-0003-1592-6407'}, 'institutions': [{'id': 'https://openalex.org/I124357947', 'display_name': 'University of London', 'ror': 'https://ror.org/04cw6st05', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947']}, {'id': 'https://openalex.org/I4210089966', 'display_name': 'London School of Hygiene & Tropical Medicine', 'ror': 'https://ror.org/00a0jsq62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I4210089966']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Colin J. Sutherland', 'raw_affiliation_strings': ['Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, U.K.'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, U.K.', 'institution_ids': ['https://openalex.org/I124357947', 'https://openalex.org/I4210089966']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5042257591'], 'corresponding_institution_ids': ['https://openalex.org/I124357947', 'https://openalex.org/I4210089966'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.756, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 5, 'citation_normalized_percentile': {'value': 0.721009, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 81}, 'biblio': {'volume': '1', 'issue': '6', 'first_page': '525', 'last_page': '531'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10211', 'display_name': 'Computational Drug Discovery Methods', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/1703', 'display_name': 'Computational Theory and Mathematics'}, 'field': {'id': 'https://openalex.org/fields/17', 'display_name': 'Computer Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10823', 'display_name': 'Research on Leishmaniasis Studies', 'score': 0.9711, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/plasmodium-chabaudi', 'display_name': 'Plasmodium chabaudi', 'score': 0.5020597}], 'concepts': [{'id': 'https://openalex.org/C2776120307', 'wikidata': 'https://www.wikidata.org/wiki/Q426921', 'display_name': 'Artemisinin', 'level': 4, 'score': 0.91457677}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.79428196}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.69426745}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6106297}, {'id': 'https://openalex.org/C2780789526', 'wikidata': 'https://www.wikidata.org/wiki/Q7201860', 'display_name': 'Plasmodium chabaudi', 'level': 5, 'score': 0.5020597}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.38011742}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.36119926}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.30528882}, {'id': 'https://openalex.org/C2775867548', 'wikidata': 'https://www.wikidata.org/wiki/Q1897162', 'display_name': 'Parasitemia', 'level': 4, 'score': 0.20366329}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1042/etls20170100', 'pdf_url': 'https://portlandpress.com/emergtoplifesci/article-pdf/1/6/525/484067/etls-2017-0100c.pdf', 'source': {'id': 'https://openalex.org/S4210170546', 'display_name': 'Emerging Topics in Life Sciences', 'issn_l': '2397-8554', 'issn': ['2397-8554', '2397-8562'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://researchonline.lshtm.ac.uk/id/eprint/4659914/1/Genetic%20markers%20of%20artemisinin%20resistance%20in%20Plasmodium%20spp.%20parasites.pdf', 'pdf_url': 'https://researchonline.lshtm.ac.uk/id/eprint/4659914/1/Genetic%20markers%20of%20artemisinin%20resistance%20in%20Plasmodium%20spp.%20parasites.pdf', 'source': {'id': 'https://openalex.org/S4306402527', 'display_name': 'LSHTM Research Online (London School of Hygiene and Tropical Medicine)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210089966', 'host_organization_name': 'London School of Hygiene & Tropical Medicine', 'host_organization_lineage': ['https://openalex.org/I4210089966'], 'host_organization_lineage_names': ['London School of Hygiene & Tropical Medicine'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288991', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1042/etls20170100', 'pdf_url': 'https://portlandpress.com/emergtoplifesci/article-pdf/1/6/525/484067/etls-2017-0100c.pdf', 'source': {'id': 'https://openalex.org/S4210170546', 'display_name': 'Emerging Topics in Life Sciences', 'issn_l': '2397-8554', 'issn': ['2397-8554', '2397-8562'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.84, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1919623352', 'https://openalex.org/W1969571661', 'https://openalex.org/W1973603244', 'https://openalex.org/W1975192103', 'https://openalex.org/W1977256372', 'https://openalex.org/W1993347313', 'https://openalex.org/W2001500896', 'https://openalex.org/W2020465799', 'https://openalex.org/W2025946325', 'https://openalex.org/W2040713555', 'https://openalex.org/W2045910215', 'https://openalex.org/W2047565128', 'https://openalex.org/W2055730063', 'https://openalex.org/W2064110684', 'https://openalex.org/W2111017284', 'https://openalex.org/W2119156545', 'https://openalex.org/W2123030025', 'https://openalex.org/W2124634096', 'https://openalex.org/W2129428401', 'https://openalex.org/W2131276058', 'https://openalex.org/W2161311583', 'https://openalex.org/W2164704398', 'https://openalex.org/W2168697703', 'https://openalex.org/W2171102256', 'https://openalex.org/W2275389436', 'https://openalex.org/W2277920228', 'https://openalex.org/W2415187468', 'https://openalex.org/W2467259677', 'https://openalex.org/W2515855675', 'https://openalex.org/W2546056126', 'https://openalex.org/W2574355394', 'https://openalex.org/W2579721738', 'https://openalex.org/W2584480708', 'https://openalex.org/W2746542479', 'https://openalex.org/W2752428116', 'https://openalex.org/W2755621348', 'https://openalex.org/W2804191972'], 'related_works': ['https://openalex.org/W2748724723', 'https://openalex.org/W2157389448', 'https://openalex.org/W2153513019', 'https://openalex.org/W2145915495', 'https://openalex.org/W2127394206', 'https://openalex.org/W2088228064', 'https://openalex.org/W2084982748', 'https://openalex.org/W2037209505', 'https://openalex.org/W2026268919', 'https://openalex.org/W1967637988'], 'abstract_inverted_index': {'The': [0], 'vast': [1], 'majority': [2], 'of': [3, 15, 19, 65, 95, 103, 140, 155, 173, 190], 'malaria': [4, 211], 'patients': [5], 'worldwide': [6], 'are': [7, 121, 193], 'currently': [8], 'treated': [9], 'with': [10, 30, 124, 143], 'combination': [11], 'therapy': [12], 'comprising': [13], 'one': [14], 'the': [16, 35, 69, 104, 117, 131, 137, 150, 171, 209], 'artemisinin': [17, 56, 129, 191], 'family': [18], 'drugs,': [20], 'characterised': [21], 'by': [22, 128], 'rapid': [23, 55], 'action': [24], 'and': [25, 77, 87, 149, 207], 'short': [26], 'plasma': [27], 'half-life,': [28], 'co-formulated': [29], 'a': [31, 44, 111, 183], 'longer-lasting': [32], 'drug': [33, 80], 'from': [34], 'amino': [36], 'aryl-alcohol': [37], 'or': [38], 'quinoline': [39], 'families.': [40], 'There': [41], 'is': [42], 'now': [43], 'widely': [45], 'perceived': [46], 'threat': [47], 'to': [48, 54, 99], 'treatment': [49, 145, 198], 'efficacy,': [50], 'as': [51, 196], 'reduced': [52, 96], 'susceptibility': [53, 98, 192], 'clearance': [57, 127], 'in': [58, 68, 78, 116, 130, 136, 147, 158, 162, 203, 208], 'vivo': [59, 79, 148], 'has': [60, 179, 200], 'become': [61], 'prevalent': [62], 'among': [63], 'populations': [64], 'Plasmodium': [66, 213], 'falciparum': [67, 106, 175, 206], 'Greater': [70], 'Mekong': [71, 132], 'subregion': [72], 'since': [73], '2008.': [74], 'In': [75], 'vitro': [76, 159], 'selection': [81], 'studies,': [82], 'heterologous': [83], 'cell': [84], 'expression': [85], 'experiments': [86], 'genetic': [88], 'epidemiology': [89], 'have': [90], 'identified': [91], 'many': [92], 'candidate': [93, 188], 'markers': [94, 189], 'ring-stage': [97], 'artemisinin.': [100], 'Certain': [101], 'variants': [102, 142, 178], 'P.': [105, 174, 205], 'pfk13': [107, 141], 'gene,': [108], 'which': [109], 'encodes': [110], 'kelch': [112], 'domain': [113], 'protein': [114, 119], 'implicated': [115], 'unfolded': [118], 'response,': [120], 'strongly': [122], 'associated': [123], 'slow': [125], 'parasite': [126, 212], 'subregion.': [133], 'However,': [134], 'anomalies': [135], 'epidemiological': [138], 'association': [139], 'true': [144], 'failure': [146, 199], 'curious': [151], 'cell-cycle': [152], 'stage': [153], 'specificity': [154], 'this': [156], 'phenotype': [157], 'warrant': [160], 'exploration': [161], 'some': [163], 'depth.': [164], 'Taken': [165], 'together,': [166], 'available': [167], 'data': [168], 'suggest': [169], 'that': [170], 'emergence': [172], 'expressing': [176], 'K13': [177], 'not': [180], 'yet': [181], 'precipitated': [182], 'public': [184], 'health': [185], 'emergency.': [186], 'Alternative': [187], 'also': [194], 'described,': [195], 'K13-independent': [197], 'been': [201], 'observed': [202], 'African': [204], 'rodent': [210], 'chabaudi.': [214]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2777921000', 'counts_by_year': [{'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-12T23:35:35.564002', 'created_date': '2018-01-05'}