Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2777559376', 'doi': 'https://doi.org/10.1242/dmm.031575', 'title': 'Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish', 'display_name': 'Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish', 'publication_year': 2017, 'publication_date': '2017-01-01', 'ids': {'openalex': 'https://openalex.org/W2777559376', 'doi': 'https://doi.org/10.1242/dmm.031575', 'mag': '2777559376', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29361514', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5894941'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dmm.031575', 'pdf_url': 'https://dmm.biologists.org/content/dmm/11/2/dmm031575.full.pdf', 'source': {'id': 'https://openalex.org/S45087425', 'display_name': 'Disease Models & Mechanisms', 'issn_l': '1754-8403', 'issn': ['1754-8403', '1754-8411'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://dmm.biologists.org/content/dmm/11/2/dmm031575.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026763364', 'display_name': 'Kathryn Bambino', 'orcid': 'https://orcid.org/0000-0001-8541-973X'}, 'institutions': [{'id': 'https://openalex.org/I98704320', 'display_name': 'Icahn School of Medicine at Mount Sinai', 'ror': 'https://ror.org/04a9tmd77', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I98704320']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kathryn Bambino', 'raw_affiliation_strings': ['Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA', 'institution_ids': ['https://openalex.org/I98704320']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100458170', 'display_name': 'Chi Zhang', 'orcid': 'https://orcid.org/0000-0002-3252-0946'}, 'institutions': [{'id': 'https://openalex.org/I120250893', 'display_name': 'New York University Abu Dhabi', 'ror': 'https://ror.org/00e5k0821', 'country_code': 'AE', 'type': 'education', 'lineage': ['https://openalex.org/I120250893', 'https://openalex.org/I57206974']}], 'countries': ['AE'], 'is_corresponding': False, 'raw_author_name': 'Chi Zhang', 'raw_affiliation_strings': ['Program in Biology, New York University Abu Dhabi, Saadiyat Island Campus, PO Box 129188 Abu Dhabi, United Arab Emirates'], 'affiliations': [{'raw_affiliation_string': 'Program in Biology, New York University Abu Dhabi, Saadiyat Island Campus, PO Box 129188 Abu Dhabi, United Arab Emirates', 'institution_ids': ['https://openalex.org/I120250893']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020009191', 'display_name': 'Christine Austin', 'orcid': 'https://orcid.org/0000-0002-9966-0492'}, 'institutions': [{'id': 'https://openalex.org/I98704320', 'display_name': 'Icahn School of Medicine at Mount Sinai', 'ror': 'https://ror.org/04a9tmd77', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I98704320']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christine Austin', 'raw_affiliation_strings': ['Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA', 'institution_ids': ['https://openalex.org/I98704320']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016280733', 'display_name': 'Chitra Amarasiriwardena', 'orcid': 'https://orcid.org/0000-0002-7031-8140'}, 'institutions': [{'id': 'https://openalex.org/I98704320', 'display_name': 'Icahn School of Medicine at Mount Sinai', 'ror': 'https://ror.org/04a9tmd77', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I98704320']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chitra Amarasiriwardena', 'raw_affiliation_strings': ['Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA', 'institution_ids': ['https://openalex.org/I98704320']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073674118', 'display_name': 'Manish Arora', 'orcid': 'https://orcid.org/0000-0002-3350-4657'}, 'institutions': [{'id': 'https://openalex.org/I98704320', 'display_name': 'Icahn School of Medicine at Mount Sinai', 'ror': 'https://ror.org/04a9tmd77', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I98704320']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Manish Arora', 'raw_affiliation_strings': ['Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA', 'institution_ids': ['https://openalex.org/I98704320']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056746517', 'display_name': 'Jaime Chu', 'orcid': 'https://orcid.org/0000-0002-9291-8630'}, 'institutions': [{'id': 'https://openalex.org/I98704320', 'display_name': 'Icahn School of Medicine at Mount Sinai', 'ror': 'https://ror.org/04a9tmd77', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I98704320']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jaime Chu', 'raw_affiliation_strings': ['Department of Pediatrics, Division of Pediatric Hepatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pediatrics, Division of Pediatric Hepatology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA', 'institution_ids': ['https://openalex.org/I98704320']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017793066', 'display_name': 'Kirsten C. Sadler', 'orcid': 'https://orcid.org/0000-0002-1100-4125'}, 'institutions': [{'id': 'https://openalex.org/I120250893', 'display_name': 'New York University Abu Dhabi', 'ror': 'https://ror.org/00e5k0821', 'country_code': 'AE', 'type': 'education', 'lineage': ['https://openalex.org/I120250893', 'https://openalex.org/I57206974']}], 'countries': ['AE'], 'is_corresponding': False, 'raw_author_name': 'Kirsten C. Sadler', 'raw_affiliation_strings': ['Program in Biology, New York University Abu Dhabi, Saadiyat Island Campus, PO Box 129188 Abu Dhabi, United Arab Emirates'], 'affiliations': [{'raw_affiliation_string': 'Program in Biology, New York University Abu Dhabi, Saadiyat Island Campus, PO Box 129188 Abu Dhabi, United Arab Emirates', 'institution_ids': ['https://openalex.org/I120250893']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'GBP', 'value_usd': 3750, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'GBP', 'value_usd': 3750, 'provenance': 'doaj'}, 'fwci': 3.087, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 52, 'citation_normalized_percentile': {'value': 0.886736, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11207', 'display_name': 'Pathogenesis and Treatment of Alcoholic Liver Disease', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11207', 'display_name': 'Pathogenesis and Treatment of Alcoholic Liver Disease', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Unfolded Protein Response', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10351', 'display_name': 'Epidemiology and Management of NAFLD', 'score': 0.9946, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/arsenic-toxicity', 'display_name': 'Arsenic toxicity', 'score': 0.5956614}, {'id': 'https://openalex.org/keywords/liver-diseases', 'display_name': 'Liver Diseases', 'score': 0.49472}, {'id': 'https://openalex.org/keywords/liver-disease', 'display_name': 'Liver disease', 'score': 0.48365176}], 'concepts': [{'id': 'https://openalex.org/C2778772119', 'wikidata': 'https://www.wikidata.org/wiki/Q6058862', 'display_name': 'Fatty liver', 'level': 3, 'score': 0.69523704}, {'id': 'https://openalex.org/C2776878037', 'wikidata': 'https://www.wikidata.org/wiki/Q169444', 'display_name': 'Zebrafish', 'level': 3, 'score': 0.68385655}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.60627174}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.5980036}, {'id': 'https://openalex.org/C172507514', 'wikidata': 'https://www.wikidata.org/wiki/Q730249', 'display_name': 'Arsenic toxicity', 'level': 3, 'score': 0.5956614}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.57141817}, {'id': 'https://openalex.org/C2777575235', 'wikidata': 'https://www.wikidata.org/wiki/Q558404', 'display_name': 'Alcoholic liver disease', 'level': 3, 'score': 0.53150976}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5276555}, {'id': 'https://openalex.org/C2777075537', 'wikidata': 'https://www.wikidata.org/wiki/Q929737', 'display_name': 'Liver disease', 'level': 2, 'score': 0.48365176}, {'id': 'https://openalex.org/C502230775', 'wikidata': 'https://www.wikidata.org/wiki/Q871', 'display_name': 'Arsenic', 'level': 2, 'score': 0.44333988}, {'id': 'https://openalex.org/C162317418', 'wikidata': 'https://www.wikidata.org/wiki/Q252857', 'display_name': 'Transcriptome', 'level': 4, 'score': 0.42762125}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.39757246}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.33763337}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.31285447}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.31037343}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.2933788}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.26830384}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.26538545}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.22935313}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.18361577}, {'id': 'https://openalex.org/C2777214474', 'wikidata': 'https://www.wikidata.org/wiki/Q147778', 'display_name': 'Cirrhosis', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001151', 'descriptor_name': 'Arsenic', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D000431', 'descriptor_name': 'Ethanol', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D005234', 'descriptor_name': 'Fatty Liver', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D005234', 'descriptor_name': 'Fatty Liver', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D008108', 'descriptor_name': 'Liver Diseases, Alcoholic', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': True}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001151', 'descriptor_name': 'Arsenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004198', 'descriptor_name': 'Disease Susceptibility', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004625', 'descriptor_name': 'Embryo, Nonmammalian', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004625', 'descriptor_name': 'Embryo, Nonmammalian', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004625', 'descriptor_name': 'Embryo, Nonmammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059865', 'descriptor_name': 'Endoplasmic Reticulum Stress', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D059865', 'descriptor_name': 'Endoplasmic Reticulum Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000431', 'descriptor_name': 'Ethanol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005234', 'descriptor_name': 'Fatty Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007814', 'descriptor_name': 'Larva', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007814', 'descriptor_name': 'Larva', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008108', 'descriptor_name': 'Liver Diseases, Alcoholic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dmm.031575', 'pdf_url': 'https://dmm.biologists.org/content/dmm/11/2/dmm031575.full.pdf', 'source': {'id': 'https://openalex.org/S45087425', 'display_name': 'Disease Models & Mechanisms', 'issn_l': '1754-8403', 'issn': ['1754-8403', '1754-8411'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/0e2f83cc1c554cca8baa1dfa528c7c73', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5894941', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894941', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29361514', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/dmm.031575', 'pdf_url': 'https://dmm.biologists.org/content/dmm/11/2/dmm031575.full.pdf', 'source': {'id': 'https://openalex.org/S45087425', 'display_name': 'Disease Models & Mechanisms', 'issn_l': '1754-8403', 'issn': ['1754-8403', '1754-8411'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320337330', 'funder_display_name': 'National Institute on Alcohol Abuse and Alcoholism', 'award_id': 'RO1AA018886'}, {'funder': 'https://openalex.org/F4320337361', 'funder_display_name': 'National Institute of Environmental Health Sciences', 'award_id': 'P30ES023515'}, {'funder': 'https://openalex.org/F4320337611', 'funder_display_name': 'Eunice Kennedy Shriver National Institute of Child Health and Human Development', 'award_id': 'T32 HD049311-09'}], 'datasets': [], 'versions': [], 'referenced_works_count': 118, 'referenced_works': ['https://openalex.org/W1121521847', 'https://openalex.org/W117048748', 'https://openalex.org/W1578013828', 'https://openalex.org/W1591303624', 'https://openalex.org/W1595565189', 'https://openalex.org/W1852438813', 'https://openalex.org/W1930616904', 'https://openalex.org/W1968569852', 'https://openalex.org/W1971442774', 'https://openalex.org/W1972709924', 'https://openalex.org/W1972754197', 'https://openalex.org/W1972943167', 'https://openalex.org/W1973290552', 'https://openalex.org/W1975015609', 'https://openalex.org/W1982573446', 'https://openalex.org/W1983103272', 'https://openalex.org/W1984144383', 'https://openalex.org/W1984580491', 'https://openalex.org/W1985810362', 'https://openalex.org/W1985818628', 'https://openalex.org/W1987484473', 'https://openalex.org/W1990273665', 'https://openalex.org/W1992683487', 'https://openalex.org/W1994772574', 'https://openalex.org/W1997484425', 'https://openalex.org/W1998988100', 'https://openalex.org/W1999948851', 'https://openalex.org/W2002190789', 'https://openalex.org/W2002721333', 'https://openalex.org/W2004599580', 'https://openalex.org/W2007078899', 'https://openalex.org/W2007697781', 'https://openalex.org/W2010243470', 'https://openalex.org/W2016503875', 'https://openalex.org/W2027336893', 'https://openalex.org/W2035635224', 'https://openalex.org/W2044556901', 'https://openalex.org/W2046471358', 'https://openalex.org/W2047304262', 'https://openalex.org/W2047763620', 'https://openalex.org/W2048859385', 'https://openalex.org/W2055036854', 'https://openalex.org/W2057557272', 'https://openalex.org/W2059714773', 'https://openalex.org/W2059841058', 'https://openalex.org/W2062366543', 'https://openalex.org/W2064697408', 'https://openalex.org/W2067392119', 'https://openalex.org/W2069537206', 'https://openalex.org/W2079629819', 'https://openalex.org/W2082435121', 'https://openalex.org/W2083278580', 'https://openalex.org/W2085206136', 'https://openalex.org/W2085603812', 'https://openalex.org/W2085901079', 'https://openalex.org/W2086106620', 'https://openalex.org/W2086307741', 'https://openalex.org/W2087300676', 'https://openalex.org/W2088546840', 'https://openalex.org/W2089108588', 'https://openalex.org/W2092602838', 'https://openalex.org/W2093037700', 'https://openalex.org/W2097065948', 'https://openalex.org/W2097226705', 'https://openalex.org/W2097504848', 'https://openalex.org/W2103868572', 'https://openalex.org/W2107158764', 'https://openalex.org/W2109887269', 'https://openalex.org/W2110033768', 'https://openalex.org/W2111143199', 'https://openalex.org/W2116786898', 'https://openalex.org/W2119420834', 'https://openalex.org/W2128852331', 'https://openalex.org/W2131271579', 'https://openalex.org/W2131634481', 'https://openalex.org/W2134526812', 'https://openalex.org/W2135699074', 'https://openalex.org/W2136142349', 'https://openalex.org/W2136753360', 'https://openalex.org/W2141436683', 'https://openalex.org/W2144178804', 'https://openalex.org/W2146784968', 'https://openalex.org/W2147875221', 'https://openalex.org/W2148769103', 'https://openalex.org/W2151106782', 'https://openalex.org/W2156425202', 'https://openalex.org/W2160697532', 'https://openalex.org/W2163666912', 'https://openalex.org/W2164892324', 'https://openalex.org/W2165820110', 'https://openalex.org/W2165877375', 'https://openalex.org/W2171209272', 'https://openalex.org/W2171421571', 'https://openalex.org/W2176846237', 'https://openalex.org/W2179438025', 'https://openalex.org/W2261410663', 'https://openalex.org/W2263498456', 'https://openalex.org/W2299292532', 'https://openalex.org/W2305729456', 'https://openalex.org/W2339979339', 'https://openalex.org/W2344086296', 'https://openalex.org/W2345912548', 'https://openalex.org/W2402318285', 'https://openalex.org/W2414324194', 'https://openalex.org/W2464717012', 'https://openalex.org/W2495240855', 'https://openalex.org/W2510053433', 'https://openalex.org/W2518861913', 'https://openalex.org/W2548980315', 'https://openalex.org/W2554404775', 'https://openalex.org/W2564874325', 'https://openalex.org/W2580400995', 'https://openalex.org/W2595037579', 'https://openalex.org/W2604777094', 'https://openalex.org/W2734775561', 'https://openalex.org/W2802343654', 'https://openalex.org/W4230280576', 'https://openalex.org/W787589739'], 'related_works': ['https://openalex.org/W4303648544', 'https://openalex.org/W4283069614', 'https://openalex.org/W4256528904', 'https://openalex.org/W4245153001', 'https://openalex.org/W4243165149', 'https://openalex.org/W4237600267', 'https://openalex.org/W3147492987', 'https://openalex.org/W3132255551', 'https://openalex.org/W2938575486', 'https://openalex.org/W1597543017'], 'abstract_inverted_index': {'The': [0], 'rapid': [1], 'increase': [2], 'in': [3, 47, 116, 157, 241], 'fatty': [4], 'liver': [5, 45, 90, 268], 'disease': [6, 46, 91], '(FLD)': [7], 'incidence': [8], 'is': [9, 42, 178, 249], 'attributed': [10], 'largely': [11], 'to': [12, 38, 77, 87, 98, 132, 199, 207, 221, 251, 266], 'genetic': [13], 'and': [14, 49, 81, 142, 184, 212, 234, 254], 'lifestyle': [15], 'factors;': [16], 'however,': [17], 'environmental': [18], 'toxicants': [19], 'are': [20], 'a': [21, 185], 'frequently': [22], 'overlooked': [23], 'factor': [24], 'that': [25, 95, 164, 176, 191, 246, 255], 'can': [26, 260], 'modify': [27], 'the': [28, 54, 59, 73, 83, 112, 138, 143, 215, 225, 237, 242, 262, 278, 282], 'effects': [29, 263], 'of': [30, 34, 56, 75, 114, 119, 127, 161, 210, 217, 227, 239, 258, 264, 281], 'more': [31], 'common': [32, 155], 'causes': [33], 'FLD.': [35], 'Chronic': [36], 'exposure': [37, 206, 248], 'inorganic': [39], 'arsenic': [40, 177], '(iAs)': [41], 'associated': [43, 273], 'with': [44, 62, 85, 181, 277], 'humans': [48], 'animal': [50], 'models,': [51], 'but': [52], 'neither': [53], 'mechanism': [55], 'action': [57], 'nor': [58], 'combinatorial': [60], 'interaction': [61, 84], 'other': [63], 'disease-causing': [64], 'factors': [65], 'has': [66, 271], 'been': [67], 'fully': [68], 'investigated.': [69], 'Here,': [70], 'we': [71], 'examined': [72], 'contribution': [74], 'iAs': [76, 99, 134, 201, 211, 240, 247, 259], 'FLD': [78, 115, 253], 'using': [79], 'zebrafish': [80, 96], 'tested': [82], 'ethanol': [86, 136, 183, 213, 265], 'cause': [88, 200, 252, 267], 'alcoholic': [89], '(ALD).': [92], 'We': [93], 'report': [94], 'exposed': [97, 131], 'throughout': [100], 'development': [101, 113], 'developed': [102], 'specific': [103], 'phenotypes': [104], 'beginning': [105], 'at': [106], '4': [107], 'days': [108], 'post-fertilization': [109], '(dpf),': [110], 'including': [111], 'over': [117], '50%': [118], 'larvae': [120, 130], 'by': [121, 149, 173], '5': [122], 'dpf.': [123], 'Comparative': [124], 'transcriptomic': [125], 'analysis': [126], 'livers': [128], 'from': [129], 'either': [133], 'or': [135], 'revealed': [137], 'oxidative': [139], 'stress': [140, 153], 'response': [141, 146], 'unfolded': [144], 'protein': [145], '(UPR)': [147], 'caused': [148], 'endoplasmic': [150], 'reticulum': [151], '(ER)': [152], 'as': [154], 'pathways': [156], 'both': [158, 182], 'these': [159, 192], 'models': [160], 'FLD,': [162, 223], 'suggesting': [163, 190], 'they': [165], 'target': [166], 'similar': [167], 'cellular': [168], 'processes.': [169], 'This': [170, 244], 'was': [171], 'confirmed': [172], 'our': [174], 'finding': [175], 'synthetically': [179], 'lethal': [180], 'well-characterized': [186], 'ER-stress-inducing': [187], 'agent': [188], '(tunicamycin),': [189], 'exposures': [193], 'work': [194], 'together': [195], 'through': [196], 'UPR': [197], 'activation': [198], 'toxicity.': [202], 'Most': [203], 'significantly,': [204], 'combined': [205], 'sub-toxic': [208], 'concentrations': [209], 'potentiated': [214], 'expression': [216, 226], 'UPR-associated': [218], 'genes,': [219], 'cooperated': [220], 'induce': [222], 'reduced': [224], 'as3mt,': [228], 'which': [229], 'encodes': [230], 'an': [231, 272], 'arsenic-metabolizing': [232], 'enzyme,': [233], 'significantly': [235], 'increased': [236], 'concentration': [238], 'liver.': [243], 'demonstrates': [245], 'sufficient': [250], 'low': [256], 'doses': [257], 'potentiate': [261], 'disease.This': [269], 'article': [270], 'First': [274], 'Person': [275], 'interview': [276], 'first': [279], 'author': [280], 'paper.': [283]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2777559376', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-09-01T06:58:07.894604', 'created_date': '2018-01-05'}