Title: Corneal collagen crosslinking in progressive keratoconus: Changes in corneal irregularity indices and correlation with the best spectacle-corrected visual acuity
Abstract: PURPOSE: To report the mean refractive and topographic changes in progressive keratoconus
(KC) patients post corneal collagen crosslinking (CXL) to assess the progression of corneal
irregularity indices and their relationship with best spectacle-corrected visual acuity (BSCVA).
SETTING: Ocular Microsurgery Institute (IMO) of Barcelona, Spain.
METHODS: This is a retrospective uncontrolled study in eyes with progressive KC. In all 62
eyes from 48 patients, BSCVA, mean K, corneal irregularity at 3 mm and 5 mm were measured
before CXL, at six months, and then annually until the last visit. For data analysis, patients were
divided into three groups according to their mean preoperative K: group 1 included 12 patients
with mean K value less than 43.9 D, group 2 included 41 patients with mean K value between
44-47.9 D, and group 3 included 10 patients with mean K value greater than 48 D.
RESULTS: All patients showed an improvement in BSCVA from 0.13 to 0.06 (p < 0.001) and
a statistically significant decrease in maximum keratometry (Kmax) from 48.22 to 47.25 D
(p < 0.001) and minimum keratometry (Kmin) from 45.7 to 44.89 D (p < 0.001). Measurement
of corneal irregularity also showed a statistically significant decrease at 3 mm from 4.71 to 4.25
(p < 0.001) and at 5 mm from 4.87 to 4.51 (p < 0.007). No statistically significant results were
found according to study group.
CONCLUSION: The improvement in ocular surface regularity indices was statistically
significant in all patients studied, with a possible association between changes in corneal
irregularity, corneal flattening and other topographic changes and the improvement in vision
observed in KC patients undergoing CXL.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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