Title: Beneficial effects of the natural phenol rosmarinic acid against alcohol-induced hepatotoxicity in rats
Abstract: Alcohol is a severe hepatotoxicant that causes a variety of liver disorders. Rosmarinic acid (RA), a natural phenol, shows some biological activities, including antioxidant and anti-inflammatory effects. We investigated the effects of RA (10 mg/kg) against ethanol-induced oxidative damage and hepatotoxicity in rats. Animals received ethanol (4 g/kg, i.g.) and/or RA (10 mg/kg, i.g.) daily for 4 weeks. At the end, rats were weighed and use for biochemical, molecular and histopathological examinations. Ethanol increased hepatic lipid peroxidation (P < 0.001) and decreased hepatic levels of reduced glutathione (GSH) (P < 0.01), catalase (CAT) (P < 0.05) and superoxide dismutase (SOD) (P < 0.001) compared with control group. RA prevented the proxidant and antioxidant imbalance induced by ethanol in liver. Furthermore, RA ameliorated the increased liver weight, serum levels of ALT, AST, LDH, TNF-α and IL-6 in ethanol group. Necrosis and infiltration of inflammatory cells in liver parenchyma were attenuated by R...
Publication Year: 2017
Publication Date: 2017-07-04
Language: en
Type: article
Access and Citation
Cited By Count: 1
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot