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303, 429], 'definition': [44], 'included': [45, 161], 'removal': [46, 80], 'distinction': [49, 83], 'between': [50, 84], 'symptomatic': [51, 85, 346, 461], 'asymptomatic': [53, 87], 'lesions,': [54, 71], 'increasing': [55], 'number': [57], 'lesions': [59, 88, 347, 359, 373, 462, 483], 'needed': [60], 'periventricular': [63, 372, 486], 'involvement': [64, 487], 'three,': [66], 'combining': [67], 'cortical': [68, 358], 'juxtacortical': [70], 'inclusion': [73, 277, 344], 'optic': [75, 134, 393], 'nerve': [76, 135, 394], 'evaluation.': [77], 'For': [78], 'DIT,': [79, 243], 'was': [89, 340], 'suggested.': [90], 'We': [91, 219, 236], 'compared': [92], 'performance': [94, 240], '2010': [97, 447], 'McDonald': [98, 309, 420, 448], '2016': [100, 315, 424, 439], 'MAGNIMS': [101, 316, 425, 440], 'a': [108, 173, 186, 190, 207, 223, 249], 'large': [109], 'multicentre': [110], 'cohort': [111], 'CIS': [115, 141, 175, 217, 268], 'provide': [117], 'evidence': [118], 'guide': [120], 'revisions': [121, 502], 'diagnostic': [125, 506], 'criteria.': [126, 278, 507], '<h3>Methods</h3>': [127], 'Brain': [128], 'spinal': [130, 194], 'cord': [131, 195], 'assessments': [136], 'from': [137, 151, 203, 216], 'typical': [140, 181], 'suggestive': [142, 176], 'done': [146], 'less': [147, 199, 212], 'than': [148, 200, 213], '3': [149, 201], 'months': [150, 202, 215, 232, 285], 'clinical': [152, 204, 225, 468], 'onset': [153], 'eight': [155], 'European': [156], 'centres': [159], 'were': [160, 168, 269, 414], 'this': [163], 'retrospective': [164], 'study.': [165], 'Eligible': [166], '16–60': [169], 'years,': [170], 'had': [172], 'first': [174], 'CNS': [178], 'demyelination': [179], 'relapsing-remitting': [183], 'sclerosis,': [185], 'complete': [187], 'neurological': [188], 'examination,': [189], 'baseline': [191], 'brain': [192, 209], 'scan': [197, 210], 'obtained': [198, 211], 'onset,': [205], 'follow-up': [208], '12': [214], 'onset.': [218], 'recorded': [220], 'occurrence': [221], 'second': [224], 'attack': [226], '(clinically': [227], 'definite': [228, 295, 456], 'sclerosis)': [230], 'at': [231], '36': [233, 299], '60.': [235], 'evaluated': [237], 'DIS,': [242], 'plus': [246, 430], 'DIT': [247, 418, 431], 'time-dependent': [250], 'receiver': [251], 'operating': [252], 'characteristic': [253], 'curve': [254, 331], 'analysis.': [255], '<h3>Findings</h3>': [256], 'Between': [257], 'June': [258], '16,': [259], '1995,': [260], 'Jan': [262], '27,': [263], '2017,': [264], '571': [265], 'screened,': [270], 'whom': [272], '368': [273, 291], 'met': [274], 'all': [275], 'study': [276], 'At': [279, 298], 'last': [281], 'evaluation': [282, 395], '(median': [283], '50·0': [284], '[IQR': [286], '27·0–78·4]),': [287], '189': [288], '(51%)': [289], 'developed': [293], 'sclerosis.': [297, 458], 'months,': [300], 'two': [302, 495], 'showed': [305, 442], 'high': [306], 'sensitivity': [307, 378, 399], '(2010': [308, 419], '0·91': [310], '[95%': [311], 'CI': [312], '0·85–0·94]': [313], '0·93': [317], '[0·88–0·96]),': [318], 'similar': [319, 327, 387, 398, 416, 443], 'specificity': [320, 351, 363, 383, 405], '(0·33': [321], '[0·25–0·42]': [322], '0·32': [324, 364], '[0·24–0·41]),': [325], 'area': [328], 'under': [329], 'values': [332, 413], '(AUC;': [333], '0·62': [334, 355, 367], '[0·57–0·67]': [335], '0·63': [337], '[0·58–0·67]).': [338], 'Performance': [339], 'not': [341], 'affected': [342], 'by': [343], '(sensitivity': [348, 360], '0·92': [349, 361], '[0·87–0·96],': [350], '0·31': [352], '[0·23–0·40],': [353], 'AUC': [354, 366, 388, 409, 412], '[0·57–0·66])': [356], 'or': [357], '[0·87–0·95],': [362], '[0·24–0·41],': [365], '[0·57–0·67]).': [368], 'Requirement': [369], 'three': [371, 482], 'resulted': [374, 396], 'slightly': [376, 381, 403, 489], 'lower': [377, 404], '(0·85': [379], '[0·78–0·90],': [380], 'higher': [382], '(0·40': [384], '[0·32–0·50],': [385], '(0·63': [389], '[0·57–0·68]).': [390], 'Inclusion': [391, 459], '(0·92': [400], '[0·87–0·96]),': [401], '(0·26': [406], '[0·18–0·34])': [407], '(0·59': [410], '[0·55–0·64]).': [411], 'also': [415], '0·61': [421, 426], '[0·55–0·67]': [422], '[0·55–0·66])': [427], '(0·62': [432], '[0·56–0·67]': [433], '0·64': [435], '[0·58–0·69]).': [436], '<h3>Interpretation</h3>': [437], 'The': [438], 'accuracy': [444], 'predicting': [451], 'development': [453], 'is': [463], 'expected': [464], 'simplify': [466], 'use': [469], 'without': [473], 'reducing': [474], 'accuracy,': [475], 'our': [477], 'findings': [478], 'suggest': [479], 'that': [480, 493], 'needing': [481], 'might': [488], 'increase': [490], 'specificity,': [491], 'suggesting': [492], 'these': [494], 'factors': [496], 'could': [497], 'be': [498], 'considered': [499], 'during': [500], 'further': [501], '<h3>Funding</h3>': [508], 'UK': [509], 'MS': [510, 525], 'Society,': [511], 'National': [512], 'Institute': [513], 'Health': [515], 'Research': [516, 522, 526], 'University': [517], 'College': [518], 'London': [519], 'Hospitals': [520], 'Biomedical': [521], 'Centre,': [523], 'Dutch': [524], 'Foundation.': [527]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2776062928', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 20}, {'year': 2018, 'cited_by_count': 23}], 'updated_date': '2024-09-17T19:36:50.549617', 'created_date': '2018-01-05'}