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4365, 4395, 4410, 4454, 4464, 4500, 4581, 4606], 'cancer': [152, 251, 1015, 1042, 1150, 1178, 1185, 1207, 1332, 1464, 1795, 2823, 2989, 3019, 3050, 3194, 3300, 3310, 3521], 'treatment.': [153, 682], 'Unfortunately,': [154], 'cardiotoxicity': [155, 866, 1204, 1540, 1567, 2066, 2991, 3394, 3806], 'seems': [156], 'have': [158, 173, 249, 646, 652, 668, 858, 998, 1043], 'emerged': [159], 'an': [161, 1093, 1156, 1160, 3776], 'issue': [162], 'reports.1Stimulating': [165], 'Antitumoral': [166], 'ResponsesFor': [168], 'decades,': [169], 'immunologists': [170, 1647], 'oncologists': [172, 879], 'attempted': [174], 'stimulate': [176, 405], 'antitumor': [177, 215, 281, 432], 'immune': [178, 245, 296, 313, 322, 422, 433, 487, 533, 1171, 1246, 1518, 1602, 1638, 1892, 2199, 2232, 2351, 2405, 2548, 2610, 2747, 2936, 3397, 3495, 3773, 3808], 'responses': [179, 255, 488], 'fight': [181], 'cancer.': [182], 'Initial': [183], 'attempts': [184], 'displayed': [185], 'marginal': [186], 'success': [187], 'because': [188, 263, 886, 1210], 'several': [189, 1193], 'inhibitory': [190, 423], 'pathways': [191, 223, 270, 1607], 'cytotoxic': [194, 348, 381, 1512], 'T': [195, 218, 226, 350, 382, 729, 756, 957, 1182, 1249, 1513, 2818, 3184, 3486, 3668, 3892, 4291], 'lymphocyte–associated': [196, 383, 1514], 'protein': [197, 203, 384, 391, 1515, 1529], '4': [198, 385], '(CTLA-4),': [199], 'programmed': [200, 207, 325, 388, 1526, 1533], 'cell': [201, 208, 326, 389, 438, 740, 1527, 1534], 'death': [202, 209, 327, 390, 439, 1528, 1535], '1': [204, 211, 329, 392], '(PD-1),': [205], 'ligand': [210, 328, 1536], '(PD-L1)': [212, 330], 'dampen': [213, 395], 'the': [214, 265, 321, 353, 372, 516, 529, 536, 587, 596, 612, 629, 677, 696, 698, 702, 709, 737, 744, 766, 773, 781, 842, 846, 863, 924, 983, 987, 1058, 1096, 1115, 1118, 1142, 1147, 1202, 1260, 1268, 1349, 1381, 1446, 1475, 1550, 1554, 1581, 1609, 1626, 1671, 1732, 1736, 2017, 2195, 2242, 2505, 2676, 2836, 2841, 2852, 2892, 2897, 3205, 3215, 3229, 3234, 3641, 3648, 3729, 4138, 4180, 4224, 4334, 4455], 'functions': [216], 'lymphocytes.': [219], 'Tumors': [220], 'exploit': [221], 'these': [222, 717, 784, 800, 918, 1061, 1090, 1211, 1629], 'escape': [225, 312], 'cell–mediated': [227, 757, 958], 'tumor-specific': [228], 'immunity.': [229], 'Monoclonal': [230, 408], 'antibodies': [231, 409, 1168, 1244], 'targeting': [232, 410, 1169, 1245], 'CTLA-4': [233, 411, 905, 951, 1336], '(ipilimumab),': [234, 412], 'PD-1': [235, 413, 907, 970, 1334, 1572, 1929, 3045], '(nivolumab': [236, 814], 'pembrolizumab),': [238, 415], 'PD-L1': [240, 417, 463, 719, 735, 748, 972, 1420, 1574, 1585, 3047], '(atezolizumab,': [241, 418], 'avelumab,': [242, 419], 'durvalumab),': [243], 'called': [244, 1291], 'checkpoint': [246, 307, 317, 323, 456, 481, 1519, 1596, 1893, 2200, 2233, 2352, 2406, 2549, 2611, 2748, 2937, 3398, 3496, 3774, 3809], 'inhibitors': [247, 404, 457, 2268, 2612, 3048], '(ICIs),': [248], 'revolutionized': [250], 'treatments.': [252], 'However,': [253], 'dramatic': [254], 'are': [256, 286, 337, 561, 1019, 1029, 1133, 1137, 1189, 1213, 1256, 1377, 1421, 1494, 1727, 2269], 'currently': [257], 'confined': [258], 'few': [260], 'patients,': [261, 291], 'presumably': [262], 'complex': [266, 358], 'network': [267, 3057], 'immunosuppressive': [269, 615], 'tumor': [272, 400, 437, 446, 618], 'microenvironments.': [273], 'Combined': [274], 'anti–CTLA-4': [275], 'anti–PD-1': [277, 1105], 'blockade': [278, 482, 542], 'further': [279, 1624], 'enhances': [280], 'activity': [282], '(Figure,': [283, 731, 1612], 'A).': [284], 'ICIs': [285, 645, 868, 899, 1018, 1295, 1358, 1387, 1467, 1543], 'being': [287], 'tested': [288], 'HIV-infected': [290], 'characterized': [292], 'overexpression': [294], 'checkpoints': [297, 394, 424, 534, 1172, 1247], 'T-cell': [299, 362, 365, 396, 406, 518, 2615], 'exhaustion.Download': [300], 'figureDownload': [301], 'PowerPointFigure.': [302], 'Mechanism': [303, 3670], 'action': [305], 'inhibitors.': [308], 'A,': [309, 1914, 1918, 1964, 1968, 2123, 2169, 2298, 2300, 2304, 2479, 2487, 2594, 2803, 2807, 2809, 2864, 2866, 2868, 2870, 3005, 3106, 3178, 3260, 3427, 3463, 3479, 3510, 3593, 3597, 3612, 3744, 3752, 3754, 3881, 3963, 3990, 3992, 3994, 4006, 4040, 4048, 4087, 4125, 4149, 4155, 4159, 4196, 4205, 4269, 4320, 4349, 4429, 4439, 4545, 4561], 'Tumor': [310], 'cells': [311, 319, 341, 344, 351, 730, 1183, 1603], 'surveillance': [314], 'promoting': [316], 'activation.Tumor': [318], 'express': [320], 'activator': [324], 'produce': [332], 'antigens': [333, 346, 511], '(blue': [334, 512], 'dots)': [335], 'that': [336, 505, 585, 713, 917, 948, 1051, 1099, 1158, 1359, 1599], 'captured': [338], 'antigen-presenting': [340], '(APCs).': [342], 'These': [343], 'present': [345], 'CD8+': [349, 728], 'through': [352, 1367], 'interaction': [354, 373], 'major': [356, 1989], 'histocompatibility': [357], '(MHC)': [359], 'molecules': [360, 444, 919], 'receptor': [363], '(TCR).': [364], 'activation': [366], 'requires': [367], 'costimulatory': [368], 'signals': [369, 379], 'mediated': [370], 'between': [374], 'B7': [375], 'CD28.': [377], 'Inhibitory': [378], 'from': [380, 1032, 1689, 1714, 2835, 3631, 3640, 3832, 4527], '(CTLA-4)': [386], '(PD-1)': [393], 'response': [397], 'promote': [399, 459], 'proliferation.': [401], 'B,': [402, 450, 2647, 2691, 2781, 3140, 3170, 3610, 3748, 3822, 3968, 4437], 'activation.': [407], '(nivolumab,': [414], 'durvalumab)': [420], 'block': [421, 712], '(CTLA-4,': [425], 'PD-1,': [426, 1525], 'PD-L1,': [428, 933, 1532], 'respectively)': [429], 'restore': [431], 'response,': [434], 'resulting': [435], 'via': [440, 2067], 'release': [441], 'cytolytic': [443], '(eg,': [445, 578, 617, 1180, 1251, 1324, 1441], 'necrosis': [447, 619], 'factor-α,': [448], 'granzyme': [449], 'interferon-γ).': [451], 'C,Hypothetical': [452], 'mechanism': [453], 'which': [455], 'can': [458, 474, 490, 509, 543, 707, 714, 909, 940, 997, 1284, 1338, 1432, 1568, 1604, 2192], 'autoimmune': [460, 492, 588, 911, 959, 1010, 1027, 1048, 1076, 1094, 1124, 1288, 1303, 1307, 1327, 1340, 1986], 'lymphocytic': [461, 493, 693], 'myocarditis.': [462, 494, 960, 1002], 'expressed': [465, 721, 1423, 1723], 'human': [467, 750, 1427, 1576, 1610, 1811], 'murine': [469, 1425, 1578], 'cardiomyocytes,': [470], 'its': [472, 753, 888, 2574], 'expression': [473, 746, 968, 1431, 1570], 'increase': [475], 'during': [476, 1435, 1553], 'myocardial': [477, 739, 1438], 'injury.': [478], 'Combination': [479], '(ipilimumab': [483], 'plus': [484, 664, 815], 'nivolumab)': [485], 'unleashes': [486], 'cause': [491, 544, 910, 1339], 'Lymphocytes': [495], 'myocardium': [497, 1611], 'tumors': [499, 508], 'showed': [500, 966], 'clonality': [501], 'TCR,': [503], 'suggesting': [504, 845, 916, 947], 'heart': [506, 711, 2581], 'share': [510], 'dot)': [513], 'recognized': [514], 'same': [517], 'clones.Immune-Related': [519], 'Adverse': [520, 2985, 4392], 'Events': [521], 'Associated': [522, 3977, 4170], 'With': [523, 639, 3272, 3723, 3897, 4060, 4111], 'InhibitorsAs': [525], 'a': [526, 836, 869, 921, 977, 1044, 1164, 1174, 1632, 1640, 2236, 2272, 2355, 2408, 2888, 3053, 3199, 3336], 'result': [527], 'role': [530, 922], 'played': [531], 'maintenance': [537], 'self-tolerance,': [539], 'their': [540, 685, 1067, 1430], 'therapeutic': [541], 'immune-related': [545, 1522], 'adverse': [546, 1523, 2743, 2886, 3042], 'events': [547, 785, 857, 2276, 2401, 2744, 3043], '(IRAEs).': [548], 'IRAEs': [549, 560, 577, 593, 1305], 'associated': [550, 594, 1277, 1356, 1541, 1793, 2270, 2349, 2608, 2745, 3395, 3524, 3771], 'with': [551, 595, 662, 743, 789, 799, 898, 938, 995, 1014, 1017, 1026, 1034, 1040, 1069, 1074, 1081, 1101, 1110, 1218, 1278, 1301, 1357, 1390, 1463, 1466, 1497, 1542, 1591, 1595, 1794, 1890, 1981, 1991, 2271, 2279, 2350, 2461, 2609, 2663, 3079, 3308, 3396, 3772, 3838, 3978, 4171], 'ipilimumab': [552, 663, 1082, 1103], 'were': [553, 807], 'already': [554], 'evident': [555], 'phase': [557], 'I': [558, 3223, 3915, 3970, 4166], 'studies.': [559], 'common,': [562], 'usually': [563, 1030], 'reversible,': [564], 'not': [566, 1728], 'severe': [567, 632, 819, 852], 'most': [569], 'patients.1,2': [570], 'PD-1–': [571], 'PD-L1–blocking': [573], 'agents': [574, 616, 1212], 'display': [575], 'different': [576, 1170, 1386, 1482, 2577], 'renal': [579], 'endocrine': [581], 'effects': [582, 1290, 2987, 3013], 'cardiomyopathy)': [584], 'resemble': [586, 1306], 'manifestations': [589, 1308], 'PD-1–deficient': [591, 1313], 'mice.3': [592], 'ipilimumab/nivolumab': [597], 'combination': [598, 812, 1217, 1891], 'require': [599], 'discontinuation': [600], 'therapy': [602, 813, 1809, 1978], 'nearly': [604], '40%': [605], 'patients.': [607, 718], 'It': [608], 'unclear': [610], 'whether': [611, 1294, 1564], 'use': [613], 'factor-α': [620], 'inhibitors)': [621], 'more': [623, 818, 1495], 'appropriate': [624], 'than': [625, 823, 1373], 'high-dose': [626], 'glucocorticoids': [627], 'treatment': [630, 661, 937, 1100, 1132, 1143, 1352, 2934], 'IRAEs.Cardiotoxicity': [633], 'Patients': [638, 809, 2460, 3721, 3837], 'CancerThe': [640], 'majority': [641], 'studies': [643, 1561], 'on': [644, 722, 726, 736, 1021, 1248, 1409, 1586, 2016, 2204, 2576, 3202, 3518], 'underestimated': [647], 'cardiotoxicity3;': [648], 'however,': [649], 'occasional': [650], 'cases': [651, 656, 805, 1538], 'reported.': [654, 808], 'Two': [655, 3075], 'fulminant': [658, 889, 1592], 'myocarditis': [659, 758, 769, 804, 822, 885, 894, 912, 943, 1145, 1298, 1436, 1458, 1593, 1889, 2229, 3491], 'after': [660, 675, 841, 1549, 2464, 4524], 'nivolumab': [665, 827], 'melanoma': [667, 1079, 1983], 'recently': [670], 'described.3': [671], 'Both': [672], 'patients': [673, 787, 797, 896, 994, 1013, 1025, 1039, 1073, 1091, 1109, 1300, 1330, 1389, 1462, 1590, 1636, 1980, 2278, 2403, 3195, 3493], 'died': [674], 'receiving': [676, 2404, 3196, 3494], 'first': [678, 843, 1555], 'doses': [679], 'despite': [680], 'intensive': [681, 2898], 'Hypertension': [683], 'was': [684, 720, 833, 1683], 'only': [686], 'cardiovascular': [687, 856, 1196, 1325, 1403, 1410, 3191], 'risk': [688, 1411, 2398], 'factor.': [689], 'Histological': [690], 'analysis': [691, 861], 'demonstrated': [692], 'infiltrates': [694], 'within': [695], 'myocardium,': [697], 'cardiac': [699, 1275, 1354, 1401, 1449, 1478, 1506, 2020, 2196, 2275, 2320, 2400, 2986], 'sinus,': [700], 'atrioventricular': [703], 'nodes.': [704], 'This': [705], 'observation': [706], 'explain': [708], 'complete': [710], 'occur': [715], 'injured': [723, 738, 1587], 'cardiomyocytes': [724], 'infiltrating': [727], 'B).': [732], 'Overexpression': [733], 'consistent': [742], 'constitutive': [745], 'hearts': [751, 965], 'upregulation': [754], 'mice.4': [760], 'Johnson': [761, 1787, 1824, 1939, 3763], 'et': [762, 3571], 'al3': [763], 'also': [764], 'assessed': [765], 'frequency': [767], 'myositis': [771], 'safety': [774, 1382], 'databases': [775], 'Bristol-Myers': [777], 'Squibb': [778], 'identify': [780, 1500], 'occurrence': [782], 'treated': [788, 798, 897, 1016, 1080, 1465, 1594, 1637], 'nivolumab,': [790], 'ipilimumab,': [791], 'or': [792, 1000, 1083, 1104, 1370, 1552, 1734, 1749, 1778, 1988], 'both.': [793], 'Among': [794], '20': [795], '594': [796], 'ICIs,': [801, 1188, 1279, 1453, 1483, 1517, 1639], '18': [802], 'drug-related': [803], '(0.09%)': [806], 'who': [810, 825], 'received': [811, 826, 1711], 'ipilimumab)': [816], 'had': [817], 'frequent': [821, 1496], 'those': [824, 1730], 'alone': [828, 1280, 1454, 1484], '(0.27%': [829], 'versus': [830], '0.06%).3': [831], 'Myocarditis': [832, 975, 2662, 3896], 'diagnosed': [834], 'at': [835, 1742], 'median': [837], '17': [839], 'days': [840], 'treatment,': [844], 'presence': [847], 'early': [849, 1272, 1503], 'cardiotoxicity.': [850], 'Finally,': [851], 'even': [854], 'fatal': [855], 'occurred,': [859], 'making': [860], 'incidence': [864, 1270], 'priority.Moving': [870], 'Forward:': [871], 'The': [872, 891, 1716, 2397, 2456, 2617, 2672, 3781, 3811, 4327], 'Integration': [873], 'Cardio-Oncology': [875], 'ImmunologyCardiologists': [877], 'should': [880, 1562], 'be': [881, 1055, 1362, 1433], 'aware': [882], 'immune-mediated': [884], 'progression.3': [890], 'development': [892, 1191], 'biological': [901], 'plausibility.': [902], 'Deletion': [903], 'axes': [908], 'dilated': [914, 1926, 3636], 'cardiomyopathy,4': [915], 'play': [920, 952], 'prevention': [925, 1350], 'autoimmunity.': [927], 'addition,': [929], 'genetic': [930], 'deletion': [931], 'anti–PD-L1,': [939], 'transform': [941], 'transient': [942], 'into': [944, 2891], 'lethal': [945], 'disease,': [946, 1049], 'PD-1/PD-L1': [949, 1606, 2064], 'important': [953], 'roles': [954], 'limiting': [956], 'Moreover,': [961, 993], 'isolated': [962, 2545], 'ischemic-reperfused': [963], 'rat': [964], 'increased': [967, 1434], 'cardiomyocytes.': [974], 'wide': [978, 1119], 'spectrum': [979, 1120, 2273], 'presentations': [981], 'reflecting': [982], 'many': [984], 'causes': [985], 'variable': [988], 'pattern': [989], 'tissue': [991], 'involvement.': [992], 'autoimmunity': [996, 1052], 'subclinical': [999], 'subacute': [1001], 'At': [1003], 'present,': [1004, 1814], 'exclusion': [1005, 1129, 1322], 'criteria': [1006, 1130, 1323], 'related': [1007], 'preexisting': [1009, 1075, 1112, 1985], 'diseases': [1011], 'based': [1020], 'personal': [1022], 'experience,1,5': [1023], 'but': [1024, 1559, 4521], 'disorders': [1028, 1987], 'excluded': [1031], 'trials': [1033, 1369, 1376, 1398], 'ICIs.': [1035], 'Approximately': [1036], '14%': [1037], 'lung': [1041, 3018], 'concurrent': [1045], 'diagnosis': [1046], 'indicating': [1050], 'needs': [1053], 'considered': [1056], 'before': [1057], 'initiation': [1059], 'therapies.': [1062], 'Menzies': [1063, 1937], 'collaborators5': [1065], 'reported': [1066, 1544], 'experience': [1068], '2': [1070], 'groups': [1071], 'disease': [1077], 'anti–PD-1.': [1084], 'Although': [1085], '20%': [1086], '30%': [1088], 'experienced': [1092], 'flare,': [1095], 'authors': [1097, 1656, 1718], 'concluded': [1098], 'either': [1102], 'feasible': [1107], 'certain': [1111], 'autoimmunities.': [1113], 'Given': [1114], 'heterogeneity': [1116], 'severity': [1122], 'disorders,': [1125], 'specific': [1126], 'guidelines': [1127, 1140, 1320, 1347], 'needed.': [1134], 'Similarly,': [1135], 'there': [1136], 'no': [1138, 1720], 'validated': [1139], 'setting': [1148], 'immunotherapy.': [1151], 'Wang': [1152, 1781, 2041, 2045, 2214], 'collaborators1': [1154], 'proposed': [1155], 'algorithm': [1157], 'represents': [1159], 'excellent': [1161, 1677], 'basis': [1162], 'consensus': [1165], 'guideline.Newer': [1166], 'monoclonal': [1167], 'new': [1175], 'generation': [1176], 'therapies': [1179, 3016], 'engineered': [1181], 'vaccines),': [1186], 'beyond': [1187, 2825], 'under': [1190], 'tumors.': [1194], 'Therefore,': [1195], 'evaluation': [1197], 'appears': [1198, 1648], 'necessary': [1199, 1649], 'detect': [1201], 'potential': [1203], 'newer': [1206], 'immunotherapies': [1208], '(Table)': [1209], 'often': [1214], 'used': [1215, 1258, 1468], 'cardiotoxic': [1219, 3081, 3197], 'kinase': [1220], 'inhibitors.Table.': [1221], 'What': [1222, 1226], 'Known': [1224], 'Needs': [1227, 1240, 4409], 'Be': [1229, 1242], 'Done': [1230], 'About': [1231], 'Cardiotoxicity': [1232, 2348, 2607, 3271, 4359], 'CancerWhat': [1237], 'Is': [1238], 'KnownWhat': [1239], 'DoneMonoclonal': [1243], 'lymphocytes': [1250], 'anti–CTLA-4,': [1252], 'anti–PD-1,': [1253], 'anti–PD-L1)': [1255], 'increasingly': [1257], 'management': [1261, 1652], 'solid': [1263, 1391], 'hematologic': [1265, 1393], 'malignanciesTo': [1266], 'assess': [1267, 1563], 'real': [1269], 'late': [1274, 1505], 'toxicity': [1276, 1355, 1450, 1479, 1507, 1990, 2197, 3303], 'combinationICIs': [1283], 'give': [1285], 'rise': [1286], 'side': [1289], 'IRAEsTo': [1292], 'evaluate': [1293, 1380], 'exacerbate': [1296], 'subclinical/subacute': [1297], 'systemic': [1302], 'disordersSome': [1304], 'seen': [1309], 'CTLA-4–': [1311], 'animalsTo': [1314], 'construct': [1315, 1342], 'collaborative': [1316, 1343], '(cardiologists,': [1317, 1344], 'oncologists,': [1318, 1345, 1645], 'immunologists)': [1319, 1346], 'disorders)': [1328], 'undergoing': [1331], 'immunotherapyExperimental': [1333], 'deficiency': [1337], 'myocarditisTo': [1341], 'need': [1360], 'driven': [1363], 'data': [1365, 1404, 1408], 'obtained': [1366], 'clinical': [1368, 1375, 1397], 'large': [1371], 'registriesMore': [1372], '200': [1374], 'ongoing': [1378], 'efficacy': [1384], 'tumorsOngoing': [1394], 'future': [1396, 2893], 'collect': [1400], 'points': [1405], 'prospective': [1407, 1560], 'outcomes,': [1413], 'especially': [1414], 'potentially': [1416], 'high-risk': [1417], 'patientsPD-1': [1418], 'constitutively': [1422], 'myocytes,': [1428], 'ischemiaExperimental': [1439], 'research': [1440, 1620], 'gut': [1442], 'microbiota)': [1443], 'understand': [1445, 1474, 1625], 'mechanisms': [1447, 1476, 1627], 'underlying': [1448, 1477], 'combinationAutoimmune': [1457], 'rarely': [1459], 'occurs': [1460], 'single': [1470], 'agentsClinical': [1471], 'investigation': [1472], 'combination,': [1487], 'various': [1489], 'types': [1490], 'cancerCardiac': [1492], 'complications': [1493], 'combined': [1498], 'ICIsTo': [1499], 'biomarkers': [1501], 'ICIsCTLA-4': [1510], 'indicates': [1511], '4;': [1516], 'inhibitors;': [1520], 'IRAE,': [1521], 'event;': [1524], '1;': [1530], '1.All': [1537], 'so': [1545], 'far': [1546], 'occurred': [1547], 'immediately': [1548], 'infusion': [1551], 'year': [1556], 'therapy,3,5': [1558], 'late-onset': [1565], 'chronic': [1566], 'occur.Constitutive': [1569], 'myocytes': [1579, 1588], 'identification': [1583], 'inhibitors3,4': [1597], 'suggest': [1598], 'cytokines': [1600], 'upregulate': [1605], 'C).': [1613], 'Additional': [1614], 'vitro': [1616], 'vivo': [1619], 'needed': [1622], 'cardiotoxicities': [1630], '(Table).With': [1631], 'growing': [1633], 'number': [1634], 'tight': [1641], 'collaboration': [1642], 'among': [1643, 3492], 'cardiologists,': [1644], 'better': [1651], 'ICI': [1654], 'cardiotoxicity.AcknowledgmentsThe': [1655], 'thank': [1657], 'Prof.': [1658], 'Gianni': [1659], 'Marone,': [1660], 'his': [1663], 'invaluable': [1664], 'intellectual': [1665], 'suggestions,': [1666], 'Fabrizio': [1667], 'Fiorbianco': [1668], 'preparing': [1670], 'Figure,': [1672], 'Gjada': [1674], 'Criscuolo': [1675, 4193, 4374], 'secretarial': [1678], 'help.Sources': [1679], 'FundingThis': [1681], 'work': [1682], 'supported': [1684], 'part': [1686], 'grants': [1688], 'Regione': [1690], 'Campania': [1691], 'Research': [1698, 2753], 'Laboratory,': [1699], 'CRÈME': [1700], 'Project,': [1701, 1703], 'TIMING': [1702], 'II.DisclosuresDr': [1709], 'speaker': [1712], 'fees': [1713], 'Alere.': [1715], 'other': [1717, 3309], 'report': [1719, 2238], 'conflicts.FootnotesThe': [1721], 'opinions': [1722], 'this': [1725], 'article': [1726], 'necessarily': [1729], 'editors': [1733], 'American': [1737, 2618, 2673, 3730, 4629], 'Heart': [1738, 2028, 2282, 2360, 2413, 2514, 3249, 4017, 4630, 4644], 'Association.Circulation': [1739], 'available': [1741], 'http://circ.ahajournals.org.Correspondence': [1743], 'to:': [1744], 'Dipartimento': [1755], 'di': [1756, 1763], 'Scienze': [1757], 'Mediche': [1758], 'Traslazionali,': [1759], 'Universita’': [1760], 'degli': [1761], 'Studi': [1762], 'Napoli': [1764], 'II': [1766], 'Via': [1767], 'Pansini': [1768], '5,': [1769], 'Edificio': [1770], '2,': [1771], '80131': [1772], 'Napoli,': [1773], 'E-mail': [1775], '[email': [1776, 1779], 'protected]': [1777], 'protected]References1.': [1780], 'DY,': [1782], 'Okoye': [1783], 'GD,': [1784], 'Neilan': [1785, 3485], 'TG,': [1786], 'DB,': [1788, 1825, 1940], 'Moslehi': [1789, 1886, 3450, 3766], 'JJ.': [1790, 1887], 'Cardiovascular': [1791, 2142, 2854, 2944, 2968, 3012, 3020, 3302, 3347, 3370, 3375, 3528, 3653, 3769, 3920, 3929, 3950, 3956, 4116, 4142, 4366], 'toxicities': [1792, 3770], 'immunotherapies.Curr': [1796], 'Cardiol': [1797], 'Rep.': [1798], '2017;': [1799, 1994], '19:21.': [1800], 'doi:': [1801, 1821, 1900, 1934, 1996], '10.1007/s11886-017-0835-0.CrossrefMedlineGoogle': [1802], 'Scholar2.': [1803], 'Chen': [1804, 2037, 2043, 2047, 3444], 'L,': [1805, 1853, 2052, 2121, 2171, 2384, 2531, 2649, 2783, 2922, 3437, 3750, 4004, 4190, 4200, 4278, 4313, 4427, 4484], 'Han': [1806, 3027], 'X.': [1807], 'Anti-PD-1/PD-L1': [1808], 'cancer:': [1812], 'past,': [1813], 'future.J': [1816], 'Clin': [1817], 'Invest.': [1818], '2015;': [1819], '125:3384–3391.': [1820], '10.1172/JCI80011.CrossrefMedlineGoogle': [1822], 'Scholar3.': [1823], 'Balko': [1826, 3757], 'JM,': [1827, 1879], 'Compton': [1828], 'ML,': [1829], 'Chalkias': [1830], 'S,': [1831, 1916, 1942, 2180, 2596, 2722, 2728, 2801, 2874, 3112, 3126, 3166, 3325, 3384, 3417, 3431, 3453, 3455, 3471, 3853, 4042, 4123, 4202, 4273, 4309, 4317, 4423, 4435, 4441, 4443, 4592], 'Gorham': [1832], 'J,': [1833, 2799, 2876, 2918, 2926, 3030, 3094, 3100, 3104, 3138, 3146, 3152, 3174, 3286, 3323, 3435, 3451, 3477, 3622, 3742, 3756, 3758, 4425], 'Xu': [1834, 2218], 'Y,': [1835, 1908, 2038, 2040, 2042, 2217, 2337, 2447, 2773, 3144, 3859, 3871, 4077], 'Hicks': [1836], 'M,': [1837, 1912, 2125, 2167, 2256, 2302, 2370, 2427, 2429, 2491, 2641, 2724, 2775, 2779, 2789, 2795, 3068, 3132, 3148, 3162, 3262, 3413, 3423, 3433, 3439, 3449, 3459, 3473, 3481, 3599, 3604, 3663, 3690, 3746, 3760, 3794, 3887, 3996, 4079, 4085, 4198, 4267, 4431, 4475, 4478, 4482, 4588], 'Puzanov': [1838, 4165], 'I,': [1839, 2258, 2374, 2562, 2730, 2787, 3118, 4553], 'Alexander': [1840], 'MR,': [1841], 'Bloomer': [1842], 'TL,': [1843], 'Becker': [1844], 'JR,': [1845], 'Slosky': [1846], 'DA,': [1847], 'Phillips': [1848], 'EJ,': [1849], 'Pilkinton': [1850], 'MA,': [1851, 1972], 'Craig-Owens': [1852], 'Kola': [1854], 'N,': [1855, 1922, 2335, 2425, 2598, 2791, 2916, 3421, 3606, 3873, 3875, 4091, 4147], 'Plautz': [1856], 'G,': [1857, 2007, 2127, 2133, 2163, 2390, 2483, 2485, 2720, 2732, 2872, 2954, 3176, 3327, 3359, 3461, 3618, 3792, 3998, 4038, 4161, 4194, 4207, 4307, 4311, 4375, 4377, 4469, 4471, 4486, 4488, 4539, 4549, 4555, 4567, 4590], 'Reshef': [1858], 'DS,': [1859], 'Deutsch': [1860], 'JS,': [1861], 'Deering': [1862], 'RP,': [1863], 'Olenchock': [1864], 'BA,': [1865], 'Lichtman': [1866], 'AH,': [1867], 'Roden': [1868, 3761], 'DM,': [1869], 'Seidman': [1870, 1874], 'CE,': [1871], 'Koralnik': [1872], 'IJ,': [1873], 'JG,': [1875], 'Hoffman': [1876], 'RD,': [1877], 'Taube': [1878], 'Diaz': [1880], 'LA,': [1881], 'Anders': [1882], 'RA,': [1883], 'Sosman': [1884, 1961], 'JA,': [1885, 1962], 'Fulminant': [1888, 2228, 3895], 'blockade.N': [1894], 'Engl': [1895], 'J': [1896, 2054, 2223, 2602, 2928, 2983, 3264, 3767, 3824, 3827], 'Med.': [1897], '2016;': [1898], '375:1749–1755.': [1899], '10.1056/NEJMoa1609214.CrossrefMedlineGoogle': [1901], 'Scholar4.': [1902], 'Nishimura': [1903], 'H,': [1904, 1920, 2535, 3032, 3386, 3867, 3885, 4081], 'Okazaki': [1905], 'T,': [1906, 2182, 2423, 2433, 2437, 2439, 2445, 2449, 2631, 2914, 3034, 3064, 3098, 3122, 3124, 3154, 3158, 3164, 3614, 3857, 3861, 3863, 3865, 3869, 4075, 4153, 4373], 'Tanaka': [1907, 4080], 'Nakatani': [1909], 'K,': [1910, 2376, 2435, 2441, 2443, 2687, 3130, 3288, 3877, 3879, 3883, 4083, 4089, 4271], 'Hara': [1911], 'Matsumori': [1913], 'Sasayama': [1915], 'Mizoguchi': [1917], 'Hiai': [1919], 'Minato': [1921], 'Honjo': [1923], 'T.': [1924], 'Autoimmune': [1925], 'cardiomyopathy': [1927], 'receptor-deficient': [1930], 'mice.Science.': [1931], '2001;': [1932], '291:319–322.': [1933], '10.1126/science.291.5502.319.CrossrefMedlineGoogle': [1935], 'Scholar5.': [1936], 'AM,': [1938], 'Ramanujam': [1941], 'Atkinson': [1943], 'VG,': [1944], 'Wong': [1945], 'ANM,': [1946], 'Park': [1947], 'JJ,': [1948], 'McQuade': [1949], 'JL,': [1950], 'Shoushtari': [1951], 'AN,': [1952], 'Tsai': [1953], 'KK,': [1954], 'Eroglu': [1955], 'Z,': [1956, 2600, 3134], 'Klein': [1957], 'O,': [1958, 2341, 2878, 3142, 3156], 'Hassel': [1959], 'JC,': [1960], 'Guminski': [1963], 'Sullivan': [1965, 3440], 'RJ,': [1966], 'Ribas': [1967], 'Carlino': [1969], 'MS,': [1970], 'Davies': [1971], 'Sandhu': [1973, 3942], 'SK,': [1974], 'Long': [1975], 'GV.': [1976], 'Anti-PD-1': [1977], 'advanced': [1982], 'ipilimumab.Ann': [1992], 'Oncol.': [1993], '28:368–376.': [1995], '10.1093/annonc/mdw443.CrossrefMedlineGoogle': [1997], 'Scholar': [1998], 'Previous': [1999], 'Back': [2000], 'top': [2002], 'Next': [2003], 'FiguresReferencesRelatedDetailsCited': [2004], 'By': [2005], 'M': [2009, 2263, 2395, 2537, 3073, 3512, 3515, 3695, 3713, 3889, 4163, 4325], 'C': [2012, 2392, 2540, 2654, 2695, 2931, 3221, 3231, 3240, 3291, 3803, 4284, 4354, 4381, 4572], '(2021)': [2013, 2093, 2141, 2190, 2227, 2264, 2314, 2347, 2455, 2501, 2541, 2568, 2606, 2655, 3944, 3974, 4133, 4213, 4449], 'Novel': [2014, 3520, 4286], 'actors': [2015], 'stage': [2018], 'dysfunction': [2021, 2821], 'induced': [2022, 2230], 'anti-PD1': [2024], 'oncological': [2025], 'treatments,': [2026], 'European': [2027, 2281, 2357, 2412, 3246, 3649], 'Journal,': [2029, 2283, 2414], '10.1093/eurheartj/ehab584,': [2030], '43:4,': [2031], '(330-332),': [2032], 'Online': [2033, 2082, 2112, 2156, 2210, 2251, 2287, 2330, 2365, 2418, 2474, 2520, 2557, 2626, 2682, 2715, 2761, 2859, 2907, 2949, 2978, 3000, 3089, 3254, 3281, 3318, 3352, 3408, 3505, 3533, 3556, 3588, 3658, 3685, 3706, 3737, 3787, 3817, 3848, 3909, 3933], 'publication': [2034, 2083, 2113, 2157, 2211, 2252, 2288, 2331, 2366, 2419, 2475, 2521, 2558, 2627, 2683, 2716, 2762, 2860, 2908, 2950, 2979, 3001, 3090, 3255, 3282, 3319, 3353, 3409, 3506, 3534, 3557, 3589, 3659, 3686, 3707, 3738, 3788, 3818, 3849, 3910, 3934], 'date:': [2035, 2084, 2114, 2158, 2212, 2253, 2289, 2332, 2367, 2420, 2476, 2522, 2559, 2628, 2684, 2717, 2763, 2861, 2909, 2951, 2980, 3002, 3091, 3256, 3283, 3320, 3354, 3410, 3507, 3535, 3558, 3590, 3660, 3687, 3708, 3739, 3789, 3819, 3850, 3911, 3935], '31-Jan-2022.': [2036], 'Liu': [2039, 2051, 2216], 'X,': [2044, 2048, 2050], 'C,': [2046, 2087, 2135, 2176, 2184, 2221, 2308, 2380, 2388, 2495, 2529, 2635, 2643, 2766, 3110, 3136, 3168, 3363, 3429, 3445, 3465, 3560, 3616, 3711, 3938, 4010, 4543, 4565], 'Yuan': [2049], 'Yang': [2053, 2640], 'Zhou': [2056], 'X': [2057], '(2022)': [2058, 4099, 4285, 4385], 'Prevotellaceae': [2059], 'produces': [2060], 'butyrate': [2061], 'alleviate': [2063], 'inhibitor-related': [2065], 'PPARα-CYP4X1': [2068], 'axis': [2069], 'colonic': [2071], 'macrophages,': [2072], 'Journal': [2073, 2244, 2358, 2619, 2674, 3247, 3498, 3677, 3727, 3903, 4259, 4299, 4341, 4415, 4505, 4531, 4611], 'Experimental': [2075], '&': [2076, 2752, 2756, 3313], 'Cancer': [2078, 2503, 3342, 3378, 3674, 3923, 4029, 4107, 4332], '10.1186/s13046-021-02201-4,': [2080], '41:1,': [2081], '1-Dec-2022.': [2085], 'Schonewolf': [2086], 'Jolly': [2088], 'S': [2089, 2226, 2815, 3237, 3365, 3627, 3692], 'Dess': [2091], 'R': [2092, 2454, 2567, 2651, 3624, 4493], 'Particle': [2094], 'Beam': [2095], 'Therapy': [2096, 3946], 'Cardiac-Sparing': [2098], 'Radiotherapy': [2099], 'Non-Small': [2101], 'Cell': [2102, 4292, 4412], 'Lung': [2103, 3839, 4106, 4220], 'Cancer,': [2104, 3502, 3840, 4503], 'Seminars': [2105], 'Radiation': [2107], 'Oncology,': [2108, 3783, 3813, 3845, 4185, 4465], '10.1016/j.semradonc.2020.11.005,': [2109], '31:2,': [2110], '(112-119),': [2111], '1-Apr-2021.': [2115], 'Pirozzi': [2116, 2164, 2293, 2499, 4558], 'F,': [2117, 2165, 2178, 2215, 2294, 2386, 2481, 2493, 2533, 2645, 2726, 3116, 3172, 3469, 4046, 4379, 4559, 4586], 'Poto': [2118, 2160, 2295, 4043, 4191, 4370], 'R,': [2119, 2161, 2173, 2296, 2431, 2633, 2689, 2771, 2813, 3066, 3096, 3128, 3180, 3419, 3441, 3443, 3855, 3965, 4000, 4044, 4093, 4127, 4192, 4276, 4371, 4547], 'Aran': [2120, 4003], 'Cuomo': [2122, 2168, 2297, 2478, 3989], 'Spadaro': [2126, 4052, 4208, 4247, 4593], 'Abete': [2128], 'P,': [2129, 2378, 2637, 2768, 2811, 2920, 3102, 3150, 3182, 3457, 4151, 4315, 4433, 4541, 4557, 4563], 'Bonaduce': [2130, 3797], 'D,': [2131, 2372, 2525, 2527, 2590, 2639, 2777, 2785, 2912, 2924, 3028, 3108, 3415, 3425, 3447, 3475, 3601, 3608, 3762, 3798, 4002, 4121, 4480], 'Marone': [2132, 2162, 2955, 3799, 4049, 4206, 4249, 4310, 4376, 4404, 4487, 4515, 4548, 4596], 'G': [2137, 2189, 2260, 2310, 2343, 2346, 2956, 3563, 3566, 3716, 3800, 4012, 4050, 4053, 4209, 4212, 4384, 4490, 4513, 4516, 4594, 4597], 'Mercurio': [2139, 2185, 2312, 2496, 3466, 3795, 4014, 4550], 'V': [2140, 2186, 2313, 2497, 2883, 3332, 4015], 'Inhibitors:': [2147, 3981, 4174], 'Risk': [2149, 3921], 'Factors,': [2150, 4230], 'Current': [2151, 2513, 3346, 3701, 3841, 3925], 'Oncology': [2152, 3702], 'Reports,': [2153, 2248, 2516, 3349, 3703], '10.1007/s11912-020-01002-w,': [2154], '23:2,': [2155], '1-Feb-2021.': [2159, 2477], 'Formisano': [2170], 'Bianco': [2172, 3596], 'Della': [2174], 'Corte': [2175], 'Morgillo': [2177], 'Napolitano': [2179], 'Troiani': [2181, 4372], 'How': [2191], 'we': [2193], 'manage': [2194], 'inhibitors?,': [2201], 'Expert': [2202], 'Opinion': [2203], 'Drug': [2205], 'Safety,': [2206], '10.1080/14740338.2021.1906860,': [2207], '20:6,': [2208, 3705, 3932], '(685-694),': [2209], '3-Jun-2021.': [2213], 'W,': [2219, 2793, 3160, 3961], 'Zhang': [2220], 'Lv': [2222], 'Ma': [2225, 3033], 'inhibitor': [2234, 2353, 2550], 'nivolumab:': [2235], 'case': [2237], 'review': [2240, 3055], 'literature,': [2243], 'Case': [2247, 2667, 4175, 4182], '10.1186/s13256-021-02934-y,': [2249], '15:1,': [2250], '1-Dec-2021.': [2254, 2629], 'D’Souza': [2255, 2369], 'Svane': [2257, 2373], 'Gislason': [2259, 2389], 'Schou': [2262, 2394], 'check': [2266], 'point': [2267], 'cancer,': [2280], '10.1093/eurheartj/ehab066,': [2284], '42:16,': [2285, 2416], '(1636-1636),': [2286], '21-Apr-2021.': [2290, 2421], 'Attanasio': [2291, 2488, 4007], 'U,': [2292, 2489, 4008], 'Carannante': [2299, 2486, 4005], 'Russo': [2301, 2774, 3367, 3995], 'Ghigo': [2303, 2802, 4544], 'Hirsch': [2305, 2804], 'E,': [2306, 2339, 2382, 2592, 2693, 2805, 3120, 3357, 3595, 4157], 'Oxidative': [2315], 'stress': [2316], 'anticancer': [2318, 2830, 3077], 'therapies-related': [2319], 'dysfunction,': [2321], 'Radical': [2323], 'Biology': [2324, 2850], 'Medicine,': [2326, 2470, 2622, 3059, 3404, 3529, 3930, 3957, 4117, 4143, 4367], '10.1016/j.freeradbiomed.2021.04.021,': [2327], '169,': [2328], '(410-415),': [2329], '1-Jun-2021.': [2333], 'Rubio‐Infante': [2334], 'Ramírez‐Flores': [2336], 'Castillo': [2338], 'Lozano': [2340], 'García‐Rivas': [2342], 'Torre‐Amione': [2345], 'therapy:': [2354], 'meta‐analysis,': [2356], 'Failure,': [2361, 3250], '10.1002/ejhf.2289,': [2362], '23:10,': [2363], '(1739-1747),': [2364], '1-Oct-2021.': [2368, 2685], 'Nielsen': [2371], 'Iversen': [2375], 'Rasmussen': [2377], 'Madelaire': [2379], 'Fosbøl': [2381], 'Køber': [2383], 'Gustafsson': [2385], 'Andersson': [2387], 'Torp-Pedersen': [2391], '(2020)': [2396, 2699, 2738, 2819, 2884, 2932, 2960, 2984, 3011, 3040, 3074, 3188, 3268, 4355, 4517], 'inhibitors:': [2407, 3775], 'nationwide': [2409], 'Danish': [2410], 'study,': [2411, 3780], '10.1093/eurheartj/ehaa884,': [2415], '(1621-1631),': [2417], 'Tsuruda': [2422, 4074], 'Yoshikawa': [2424, 4090], 'Kai': [2426], 'Yamaguchi': [2428, 3852], 'Toida': [2430], 'Kodama': [2432], 'Kajihara': [2434], 'Kawabata': [2436], 'Nakamura': [2438, 4279], 'Sakata': [2440], 'Hatakeyama': [2442, 4082], 'Gi': [2444], 'Asada': [2446, 4094], 'Tono': [2448], 'Kitamura': [2450], 'K': [2451, 3388, 3483, 3665, 4098, 4280], 'Ikeda': [2453, 4092], 'Cytokine': [2457], 'Expression': [2458, 4065, 4101], 'Cardiac': [2462, 2820, 2961, 3041, 3334, 3344, 3718, 3975, 4031, 4103, 4168, 4255, 4452], 'Complication': [2463], 'Inhibitor': [2467, 2661, 3900], 'Therapy,': [2468, 3379], 'Internal': [2469], '10.2169/internalmedicine.5317-20,': [2471], '60:3,': [2472], '(423-429),': [2473], 'Paudice': [2480], 'D’Angelo': [2482], 'Perrotta': [2484], 'Iengo': [2490], 'Fiore': [2492], 'F': [2500, 3208, 3267], 'New-Onset': [2502], 'HF': [2506], 'Population:': [2507], 'Epidemiology,': [2508], 'Pathophysiology,': [2509], 'Management,': [2512, 3577], 'Failure': [2515, 4018, 4032], '10.1007/s11897-021-00517-y,': [2517], '18:4,': [2518], '(191-199),': [2519], '1-Aug-2021.': [2523, 2560], 'Delombaerde': [2524], 'Vervloet': [2526], 'Franssen': [2528], 'Croes': [2530], 'Gremonprez': [2532], 'Prenen': [2534], 'Peeters': [2536], 'Vulsteke': [2539], 'implications': [2543, 3305], 'troponinemia': [2546], 'following': [2547], 'therapy,': [2551, 2616, 2943], 'ESMO': [2552], 'Open,': [2553], '10.1016/j.esmoop.2021.100216,': [2554], '6:4,': [2555], '(100216),': [2556], 'Dobrokhotov': [2561], 'Veselova': [2563], 'O': [2564], 'Lyubimov': [2566], 'Cardioprotective': [2569], 'effect': [2570], 'galanin': [2572], 'analogues': [2575], 'experimental': [2578], 'models': [2579], 'damage,': [2582], 'Kardiologicheskii': [2583], 'vestnik,': [2584], '10.17116/Cardiobulletin20211604111,': [2585], '16:4,': [2586], '(11),': [2587], '.': [2588, 3382], 'Lipe': [2589], 'Rajha': [2591], 'Wechsler': [2593], 'Gaeta': [2595], 'Palaskas': [2597, 2915], 'Alhajji': [2599], 'Viets-Upchurch': [2601], 'Chaftari': [2604], 'P': [2605, 2734, 2959, 4569], 'CAR': [2614], 'Emergency': [2621], '10.1016/j.ajem.2021.07.014,': [2623], '50,': [2624], '(51-58),': [2625], 'Barry': [2630], 'Gallen': [2632], 'Freeman': [2634], 'Agasthi': [2636], 'Pedrotty': [2638], 'Jokerst': [2642], 'Mookadam': [2644], 'Hardaway': [2646], 'LeMond': [2648], 'Arsanjani': [2650], 'Larsen': [2653], 'Successful': [2656], 'Treatment': [2657, 3829, 3842, 3926], 'Steroid-Refractory': [2659], 'Globulin': [2664], 'Derived-Therapy:': [2665], 'A': [2666, 2698, 2737, 3187, 3210, 3218, 3294, 3368, 3973, 3982, 4129, 4132, 4322, 4448, 4577], 'Report': [2668], 'Literature': [2670], 'Review,': [2671, 3984, 4033], '10.1016/j.amjms.2021.04.018,': [2679], '362:4,': [2680], '(424-432),': [2681], 'Kumar': [2686], 'Przybylowicz': [2688], 'Nazer': [2690], 'Stecker': [2692], 'Henrikson': [2694], 'Masri': [2697], 'Sinus': [2700], 'Arrest': [2701], 'Cardiogenic': [2703], 'Shock': [2704], 'Precipitated': [2705], 'Inhibitors,': [2709, 3726], 'JACC:': [2710], 'CardioOncology,': [2711], '10.1016/j.jaccao.2020.10.012,': [2712], '2:5,': [2713], '(810-814),': [2714], '1-Dec-2020.': [2718, 2910, 3092], 'Elia': [2719], 'Ferrari': [2721, 4316], 'Ragusa': [2725], 'Paparo': [2727], 'Ruffilli': [2729], 'Fallahi': [2733, 4314], 'Antonelli': [2736, 4321], 'New': [2739, 4025], 'insight': [2740], 'endocrine-related': [2742], 'blockade,': [2749], 'Best': [2750], 'Practice': [2751], 'Endocrinology': [2755], 'Metabolism,': [2757], '10.1016/j.beem.2019.101370,': [2758], '34:1,': [2759], '(101370),': [2760], '1-Jan-2020.': [2764], 'Ameri': [2767, 4540], 'de': [2769, 4203, 4318, 4401], 'Boer': [2770, 3127], 'D’Alessandra': [2772], 'Sorriento': [2776], 'Ciccarelli': [2778, 3598], 'Kiss': [2780], 'Bertrand': [2782], 'Dawson': [2784, 3600], 'Falcao-Pires': [2786], 'Giacca': [2788], 'Hamdani': [2790, 3605], 'Linke': [2792], 'Mayr': [2794], 'van': [2796], 'der': [2797, 3620], 'Velden': [2798, 3621], 'Zacchigna': [2800], 'Lyon': [2806, 3186, 3462], 'Görbe': [2808], 'Ferdinandy': [2810], 'Madonna': [2812, 4546], 'Heymans': [2814, 3165, 3626], 'Thum': [2817, 3163, 3613], 'patients:': [2824], 'direct': [2826], 'cardiomyocyte': [2827], 'damage': [2828], 'drugs:': [2831], 'novel': [2832, 3076], 'cardio-oncology': [2833], 'insights': [2834], 'joint': [2837], '2019': [2838], 'meeting': [2839], 'ESC': [2842, 3243], 'Working': [2843, 3642], 'Groups': [2844], 'Myocardial': [2846, 3645], 'Function': [2847, 3646], 'Cellular': [2849, 4070], 'Heart,': [2853, 4139], '10.1093/cvr/cvaa222,': [2856], '116:11,': [2857], '(1820-1834),': [2858], '1-Sep-2020.': [2862, 3257], 'Joseph': [2863], 'Simonaggio': [2865], 'Stoclin': [2867], 'Vieillard-Baron': [2869], 'Geri': [2871], 'Oudard': [2873], 'Michot': [2875], 'Lambotte': [2877], 'Azoulay': [2879], 'E': [2880, 3216, 3235, 3329, 3538, 3541], 'Lemiale': [2882], 'Immune-related': [2885], 'events:': [2887], 'retrospective': [2889], 'look': [2890], 'oncology': [2895], 'care': [2899], 'unit,': [2900], 'Annals': [2901], 'Intensive': [2903], 'Care,': [2904], '10.1186/s13613-020-00761-w,': [2905], '10:1,': [2906, 4233], 'Balanescu': [2911], 'Donisan': [2913], 'Lopez-Mattei': [2917], 'Kim': [2919], 'Buja': [2921], 'McNamara': [2923], 'Kobashigawa': [2925], 'Durand': [2927], 'Iliescu': [2930], 'Immunomodulatory': [2933], 'inhibitor-induced': [2938], 'myocarditis:': [2939], 'Pathway': [2940], 'toward': [2941], 'precision-based': [2942], 'Pathology,': [2945], '10.1016/j.carpath.2020.107211,': [2946], '47,': [2947], '(107211),': [2948], '1-Jul-2020.': [2952], 'Kovanen': [2958], 'Mast': [2962, 4058, 4221, 4256, 4411, 4495, 4518], 'Cells:': [2963, 4519], 'Underappreciated': [2964], 'Cells': [2966, 4059, 4222], 'Homeostasis': [2969], 'Disease,': [2971, 4609], 'Trends': [2972, 3526], 'Immunology,': [2974, 4396], '10.1016/j.it.2020.06.006,': [2975], '41:8,': [2976], '(734-746),': [2977], '1-Aug-2020.': [2981, 3003], 'Herrmann': [2982], 'therapies:': [2990, 3198], 'arrhythmia,': [2993], 'Nature': [2994], 'Reviews': [2995], 'Cardiology,': [2996, 3652, 3733, 3905], '10.1038/s41569-020-0348-1,': [2997], '17:8,': [2998], '(474-502),': [2999], 'Toffart': [3004], 'Pluchart': [3006], 'H': [3007, 3206, 3940, 3943], 'Girard': [3009], 'N': [3010], 'innovative': [3015], 'Complications': [3021, 3376, 3831], 'Respiratory': [3023], 'Disorders,': [3024], '10.1183/2312508X.10028019,': [3025], '(154-166)': [3026], 'Dong': [3029], 'Li': [3031], 'Yu': [3035], 'W': [3036], 'Song': [3038], 'L': [3039, 3391, 4351, 4445], 'protocol': [3051], 'systematic': [3054], 'meta-analysis,': [3058], '10.1097/MD.0000000000018701,': [3060], '99:5,': [3061], '(e18701)': [3062], 'Afsharirad': [3063], 'Tahmasvand': [3065], 'Amini': [3067], 'Daraei': [3069], 'B': [3070], 'Salimi': [3072], 'compounds': [3078], 'minimum': [3080], 'property,': [3082], 'BMC': [3083], 'Pharmacology': [3084, 3312], 'Toxicology,': [3086], '10.1186/s40360-020-00457-8,': [3087], '21:1,': [3088], 'Čelutkienė': [3093], 'Pudil': [3095], 'López‐Fernández': [3097], 'Grapsa': [3099], 'Nihoyannopoulos': [3101], 'Bergler‐Klein': [3103], 'Cohen‐Solal': [3105], 'Farmakis': [3107], 'Haehling': [3111], 'Barberis': [3113], 'V,': [3114, 3361, 3467, 3796, 4473, 4551], 'Flachskampf': [3115], 'Čeponienė': [3117], 'Haegler‐Laube': [3119], 'Suter': [3121], 'Lapinskas': [3123], 'Prasad': [3125], 'Wechalekar': [3129], 'Anker': [3131], 'Iakobishvili': [3133, 3917], 'Bucciarelli‐Ducci': [3135], 'Schulz‐Menger': [3137], 'Cosyns': [3139], 'Gaemperli': [3141], 'Belenkov': [3143], 'Hulot': [3145], 'Galderisi': [3147], 'Lancellotti': [3149], 'Bax': [3151], 'Marwick': [3153], 'Chioncel': [3155], 'Jaarsma': [3157], 'Mullens': [3159], 'Piepoli': [3161], 'Mueller': [3167], 'Moura': [3169], 'Ruschitzka': [3171], 'Zamorano': [3173], 'Rosano': [3175], 'Coats': [3177], 'Asteggiano': [3179], 'Seferovic': [3181], 'Edvardsen': [3183], 'Role': [3189, 4450], 'imaging': [3192], 'position': [3200], 'statement': [3201], 'behalf': [3203], 'eart': [3207], 'ailure': [3209], 'ssociation': [3211, 3219], '(': [3212, 3225, 3242], 'HFA': [3213], '),': [3214], 'uropean': [3217, 3236], 'ardiovascular': [3222], 'maging': [3224], 'EACVI': [3226], ')': [3227, 3244], 'Cardio‐Oncology': [3230], 'ouncil': [3232], 'ociety': [3238], 'ardiology': [3241], '10.1002/ejhf.1957,': [3251], '22:9,': [3252], '(1504-1524),': [3253], 'Stella': [3258], 'Stoter': [3259], 'Hirt': [3261], 'Stenzig': [3263], 'Weinberger': [3266], 'Assessment': [3269], 'Stem': [3273], 'Cell-based': [3274], 'Strategies,': [3275], 'Therapeutics,': [3277, 3314], '10.1016/j.clinthera.2020.08.012,': [3278], '42:10,': [3279], '(1892-1910),': [3280], '1-Oct-2020.': [3284], 'Gill': [3285], 'Rockley': [3287], 'De': [3289, 3561, 3602, 4282, 4476], 'Santis': [3290], 'Mohamed': [3293], '(2019)': [3295, 3333, 3369, 3392, 3487, 3516, 4016, 4054, 4167, 4250, 4326, 4407, 4494, 4598], 'Vascular': [3296, 3552], 'Disrupting': [3297], 'Agents': [3298], 'treatment:': [3301], 'co-administration': [3307], 'chemotherapeutics,': [3311], '10.1016/j.pharmthera.2019.06.001,': [3315], '202,': [3316], '(18-31),': [3317], '1-Oct-2019.': [3321], 'Haslbauer': [3322], 'Lindner': [3324], 'Bug': [3326], 'Nagel': [3328], 'Puntmann': [3331], 'MRI:': [3335], 'Promising': [3337], 'Diagnostic': [3338], 'Tool': [3339], 'Detect': [3341], 'Therapeutics–Related': [3343], 'Dysfunction,': [3345], 'Imaging': [3348, 4453], '10.1007/s12410-019-9489-1,': [3350], '12:5,': [3351], '1-May-2019.': [3355], 'Bronte': [3356], 'Novo': [3358, 4554], 'Bazan': [3360], 'Rolfo': [3362], 'Gori': [3364], 'Damage': [3371], 'Trials': [3374], '10.1007/978-3-319-93402-0_20,': [3380], '(205-217),': [3381], 'Upadhrasta': [3383], 'Elias': [3385], 'Patel': [3387], 'Zheng': [3390], 'Managing': [3393], 'inhibitors,': [3399, 3497, 3810], 'Chronic': [3400], 'Diseases': [3401], '10.1016/j.cdtm.2019.02.004,': [3405], '5:1,': [3406], '(6-14),': [3407], '1-Mar-2019.': [3411], 'Awadalla': [3412], 'Golden': [3414], 'Mahmood': [3416], 'Alvi': [3418], 'Mercaldo': [3420], 'Hassan': [3422], 'Banerji': [3424], 'Rokicki': [3426], 'Mulligan': [3428], 'Murphy': [3430], 'Jones-O’Connor': [3432], 'Cohen': [3434, 4447], 'Heinzerling': [3436], 'Armanious': [3438, 3511, 3689], 'Damrongwatanasuk': [3442], 'Gupta': [3446], 'Kirchberger': [3448], 'Shah': [3452], 'Ganatra': [3454], 'Thavendiranathan': [3456], 'Rizvi': [3458], 'Sahni': [3460], 'Thuny': [3468], 'Ederhy': [3470, 4422], 'Mahmoudi': [3472], 'Lawrence': [3474], 'Groarke': [3476], 'Nohria': [3478], 'Fradley': [3480, 3514, 3694], 'Reynolds': [3482], 'Influenza': [3488], 'vaccination': [3489], 'ImmunoTherapy': [3500], '10.1186/s40425-019-0535-y,': [3503], '7:1,': [3504], '1-Dec-2019.': [3508], 'Guha': [3509], 'Update': [3517], 'cardio-oncology:': [3519], 'therapeutics': [3522], 'cardiotoxicities,': [3525], '10.1016/j.tcm.2018.06.001,': [3530], '29:1,': [3531], '(29-39),': [3532], '1-Jan-2019.': [3536], 'Rouwet': [3537], 'Lutgens': [3540], '(2018)': [3542, 3567, 3628, 3669, 3696, 3717, 3768, 3804, 3828, 3893, 3919, 4573], '2016': [3543], 'Jeffrey': [3544], 'M.': [3545], 'Hoeg': [3546], 'Award': [3547], 'Lecture,': [3548], 'Arteriosclerosis,': [3549], 'Thrombosis,': [3550, 3681], 'Biology,': [3553, 4413], '38:8,': [3554], '(1678-1688),': [3555], '1-Aug-2018.Campochiaro': [3559], 'Luca': [3562], 'Cavalli': [3565], 'Letter': [3568], 'Campochiaro': [3570], 'al': [3572], 'Regarding': [3573], 'Article,': [3574], '“Clinical': [3575], 'Features,': [3576], 'Outcomes': [3579], 'Inhibitor–Related': [3583], 'Cardiotoxicity”,': [3584], 'Circulation,': [3585], '137:22,': [3586], '(2421-2422),': [3587], '29-May-2018.': [3591], 'Bondue': [3592], 'Arbustini': [3594], 'Rosa': [3603], 'Hilfiker-Kleiner': [3607], 'Meder': [3609], 'Leite-Moreira': [3611], 'Van': [3619], 'Walsh': [3623], 'Complex': [3629], 'roads': [3630], 'genotype': [3632], 'phenotype': [3634], 'cardiomyopathy:': [3637], 'scientific': [3638], 'update': [3639], 'Group': [3643], 'Society': [3650], '10.1093/cvr/cvy122,': [3655], '114:10,': [3656], '(1287-1303),': [3657], '1-Aug-2018.': [3661], 'Mukai': [3662], 'Komori': [3664], 'Oka': [3667], 'Management': [3672], 'Chemotherapy-Induced': [3675], 'Atherosclerosis,': [3676], 'Atherosclerosis': [3679], '10.5551/jat.RV17027,': [3682], '25:10,': [3683], '(994-1002),': [3684], '1-Oct-2018.': [3688], 'Mishra': [3691], 'Electrophysiologic': [3697], 'Chemoradiation,': [3700], '10.1007/s11912-018-0691-0,': [3704], '1-Jun-2018.': [3709, 3912, 3936], 'Treated': [3722], 'College': [3731], '10.1016/j.jacc.2018.02.038,': [3734], '71:16,': [3735], '(1765-1767),': [3736], '1-Apr-2018.': [3740], 'Salem': [3741, 4424], 'Manouchehri': [3743], 'Moey': [3745], 'Lebrun-Vignes': [3747], 'Bastarache': [3749], 'Pariente': [3751], 'Gobert': [3753], 'Spano': [3755], 'Bonaca': [3759], 'D': [3764], 'observational,': [3777], 'retrospective,': [3778], 'pharmacovigilance': [3779], 'Lancet': [3782, 3812], '10.1016/S1470-2045(18)30608-9,': [3784], '19:12,': [3785, 3815], '(1579-1589),': [3786], '1-Dec-2018.': [3790, 3820], 'Pharmacovigilating': [3805], '10.1016/S1470-2045(18)30622-3,': [3814], '(1545-1546),': [3816], 'Wills': [3821], 'Brahmer': [3823], 'Naidoo': [3826], 'Inhibition': [3835], 'Options': [3843, 3927], '10.1007/s11864-018-0562-9,': [3846], '19:9,': [3847], '1-Sep-2018.': [3851], 'Morimoto': [3854], 'Okumura': [3856], 'Yamashita': [3858], 'Haga': [3860], 'Kuwayama': [3862], 'Yokoi': [3864], 'Hiraiwa': [3866], 'Kondo': [3868], 'Sugiura': [3870], 'Watanabe': [3872], 'Kano': [3874], 'Kohno': [3876], 'Fukaya': [3878], 'Sawamura': [3880], 'Yokota': [3882], 'Ishii': [3884], 'Nakaguro': [3886], 'Akiyama': [3888], 'Murohara': [3891], 'Late-Onset': [3894], 'Nivolumab,': [3901], 'Canadian': [3902], '10.1016/j.cjca.2018.03.007,': [3906], '34:6,': [3907], '(812.e1-812.e3),': [3908], 'Agmon': [3913], 'Nardi': [3914], 'Z': [3918], 'Survivors,': [3924], '10.1007/s11936-018-0645-8,': [3931], 'Lozahic': [3937], 'Maddock': [3939], 'Anti-cancer': [3945], 'Leads': [3947], 'Increased': [3949], 'Susceptibility': [3951], 'COVID-19,': [3953], 'Frontiers': [3954, 4068, 4114, 4140, 4364, 4394, 4463, 4580], '10.3389/fcvm.2021.634291,': [3958], '8': [3959, 4145], 'Shalata': [3960], 'Abu-salman': [3962], 'Steckbeck': [3964], 'Mathew': [3966], 'Jacob': [3967], 'Massalha': [3969], 'Yakobson': [3972], 'Systematic': [3983], 'Cancers,': [3985], '10.3390/cancers13205218,': [3986], '13:20,': [3987], '(5218)': [3988], 'Rodolico': [3991], 'Galdieri': [3993], 'Campi': [3997], 'Franco': [3999], 'Bruno': [4001], 'Cancer:': [4020], 'Mechanisms': [4021], 'Old': [4023], 'Cardiotoxic': [4026], 'Drugs': [4027], 'Patients,': [4030], '10.15420/cfr.2018.32.2,': [4034], '5:2,': [4035], '(112-118)': [4036], 'Pecoraro': [4039, 4241, 4560], 'Loffredo': [4041, 4201, 4237, 4308, 4591], 'Rivellese': [4045, 4243], 'Genovese': [4047, 4245], 'Heterogeneity': [4055], 'Human': [4057, 4219, 4254, 4501], 'Respect': [4061], 'MRGPRX2': [4063], 'Receptor': [4064], 'Function,': [4067], 'Neuroscience,': [4071], '10.3389/fncel.2019.00299,': [4072], '13': [4073, 4398], 'Sato': [4076], 'Tomita': [4078], 'Otsu': [4084], 'Kawano': [4086], 'Nagatomo': [4088], 'Y': [4095], 'Kaikita': [4097], 'Aberrant': [4100], 'Troponin-T': [4104], 'Tissues': [4108], 'Association': [4110], 'Pathological': [4112], 'Severity,': [4113], '10.3389/fcvm.2022.833649,': [4118], '9': [4119, 4584], 'Mocan-Hognogi': [4120, 4126], 'Trancǎ': [4122], 'Farcaş': [4124], 'Pârvu': [4128], 'Bojan': [4131], '10.3389/fcvm.2021.726426,': [4144], 'Agrawal': [4146], 'Khunger': [4148], 'Vachhani': [4150], 'Colvin': [4152], 'Hattoum': [4154], 'Spangenthal': [4156], 'Curtis': [4158], 'Dy': [4160], 'Ernstoff': [4162], 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