Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2772624397', 'doi': 'https://doi.org/10.1055/s-0043-122222', 'title': 'Glycyrrhetic Acid Derivative TY501 Protects Against Lithocholic Acid–Induced Cholestasis', 'display_name': 'Glycyrrhetic Acid Derivative TY501 Protects Against Lithocholic Acid–Induced Cholestasis', 'publication_year': 2017, 'publication_date': '2017-12-04', 'ids': {'openalex': 'https://openalex.org/W2772624397', 'doi': 'https://doi.org/10.1055/s-0043-122222', 'mag': '2772624397', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29202514'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-0043-122222', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210226141', 'display_name': 'Drug Research', 'issn_l': '2194-9379', 'issn': ['2194-9379', '2194-9387'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100932463', 'display_name': 'Xuemin Zheng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105139', 'display_name': 'Tianjin Institute of Pharmaceutical Research (China)', 'ror': 'https://ror.org/01g9y2x13', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210105139']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xuemin Zheng', 'raw_affiliation_strings': ['Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research,Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research,Tianjin, China', 'institution_ids': ['https://openalex.org/I4210105139']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101470026', 'display_name': 'Shichao Zhu', 'orcid': 'https://orcid.org/0000-0003-3408-2676'}, 'institutions': [{'id': 'https://openalex.org/I4210105139', 'display_name': 'Tianjin Institute of Pharmaceutical Research (China)', 'ror': 'https://ror.org/01g9y2x13', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210105139']}, {'id': 'https://openalex.org/I5740404', 'display_name': 'Tianjin Medical University', 'ror': 'https://ror.org/02mh8wx89', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I5740404']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shichao Zhu', 'raw_affiliation_strings': ['Basic Medical College, Tianjin Medical University, Tianjin,China', 'Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research,Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research,Tianjin, China', 'institution_ids': ['https://openalex.org/I4210105139']}, {'raw_affiliation_string': 'Basic Medical College, Tianjin Medical University, Tianjin,China', 'institution_ids': ['https://openalex.org/I5740404']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110370464', 'display_name': 'Zhixing Zhou', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105139', 'display_name': 'Tianjin Institute of Pharmaceutical Research (China)', 'ror': 'https://ror.org/01g9y2x13', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210105139']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhixing Zhou', 'raw_affiliation_strings': ['Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research,Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research,Tianjin, China', 'institution_ids': ['https://openalex.org/I4210105139']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5115590498', 'display_name': 'Wei Liu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105139', 'display_name': 'Tianjin Institute of Pharmaceutical Research (China)', 'ror': 'https://ror.org/01g9y2x13', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210105139']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Liu', 'raw_affiliation_strings': ['Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research,Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research,Tianjin, China', 'institution_ids': ['https://openalex.org/I4210105139']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5102213652', 'display_name': 'Weiren Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210105139', 'display_name': 'Tianjin Institute of Pharmaceutical Research (China)', 'ror': 'https://ror.org/01g9y2x13', 'country_code': 'CN', 'type': 'company', 'lineage': ['https://openalex.org/I4210105139']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weiren Xu', 'raw_affiliation_strings': ['Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research,Tianjin, China'], 'affiliations': [{'raw_affiliation_string': 'Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research,Tianjin, China', 'institution_ids': ['https://openalex.org/I4210105139']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.497, 'has_fulltext': False, 'cited_by_count': 4, 'citation_normalized_percentile': {'value': 0.596805, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 77, 'max': 79}, 'biblio': {'volume': '68', 'issue': '07', 'first_page': '370', 'last_page': '377'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Natural Compounds', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12817', 'display_name': 'Pharmacological Effects of Natural Compounds', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13430', 'display_name': 'Lipid metabolism and disorders', 'score': 0.9936, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lithocholic-acid', 'display_name': 'Lithocholic acid', 'score': 0.91171706}, {'id': 'https://openalex.org/keywords/farnesoid-x-receptor', 'display_name': 'Farnesoid X receptor', 'score': 0.44882777}], 'concepts': [{'id': 'https://openalex.org/C36201501', 'wikidata': 'https://www.wikidata.org/wiki/Q17907816', 'display_name': 'Multidrug resistance-associated protein 2', 'level': 5, 'score': 0.91698515}, {'id': 'https://openalex.org/C2780420665', 'wikidata': 'https://www.wikidata.org/wiki/Q3323035', 'display_name': 'Lithocholic acid', 'level': 3, 'score': 0.91171706}, {'id': 'https://openalex.org/C2778593092', 'wikidata': 'https://www.wikidata.org/wiki/Q1075923', 'display_name': 'Cholestasis', 'level': 2, 'score': 0.9006783}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.7656481}, {'id': 'https://openalex.org/C2779399885', 'wikidata': 'https://www.wikidata.org/wiki/Q413288', 'display_name': 'Bile acid', 'level': 2, 'score': 0.69947875}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.68567884}, {'id': 'https://openalex.org/C2910800957', 'wikidata': 'https://www.wikidata.org/wiki/Q15315873', 'display_name': 'Bile Salt Export Pump', 'level': 4, 'score': 0.66193867}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5570736}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5035445}, {'id': 'https://openalex.org/C2777513400', 'wikidata': 'https://www.wikidata.org/wiki/Q104219', 'display_name': 'Bilirubin', 'level': 2, 'score': 0.4642523}, {'id': 'https://openalex.org/C203862802', 'wikidata': 'https://www.wikidata.org/wiki/Q14905041', 'display_name': 'Farnesoid X receptor', 'level': 5, 'score': 0.44882777}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4061975}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3630678}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.25635064}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.16972476}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.108528286}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07447159}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.048511267}, {'id': 'https://openalex.org/C44312359', 'wikidata': 'https://www.wikidata.org/wiki/Q286958', 'display_name': 'ATP-binding cassette transporter', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002779', 'descriptor_name': 'Cholestasis', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': True}, {'descriptor_ui': 'D002779', 'descriptor_name': 'Cholestasis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D006034', 'descriptor_name': 'Glycyrrhetinic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008095', 'descriptor_name': 'Lithocholic Acid', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D020011', 'descriptor_name': 'Protective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000074020', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B, Member 11', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000074020', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily B, Member 11', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002779', 'descriptor_name': 'Cholestasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006034', 'descriptor_name': 'Glycyrrhetinic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056945', 'descriptor_name': 'Hep G2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008095', 'descriptor_name': 'Lithocholic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000089762', 'descriptor_name': 'Multidrug Resistance-Associated Protein 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027425', 'descriptor_name': 'Multidrug Resistance-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027425', 'descriptor_name': 'Multidrug Resistance-Associated Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D029363', 'descriptor_name': 'Organic Anion Transporters, Sodium-Dependent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029363', 'descriptor_name': 'Organic Anion Transporters, Sodium-Dependent', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020011', 'descriptor_name': 'Protective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027981', 'descriptor_name': 'Symporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027981', 'descriptor_name': 'Symporters', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-0043-122222', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210226141', 'display_name': 'Drug Research', 'issn_l': '2194-9379', 'issn': ['2194-9379', '2194-9387'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29202514', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.51, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1119423221', 'https://openalex.org/W1966916675', 'https://openalex.org/W1968928885', 'https://openalex.org/W1972593802', 'https://openalex.org/W1988225800', 'https://openalex.org/W2001907052', 'https://openalex.org/W2015098698', 'https://openalex.org/W2039472410', 'https://openalex.org/W2058419808', 'https://openalex.org/W2086067198', 'https://openalex.org/W2091544674', 'https://openalex.org/W2098462548', 'https://openalex.org/W2111837806', 'https://openalex.org/W2124025733', 'https://openalex.org/W2126838672', 'https://openalex.org/W2134059673', 'https://openalex.org/W2134613519', 'https://openalex.org/W2137855409', 'https://openalex.org/W2155864743', 'https://openalex.org/W2157050265', 'https://openalex.org/W2166661344', 'https://openalex.org/W2211664220', 'https://openalex.org/W2272772407', 'https://openalex.org/W2276989234', 'https://openalex.org/W2333755525', 'https://openalex.org/W2437132565', 'https://openalex.org/W2510157910', 'https://openalex.org/W2529441838', 'https://openalex.org/W2580021799', 'https://openalex.org/W2739245296'], 'related_works': ['https://openalex.org/W768371444', 'https://openalex.org/W4327966545', 'https://openalex.org/W4211055382', 'https://openalex.org/W4200486880', 'https://openalex.org/W2994732525', 'https://openalex.org/W2772624397', 'https://openalex.org/W2529441838', 'https://openalex.org/W2437132565', 'https://openalex.org/W2139760558', 'https://openalex.org/W2107790148'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'aim': [2], 'of': [3, 12, 40, 86, 100, 130, 134], 'the': [4, 9, 22, 38, 84], 'study': [5], 'is': [6], 'to': [7, 20], 'investigate': [8], 'protective': [10], 'effects': [11, 123], 'TY501': [13, 51, 66, 82, 106, 120], 'against': [14], 'LCA-induced': [15, 73, 125], 'cholestasis': [16], 'in': [17, 63, 105, 111], 'mice': [18, 108], 'and': [19, 43, 59, 76, 89, 98, 137], 'explore': [21], 'potential': [23], 'mechanisms.': [24], 'It': [25, 115], 'was': [26, 102], 'demonstrated': [27], 'that': [28, 81, 119], 'TY501(5,': [29], '15': [30], 'or': [31], '45': [32], 'mg/kg,': [33], 'i.g.)': [34], 'can': [35, 67, 116], 'markedly': [36], 'reduced': [37], 'level': [39], 'ALT,': [41], 'AST': [42], 'ALP': [44], 'which': [45, 91], 'increased': [46], 'by': [47, 94], 'LCA': [48], 'treatment.': [49], 'Meanwhile,': [50], 'also': [52, 103], 'lowered': [53], 'total': [54, 57, 60], 'bile': [55], 'acids,': [56], 'bilirubin': [58], 'cholesterol': [61], 'levels': [62], 'serum.': [64], 'Furthermore,': [65], 'protect': [68], 'HepG2': [69], 'cell': [70], 'cultures': [71], 'from': [72], 'cytotoxicity.': [74], 'RT-PCR': [75], 'Western': [77], 'Blot': [78], 'analysis': [79], 'showed': [80], 'recovered': [83], 'expression': [85], 'BSEP,': [87, 135], 'MRP2': [88, 136], 'NTCP': [90], 'were': [92], 'down-regulated': [93], 'LCA.': [95], 'Moreover,': [96], 'mRNA': [97], 'protein': [99], 'FXR': [101, 131], 'observed': [104], 'treated': [107], 'significantly': [109], 'accumulation': [110], 'nucleus.': [112], 'Taken': [113], 'together,': [114], 'be': [117], 'concluded': [118], 'exerted': [121], 'beneficial': [122], 'on': [124], 'cholestasis,': [126], 'possibly': [127], 'via': [128], 'activation': [129], 'mediated': [132], 'upregulation': [133], 'NTCP.': [138]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2772624397', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2025-01-22T15:17:54.977582', 'created_date': '2017-12-22'}