Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2776243106', 'doi': 'https://doi.org/10.1016/j.jiac.2017.08.009', 'title': 'Mutant selection window of four quinolone antibiotics against clinical isolates of Streptococcus pneumoniae , Haemophilus influenzae and Moraxella catarrhalis', 'display_name': 'Mutant selection window of four quinolone antibiotics against clinical isolates of Streptococcus pneumoniae , Haemophilus influenzae and Moraxella catarrhalis', 'publication_year': 2017, 'publication_date': '2017-12-29', 'ids': {'openalex': 'https://openalex.org/W2776243106', 'doi': 'https://doi.org/10.1016/j.jiac.2017.08.009', 'mag': '2776243106', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29290527'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jiac.2017.08.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S141781860', 'display_name': 'Journal of Infection and Chemotherapy', 'issn_l': '1341-321X', 'issn': ['1341-321X', '1437-7780'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079474076', 'display_name': 'Hajime Nakai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I85324120', 'display_name': 'Tohoku Medical and Pharmaceutical University', 'ror': 'https://ror.org/0264zxa45', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I85324120']}, {'id': 'https://openalex.org/I4210135094', 'display_name': 'Tohoku Rosai Hospital', 'ror': 'https://ror.org/037p13728', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210135094']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hajime Nakai', 'raw_affiliation_strings': ['Department of Pharmacy, Tohoku-Rosai Hospital, Sendai, Japan', 'Division of Clinical Infection Diseases & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Clinical Infection Diseases & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan', 'institution_ids': ['https://openalex.org/I85324120']}, {'raw_affiliation_string': 'Department of Pharmacy, Tohoku-Rosai Hospital, Sendai, Japan', 'institution_ids': ['https://openalex.org/I4210135094']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082458553', 'display_name': 'Takumi Sato', 'orcid': 'https://orcid.org/0000-0003-4277-0583'}, 'institutions': [{'id': 'https://openalex.org/I85324120', 'display_name': 'Tohoku Medical and Pharmaceutical University', 'ror': 'https://ror.org/0264zxa45', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I85324120']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takumi Sato', 'raw_affiliation_strings': ['Division of Clinical Infection Diseases & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Clinical Infection Diseases & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan', 'institution_ids': ['https://openalex.org/I85324120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085979912', 'display_name': 'Takashi Uno', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I85324120', 'display_name': 'Tohoku Medical and Pharmaceutical University', 'ror': 'https://ror.org/0264zxa45', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I85324120']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takashi Uno', 'raw_affiliation_strings': ['Division of Clinical Infection Diseases & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Clinical Infection Diseases & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan', 'institution_ids': ['https://openalex.org/I85324120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019247789', 'display_name': 'Emiko Furukawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I85324120', 'display_name': 'Tohoku Medical and Pharmaceutical University', 'ror': 'https://ror.org/0264zxa45', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I85324120']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Emiko Furukawa', 'raw_affiliation_strings': ['Division of Clinical Infection Diseases & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Clinical Infection Diseases & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan', 'institution_ids': ['https://openalex.org/I85324120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081757857', 'display_name': 'Mieko Kawamura', 'orcid': 'https://orcid.org/0000-0003-1863-1241'}, 'institutions': [{'id': 'https://openalex.org/I85324120', 'display_name': 'Tohoku Medical and Pharmaceutical University', 'ror': 'https://ror.org/0264zxa45', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I85324120']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masato Kawamura', 'raw_affiliation_strings': ['Division of Clinical Infection Diseases & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Clinical Infection Diseases & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan', 'institution_ids': ['https://openalex.org/I85324120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062022557', 'display_name': 'Hiroshi Takahashi', 'orcid': 'https://orcid.org/0000-0002-3620-1352'}, 'institutions': [{'id': 'https://openalex.org/I4210101044', 'display_name': 'Showa General Hospital', 'ror': 'https://ror.org/015hppy16', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210101044']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Takahashi', 'raw_affiliation_strings': ['Department of Respiratory Medicine, Saka General Hospital, Sendai, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Respiratory Medicine, Saka General Hospital, Sendai, Japan', 'institution_ids': ['https://openalex.org/I4210101044']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101964374', 'display_name': 'Akira Watanabe', 'orcid': 'https://orcid.org/0000-0002-7798-0997'}, 'institutions': [{'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Akira Watanabe', 'raw_affiliation_strings': ['Research Division for Development of Anti-infective Agents, Institute of Development Aging and Cancer, Tohoku University, Sendai, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division for Development of Anti-infective Agents, Institute of Development Aging and Cancer, Tohoku University, Sendai, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5015913121', 'display_name': 'Shigeru Fujimura', 'orcid': 'https://orcid.org/0000-0002-7419-3293'}, 'institutions': [{'id': 'https://openalex.org/I85324120', 'display_name': 'Tohoku Medical and Pharmaceutical University', 'ror': 'https://ror.org/0264zxa45', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I85324120']}, {'id': 'https://openalex.org/I201537933', 'display_name': 'Tohoku University', 'ror': 'https://ror.org/01dq60k83', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201537933']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Shigeru Fujimura', 'raw_affiliation_strings': ['Division of Clinical Infection Diseases & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan', 'Research Division for Development of Anti-infective Agents, Institute of Development Aging and Cancer, Tohoku University, Sendai, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Clinical Infection Diseases & Chemotherapy, Tohoku Medical and Pharmaceutical University, Sendai, Japan', 'institution_ids': ['https://openalex.org/I85324120']}, {'raw_affiliation_string': 'Research Division for Development of Anti-infective Agents, Institute of Development Aging and Cancer, Tohoku University, Sendai, Japan', 'institution_ids': ['https://openalex.org/I201537933']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5015913121'], 'corresponding_institution_ids': ['https://openalex.org/I85324120', 'https://openalex.org/I201537933'], 'apc_list': {'value': 2650, 'currency': 'USD', 'value_usd': 2650, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.503, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.732839, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '24', 'issue': '2', 'first_page': '83', 'last_page': '87'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10654', 'display_name': 'Management and Epidemiology of Pneumonia', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10654', 'display_name': 'Management and Epidemiology of Pneumonia', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11036', 'display_name': 'Pharmacokinetics of Antibiotics in Critically Ill Patients', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10147', 'display_name': 'Global Challenge of Antibiotic Resistance in Bacteria', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/moraxella', 'display_name': 'Moraxella (Branhamella) catarrhalis', 'score': 0.7207408}, {'id': 'https://openalex.org/keywords/quinolone', 'display_name': 'Quinolone', 'score': 0.66376644}, {'id': 'https://openalex.org/keywords/multidrug-resistant-bacteria', 'display_name': 'Multidrug-Resistant Bacteria', 'score': 0.479372}, {'id': 'https://openalex.org/keywords/gemifloxacin', 'display_name': 'Gemifloxacin', 'score': 0.41299617}], 'concepts': [{'id': 'https://openalex.org/C2776551000', 'wikidata': 'https://www.wikidata.org/wiki/Q2046669', 'display_name': 'Moraxella catarrhalis', 'level': 4, 'score': 0.9414552}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.85371053}, {'id': 'https://openalex.org/C2781276175', 'wikidata': 'https://www.wikidata.org/wiki/Q424193', 'display_name': 'Levofloxacin', 'level': 3, 'score': 0.8523247}, {'id': 'https://openalex.org/C2781253189', 'wikidata': 'https://www.wikidata.org/wiki/Q221179', 'display_name': 'Streptococcus pneumoniae', 'level': 3, 'score': 0.8188573}, {'id': 'https://openalex.org/C2776925733', 'wikidata': 'https://www.wikidata.org/wiki/Q1141979', 'display_name': 'Haemophilus influenzae', 'level': 3, 'score': 0.7783929}, {'id': 'https://openalex.org/C2910443534', 'wikidata': 'https://www.wikidata.org/wiki/Q2046669', 'display_name': 'Moraxella (Branhamella) catarrhalis', 'level': 5, 'score': 0.7207408}, {'id': 'https://openalex.org/C2779922871', 'wikidata': 'https://www.wikidata.org/wiki/Q426549', 'display_name': 'Quinolone', 'level': 3, 'score': 0.66376644}, {'id': 'https://openalex.org/C2776209642', 'wikidata': 'https://www.wikidata.org/wiki/Q138309', 'display_name': 'Moraxella', 'level': 3, 'score': 0.49386126}, {'id': 'https://openalex.org/C2778049240', 'wikidata': 'https://www.wikidata.org/wiki/Q411447', 'display_name': 'Ofloxacin', 'level': 4, 'score': 0.42048246}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.4134441}, {'id': 'https://openalex.org/C2776088887', 'wikidata': 'https://www.wikidata.org/wiki/Q1639595', 'display_name': 'Gemifloxacin', 'level': 4, 'score': 0.41299617}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38068902}, {'id': 'https://openalex.org/C2778512257', 'wikidata': 'https://www.wikidata.org/wiki/Q256602', 'display_name': 'Ciprofloxacin', 'level': 3, 'score': 0.36505562}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.33180976}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.16701183}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D024881', 'descriptor_name': 'Drug Resistance, Bacterial', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D006193', 'descriptor_name': 'Haemophilus influenzae', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D001936', 'descriptor_name': 'Moraxella catarrhalis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010033', 'descriptor_name': 'Otitis Media', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D018410', 'descriptor_name': 'Pneumonia, Bacterial', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': True}, {'descriptor_ui': 'D015363', 'descriptor_name': 'Quinolones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D013296', 'descriptor_name': 'Streptococcus pneumoniae', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000900', 'descriptor_name': 'Anti-Bacterial Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027081', 'descriptor_name': 'DNA Gyrase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D027081', 'descriptor_name': 'DNA Gyrase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004252', 'descriptor_name': 'DNA Mutational Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027101', 'descriptor_name': 'DNA Topoisomerase IV', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D027101', 'descriptor_name': 'DNA Topoisomerase IV', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024881', 'descriptor_name': 'Drug Resistance, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006193', 'descriptor_name': 'Haemophilus influenzae', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D006193', 'descriptor_name': 'Haemophilus influenzae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006193', 'descriptor_name': 'Haemophilus influenzae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001936', 'descriptor_name': 'Moraxella catarrhalis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001936', 'descriptor_name': 'Moraxella catarrhalis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001936', 'descriptor_name': 'Moraxella catarrhalis', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D010033', 'descriptor_name': 'Otitis Media', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010033', 'descriptor_name': 'Otitis Media', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D018410', 'descriptor_name': 'Pneumonia, Bacterial', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D018410', 'descriptor_name': 'Pneumonia, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015363', 'descriptor_name': 'Quinolones', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D015363', 'descriptor_name': 'Quinolones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012641', 'descriptor_name': 'Selection, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013296', 'descriptor_name': 'Streptococcus pneumoniae', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D013296', 'descriptor_name': 'Streptococcus pneumoniae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013296', 'descriptor_name': 'Streptococcus pneumoniae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.jiac.2017.08.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S141781860', 'display_name': 'Journal of Infection and Chemotherapy', 'issn_l': '1341-321X', 'issn': ['1341-321X', '1437-7780'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29290527', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.58}], 'grants': [{'funder': 'https://openalex.org/F4320307769', 'funder_display_name': 'Astellas Pharma US', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 27, 'referenced_works': ['https://openalex.org/W1032135940', 'https://openalex.org/W1759690985', 'https://openalex.org/W1964168847', 'https://openalex.org/W1981503817', 'https://openalex.org/W1983590978', 'https://openalex.org/W1985792455', 'https://openalex.org/W2040485501', 'https://openalex.org/W2059040676', 'https://openalex.org/W2067770912', 'https://openalex.org/W2097845035', 'https://openalex.org/W2106627363', 'https://openalex.org/W2107131874', 'https://openalex.org/W2107665004', 'https://openalex.org/W2116542524', 'https://openalex.org/W2121521963', 'https://openalex.org/W2134413540', 'https://openalex.org/W2135497327', 'https://openalex.org/W2140029055', 'https://openalex.org/W2149166791', 'https://openalex.org/W2158438131', 'https://openalex.org/W2167269704', 'https://openalex.org/W2179949285', 'https://openalex.org/W2343187398', 'https://openalex.org/W2463722508', 'https://openalex.org/W2509893140', 'https://openalex.org/W3108422415', 'https://openalex.org/W3158263484'], 'related_works': ['https://openalex.org/W651522786', 'https://openalex.org/W4383199037', 'https://openalex.org/W426638802', 'https://openalex.org/W2426277807', 'https://openalex.org/W2357257689', 'https://openalex.org/W2242788924', 'https://openalex.org/W2024287671', 'https://openalex.org/W1994988080', 'https://openalex.org/W1597891191', 'https://openalex.org/W1500198552'], 'abstract_inverted_index': {'Community-acquired': [0], 'pneumonia': [1], 'and': [2, 16, 43, 49, 79, 86, 92, 95, 101, 182, 218], 'otitis': [3], 'media': [4], 'are': [5, 27], 'caused': [6], 'by': [7, 174], 'several': [8], 'bacterial': [9], 'species,': [10], 'including': [11], 'Streptococcus': [12], 'pneumoniae,': [13], 'Haemophilus': [14], 'influenzae,': [15], 'Moraxella': [17], 'catarrhalis.': [18, 220], 'For': [19], 'the': [20, 32, 57, 61, 67, 73, 107, 123, 153, 158, 163, 183, 187, 204, 212], 'treatment': [21], 'of': [22, 37, 60, 81, 115, 125, 138, 155, 157, 168, 207, 215], 'these': [23, 133], 'diseases,': [24], 'various': [25], 'quinolones': [26], 'frequently': [28], 'used.': [29], 'We': [30], 'determined': [31], 'mutant': [33, 52, 69, 149], 'prevention': [34], 'concentration': [35], '(MPC)': [36], 'four': [38], 'quinolones,': [39], 'levofloxacin,': [40], 'sitafloxacin,': [41], 'tosufloxacin,': [42], 'garenoxacin,': [44], 'using': [45], '92': [46], 'clinical': [47, 166], 'isolates': [48, 167], 'evaluated': [50], 'each': [51], 'selection': [53], 'window': [54], '(MSW).': [55], 'Furthermore,': [56], 'DNA': [58], 'sequence': [59], 'quinolone': [62, 176], 'resistance-determining': [63], 'region': [64], '(QRDR)': [65], 'for': [66, 89, 98, 106], 'resistant': [68, 148], 'selected': [70, 120, 151], 'based': [71, 121], 'on': [72, 122], 'MSW': [74, 124, 154], 'was': [75, 142, 150], 'determined.': [76], 'The': [77, 179], 'MIC90': [78], 'MPC90': [80], 'levofloxacin': [82, 126, 208], 'were': [83, 102], '0.781': [84], 'μg/mL': [85, 88, 94, 97], '6.250': [87], 'S.': [90, 117, 216], 'pneumoniae': [91, 118, 217], '0.049': [93], '1.563': [96], 'M.': [99, 219], 'catarrhalis': [100], 'higher': [103], 'than': [104], 'those': [105], 'other': [108, 159, 164], 'three': [109, 160], 'quinolones.': [110, 161], 'In': [111, 132, 144, 198], 'addition,': [112], '5': [113, 134], 'strains': [114], '30': [116], '(16.7%)': [119], 'acquired': [127], 'resistance': [128, 173], 'to': [129, 211], 'only': [130], 'levofloxacin.': [131], 'strains,': [135], 'a': [136], 'mutation': [137, 184], 'gyrA': [139], 'and/or': [140], 'parC': [141], 'detected.': [143], 'this': [145], 'study,': [146], 'no': [147, 172], 'in': [152, 186, 195], 'any': [156], 'On': [162], 'hand,': [165], 'H.': [169], 'influenzae': [170], 'showed': [171], 'all': [175], 'exposure.': [177], 'Finally,': [178], 'MIC': [180], 'value': [181], 'status': [185], 'QRDR': [188], 'did': [189], 'not': [190], 'change': [191], 'after': [192], '14': [193], 'passages': [194], 'antibiotic-free': [196], 'medium.': [197], 'conclusion,': [199], 'our': [200], 'findings': [201], 'suggest': [202], 'that': [203], 'increased': [205, 213], 'use': [206], 'may': [209], 'contribute': [210], 'quinolone-resistance': [214]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2776243106', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 5}], 'updated_date': '2024-09-19T10:04:34.332216', 'created_date': '2018-01-05'}