Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2770813746', 'doi': 'https://doi.org/10.1055/s-0036-1591836', 'title': 'The Structure Elucidation of Haprolid', 'display_name': 'The Structure Elucidation of Haprolid', 'publication_year': 2017, 'publication_date': '2017-11-24', 'ids': {'openalex': 'https://openalex.org/W2770813746', 'doi': 'https://doi.org/10.1055/s-0036-1591836', 'mag': '2770813746'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-0036-1591836', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S197964166', 'display_name': 'Synthesis', 'issn_l': '0039-7881', 'issn': ['0039-7881', '1437-210X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043530392', 'display_name': 'Markus Kalesse', 'orcid': 'https://orcid.org/0000-0003-4858-3957'}, 'institutions': [{'id': 'https://openalex.org/I114112103', 'display_name': 'Leibniz University Hannover', 'ror': 'https://ror.org/0304hq317', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114112103']}, {'id': 'https://openalex.org/I4210124929', 'display_name': 'Helmholtz Centre for Infection Research', 'ror': 'https://ror.org/03d0p2685', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I4210124929']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Markus Kalesse', 'raw_affiliation_strings': ['Helmholtz-Zentrum für Infektionsforschung (HZI)', 'Leibniz Universität Hannover, Center for Biomolecular Drug Research (BMWZ)', 'Leibniz Universität Hannover, Institute for Organic Chemistry (OCI)'], 'affiliations': [{'raw_affiliation_string': 'Leibniz Universität Hannover, Institute for Organic Chemistry (OCI)', 'institution_ids': ['https://openalex.org/I114112103']}, {'raw_affiliation_string': 'Leibniz Universität Hannover, Center for Biomolecular Drug Research (BMWZ)', 'institution_ids': ['https://openalex.org/I114112103']}, {'raw_affiliation_string': 'Helmholtz-Zentrum für Infektionsforschung (HZI)', 'institution_ids': ['https://openalex.org/I4210124929']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100361689', 'display_name': 'Jun Li', 'orcid': 'https://orcid.org/0000-0001-8243-5267'}, 'institutions': [{'id': 'https://openalex.org/I114112103', 'display_name': 'Leibniz University Hannover', 'ror': 'https://ror.org/0304hq317', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114112103']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Jun Li', 'raw_affiliation_strings': ['Leibniz Universität Hannover, Center for Biomolecular Drug Research (BMWZ)', 'Leibniz Universität Hannover, Institute for Organic Chemistry (OCI)'], 'affiliations': [{'raw_affiliation_string': 'Leibniz Universität Hannover, Institute for Organic Chemistry (OCI)', 'institution_ids': ['https://openalex.org/I114112103']}, {'raw_affiliation_string': 'Leibniz Universität Hannover, Center for Biomolecular Drug Research (BMWZ)', 'institution_ids': ['https://openalex.org/I114112103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100638188', 'display_name': 'Jun Xing', 'orcid': 'https://orcid.org/0000-0002-2771-6725'}, 'institutions': [{'id': 'https://openalex.org/I4210094118', 'display_name': 'Universitätsklinikum Tübingen', 'ror': 'https://ror.org/00pjgxh97', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094118']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Jun Xing', 'raw_affiliation_strings': ['Universitätsklinikum und Medizinische Fakultät Tübingen'], 'affiliations': [{'raw_affiliation_string': 'Universitätsklinikum und Medizinische Fakultät Tübingen', 'institution_ids': ['https://openalex.org/I4210094118']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015953059', 'display_name': 'Daniel Lücke', 'orcid': 'https://orcid.org/0000-0001-5993-8261'}, 'institutions': [{'id': 'https://openalex.org/I114112103', 'display_name': 'Leibniz University Hannover', 'ror': 'https://ror.org/0304hq317', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114112103']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Daniel Lücke', 'raw_affiliation_strings': ['Leibniz Universität Hannover, Center for Biomolecular Drug Research (BMWZ)', 'Leibniz Universität Hannover, Institute for Organic Chemistry (OCI)'], 'affiliations': [{'raw_affiliation_string': 'Leibniz Universität Hannover, Institute for Organic Chemistry (OCI)', 'institution_ids': ['https://openalex.org/I114112103']}, {'raw_affiliation_string': 'Leibniz Universität Hannover, Center for Biomolecular Drug Research (BMWZ)', 'institution_ids': ['https://openalex.org/I114112103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068540223', 'display_name': 'Dennis Lübken', 'orcid': 'https://orcid.org/0000-0001-9506-1065'}, 'institutions': [{'id': 'https://openalex.org/I114112103', 'display_name': 'Leibniz University Hannover', 'ror': 'https://ror.org/0304hq317', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114112103']}, {'id': 'https://openalex.org/I4210124929', 'display_name': 'Helmholtz Centre for Infection Research', 'ror': 'https://ror.org/03d0p2685', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I4210124929']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Dennis Lübken', 'raw_affiliation_strings': ['Helmholtz-Zentrum für Infektionsforschung (HZI)', 'Leibniz Universität Hannover, Center for Biomolecular Drug Research (BMWZ)', 'Leibniz Universität Hannover, Institute for Organic Chemistry (OCI)'], 'affiliations': [{'raw_affiliation_string': 'Leibniz Universität Hannover, Institute for Organic Chemistry (OCI)', 'institution_ids': ['https://openalex.org/I114112103']}, {'raw_affiliation_string': 'Leibniz Universität Hannover, Center for Biomolecular Drug Research (BMWZ)', 'institution_ids': ['https://openalex.org/I114112103']}, {'raw_affiliation_string': 'Helmholtz-Zentrum für Infektionsforschung (HZI)', 'institution_ids': ['https://openalex.org/I4210124929']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013457388', 'display_name': 'Lucas Millbrodt', 'orcid': 'https://orcid.org/0000-0002-2953-3586'}, 'institutions': [{'id': 'https://openalex.org/I114112103', 'display_name': 'Leibniz University Hannover', 'ror': 'https://ror.org/0304hq317', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I114112103']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Lucas Millbrodt', 'raw_affiliation_strings': ['Leibniz Universität Hannover, Center for Biomolecular Drug Research (BMWZ)', 'Leibniz Universität Hannover, Institute for Organic Chemistry (OCI)'], 'affiliations': [{'raw_affiliation_string': 'Leibniz Universität Hannover, Institute for Organic Chemistry (OCI)', 'institution_ids': ['https://openalex.org/I114112103']}, {'raw_affiliation_string': 'Leibniz Universität Hannover, Center for Biomolecular Drug Research (BMWZ)', 'institution_ids': ['https://openalex.org/I114112103']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103338850', 'display_name': 'Ruben R. Plentz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210094118', 'display_name': 'Universitätsklinikum Tübingen', 'ror': 'https://ror.org/00pjgxh97', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094118']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ruben Plentz', 'raw_affiliation_strings': ['Universitätsklinikum und Medizinische Fakultät Tübingen'], 'affiliations': [{'raw_affiliation_string': 'Universitätsklinikum und Medizinische Fakultät Tübingen', 'institution_ids': ['https://openalex.org/I4210094118']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5043530392', 'https://openalex.org/A5100361689', 'https://openalex.org/A5015953059', 'https://openalex.org/A5068540223', 'https://openalex.org/A5013457388'], 'corresponding_institution_ids': ['https://openalex.org/I114112103', 'https://openalex.org/I4210124929', 'https://openalex.org/I114112103', 'https://openalex.org/I114112103', 'https://openalex.org/I114112103', 'https://openalex.org/I4210124929', 'https://openalex.org/I114112103'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.385, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.439029, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 71, 'max': 75}, 'biblio': {'volume': '50', 'issue': '03', 'first_page': '529', 'last_page': '538'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10252', 'display_name': 'Microbial Natural Products and Biosynthesis', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10252', 'display_name': 'Microbial Natural Products and Biosynthesis', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11549', 'display_name': 'Synthetic Organic Chemistry Methods', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10835', 'display_name': 'Carbohydrate Chemistry and Synthesis', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/stereocenter', 'display_name': 'Stereocenter', 'score': 0.9425696}, {'id': 'https://openalex.org/keywords/diastereomer', 'display_name': 'Diastereomer', 'score': 0.84513474}, {'id': 'https://openalex.org/keywords/natural-product', 'display_name': 'Natural product', 'score': 0.7824241}, {'id': 'https://openalex.org/keywords/absolute-configuration', 'display_name': 'Absolute Configuration', 'score': 0.44453818}], 'concepts': [{'id': 'https://openalex.org/C134195300', 'wikidata': 'https://www.wikidata.org/wiki/Q902071', 'display_name': 'Stereocenter', 'level': 4, 'score': 0.9425696}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.9092506}, {'id': 'https://openalex.org/C138716334', 'wikidata': 'https://www.wikidata.org/wiki/Q268477', 'display_name': 'Diastereomer', 'level': 2, 'score': 0.84513474}, {'id': 'https://openalex.org/C2779396153', 'wikidata': 'https://www.wikidata.org/wiki/Q901227', 'display_name': 'Natural product', 'level': 2, 'score': 0.7824241}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.64849985}, {'id': 'https://openalex.org/C35753019', 'wikidata': 'https://www.wikidata.org/wiki/Q644785', 'display_name': 'Total synthesis', 'level': 2, 'score': 0.6273483}, {'id': 'https://openalex.org/C2778635478', 'wikidata': 'https://www.wikidata.org/wiki/Q516751', 'display_name': 'Polyketide', 'level': 4, 'score': 0.60060525}, {'id': 'https://openalex.org/C51886252', 'wikidata': 'https://www.wikidata.org/wiki/Q4118667', 'display_name': 'Olefin fiber', 'level': 3, 'score': 0.526323}, {'id': 'https://openalex.org/C25170562', 'wikidata': 'https://www.wikidata.org/wiki/Q2052053', 'display_name': 'Absolute configuration', 'level': 2, 'score': 0.44453818}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.4168569}, {'id': 'https://openalex.org/C146686406', 'wikidata': 'https://www.wikidata.org/wiki/Q898628', 'display_name': 'Enantioselective synthesis', 'level': 3, 'score': 0.18407151}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.14556992}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.12915778}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1172452}, {'id': 'https://openalex.org/C553450214', 'wikidata': 'https://www.wikidata.org/wiki/Q851162', 'display_name': 'Biosynthesis', 'level': 3, 'score': 0.09854534}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.08297494}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-0036-1591836', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S197964166', 'display_name': 'Synthesis', 'issn_l': '0039-7881', 'issn': ['0039-7881', '1437-210X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 11, 'referenced_works': ['https://openalex.org/W1970954035', 'https://openalex.org/W2023645786', 'https://openalex.org/W2052697727', 'https://openalex.org/W2077852575', 'https://openalex.org/W2092658289', 'https://openalex.org/W2104516185', 'https://openalex.org/W2132902903', 'https://openalex.org/W2137297265', 'https://openalex.org/W2145075103', 'https://openalex.org/W2465207527', 'https://openalex.org/W2558481951'], 'related_works': ['https://openalex.org/W2577783630', 'https://openalex.org/W2554097823', 'https://openalex.org/W2084913667', 'https://openalex.org/W2043022507', 'https://openalex.org/W2025954821', 'https://openalex.org/W2014150068', 'https://openalex.org/W1994227461', 'https://openalex.org/W1986013545', 'https://openalex.org/W1971590901', 'https://openalex.org/W1504302285'], 'abstract_inverted_index': {'The': [0, 38, 76], 'assignment': [1], 'of': [2, 5, 13, 26, 31, 33, 41, 51, 62, 68, 79, 86, 99, 109], 'two': [3, 32], 'stereocenters': [4, 64], 'the': [6, 11, 27, 59, 66, 80, 91, 96], 'natural': [7, 28, 45], 'product': [8, 29, 46], 'haprolid': [9], 'through': [10, 23], 'application': [12], 'a': [14, 48, 69, 83, 87], 'profile': [15], 'hidden': [16], 'Markov': [17], 'model': [18], '(HMM)': [19], 'and': [20, 30, 65, 90], 'its': [21, 34], 'confirmation': [22], 'total': [24], 'synthesis': [25, 81], 'diastereomers': [35, 105], 'are': [36, 82, 106], 'reported.': [37], 'structure': [39, 74], 'elucidation': [40], 'this': [42], 'polyketide-peptide': [43], 'hybrid': [44], 'is': [47], 'telling': [49], 'showcase': [50], 'how': [52], 'difficult': [53], 'it': [54], 'can': [55], 'be': [56], 'to': [57], 'determine': [58], 'absolute': [60], 'configuration': [61], 'isolated': [63], 'benefits': [67], 'gene': [70], 'cluster': [71], 'analysis': [72], 'for': [73], 'determination.': [75], 'key': [77], 'steps': [78], 'selective': [84], 'epoxidation': [85], 'terminal': [88], 'olefin': [89], 'stereodivergent': [92], 'macrolactonization': [93], 'strategy.': [94], 'Furthermore,': [95], 'biological': [97], 'evaluation': [98], 'all': [100, 104], 'products': [101], 'showed': [102], 'that': [103], 'potent': [107], 'inhibitors': [108], 'hepatocellular': [110], 'carcinoma': [111], 'cell': [112], 'lines.': [113]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2770813746', 'counts_by_year': [{'year': 2020, 'cited_by_count': 2}], 'updated_date': '2024-12-15T21:51:25.805028', 'created_date': '2017-12-04'}