Publication Information

{'id': 'https://openalex.org/W2769496568', 'doi': 'https://doi.org/10.1111/bjh.15039', 'title': 'Aggressive lymphomas of the elderly: the <scp>DEVEC</scp> metronomic chemotherapy schedule fits the unfit', 'display_name': 'Aggressive lymphomas of the elderly: the <scp>DEVEC</scp> metronomic chemotherapy schedule fits the unfit', 'publication_year': 2017, 'publication_date': '2017-11-28', 'ids': {'openalex': 'https://openalex.org/W2769496568', 'doi': 'https://doi.org/10.1111/bjh.15039', 'mag': '2769496568', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/29193017'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/bjh.15039', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15039', 'source': {'id': 'https://openalex.org/S153015021', 'display_name': 'British Journal of Haematology', 'issn_l': '0007-1048', 'issn': ['0007-1048', '1365-2141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15039', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5070384560', 'display_name': 'Maria Christina Cox', 'orcid': 'https://orcid.org/0000-0002-8597-8459'}, 'institutions': [{'id': 'https://openalex.org/I4210125574', 'display_name': "Azienda Ospedaliera Sant'Andrea", 'ror': 'https://ror.org/032298f51', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210125574']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Maria Christina Cox', 'raw_affiliation_strings': ["Haematology unit, AOU Sant'Andrea, Rome, Italy"], 'affiliations': [{'raw_affiliation_string': "Haematology unit, AOU Sant'Andrea, Rome, Italy", 'institution_ids': ['https://openalex.org/I4210125574']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082964368', 'display_name': 'Gerardo Musuraca', 'orcid': 'https://orcid.org/0000-0003-1947-1032'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gerardo Musuraca', 'raw_affiliation_strings': ['Haematology unit IRCCS – Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Meldola Italy'], 'affiliations': [{'raw_affiliation_string': 'Haematology unit IRCCS – Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Meldola Italy', 'institution_ids': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019407435', 'display_name': 'Roberta Battistini', 'orcid': 'https://orcid.org/0000-0002-1470-3941'}, 'institutions': [{'id': 'https://openalex.org/I4210153088', 'display_name': 'Carlo Forlanini Hospital', 'ror': 'https://ror.org/04z5vy146', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153088']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Roberta Battistini', 'raw_affiliation_strings': ['Haematology unit, AO San Camillo Forlanini, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Haematology unit, AO San Camillo Forlanini, Rome, Italy', 'institution_ids': ['https://openalex.org/I4210153088']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078865689', 'display_name': 'Ivana Casaroli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210110840', 'display_name': 'Azienda Ospedaliera San Gerardo', 'ror': 'https://ror.org/01xf83457', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210110840']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Ivana Casaroli', 'raw_affiliation_strings': ['Haematology unit, Ospedale San Gerardo, Monza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Haematology unit, Ospedale San Gerardo, Monza, Italy', 'institution_ids': ['https://openalex.org/I4210110840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026242819', 'display_name': 'Valerio Zoli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153088', 'display_name': 'Carlo Forlanini Hospital', 'ror': 'https://ror.org/04z5vy146', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153088']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Valerio Zoli', 'raw_affiliation_strings': ['Haematology unit, AO San Camillo Forlanini, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Haematology unit, AO San Camillo Forlanini, Rome, Italy', 'institution_ids': ['https://openalex.org/I4210153088']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012233596', 'display_name': 'Paola Anticoli‐Borza', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799358833', 'display_name': 'Azienda Ospedaliera San Giovanni Addolorata', 'ror': 'https://ror.org/04pr9pz75', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799358833']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Paola Anticoli‐Borza', 'raw_affiliation_strings': ['Haematology unit, Ospedale San Giovanni Addolorata, Rome, Italy'], 'affiliations': [{'raw_affiliation_string': 'Haematology unit, Ospedale San Giovanni Addolorata, Rome, Italy', 'institution_ids': ['https://openalex.org/I2799358833']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085955672', 'display_name': 'Annalisa Arcari', 'orcid': 'https://orcid.org/0000-0001-5337-5947'}, 'institutions': [{'id': 'https://openalex.org/I4210103438', 'display_name': 'Azienda Unità Sanitaria Locale Piacenza', 'ror': 'https://ror.org/01j1w4v71', 'country_code': 'IT', 'type': 'government', 'lineage': ['https://openalex.org/I4210103438']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Annalisa Arcari', 'raw_affiliation_strings': ['Haematology unit, Azienda AUSL, Piacenza, Italy'], 'affiliations': [{'raw_affiliation_string': 'Haematology unit, Azienda AUSL, Piacenza, Italy', 'institution_ids': ['https://openalex.org/I4210103438']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062082063', 'display_name': 'Virginia Naso', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210125574', 'display_name': "Azienda Ospedaliera Sant'Andrea", 'ror': 'https://ror.org/032298f51', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210125574']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Virginia Naso', 'raw_affiliation_strings': ["Haematology unit, AOU Sant'Andrea, Rome, Italy"], 'affiliations': [{'raw_affiliation_string': "Haematology unit, AOU Sant'Andrea, Rome, Italy", 'institution_ids': ['https://openalex.org/I4210125574']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057981061', 'display_name': 'Francesca Di Landro', 'orcid': 'https://orcid.org/0000-0003-1824-3038'}, 'institutions': [{'id': 'https://openalex.org/I4210125574', 'display_name': "Azienda Ospedaliera Sant'Andrea", 'ror': 'https://ror.org/032298f51', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210125574']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesca di Landro', 'raw_affiliation_strings': ["Haematology unit, AOU Sant'Andrea, Rome, Italy"], 'affiliations': [{'raw_affiliation_string': "Haematology unit, AOU Sant'Andrea, Rome, Italy", 'institution_ids': ['https://openalex.org/I4210125574']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071741417', 'display_name': 'Francesca Fabbri', 'orcid': 'https://orcid.org/0000-0003-4923-9875'}, 'institutions': [{'id': 'https://openalex.org/I4210097834', 'display_name': 'Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori', 'ror': 'https://ror.org/013wkc921', 'country_code': 'IT', 'type': 'facility', 'lineage': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}, {'id': 'https://openalex.org/I4210153126', 'display_name': 'Istituti di Ricovero e Cura a Carattere Scientifico', 'ror': 'https://ror.org/04tfzc498', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesca Fabbri', 'raw_affiliation_strings': ['Haematology unit IRCCS – Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Meldola Italy'], 'affiliations': [{'raw_affiliation_string': 'Haematology unit IRCCS – Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori Meldola Italy', 'institution_ids': ['https://openalex.org/I4210097834', 'https://openalex.org/I4210153126']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000262370', 'display_name': 'Agostino Tafuri', 'orcid': 'https://orcid.org/0000-0001-7911-9263'}, 'institutions': [{'id': 'https://openalex.org/I861853513', 'display_name': 'Sapienza University of Rome', 'ror': 'https://ror.org/02be6w209', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I861853513']}, {'id': 'https://openalex.org/I4210125574', 'display_name': "Azienda Ospedaliera Sant'Andrea", 'ror': 'https://ror.org/032298f51', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210125574']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Agostino Tafuri', 'raw_affiliation_strings': ['Department of Clinic and Molecular Medicine, Sapienza University, Roma, Italy', "Haematology unit, AOU Sant'Andrea, Rome, Italy"], 'affiliations': [{'raw_affiliation_string': 'Department of Clinic and Molecular Medicine, Sapienza University, Roma, Italy', 'institution_ids': ['https://openalex.org/I861853513']}, {'raw_affiliation_string': "Haematology unit, AOU Sant'Andrea, Rome, Italy", 'institution_ids': ['https://openalex.org/I4210125574']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025020524', 'display_name': 'Guido Bocci', 'orcid': 'https://orcid.org/0000-0001-7120-9141'}, 'institutions': [{'id': 'https://openalex.org/I108290504', 'display_name': 'University of Pisa', 'ror': 'https://ror.org/03ad39j10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I108290504']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Guido Bocci', 'raw_affiliation_strings': ['Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy', 'institution_ids': ['https://openalex.org/I108290504']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066201212', 'display_name': 'Francesco Merli', 'orcid': 'https://orcid.org/0000-0002-0979-7883'}, 'institutions': [{'id': 'https://openalex.org/I4210123105', 'display_name': 'Azienda Ospedaliera S.Maria', 'ror': 'https://ror.org/02t96cy48', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123105']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Merli', 'raw_affiliation_strings': ['Haematology unit, Azienda Ospedaliera Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy'], 'affiliations': [{'raw_affiliation_string': 'Haematology unit, Azienda Ospedaliera Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy', 'institution_ids': ['https://openalex.org/I4210123105']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 10, 'corresponding_author_ids': ['https://openalex.org/A5070384560'], 'corresponding_institution_ids': ['https://openalex.org/I4210125574'], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.864747, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '183', 'issue': '5', 'first_page': '819', 'last_page': '822'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10185', 'display_name': 'Lymphoma Diagnosis and Treatment', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10185', 'display_name': 'Lymphoma Diagnosis and Treatment', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12212', 'display_name': 'CNS Lymphoma Diagnosis and Treatment', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10950', 'display_name': 'Acute Lymphoblastic Leukemia research', 'score': 0.9869, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/aggressive-lymphoma', 'display_name': 'Aggressive lymphoma', 'score': 0.47666317}], 'concepts': [{'id': 'https://openalex.org/C68387754', 'wikidata': 'https://www.wikidata.org/wiki/Q7271585', 'display_name': 'Schedule', 'level': 2, 'score': 0.61051196}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.58496267}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.53744894}, {'id': 'https://openalex.org/C2781214270', 'wikidata': 'https://www.wikidata.org/wiki/Q4692282', 'display_name': 'Aggressive lymphoma', 'level': 4, 'score': 0.47666317}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42999122}, {'id': 'https://openalex.org/C2779338263', 'wikidata': 'https://www.wikidata.org/wiki/Q208414', 'display_name': 'Lymphoma', 'level': 2, 'score': 0.42260772}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.41239288}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.18133625}, {'id': 'https://openalex.org/C2780653079', 'wikidata': 'https://www.wikidata.org/wiki/Q412323', 'display_name': 'Rituximab', 'level': 3, 'score': 0.13791698}, {'id': 'https://openalex.org/C111919701', 'wikidata': 'https://www.wikidata.org/wiki/Q9135', 'display_name': 'Operating system', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D016403', 'descriptor_name': 'Lymphoma, Large B-Cell, Diffuse', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D016399', 'descriptor_name': 'Lymphoma, T-Cell', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D059250', 'descriptor_name': 'Administration, Metronomic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003520', 'descriptor_name': 'Cyclophosphamide', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D003520', 'descriptor_name': 'Cyclophosphamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004334', 'descriptor_name': 'Drug Administration Schedule', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005047', 'descriptor_name': 'Etoposide', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D005047', 'descriptor_name': 'Etoposide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016403', 'descriptor_name': 'Lymphoma, Large B-Cell, Diffuse', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016399', 'descriptor_name': 'Lymphoma, T-Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009930', 'descriptor_name': 'Organic Chemicals', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D009930', 'descriptor_name': 'Organic Chemicals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077235', 'descriptor_name': 'Vinorelbine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077235', 'descriptor_name': 'Vinorelbine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/bjh.15039', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15039', 'source': {'id': 'https://openalex.org/S153015021', 'display_name': 'British Journal of Haematology', 'issn_l': '0007-1048', 'issn': ['0007-1048', '1365-2141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/29193017', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/bjh.15039', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15039', 'source': {'id': 'https://openalex.org/S153015021', 'display_name': 'British Journal of Haematology', 'issn_l': '0007-1048', 'issn': ['0007-1048', '1365-2141'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'score': 0.56, 'id': 'https://metadata.un.org/sdg/2'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 10, 'referenced_works': ['https://openalex.org/W2015017263', 'https://openalex.org/W2090806526', 'https://openalex.org/W2129827192', 'https://openalex.org/W2154736427', 'https://openalex.org/W2208577333', 'https://openalex.org/W2396078839', 'https://openalex.org/W2460811036', 'https://openalex.org/W2465096688', 'https://openalex.org/W2514439063', 'https://openalex.org/W2605009867'], 'related_works': ['https://openalex.org/W3198975203', 'https://openalex.org/W3032505482', 'https://openalex.org/W2952959794', 'https://openalex.org/W2168656234', 'https://openalex.org/W2146915910', 'https://openalex.org/W2101782429', 'https://openalex.org/W2074104220', 'https://openalex.org/W1972476775', 'https://openalex.org/W1958784597', 'https://openalex.org/W1844082354'], 'abstract_inverted_index': {'Elderly': [0], 'patients': [1, 125, 145, 190, 205, 255, 280, 345, 355, 383, 432, 448, 476, 570, 646, 665, 683, 693, 933, 1160, 1173], 'with': [2, 46, 146, 165, 178, 256, 581, 585, 694, 877, 963, 1021, 1162, 1174], 'aggressive': [3, 147, 726, 762], 'lymphomas': [4, 61, 151, 702, 727, 763, 1031], 'have': [5, 755, 1140], 'less': [6, 1048], 'benefit': [7], 'than': [8, 662, 1232], 'younger': [9], 'subjects': [10, 653, 821], 'from': [11, 368], 'standard': [12, 964], 'maximum-tolerated-dose': [13], 'chemotherapies': [14], '(Chihara': [15], 'et': [16, 63, 67, 71, 159, 207, 765, 769, 773, 777, 791, 827, 832, 857, 861, 865, 969, 977, 1033], 'al,': [17, 64, 68, 72, 160, 208, 766, 770, 774, 778, 792, 828, 858, 862, 866, 970, 978, 1034], '2016).': [18, 54, 779, 912], 'Metronomic': [19], 'chemotherapy': [20], '(MC)': [21], 'has': [22], 'been': [23], 'recently': [24], 'defined': [25], 'as': [26], 'the': [27, 214, 218, 351, 377, 417, 425, 438, 443, 474, 484, 517, 558, 567, 624, 715, 747, 757, 795, 816, 819, 851, 900, 904, 921, 930, 947, 981, 1014, 1043, 1060, 1066, 1073, 1076, 1086, 1098, 1106, 1122, 1127, 1133, 1137, 1217, 1227, 1239, 1243], 'frequent,': [28], 'regular': [29], 'administration': [30, 870], 'of': [31, 43, 108, 121, 220, 241, 260, 343, 379, 440, 486, 490, 519, 620, 651, 759, 812, 818, 844, 871, 906, 932, 956, 984, 1016, 1136, 1144, 1158, 1183, 1191, 1200, 1221], 'chemotherapeutic': [32], 'drug': [33, 907], 'doses': [34, 123], 'that': [35, 650, 714, 915, 929, 955], 'maintain': [36, 892], 'a': [37, 47, 78, 102, 119, 166, 257, 635, 809, 841, 893, 1008], 'low,': [38], 'prolonged': [39], 'and': [40, 101, 135, 149, 223, 275, 286, 336, 359, 397, 412, 466, 499, 506, 521, 551, 553, 557, 583, 594, 606, 632, 638, 686, 691, 724, 728, 743, 890, 920, 939, 1018, 1050, 1058, 1064, 1071, 1084, 1096, 1104, 1120, 1154, 1168], 'active': [41, 705, 720], 'range': [42], 'plasma': [44], 'concentrations': [45], 'favourable': [48], 'toxicity': [49, 740], 'profile': [50], '(Bocci': [51, 909], '&': [52, 910], 'Kerbel,': [53, 911], 'As': [55, 1013], 'MC': [56, 81, 760, 788, 837, 852], 'is': [57, 522, 560, 923, 988, 1004, 1213], 'poorly': [58], 'studied': [59], 'in': [60, 74, 92, 188, 430, 445, 501, 523, 561, 623, 628, 644, 660, 663, 671, 721, 733, 761, 808, 840, 850, 884, 965, 1007, 1030, 1172, 1193, 1202], '(Buckstein': [62, 856], '2006;': [65, 771, 859], 'Coleman': [66, 772, 860], '2008;': [69, 775, 863], 'Zeng': [70, 776, 831, 864], '2016),': [73, 867], '2011,': [75], 'we': [76, 1036], 'formulated': [77], 'new': [79, 973], 'oral': [80, 625], 'regimen': [82], 'termed': [83], 'DEVEC': [84, 97, 194, 402, 410, 542, 626, 703, 717, 874, 1006, 1148], '(Deltacortene®,': [85], 'etoposide,': [86, 803], 'vinorelbine,': [87], 'cyclophosphamide),': [88], 'which': [89], 'was': [90, 115, 201, 211, 371, 433, 449, 598, 630, 647, 657, 704, 719, 741, 785, 806, 875], 'adopted': [91], 'six': [93, 109, 225, 569], 'Italian': [94, 1001], 'clinical': [95], 'centres.': [96], 'foresees': [98], 'an': [99, 786, 823, 990], 'induction': [100, 221, 352, 441, 487, 520, 637, 1195], 'deescalated': [103], 'maintenance': [104, 577, 639, 1203], 'phase': [105, 222, 442, 488, 1204], 'both': [106, 722], 'consisting': [107], 'cycles.': [110], 'In': [111, 700, 794, 980], 'CD20+': [112], 'lymphomas,': [113, 846], 'rituximab': [114, 708], 'administered': [116], 'weekly': [117], 'for': [118, 156, 203, 231, 388, 392, 405, 419, 634, 675, 692, 993, 996, 1045, 1216, 1242], 'maximum': [120], 'four': [122, 347, 574], '(excluding': [124], 'who': [126, 152, 477, 538, 571], 'relapsed': [127, 274, 529, 548], '<6': [128], 'months': [129, 226, 373, 408, 532], 'after': [130, 213, 401, 409, 510, 533], 'rituximab).': [131], 'A': [132], 'post': [133], 'maintenance-phase': [134], 'dose': [136], 'modifications': [137], 'were': [138, 153, 162, 183, 186, 229, 244, 264, 267, 277, 281, 315, 497, 539, 673, 746, 934], 'also': [139, 732], 'suggested': [140, 202], '(Tables': [141], 'SI,SII,': [142], 'SIII).': [143], 'Consecutive': [144], 'B-': [148], 'T-cell': [150], 'considered': [154], 'unsuitable': [155], 'standard-chemotherapies': [157], '(Merli': [158, 206], '2014)': [161], 'enrolled.': [163], 'Subjects': [164], 'malabsorption': [167], 'syndrome': [168], 'or': [169, 177, 319, 492, 678, 1178, 1219], 'swallow': [170], 'dysfunctions,': [171], 'infected': [172], 'by': [173, 457, 1226], 'human': [174], 'immunodeficiency': [175], 'virus': [176], 'central': [179], 'nervous': [180], 'system': [181], 'involvement,': [182], 'excluded.': [184], 'Caregivers': [185], 'required': [187], 'elderly/frail': [189], 'to': [191, 269, 649, 838, 886, 891, 896, 954, 1026, 1238], 'ensure': [192], 'proper': [193], 'administration.': [195], 'Pre-treatment': [196], 'comprehensive': [197], 'geriatric': [198], 'assessment': [199], '(CGA)': [200], 'elderly': [204, 735, 997], '2014).': [209], 'Restaging': [210], 'scheduled': [212], 'second': [215], 'induction-cycle,': [216], 'at': [217, 237, 395, 483, 503, 516, 525, 530, 541, 549, 563, 950], 'end': [219, 439, 485, 518], 'every': [224], 'thereafter.': [227], 'Patients': [228, 1207], 'eligible': [230], 'analysis': [232], 'if': [233], 'they': [234], 'had': [235, 273, 356, 362, 384, 822], 'completed': [236, 544], 'least': [238, 951], 'two': [239, 360, 423, 467], 'cycles': [240, 883, 1196], 'DEVEC.': [242, 535, 1163], 'Data': [243], 'retrieved': [245], 'on': [246, 799, 959], '30': [247, 301], 'April': [248], '2017': [249], '(EC': [250], 'approval': [251], 'no.': [252], '4640).': [253], 'Forty-five': [254], 'median': [258, 366, 590], 'age': [259], '80': [261], 'years': [262, 688, 936], '(56–93)': [263], 'evaluable:': [265], '18(40%)': [266], 'refractory': [268, 664], 'previous': [270, 957], 'treatments,': [271], '17(37·8%)': [272], '10(22·2%)': [276], 'treatment-naïve.': [278], 'Twenty-five': [279], 'diffuse-large-B-cell-lymphoma': [282], '(DLBCL),': [283], '9': [284], 'transformed-DLBCL': [285, 679], '11': [287, 297, 607], 'peripheral-T-cell-lymphoma': [288], '(PTCL).': [289], 'CGA': [290], 'scores': [291], 'were:': [292], '1': [293], '=': [294, 298, 302, 324, 329, 334, 340, 604, 610], 'Fit': [295], '(2·3%),': [296], 'Unfit': [299], '(26·2%),': [300], 'Frail': [303, 645], '(71·4%)': [304], '(Table': [305, 471], '1).': [306, 341, 436, 472], 'Ten': [307], '(22·2%)': [308], 'extra-haematological': [309, 750], 'adverse': [310], 'events': [311], '≥grade': [312], '3': [313, 396], '(G3)': [314], 'reported:': [316], 'neutropenic': [317], 'fever': [318], 'infection': [320], 'requiring': [321], 'hospitalization': [322], '(n': [323, 328, 333, 339], '7),': [325], 'pulmonary': [326], 'embolism': [327], '1),': [330], 'heart': [331, 420], 'failure': [332, 338, 394], '1)': [335], 'multi-organ': [337, 393, 586], 'One': [342], 'these': [344, 926, 941], 'died,': [346], 'discontinued': [348, 481], 'treatment.': [349], 'During': [350], 'phase,': [353], '27(60%)': [354], '≥G3': [357, 363], 'neutropenia': [358, 1184, 1192, 1201], '(4·4%)': [361], 'anaemia.': [364], 'The': [365, 588, 616, 1000, 1211], 'follow-up': [367], 'treatment': [369, 482], 'start': [370], '18': [372], '(range': [374], '6-67).': [375], 'At': [376, 437], 'time': [378], 'analysis,': [380], '27': [381], '(60%)': [382], 'died:': [385], '23/27': [386], '(85·2%)': [387], 'lymphoma': [389, 813], 'progression,': [390], '2/27(7·4%)': [391], '4': [398], 'months,': [399, 508, 555, 612], 'respectively,': [400, 509, 556], 'discontinuation,': [403], '1/27(3·7%)': [404, 413], 'pneumonia': [406], '2': [407], 'discontinuation': [411], 'cardiopath': [414], 'patient,': [415], 'during': [416, 899, 1185], 'induction-phase': [418], 'failure.': [421, 587], 'After': [422], 'cycles,': [424, 578], 'overall': [426, 591], 'response': [427], 'rate': [428], '(ORR)': [429], '45': [431, 1159], '73·3%': [434], '(Fig': [435, 614, 654, 666, 680, 689, 698, 709], 'ORR': [444, 948], '43': [446], 'evaluable': [447], '67·4%:': [450], '15(34·9%)': [451], 'achieved': [452, 478, 572], 'complete': [453], 'remission': [454, 464], '(CR,': [455], 'assessed': [456], 'positron': [458], 'emission': [459], 'tomography': [460], 'scan),': [461], '14(32·4%)': [462], 'partial': [463], '(PR)': [465], '(4·6%)': [468], 'stable': [469], 'disease': [470], 'Among': [473], '15': [475], 'CR,': [479, 573], 'five': [480], 'because': [489], 'personal': [491], 'medical': [493], 'choice': [494], '(Table-SIV):': [495], '3/5': [496], 'treatment-naïve': [498], 'are': [500, 575, 918], 'CR': [502, 524, 562], '+11,': [504], '+10': [505], '+5': [507], 'stopping': [511, 534], 'DEVEC;': [512], '1/5': [513, 528], 'started': [514], 'lenalidomide-maintenance': [515], '+24': [526], 'months;': [527], '+8': [531], 'Four': [536], 'patients,': [537], 'relapsed/refractory': [540, 725, 938, 960], 'initiation,': [543], '24': [545], 'cycles:': [546], 'three': [547], '+26': [550], '+29': [552], '+32': [554], 'latter': [559], '+48': [564], 'months.': [565], 'Of': [566], 'remaining': [568], 'continuing': [576], 'one': [579, 584], 'died': [580], 'progression': [582, 1155, 1169], 'estimated': [589, 617], 'survival': [592, 596, 1153, 1157, 1167, 1171], '(OS)': [593], 'progression-free': [595], '(PFS)': [597], '13': [599], '(95%': [600, 608], 'confidence': [601], 'interval': [602], '[CI]': [603], '8·236–17·764)': [605], 'CI': [609], '5·997–16·003)': [611], 'respectively': [613], 'S1A).': [615], 'direct': [618], 'cost': [619], 'drugs': [621, 898, 975], 'included': [622], 'schedule': [627, 718, 789], '2016': [629], '€930': [631], '€817': [633], 'single': [636], 'cycle,': [640, 901], 'respectively.': [641], 'Notably,': [642], 'OS': [643], 'comparable': [648], 'Fit/Unfit': [652], 'S2B).': [655], 'Outcome': [656], 'significantly': [658], 'better': [659, 848], 'naïve/relapsed': [661], 'S2C).': [667], 'No': [668], 'significant': [669], 'differences': [670], 'PFS': [672, 849], 'evident': [674], 'PTCL,': [676], 'DLBCL': [677], 'S2D),': [681], 'between': [682], 'aged': [684], '≤80': [685], '>80': [687], 'S2E)': [690], 'performance': [695, 1175], 'status': [696, 1176], '≥2': [697], 'S3).': [699], 'B-cell': [701], 'even': [706], 'without': [707], 'S2F).': [710], 'This': [711], 'study': [712, 797], 'shows': [713], 'all-oral': [716], 'naïve': [723], 'quite': [729], 'well': [730], 'tolerated': [731], 'very': [734], 'non-FIT': [736, 998], 'patients.': [737, 814, 999], 'Overall,': [738], 'haematological': [739, 888], 'mild': [742], 'manageable.': [744], 'Infections': [745], 'most': [748], 'frequent': [749], 'toxicities.': [751], 'Very': [752], 'few': [753], 'studies': [754, 958], 'investigated': [756, 807], 'activity': [758], '(Mandelli': [764, 790], '1980;': [767], 'Buckstein': [768], 'PROVECIP': [780], '(procarbazine,': [781], 'vinblastine,': [782], 'cyclophosphamide,': [783], 'prednisone)': [784], 'ante-litteram': [787], '1980)': [793], 'first': [796, 1186], 'reporting': [798, 847], 'MC,': [800, 1017], 'PEP-C': [801], '(prednisone,': [802], 'procarbazine,': [804], 'cyclophosphamide)': [805], 'heterogeneous': [810], 'series': [811, 843, 922, 961], 'However,': [815], 'majority': [817, 931], 'enrolled': [820], 'indolent': [824], 'subtype': [825], '(Coleman': [826], '2008).': [829], 'Recently,': [830], 'al': [833], '(2016),': [834], 'prospectively': [835], 'compared': [836], 'standard-chemotherapy': [839], 'small': [842], 'refractory/relapsed': [845], 'arm.': [853], 'These': [854], 'schedules': [855, 967], 'foresaw': [868], 'continuous': [869, 894], 'MC.': [872], 'Conversely,': [873], 'devised': [876], 'short': [878], 'chemo-free': [879], 'breaks': [880], 'within': [881], 'subsequent': [882, 1194], 'order': [885], 'allow': [887], 'recovery': [889], 'exposure': [895], 'different': [897], 'thus': [902], 'reducing': [903], 'possibility': [905], 'resistance': [908], 'We': [913], 'acknowledge': [914], 'our': [916], 'data': [917, 1063, 1083], 'retrospective': [919], 'heterogeneous.': [924], 'Despite': [925], 'limitations,': [927], 'given': [928], '>75': [935], 'old,': [937], 'frail,': [940], 'preliminary': [942], 'results': [943], 'look': [944], 'promising.': [945], 'Furthermore,': [946], 'seems': [949], 'not': [952, 1214], 'inferior': [953], 'treated': [962, 1161], 'fusional': [966], '(Arcari': [968], '2016)': [971], 'and/or': [972], 'expensive': [974], '(Czuczman': [976], '2017).': [979], 'exciting': [982], 'era': [983], 'targeted': [985], 'therapies,': [986], 'there': [987], 'still': [989, 1024], 'unmet': [991], 'need': [992], 'suitable': [994], 'treatments': [995], 'Lymphoma': [1002], 'Foundation': [1003], 'assessing': [1005], 'prospective': [1009], 'trial': [1010], '(EUDRACT': [1011], '2016-003703-62).': [1012], 'potential': [1015], 'its': [1019], 'combination': [1020], 'biological': [1022], 'drugs,': [1023], 'awaits': [1025], 'be': [1027, 1236], 'fully': [1028], 'exploited': [1029], '(Pasquier': [1032], '2010)': [1035], 'hope': [1037], 'this': [1038], 'report': [1039], 'will': [1040], 'further': [1041], 'stimulate': [1042], 'search': [1044], 'more': [1046], 'active,': [1047], 'toxic': [1049], 'financially': [1051], 'sustainable': [1052], 'treatments.': [1053], 'M': [1054], 'Christina': [1055], 'Cox:': [1056], 'designed': [1057, 1070, 1094], 'performed': [1059, 1072, 1080, 1102], 'research,': [1061, 1074, 1081], 'analysed': [1062, 1082, 1118], 'wrote': [1065, 1075, 1085, 1097, 1105, 1121, 1126], 'paper.': [1067, 1077, 1087, 1099, 1107, 1123, 1128, 1134], 'Gerardo': [1068], 'Musuraca:': [1069], 'Roberta': [1078], 'Battistini:': [1079], 'Annalisa': [1088], 'Arcari,': [1089], 'Guido': [1090], 'Bocci,': [1091], 'Francesco': [1092], 'Merli:': [1093], 'research': [1095, 1103], 'Valerio': [1100], 'Zoli:': [1101], 'Ivana': [1108], 'Casaroli,': [1109], 'Paola': [1110], 'Anticoli': [1111], 'Borza,': [1112], 'Francesca': [1113, 1116], 'di': [1114], 'Landro,': [1115], 'Fabbri:': [1117], 'data,': [1119], 'Virginia': [1124], 'Naso:': [1125], 'Agostino': [1129], 'Tafuri:': [1130], 'critically': [1131], 'revised': [1132], 'None': [1135], 'above': [1138], 'Authors': [1139], 'any': [1141, 1222], 'relevant': [1142], 'conflict': [1143], 'interest.': [1145], 'Fig': [1146, 1150], 'S1.': [1147], 'schedule.': [1149], 'S2.': [1151], 'Overall': [1152, 1166], 'free': [1156, 1170], 'Fig.': [1164], 'S3.': [1165], '2<': [1177], '≥2.': [1179], 'Table': [1180, 1188, 1197, 1205], 'SI.': [1181], 'Management': [1182, 1190, 1199], 'cycle*': [1187], 'SII.': [1189], 'SIII.': [1198], 'SIV.': [1206], 'disposition': [1208], 'Please': [1209], 'note:': [1210], 'publisher': [1212], 'responsible': [1215], 'content': [1218], 'functionality': [1220], 'supporting': [1223], 'information': [1224], 'supplied': [1225], 'authors.': [1228], 'Any': [1229], 'queries': [1230], '(other': [1231], 'missing': [1233], 'content)': [1234], 'should': [1235], 'directed': [1237], 'corresponding': [1240], 'author': [1241], 'article.': [1244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2769496568', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-15T08:10:50.067963', 'created_date': '2017-12-04'}