Title: Unique Properties of 1,5‐Naphthyridin‐2(1<i>H</i>)‐one Derivatives as Environment‐Polarity‐Sensitive Fluorescent Dyes
Abstract: 1,5‐Naphthyridin‐2(1 H )‐one is structural component of the fluorescent natural products amarastelline A and nigakinone. Herein, we synthesized several 1,5‐naphthyridin‐2(1 H )‐one derivatives and evaluated their fluorescence properties to examine their potential application as fluorescent probes. Among them, compounds that contain a 3‐hydroxyl group have unique solvent‐dependent fluorescence properties, that is, they exhibit stronger fluorescence in polar and protic solvents. The further installation of an 8‐phenyl group resulted in a shifted fluorescence in different solvents. Our results indicate that the 1,5‐naphthyridin‐2(1 H )‐one scaffold would be a valuable and useful fluorophore that displays intense fluorescence relative to known bicyclic fluorophores such as hydroxyquinoline. Our findings suggest that the 1,5‐naphthyridin‐2(1 H )‐one scaffold would be practical as an environment‐polarity‐dependent fluorophore, that is, for the development of sensors to detect structural changes in proteins and biomolecular interactions.
Publication Year: 2018
Publication Date: 2018-02-06
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
Cited By Count: 9
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot