Title: Sudden cardiac arrest during marathon training in a young adult with short QT syndrome
Abstract: A variety of mostly hereditary, structural, or electrical cardiac disorders are associated with sudden cardiac death in young athletes and amateur sport participants [1]. Short QT syndrome (SQTS), a condition first described in 2000 [2], is a rare cardiac channelopathy characterized by abnormally short cardiac repolarization. Data from only a small group of patients identified worldwide are available. The annual risk of cardiac arrest among patients in the largest SQTS cohort to date was approximately 1%, and most of the cardiac arrests reported in the cohort occurred during rest or sleep [3]. Risk stratification and management of SQTS remain uncertain, however, as data on the natural history of SQTS are lacking. Here we report a patient with SQTS who suffered a sudden cardiac arrest when marathon training.