Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2772715662', 'doi': 'https://doi.org/10.18632/oncotarget.23250', 'title': 'Celecoxib targets breast cancer stem cells by inhibiting the synthesis of prostaglandin E2 and down-regulating the Wnt pathway activity', 'display_name': 'Celecoxib targets breast cancer stem cells by inhibiting the synthesis of prostaglandin E2 and down-regulating the Wnt pathway activity', 'publication_year': 2017, 'publication_date': '2017-12-14', 'ids': {'openalex': 'https://openalex.org/W2772715662', 'doi': 'https://doi.org/10.18632/oncotarget.23250', 'mag': '2772715662', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29383157', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5777769'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.23250', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=23250&path%5B%5D=73292', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=23250&path%5B%5D=73292', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5021557852', 'display_name': 'Chaolin Huang', 'orcid': 'https://orcid.org/0000-0002-6829-9235'}, 'institutions': [{'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chaolin Huang', 'raw_affiliation_strings': ['Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China', 'institution_ids': ['https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058617327', 'display_name': 'Yuanhong Chen', 'orcid': 'https://orcid.org/0000-0001-8979-2371'}, 'institutions': [{'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuanhong Chen', 'raw_affiliation_strings': ['Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China', 'institution_ids': ['https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101398621', 'display_name': 'Hang Liu', 'orcid': 'https://orcid.org/0000-0001-9287-9996'}, 'institutions': [{'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hang Liu', 'raw_affiliation_strings': ['Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China', 'institution_ids': ['https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086482529', 'display_name': 'Jing Yang', 'orcid': 'https://orcid.org/0000-0002-3286-0772'}, 'institutions': [{'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Yang', 'raw_affiliation_strings': ['Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China', 'institution_ids': ['https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102961888', 'display_name': 'Xuejing Song', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xuejing Song', 'raw_affiliation_strings': ['Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China', 'institution_ids': ['https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113821595', 'display_name': 'Junping Zhao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Junping Zhao', 'raw_affiliation_strings': ['Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China', 'institution_ids': ['https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064065903', 'display_name': 'Na He', 'orcid': 'https://orcid.org/0000-0001-5560-5312'}, 'institutions': [{'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Na He', 'raw_affiliation_strings': ['Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China', 'institution_ids': ['https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007431527', 'display_name': 'Chengji J. Zhou', 'orcid': 'https://orcid.org/0000-0001-8592-4680'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}, {'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Chengji J. Zhou', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Medicine, University of California at Davis, School of Medicine, Sacramento, CA 95817, USA', 'Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Medicine, University of California at Davis, School of Medicine, Sacramento, CA 95817, USA', 'institution_ids': ['https://openalex.org/I84218800']}, {'raw_affiliation_string': 'Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China', 'institution_ids': ['https://openalex.org/I27781120']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052375129', 'display_name': 'Yong-Ping Wang', 'orcid': 'https://orcid.org/0000-0002-5111-1443'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yongping Wang', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Medicine, University of California at Davis, School of Medicine, Sacramento, CA 95817, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Medicine, University of California at Davis, School of Medicine, Sacramento, CA 95817, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021750559', 'display_name': 'Changjiang Huang', 'orcid': 'https://orcid.org/0000-0001-5137-2136'}, 'institutions': [{'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Changjiang Huang', 'raw_affiliation_strings': ['Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China', 'institution_ids': ['https://openalex.org/I27781120']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108047154', 'display_name': 'Qiaoxiang Dong', 'orcid': 'https://orcid.org/0000-0003-4003-7919'}, 'institutions': [{'id': 'https://openalex.org/I27781120', 'display_name': 'Wenzhou Medical University', 'ror': 'https://ror.org/00rd5t069', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I27781120']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Qiaoxiang Dong', 'raw_affiliation_strings': ['Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Environmental Safety and Human Health, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325035, P.R. China', 'institution_ids': ['https://openalex.org/I27781120']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5108047154'], 'corresponding_institution_ids': ['https://openalex.org/I27781120'], 'apc_list': None, 'apc_paid': None, 'fwci': 3.212, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 53, 'citation_normalized_percentile': {'value': 0.872149, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '8', 'issue': '70', 'first_page': '115254', 'last_page': '115269'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12626', 'display_name': 'Cancer, Stress, Anesthesia, and Immune Response', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12626', 'display_name': 'Cancer, Stress, Anesthesia, and Immune Response', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.9917, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9903, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/celecoxib', 'display_name': 'Celecoxib', 'score': 0.81781065}], 'concepts': [{'id': 'https://openalex.org/C2776467144', 'wikidata': 'https://www.wikidata.org/wiki/Q408801', 'display_name': 'Celecoxib', 'level': 2, 'score': 0.81781065}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.6905654}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.6648349}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6643032}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.56786615}, {'id': 'https://openalex.org/C76419328', 'wikidata': 'https://www.wikidata.org/wiki/Q74419', 'display_name': 'Epithelial–mesenchymal transition', 'level': 4, 'score': 0.56609815}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.52864987}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5004885}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.45976347}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.45924735}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.43898365}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42641887}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.42378265}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.41959384}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.4116196}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.32677096}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.1875267}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.17991537}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.14407966}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.23250', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=23250&path%5B%5D=73292', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5777769', 'pdf_url': 'https://europepmc.org/articles/pmc5777769?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777769', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29383157', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.23250', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=23250&path%5B%5D=73292', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1092939784', 'https://openalex.org/W1554815317', 'https://openalex.org/W1714842717', 'https://openalex.org/W1887671912', 'https://openalex.org/W1985339653', 'https://openalex.org/W2002404925', 'https://openalex.org/W2004419844', 'https://openalex.org/W2008870230', 'https://openalex.org/W2014691022', 'https://openalex.org/W2018192635', 'https://openalex.org/W2019264784', 'https://openalex.org/W2023316892', 'https://openalex.org/W2023427658', 'https://openalex.org/W2026742412', 'https://openalex.org/W2033061169', 'https://openalex.org/W2033459915', 'https://openalex.org/W2038064173', 'https://openalex.org/W2040365233', 'https://openalex.org/W2046822797', 'https://openalex.org/W2050376918', 'https://openalex.org/W2053812538', 'https://openalex.org/W2062069198', 'https://openalex.org/W2079777624', 'https://openalex.org/W2081410358', 'https://openalex.org/W2083274861', 'https://openalex.org/W2089048280', 'https://openalex.org/W2090569921', 'https://openalex.org/W2093307943', 'https://openalex.org/W2095069572', 'https://openalex.org/W2102512718', 'https://openalex.org/W2102937816', 'https://openalex.org/W2107648723', 'https://openalex.org/W2111511846', 'https://openalex.org/W2117348416', 'https://openalex.org/W2120656656', 'https://openalex.org/W2126275835', 'https://openalex.org/W2127617517', 'https://openalex.org/W2128050375', 'https://openalex.org/W2133540952', 'https://openalex.org/W2139151018', 'https://openalex.org/W2140987848', 'https://openalex.org/W2144357057', 'https://openalex.org/W2148558073', 'https://openalex.org/W2151036184', 'https://openalex.org/W2152180761', 'https://openalex.org/W2155390148', 'https://openalex.org/W2157201048', 'https://openalex.org/W2158021558', 'https://openalex.org/W2160886507', 'https://openalex.org/W2170816578', 'https://openalex.org/W2171313040', 'https://openalex.org/W2173858545', 'https://openalex.org/W2178881521', 'https://openalex.org/W2182055431', 'https://openalex.org/W2254153826', 'https://openalex.org/W2280524699', 'https://openalex.org/W2291038537', 'https://openalex.org/W2336268115', 'https://openalex.org/W2421311443', 'https://openalex.org/W2474480562', 'https://openalex.org/W3143250791', 'https://openalex.org/W4211233744'], 'related_works': ['https://openalex.org/W4224438844', 'https://openalex.org/W3095862827', 'https://openalex.org/W2990913292', 'https://openalex.org/W2800406367', 'https://openalex.org/W2379455167', 'https://openalex.org/W2227955965', 'https://openalex.org/W2108767960', 'https://openalex.org/W2035718411', 'https://openalex.org/W2012767167', 'https://openalex.org/W1964843034'], 'abstract_inverted_index': {'//': [0], 'Chaolin': [1], 'Huang': [2, 39], '1': [3, 7, 11, 15, 19, 23, 27, 40, 44, 45], ',': [4, 8, 12, 16, 20, 24, 28, 33, 37], 'Yuanhong': [5], 'Chen': [6], 'Hang': [9], 'Liu': [10], 'Jing': [13], 'Yang': [14], 'Xuejing': [17], 'Song': [18], 'Junping': [21], 'Zhao': [22], 'Na': [25], 'He': [26], 'Chengji': [29], 'J.': [30], 'Zhou': [31], '2': [32, 36, 67, 100, 252], 'Yongping': [34], 'Wang': [35], 'Changjiang': [38, 92], 'and': [41, 50, 57, 71, 148, 171, 208, 229, 232, 253], 'Qiaoxiang': [42, 88], 'Dong': [43], 'Institute': [46], 'of': [47, 54, 69, 75, 80, 120, 132, 139, 153, 202, 249], 'Environmental': [48], 'Safety': [49], 'Human': [51], 'Health,': [52], 'School': [53, 79], 'Laboratory': [55], 'Medicine': [56], 'Life': [58], 'Science,': [59], 'Wenzhou': [60, 63], 'Medical': [61], 'University,': [62], '325035,': [64], 'P.R.': [65], 'China': [66], 'Department': [68], 'Biochemistry': [70], 'Molecular': [72], 'Medicine,': [73, 81], 'University': [74], 'California': [76], 'at': [77], 'Davis,': [78], 'Sacramento,': [82], 'CA': [83], '95817,': [84], 'USA': [85], 'Correspondence': [86], 'to:': [87], 'Dong,': [89], 'email:': [90, 94], '[email protected]': [91], 'Huang,': [93], '[email protected]': [95], 'Keywords:': [96], 'CSCs;': [97], 'celecoxib;': [98], 'PGE': [99], ';': [101], 'Wnt': [102, 256], 'pathway;': [103], 'EMT': [104], 'Received:': [105], 'June': [106], '05,': [107], '2017': [108, 112, 116], 'Accepted:': [109], 'December': [110, 114], '03,': [111], 'Published:': [113], '14,': [115], 'ABSTRACT': [117], 'Pharmacological': [118], 'targeting': [119, 265], 'breast': [121, 133, 169, 205, 243, 277], 'cancer': [122, 170, 182, 278], 'stem': [123], 'cells': [124], '(CSCs)': [125], 'is': [126, 141, 151], 'highly': [127], 'promising': [128], 'for': [129, 143, 196], 'the': [130, 136, 154, 175, 191, 197, 200, 236, 247, 255], 'treatment': [131, 279], 'cancer,': [134], 'as': [135, 270], 'small': [137], 'population': [138], 'CSCs': [140, 206, 244], 'responsible': [142], 'tumor': [144], 'initiation,': [145], 'progression,': [146], 'recurrence': [147], 'chemo-resistance.': [149], 'Celecoxib': [150], 'one': [152], 'most': [155], 'commonly': [156], 'used': [157, 269], 'non-steroidal': [158], 'anti-inflammatory': [159], 'drugs': [160], '(NSAIDs),': [161], 'which': [162, 178], 'have': [163, 185], 'chemo-preventive': [164], 'activity': [165], 'against': [166], 'cancers,': [167], 'including': [168], 'colorectal': [172], 'cancer.': [173], 'However,': [174], 'mechanisms': [176], 'by': [177, 245, 264], 'NSAIDs': [179], 'exert': [180], 'its': [181, 209], 'prevention': [183], 'effects': [184], 'yet': [186], 'been': [187], 'completely': [188], 'understood.': [189], 'In': [190], 'present': [192], 'study,': [193], 'we': [194], 'investigated': [195], 'first': [198], 'time': [199], 'effect': [201], 'celecoxib': [203, 217, 241], 'on': [204], 'inhibition': [207], 'potential': [210], 'molecular': [211], 'mechanisms.': [212], 'Our': [213, 259], 'results': [214], 'demonstrated': [215], 'that': [216, 240, 262], 'suppresses': [218], 'CSC': [219], 'self-renewal,': [220], 'sensitizes': [221], 'chemo-resistance,': [222], 'inhibits': [223], 'epithelial': [224], 'to': [225, 275], 'mesenchymal': [226], 'transition': [227], '(EMT),': [228], 'attenuates': [230], 'metastasis': [231], 'tumorigenesis.': [233], 'Further': [234], 'exploring': [235], 'underlying': [237], 'mechanism': [238], 'revealed': [239], 'targets': [242], 'inhibiting': [246], 'synthesis': [248], 'prostaglandin': [250], 'E': [251], 'down-regulating': [254], 'pathway': [257], 'activity.': [258], 'findings': [260], 'suggest': [261], 'celecoxib,': [263], 'CSCs,': [266], 'may': [267], 'be': [268], 'an': [271], 'adjuvant': [272], 'chemotherapy': [273], 'drug': [274], 'improve': [276], 'outcomes.': [280]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2772715662', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 4}], 'updated_date': '2024-12-24T09:19:23.167315', 'created_date': '2017-12-22'}